Accumulation of phosphorylated neurofilaments and increase in apoptosis-specific protein and phosphorylated c-Jun induced by proteasome inhibitors

Journal of Neuroscience Research

Volumn 62, Issue 1, 2000, Pages 75-83

  Masaki, Runa ^a   Saito, Taro ^b   Yamada, Kyoji ^a   Ohtani Kaneko, Ritsuko ^a  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOKYO METROPOLITAN UNIVERSITY   (Japan)

Author keywords

Apoptosis specific protein; ASP; c Jun; Lactacystin; Phosphorylated neurofilament; Proteasome inhibitor

Indexed keywords

CALPAIN; LACTACYSTIN; PROTEASOME; PROTEASOME INHIBITOR; PROTEIN; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IMMUNOPRECIPITATION; NEUROFILAMENT; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

EID: 0033778845     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-4547(20001001)62:1<75::AID-JNR8>3.0.CO;2-V     Document Type: Article

References (56)

1. Increased immunoreactivity for Jun-and Fos-related proteins in Alzheimer's disease: Association with pathology
2. Ubiquitin and its role in neurodegeneration
3. Specific association of c-Jun-like immunoreactivity but not c-Jun p39 with normal and induced programmed cell death in the chick embryo
4. The ubiquitin-proteasome proteolytic pathway
5. The ubiquitin-mediated proteolytic pathway: Mechanisms of recognition of the proteolytic substrate and involvement in the degradation of native cellular proteins
6. Phosphorylated neurofilament antigens in neurofibrillary tangles in Alzheimer's disease
7. Altered gene expression in neurons during programmed cell death: Identification of c-jun as necessary for neuronal apoptosis
8. Lactacystin, proteasome function, and cell fate
9. Inhibition of proteasome activities and subunit-specific aminoterminal threonine modification by lactacystin
10. Naturally occurring (programmed) and radiation-induced apoptosis are associated with selective c-Jun expression in the developing rat brain
11. Strong c-Jun immunoreactivity is associated with apoptotic cell death in human tumors of the central nervous system
12. Transient forebrain ischemia in the adult gerbil is associated with a complex c-Jun response
13. c-Jun/AP-1 (N) expression and apoptosis
14. Reaction of Leery bodies with antibodies to phosphorylated and non-phosphorylated neurofilaments
15. Immunolabelling of the cytoplasm and processes of apoptotic facial motoneurons following axotomy in the neonatal rat
16. Abberant stress-induced phosphorylation of perikaryal neurofilaments
17. Study of proline-directed protein kinases involved in phosphorylation of the heavy neurofilament subunit
18. Posttranslational modification of neurofilament polypeptides in rabbit retina
19. A novel protein expressed in mammalian cells undergoing apoptosis
20. Amyloid β protein inhibits ubiquitin-dependent protein degradation in vitro
21. Binding of amyloid β-protein to 20S proteasome
22. Phosphorylation of bovine neurofilament proteins by protein kinase FA (glycogen synthase kinase 3)
23. Differential cellular phosphorylation of neurofilament heavy side-arms by glycogen synthase kinase-3 and cyclin-dependent kinase-5
24. Homology between a human apoptosis specific protein and the product of APG5, a gene involved in autophagy
25. The c-jun transcription factor-bipotential mediator of neuronal death, survival and regeneration
26. The ubiquitin system for protein degradatioin
27. Tau protein kinase II has a similar characteristic to cdc2 kinase for phosphorylating neurofilament proteins
28. Increased phosphorylation of neurofilament subunits in PC12 cells and rat dorsal root ganglion neurons treated with N-acetyl-leu-leu-norleucinal
29. Ubiquitin and the enigma of intracellular protein degradation
30. Modes of regulation of ubiquinmediated protein degradation
31. Phosphorylation of neurofilaments is altered in amyotrophic lateral sclerosis
32. Quantitative neuronal c-los and c-jun expression in Alzheimer's disease
33. Detection of Jun but not Fos protein during developmental cell death in sympathetic neurons
34. Ubiquitin and neurofilament expression in anterior horn cells in amyotrophic lateral sclerosis: Possible clues to the pathogenesis
35. Interaction of the tail domain of high molecular weight subunits of neurofilament with the COOH-terminal region of tubulin and its regulation by tau protein kinase II
36. Accumulation of phosphorylated neurofilaments in anterior horn motoneurons of amyotrophic lateral sclerosis patients
37. Early posttranslational modification of the three neurofilament subunits in mouse retinal ganglion cells: Neuronal sites and time course in relation to subunit polymerization and axonal transport
38. Characterization of posttranslational processing of the mammalian high-molecular-weight neurofilament protein in vivo
39. Proteasome inhibitors which induce neurite outgrowth from PCl2h cells cause different subcellular accumulations of multi-ubiquitin chains
40. Lactacystin, a novel microbial metabolite, induces neuritogenesis of neurobiastoma cells
41. Structure of lactacystin, a new microbial metabolite which induces differentiation of neuroblastoma cells
42. The involvement of the ubiquitin system in Alzheimer's disease
43. p35 the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway
44. Characterization of a shared epitope on cortical Lewy body fibrils and Alzheimer paired helical filaments
45. Kainic acid-induced excitotoxicity is associated with a complex c-Fos and c-Jun response which does not preclude either cell death or survival
46. Okadaic acid-stimulated degradation of p35, an activator of CDK5, by proteasome in cultured neurons
47. The structure-function relationship between peptide aldehyde derivatives on initiation of neurite outgrowth in PC12h cells
48. Cytoskeleton pathology in Alzheimer's disease and related disorders
49. Phosphorylated high molecular weight neurofilament protein in louver motor neurons in amyotrophic lateral sclerosis and other neurodegenerative diseases involving ventral horn cells
50. Phosphorylation of the high molecular weight neurofilament protein (NF-H) by Cdk5 and p35
51. Apg7p/Crt2p: A novel protein-activation enzyme essential for autophagy
52. c-Jun/AP-1 (N) directed antibodies cross-react with 'apoptosis-specific protein' which marks an autophagic process during neuronal apoptosis
53. Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-leucine and tri-leucine
54. Mitogen-activated protein kinases (Erk1,2) phosphorylate Lys-SerPro (KSP) repeats in neurofilament proteins NF-H and NF-M
55. Phosphorylation of c-Jun is necessary for apoptosis induced by survival signal withdrawal in cerebellar granule neurons
56. Abnormal processing of multiple proteins in Alzheimer disease