Modulation by estrogen-receptor directed drugs of 5-hydroxytryptamine-2A receptors in rat brain

Neuropsychopharmacology

Volumn 23, Issue 1, 2000, Pages 69-78

  Cyr, Michel ^a   Landry, Michelle ^a   Di Paolo, Thérèse ^a  

^a UNIVERSITÉ LAVAL   (Canada)

Author keywords

5 HT(2A) receptor; DHEA; Estradiol; Ovariectomy; Raloxifene; Tamoxifen

Indexed keywords

ESTRADIOL; ESTROGEN RECEPTOR; MESSENGER RNA; PRASTERONE SULFATE; RALOXIFENE; SEROTONIN 2A RECEPTOR; TAMOXIFEN;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN REGION; BRAIN SLICE; CINGULATE GYRUS; CONTROLLED STUDY; CORPUS STRIATUM; DEPRESSION; DRUG RECEPTOR BINDING; FEMALE; FRONTAL CORTEX; IN SITU HYBRIDIZATION; NONHUMAN; NUCLEUS ACCUMBENS; OVARIECTOMY; PREMENOPAUSE; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY; SCHIZOPHRENIA; UTERUS WEIGHT;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; BRAIN; DEHYDROEPIANDROSTERONE; ESTRADIOL; ESTROGEN ANTAGONISTS; FEMALE; OVARIECTOMY; RALOXIFENE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, ESTROGEN; RECEPTORS, SEROTONIN; TAMOXIFEN;

EID: 0034130235     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0893-133X(00)00085-3     Document Type: Article

References (32)

1. Bethea C.L., Pecins-Thompson M., Schutzer W.E., Gundlah C., Lu Z.N. Ovarian steroids and serotonin neural function. Mol Neurobiol. 18:1998;87-123.
2. Biegon A., Reches A., Snyder L., McEwen B.S. Serotoninergic and noradrenergic receptors in the rat brain. Modulation by chronic exposure to ovarian hormones Life Sci. 32:1983;2015-2021.
3. A receptors by estradiol. A clue for CNS changes occurring at menopause Cell Mol Neurobiol. 16:1996;199-212.
4. Charney D.S. Monoamine dysfunction and the pathophysiology and treatment of depression. J Clin Psychiatry. 59:1998;11-14.
5. Cyr M., Bosse R., Di Paolo T. Gonadal hormones modulate 5-hydroxytryptamine2A receptors. Emphasis on the rat frontal cortex Neuroscience. 83:1998;829-836.
6. Cyr M., Ghribi O., Di Paolo T. Ovariectomy and gonadal modulation of glutamate levels and glutamate receptors of the NMDA and AMPA subtypes. J. Neuroendocrinol. in press:2000.
7. Di Paolo T. Modulation of brain dopamine transmission by sex steroids. Rev Neurosci. 5:1994;27-41.
8. Du Y.L., Wilcox B.D., Teitler M., Jeffrey J.J. Isolation and characterization of the rat 5-hydroxytryptamine type 2 receptor promoter. Constitutive and inducible activity in myometrial smooth muscle cells Mol Pharmacol. 45:1994;1125-1131.
9. Fink G., Sumner B.E. Oestrogen and mental state. Nature. 383:1996;306.
10. Fink G., Sumner B.E., McQueen J.K., Wilson H., Rosie R. Sex steroid control of mood, mental state and memory. Clin Exp Pharmacol Physiol. 25:1998;764-775.
11. Grese T.A., Dodge J.A. Selective estrogen receptor modulators (SERMs). Curr Pharm Des. 4:1998;71-92.
12. Halbreich U. Role of estrogen in postmenopausal depression. Neurology. 48:1997;S16-S19.
13. Heron D.S., Shinitzky M., Hershkowitz M., Samuel D. Lipid fluidity markedly modulates the binding of serotonin to mouse brain membranes. Proc Natl Acad Sci USA. 77:1980;7463-7467.
14. Kapur S., Remington G. Serotonin-dopamine interaction and its relevance to schizophrenia. Am J Psychiatry. 153:1996;466-476.
15. Katzenellenbogen J.A., O'Malley B.W., Katzenellenbogen B.S. Tripartite steroid hormone receptor pharmacology. Interaction with multiple effector sites as a basis for the cell- and promoter-specific action of these hormones Mol Endocrinol. 10:1996;119-131.
16. Klaiber E.L., Broverman D.M., Vogel W., Kobayashi Y. Estrogen therapy for severe persistent depressions in women. Arch Gen Psychiatry. 36:1979;550-554.
17. Labrie C., Flamand M., Belanger A., Labrie F. High bioavailability of dehydroepiandrosterone administered percutaneously in the rat. J Endocrinol. 150(Suppl):1996;S107-S118.
18. Laflamme N., Nappi R.E., Drolet G., Labrie C., Rivest S. Expression and neuropeptidergic characterization of estrogen receptors (ERalpha and ERbeta) throughout the rat brain. anatomical evidence of distinct roles of each subtype J Neurobiol. 36:1998;357-378.
19. Lieberman J.A., Mailman R.B., Duncan G., Sikich L., Chakos M., Nichols D.E., Kraus J.E. Serotonergic basis of antipsychotic drug effects in schizophrenia. Biol Psychiatry. 44:1998;1099-1117.
20. Marek G.J., Aghajanian G.K. The electrophysiology of prefrontal serotonin systems. Therapeutic implications for mood and psychosis Biol Psychiatry. 44:1998;1118-1127.
21. Martel C., Labrie C., Belanger A., Gauthier S., Merand Y., Li X., Provencher L., Candas B., Labrie F. Comparison of the effects of the new orally active antiestrogen EM-800 with ICI 182 780 and toremifene on estrogen-sensitive parameters in the ovariectomized mouse. Endocrinology. 139:1998;2486-2492.
22. Mengod G., Pompeiano M., Martinez-Mir M.I., Palacios J.M. Localization of the mRNA for the 5-HT2 receptor by in situ hybridization histochemistry. Correlation with the distribution of receptor sites. Brain Res. 524:1990;139-143.
23. Paech K., Webb P., Kuiper G.G.J.M., Nilsson S., Gustafsson J.-A., Kushner P.J., Scanlan T.S. Differential ligand activation of estrogen receptors ERα and ERβ at AP1 sites. Science. 277:1997;1508-1510.
24. Paige L.A., Christensen D.J., Gron H., Norris J.D., Gottlin E.B., Padilla K.M., Chang C.Y., Ballas L.M., Hamilton P.T., McDonnell D.P., Fowlkes D.M. Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta. Proc Natl Acad Sci USA. 96:1999;3999-4004.
25. Paxinos G., Watson C. The rat brain in stereotaxic coordinates. 4th ed:1998;Academic Press, New York.
26. Pritchett D.B., Bach A.W., Wozny M., Taleb O., Dal Toso R., Shih J.C., Seeburg P.H. Structure and functional expression of cloned rat serotonin 5HT-2 receptor. Embo J. 7:1988;4135-4140.
27. Sumner B.E.H., Fink G. Effects of acute estradiol on 5-hydroxytryptamine and dopamine receptor subtype mRNA expression in female rat brain. Molec Cell Neurosci. 4:1993;83-92.
28. Sumner B.E.H., Fink G. Estrogen increases the density of 5-hydroxytryptamine(2A) receptors in cerebral cortex and nucleus accumbens in the female rat. J Steroid Biochem Mol Biol. 54:1995;15-20.
29. Sumner B.E.H., Fink G. Testosterone as well as estrogen increases serotonin2A receptor mRNA and binding site densities in the male rat brain. Brain Res Mol Brain Res. 59:1998;205-214.
30. Truss M., Beato M. Steroid hormone receptors. Interaction with deoxyribonucleic acid and transcription factors Endocr Rev. 14:1993;459-479.
31. Willner P. The dopamine hypothesis of schizophrenia. Current status, future prospects Int Clin Psychopharmacol. 12:1997;297-308.
32. Zifa E., Fillion G. 5-Hydroxytryptamine receptors. Pharmacol Rev. 44:1992;401-458.