Human mitochondrial and cytosolic branched-chain aminotransferases are cysteine S-conjugate β-lyases, but turnover leads to inactivation

Biochemical Pharmacology

Volumn 65, Issue 2, 2003, Pages 181-192

  Cooper, Arthur J L ^a,b   Bruschi, Sam A ^c   Conway, Myra ^d   Hutson, Susan M ^d  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b BURKE MEDICAL RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Cysteine S conjugate lyases; Cysteine S conjugates; Cytosolic branched chain aminotransferase; Halogenated alkenes; Mitochondrial branched chain aminotransferase

Indexed keywords

2 OXOISOCAPROIC ACID; 3 CHLOROALANINE; 4 AMINO 4 DEOXYCHORISMATE LYASE; AMINO ACID; AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BENZOTHIAZOLYLCYSTEINE; CYSTEINE CONJUGATE BETA LYASE; DEXTRO AMINO ACID; GLUTARIC ACID DERIVATIVE; ISOENZYME; LEUCINE ALPHA KETOGLUTARATE; LYASE; MITOCHONDRIAL PROTEIN; MONOMER; PYRIDOXAL 5 PHOSPHATE; RECOMBINANT PROTEIN; S (1,1,2,2 TETRAFLUOROETHYL)CYSTEINE; S (1,2 DICHLOROVINYL)CYSTEINE; S (2 CHLORO 1,1,2 TRIFLUOROETHYL)CYSTEINE; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; CATALYSIS; CYTOSOL; ENERGY METABOLISM; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; METABOLISM; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN METABOLISM; TRANSAMINATION;

AMMONIA; BETA-ALANINE; CARBON-SULFUR LYASES; CYSTEINE; CYTOSOL; HALOGENS; HUMANS; HYDROCARBONS, FLUORINATED; KETO ACIDS; LEUCINE; MITOCHONDRIA; PYRUVIC ACID; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TEMPERATURE; TRANSAMINASES;

EID: 0037437730     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01513-7     Document Type: Article

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