Preferential induction of TH1 responses by functionally mature hepatic (CD8α- and CD8α+) dendritic cells: Association with conversion from liver transplant tolerance to acute rejection

Transplantation

Volumn 69, Issue 12, 2000, Pages 2647-2657

  Morelli, Adrian E ^a   O'Connell, Peta J ^a   Khanna, Ajai ^a   Logar, Alison J ^a   Lu, Lina ^a   Thomson, Angus W ^a,b  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; GRAFT SURVIVAL; HISTOCOMPATIBILITY; IMMUNE RESPONSE; IN VIVO STUDY; LIVER TRANSPLANTATION; MIXED LYMPHOCYTE REACTION; MORPHOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE; TH1 CELL; TH2 CELL;

EID: 0034720788     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200006270-00027     Document Type: Article

References (45)

1. Steinman RM. The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 1991; 9: 271.
2. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998; 392: 245.
3. Lotze MT, Thomson AW, eds. Dendritic cells: biology and clinical applications. San Diego: Academic Press, 1999.
4. Bell D, Young JW, Banchereau J. Dendritic cells. Adv Immunol 1999; 72: 255.
5. Cella M, Sallusto F, Lanzavecchia A. Origin, maturation and antigen presenting function of dendritic cells. Curr Opin Immunol 1997; 9: 10.
6. -) induce alloAg-specific hyporesponsiveness in murine T lymphocytes. Transplantation 1995; 60: 1539.
7. -) prolong cardiac allograft survival in non-immunosuppressed recipients. Transplantation 1996; 62: 659.
8. Hayamizu K, Huie P, Sibley K, Strober S. Monocyte-derived dendritic cell precursors facilitate tolerance to heart allografts after total lymphoid irradiation. Transplantation 1998; 66: 1285.
9. Thomson AW, Lu L, Murase N, Demetris AJ, Rao AS, Starzl TE. Microchimerism, dendritic cell progenitors and transplantation tolerance. Stem Cells 1995; 13: 622.
10. Larsen CP, Steinman RM, Witmer-Pack M, et al. Migration and maturation of Langerhans cells in skin transplants and explants. J Exp Med 1990; 172: 1483.
11. Larsen CP, Morris PJ, Austyn JM. Migration of dendritic leukocytes from cardiac allografts into host spleens: a novel route for initiation of rejection. J Exp Med 1990; 171: 307.
12. Lechler RI, Batchelor JR. Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells. J Exp Med 1982; 155: 31.
13. Austyn JM. The initiation of immune responses and allograft rejection. In: Rose ML, Yacoub MH, eds. Immunology of heart and lung transplantation. Boston: Little Brown & Co., 1993: 22.
14. Qian S, Demetris AJ, Murase N, et al. Murine liver allograft transplantation: tolerance and donor cell chimerism. Hepatology 1994; 19: 916.
15. Qian S, Thai NL, Lu L, Fung JJ, Thomson AW. Liver transplant tolerance: mechanistic insights from animal models, with particular reference to the mouse. Transplant Rev 1997; 11: 151.
16. Kamada N, Wright DG. Antigen-specific immunosuppression induced by liver transplantation in the rat. Transplantation 1984; 38: 217.
17. Calne RY, Sells RA, Pena JR, et al. Induction of immunological tolerance by porcine liver allografts. Nature 1969; 223: 472.
18. Starzl TE, Demetris AJ, Murase N, et al. Cell migration, chimerism, and graft acceptance. Lancet 1992; 339: 1579.
19. Starzl TE, Demetris AJ, Trucco M, et al. Cell migration and chimerism after whole organ transplantation: the basis of graft acceptance. Hepatology 1993; 17: 1127.
20. Starzl TE, Demetris AJ, Murase N, Trucco M, Thomson AW, Rao AS. The lost chord: microchimerism and allograft survival. Immunol Today 1996; 17: 577.
21. Thomson AW, Lu L. Are dendritic cells the key to liver transplant tolerance? Immunol Today 1999; 20: 27.
22. Lu, L, Woo J, Rao AS, et al. Propagation of dendritic cell progenitors from normal mouse liver using granulocyte/macrophage colony-stimulating factor and their maturational development in the presence of type-1 collagen. J Exp Med 1994; 179: 1823.
23. Rastellini, C, Lu L, Ricordi C, et al. Granulocyte/macrophage colony-stimulating factor-stimulated hepatic dendritic cell progenitors prolong pancreatic islet allograft survival. Transplantation 1995; 60: 1366.
24. Maraskovsky E, Brasel K, Teepe M, et al. Dramatic increase in the number of functionally mature dendritic cells in FltS ligand-treated mice: multiple dendritic cell subpopulations identified. J Exp Med 1996; 184: 1953.
25. Steptoe RJ, Fu F, Li W, et al. Augmentation of dendritic cells in murine organ donors by FItS ligand alters the balance between transplant tolerance and immunity. J Immunol 1997; 159: 5483.
26. + lymphoid-related dendritic cells. J Immunol 2000: in press.
27. Khanna AJ, Morelli AE, Zhong C, Takayama T, Lu L, Thomson AW. Effects of liver-derived dendritic cell progenitors on Th1-and Th2-like cytokine responses in vitro and in vivo. J Immunol 2000; 164: 1346.
28. Austyn JM, Hankins DF, Larsen CP, Morris PJ, Rao AS, Roake JA. Isolation and characterization of dendritic cells from mouse heart and kidney. J Immunol 1994; 152: 2401.
29. Stumbles PA, Thomas JA, Pimm CL, et al. Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity. J Exp Med 1998; 188: 2019.
30. Thomson AW, Lu L. Dendritic cells as regulators of immune reactivity: implications for transplantation. Transplantation 1999; 68: 1.
31. Steptoe RJ, Patel RK, Subbotin VM, Thomson AW. Comparative analysis of dendritic cell density and total number in commonly transplanted organs: morphometric estimation in normal mice. Transplant Immunol 2000; 8: 49.
32. Woo J, Lu L, Rao AS, Li Y, Subbotin V, Starzl TE, Thomson AW. Isolation, phenotype and allostimulatory activity of mouse liver dendritic cells. Transplantation 1994; 58: 484.
33. Thomson AW, Lu L, Subbotin VM, et al. In vitro propagation and homing of liver-derived dendritic cell progenitors to lymphoid tissues of allogeneic recipients. Transplantation 1995; 59: 544.
34. Shurin MR, Pandharipande PP, Zorina TD, et al. Flt3 Ligand induces the generation of functionally active dendritic cells in mice. Cell Immunol 1997; 179: 174.
35. Romani N, Lenz A, Glassei H, et al. Cultured human Langerhans cells resemble lymphoid dendritic cells in phenotype and function. J Invest Dermatol 1989; 93: 600.
36. Steptoe RJ, Li W, Fu F, O'Connell PJ, Thomson AW. Trafficking of stimulatory APC from livers of FltSL-treated donors is associated with a switch from transplant tolerance to rejection. Transplant Immunol 1999; 7: 51.
37. Qian S, Lu L, Fu F, et al. Donor pretreatment with Flt-3 ligand augments antidonor cytotoxic T lymphocyte, natural killer, and lymphokine-activated killer cell activities within liver allografts and alters the pattern of intragraft apoptotic activity. Transplantation 1998; 65: 1590.
38. Pulendran B, Smith JL, Caspary G, et al. Distinct dendritic cell subsets differentially regulate the class of immune response in vivo. Proc Natl Acad Sci USA 1999; 96: 1036.
39. - subclasses of dendritic cells direct the development of distinct T helper cells in vivo. J Exp Med 1999; 189: 587.
40. Rissoan MC, Soumelis V, Kadowaki N, et al. Reciprocal control of T helper cell and dendritic cell differentiation. Science 1999; 283: 1183.
41. Kapsenberg ML, Hilkens CM, Wierenga EA, Kalinski P. The paradigm of type 1 and type 2 antigen-presenting sells. Implications for atopic allergy. Clin Exp Allergy 1999; 2: 33.
42. Bishop GA, Sun J, DeCruz DJ, et al. Tolerance to rat liver allografts. III. Donor cell migration and tolerance-associated cytokine production in peripheral lymphoid tissues. J Immunol 1996; 156: 4925.
43. Rokahr KL, Sharland AF, Sun J, et al. Paradoxical early immune activation during acceptance of liver allografts compared with rejection of skin grafts in a rat model of transplantation. Immunology 1998; 95: 257.
44. Bishop GA, Sun J, Sheil, AGR, McCaughan GW. High-dose/ activation-associated tolerance: a mechanism for allograft tolerance. Transplantation 1997; 64: 1377.
45. Demetris AJ, Murase N, Fujisaki S, et al. Hematolymphoid cell trafficking, microchimerism, and GVH reactions after liver, bone marrow, and heart transplantation. Transplant Proc 1993; 25: 3337.