Virus-specific CD8+ T lymphocytes downregulate T helper cell type 2 cytokine secretion and pulmonary eosinophilia during experimental murine respiratory syncytial virus infection

Journal of Experimental Medicine

Volumn 186, Issue 3, 1997, Pages 421-432

  Srikiatkhachorn, Anon ^a,b,c   Braciale, Thomas J ^a,b,c  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE;

ANIMAL CELL; ANTIGEN RECOGNITION; ARTICLE; CELL DIFFERENTIATION; CELL TYPE; EFFECTOR CELL; HELPER CELL; IMMUNE RESPONSE; LOEFFLER PNEUMONIA; LUNG INFILTRATE; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TISSUE INJURY; VIRUS EXPRESSION; VIRUS INFECTION;

AMINO ACID SEQUENCE; ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; CYTOTOXICITY, IMMUNOLOGIC; DOWN-REGULATION; FEMALE; HN PROTEIN; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; PULMONARY EOSINOPHILIA; RECOMBINANT FUSION PROTEINS; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUSES; SPLEEN; TH2 CELLS; VIRAL ENVELOPE PROTEINS; VIRAL MATRIX PROTEINS; VIRAL PROTEINS;

EID: 0030795092     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.186.3.421     Document Type: Article

References (64)

1. Doherty, P.C., W. Allan, M. Eichelberger, and S.R. Carding. 1992. Roles of α/β and γ/δ T cell subsets in viral immunity. Annu. Rev. Immunol. 10:123-151.
2. Lukacher, A.E., V.L. Braciale, and T.J. Braciale. 1984. In vivo effector function of influenza virus-specific cytotoxic T lymphocyte clones is highly specific. J. Exp. Med. 160:814-826.
3. Braciale, T.J., and V.L. Braciale. 1992. Viral antigen presentation and MHC assembly. Semin. Immunol. 4:81-84.
4. Braciale, T.J., and V.L. Braciale. 1991. Antigen presentation: structural themes and functional variations. Immunol. Today. 12:124-129.
5. Mosmann, T.R., H. Cherwmski, M.W. Bond, M.A. Giedlin, and R.L. Coffman. 1986. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:2348-2357.
6. Mosmann, T.R., and R.L. Coffman. 1989. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145-173.
7. + T cells. Clin. Exp. Immunol. 88:527-536.
8. Alwan, W.H., W.J. Kozlowska, and P.J. Openshaw. 1994. Distinct types of lung disease caused by functional subsets of antiviral T cells. J. Exp. Med. 179:81-89.
9. Bangham, C.R., M.J. Cannon, D.T. Karzon, and B.A. Askonas. 1985. Cytotoxic T-cell response to respiratory syncytial virus in mice. J. Virol. 56:55-59.
10. Connors, M., N.A. Giese, A.B. Kulkarni, C.Y. Firestone, H.C. Morse III, and B.R. Murphy. 1994. Enhanced pulmonary histopathology induced by respiratory syncytial virus (RSV) challenge of formalin-inactivated RSV-immunized BALB/c mice is abrogated by depletion of interleukin-4 (IL-4) and IL-10. J. Virol. 68:5321-5325.
11. Graham, B.S., G.S. Henderson, Y.W. Tang, X. Lu, K.M. Neuzil, and D.G. Colley. 1993. Priming immunization determines T helper cytokine mRNA expression patterns in lungs of mice challenged with respiratory syncytial virus. J. Immunol. 151:2032-2040.
12. Openshaw, P.J., S.L. Clarke, and F.M. Record. 1992. Pulmonary eosinophilic response to respiratory syncytial virus infection in mice sensitized to the major surface glycoprotem G. Int. Immunol. 4:493-500.
13. Alwan, W.H., F.M. Record, and P.J. Openshaw. 1993. Phenotypic and functional characterization of T cell lines specific for individual respiratory syncytial virus proteins. J. Immunol. 150:5211-5218.
14. Srikiatkhachorn, A., and T.J. Braciale. 1997. Virus-specific memory and effector T lymphocytes exhibit different cytokine responses to antigens during experimental murine respiratory syncytial virus infection. J. Virol. 71:678-685.
15. Hancock, G.E., D.J. Speelman, K. Heers, E. Bortell. J. Smith, and C. Cosco. 1996. Generation of atypical pulmonary inflammatory responses in BALB/c mice after immunization with the native attachment (G) glycoprotein of respiratory syncytial virus. J. Virol. 70:7783-7791.
16. + T cells. J. Allergy Clin. Immunol. 94: 1195-1202.
17. + T cells from T cell receptor transgenic mice. J. Exp. Med. 176:1091-1098.
18. Hsieh, C.S., A.B. Heimberger, J.S. Gold, A. O'Garra, and K.M. Murphy. 1992. Differential regulation of T helper phenotype development by interleukins 4 and 10 in an αβ T-cell-receptor transgenic system. Proc. Natl. Acad. Sci. USA. 89: 6065-6069.
19. + αβ-TCR transgenic T cells is macrophage dependent. Int. Immunol. 5:371-382.
20. Nicholas, J.A., K.L. Rubino, M.E. Levely, E.G. Adams, and P.L. Collins. 1990. Cytolytic T-lymphocyte responses to respiratory syncytial virus: effector cell phenotype and target proteins. J. Virol. 64:4232-4241.
21. + T cells. Science (Wash. DC). 248: 1227-1230.
22. Wertz, G.W., E.J. Stott, K.K. Young, K. Anderson, and L.A. Ball. 1987. Expression of the fusion protein of human respiratory syncytial virus from recombinant vaccinia virus vectors and protection of vaccinated mice. J. Virol. 61:293-301.
23. Ball, L.A., K.K. Young, K. Anderson, P.L. Collins, and G.W. Wertz. 1986. Expression of the major glycoprotein G of human respiratory syncytial virus from recombinant vaccinia virus vectors. Proc. Natl. Acad. Sci. USA. 83:246-250.
24. + cytotoxic T cells. J. Virol. 67:4086-4092.
25. Pollard, A.M., and M.F. Lipscomb. 1990. Characterization of murine lung dendritic cells: similarities to Langerhans cells and thymic dendritic cells. J. Exp. Med. 172:159-167.
26. Cherrie, A.H., K. Anderson, G.W. Wertz, and P.J. Openshaw. 1992. Human cytotoxic T cells stimulated by antigen on dendritic cells recognize the N, SH, F, M, 22K, and 1b proteins of respiratory syncytial virus. J. Virol. 66:2102-2110.
27. Openshaw, P.J., K. Anderson, G.W. Wertz, and B.A. Askonas. 1990. The 22,000-kilodalton protein of respiratory syncytial virus is a major target for Kd-restricted cytotoxic T lymphocytes from mice primed by infection. J. Virol. 64: 1683-1689.
28. Kulkarni, A.B., P.L. Collins, I. Bacik, J.W. Yewdell, J.R. Bennink, J.J. Crowe, and B.R. Murphy. 1995. Cytotoxic T cells specific for a single peptide on the M2 protein of respiratory syncytial virus are the sole mediators of resistance induced by immunization with M2 encoded by a recombinant vaccinia virus. J. Virol. 69:1261-1264.
29. + T cells in vivo differentially modulates IL-4 and interferon-γ but not interleukin-2 production by splenic T cells. Immunology. 78:513-519.
30. + T cells on primary, established and Nippostrongylus brasiliensis-induced IgE responses. Immunology. 88: 252-260.
31. + T cells through IL-12 produced by Listeria-induced macrophages. Science (Wash. DC). 260:547-549.
32. + T cells to enhance priming for interferon-γ production and diminishes interleukin 4 inhibition of such priming. Proc. Natl. Acad. Sci. USA. 90:10188-10192.
33. Bradley, L.M., K. Yoshimoto, and S.L. Swain. 1995. The cytokines IL-4, IFN-γ, and IL-12 regulate the development of subsets of memory effector helper T cells in vitro. J. Immunol. 155:1713-1724.
34. + T lymphocytes. J. Immunol. 155:111-117.
35. + T cell development and cytokine polarization: an overview. J. Leukocyte Biol. 57:795-798.
36. + T-cell subsets in vivo. Immunol. Rev. 123:189-207.
37. Gajewski, T.F., J. Joyce, and F.W. Fitch. 1989. Antiproliferative effect of IFN-γ in immunoregulation. III. Differential selection of Th1 and Th2 murine helper T lymphocyte clones using recombinant IL-2 and recombinant IFN-gamma. J. Immunol. 143:15-22.
38. Del Pretes, G.F., M. de Carli, C. Mastromauro, R. Biagiotti, D. Macchia, P. Falagiani, M. Ricci, and S. Romagnani. 1991. Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production. J. Clin. Invest. 88:346-350.
39. + T helper cell phenotype development in a T cell receptor-αβ-transgenic model. J. Exp. Med. 182:1579-1584.
40. + T cells from allergic individuals is modulated by antigen concentration and antigen-presenting cell type. J. Exp. Med. 181:1081-1089.
41. Plaut, M., and E.M. Zimmerman. 1993. Allergy and mechanisms of hypersensitivity. In Fundamental Immunology. W.E. Paul, editor. Raven Press, New York. 1399-1425.
42. Bretscher, B.A., G. Wu, N. Menon, and H. Ohmann. 1992. Establishment of stable, cell-mediated immunity that makes "susceptible" mice resistant to Leishmania major. Science (Wash. DC). 257:539-542.
43. Piedra, P.A., P.R. Wyde, W.L. Castleman, M.W. Ambrose, A.M. Jewell, D.J. Speelman, and S.W. Hildreth. 1993. Enhanced pulmonary pathology associated with the use of formalin-inactivated respiratory syncytial virus vaccine in cotton rats is not a unique viral phenomenon. Vaccine. 11:1415-1423.
44. Oien, N.L., R.J. Brideau, D.R. Thomsen, F.L. Homa, and M.W. Wathen. 1993. Vaccination with a heterologous respiratory syncytial virus chimeric FG glycoprotein demonstrates significant subgroup cross-reactivity. Vaccine. 11:1040-1048.
45. Hancock, G.E., D.J. Speelman, P.J. Frenchick, K.M. Mineo, R.B. Baggs, and D.J. Hahn. 1995. Formulation of the purified fusion protein of respiratory syncytial virus with the saponin QS-21 induces protective immune responses in Balb/c mice that are similar to those generated by experimental infection. Vaccine: 13:391-400.
46. Homa, F.L., R.J. Brideau, D.J. Lehman, D.R. Thomsen, R.A. Olmsted, and M.W. Wathen. 1993. Development of a novel subunit vaccine that protects cotton rats against both human respiratory syncytial virus and human parainfluenza virus type 3. J. Gen. Virol. 7:1995-1999.
47. + T cell-dependent immune deviation resulting in selective suppression of immunoglobulin E production. J. Exp. Med. 178: 889-899.
48. McMenamin, C., C. Pimm, M. McKersey, and P.G. Holt. 1994. Regulation of IgE responses to inhaled antigen in mice by antigen-specific γδ T cells. Science (Wash. DC). 265:1869-1871.
49. + T cells in a TH2 response and in immunoglobulin E production. Science (Wash. DC). 270: 1845-1847.
50. Zhang, Y., K.H. Rogers, and D.B. Lewis. 1996. β2-microglobulin-dependent T cells are dispensable for allergen-induced T helper 2 responses. J. Exp. Med. 184:1507-1512.
51. + T cells are not essential for T helper cell 2 immune responses. J. Exp. Med. 184:1295-1304.
52. Heemels, M., and H. Ploegh. 1995. Generation, translocation, and presentation of MHC class I-restricted peptides. Annu. Rev. Biochem. 64:463-491.
53. Wertz, G.W., P.L. Collins, Y. Huang, C. Gruber, S. Levine, and L.A. Ball. 1985. Nucleotide sequence of the G protein gene of human respiratory syncytial virus reveals an unusual type of viral membrane protein. Prof. Natl. Acad. Sci. USA. 82:4075-4079.
54. Engelhard, V.H. 1994. Structure of peptides associated with MHC class I molecules. Curr. Opin. Immunol. 6:13-23.
55. Einarsson, O., G.P. Geba, Z. Zhu., M. Landry, and J.A. Elias. 1997. Interleukin-11 stimulation in vivo and in vitro by respiratory syncytial virus and induction ot airways hyperresponsiveness. J. Clin. Invest. 97:915-924.
56. Graziano, F.M., R. Tilton, T. Hirth, D. Segaloff, T. Mullins, E. Dick, C.K. Buckner, and W.W. Busse. 1989. The effect of parainfluenza 3 infection on guinea pig basophil and lung mast cell histamine release. Am. Rev. Respir. Dis. 139:715-720.
57. Welliver, R.C., and L. Duffy. 1993. The relationship of RSV-specific immunoglobulin E antibody responses in infancy, recurrent wheezing, and pulmonary function at age 7-8 years. Pediatr. Pulmonol. 15:19-27.
58. Sigurs, N., R. Bijarnason, F. Sigurbergsson. B. Kjellman, and B. Bjorksten. 1995. Asthma and immunoglobulin E antibodies after respiratory syncytial virus bronchiolitis: a prospective cohort study with matched controls. Pediatrics. 95:500-505.
59. Kim, H.W., J.G. Canchola, C.D. Brandt. G. Pyles, R.M. Chanock, K. Jensen, and R.H. Parrott. 1969. Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine. Am. J. Epidemiol. 89:422-434.
60. Chin, J., R.L. Magoffin, L.A. Shearer, J.H. Schieble, and E.H. Lennette. 1969. Field evaluation of a respiratory syncytial virus vaccine and a trivalent parainfluenza virus vaccine in a pediatric population. Am. J. Epidemiol. 89:449-463.
61. Braciale, T.J., L.A. Morrison, M.T. Sweetser, J. Sambrook, M.J. Gething, and V.L. Braciale. 1987. Antigen presentation pathway to class I and class II MHC-restricted T lymphocytes. Immunol. Rev. 98:95-114.
62. Graham, B.S. 1996. Immunological determinants of disease caused by respiratory syncytial virus. Trends Microbiol. 4:290-293.
63. Cannon, M.J., P.J. Openshaw, and B.A. Askonas. 1988. Cytotoxic T cells clear virus but augment lung pathology in mice infected with respiratory syncytial virus. J. Exp. Med. 168:1163-1168.
64. Tang, Y.W., and B.S. Graham. 1994. Anti-IL-4 treatment at immunization modulates cytokine expression, reduces illness, and increases cytotoxic T lymphocyte activity in mice challenged with respiratory syncytial virus. J. Clin. Invest. 94:1953-1958.