Nitrogen shuttling between neurons and glial cells during glutamate synthesis

Journal of Neurochemistry

Volumn 76, Issue 6, 2001, Pages 1712-1723

  Lieth, Erich ^a   LaNoue, Kathryn F ^a   Berkich, Deborah A ^a   Xu, Baiyang ^a   Ratz, Michael ^a   Taylor, Charles ^b   Hutson, Susan M ^c  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b PFIZER INC   (United States)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Brain; Branched chain aminotransferase; Gabapentin; Glutamate; Nitrogen shuttle; Retina

Indexed keywords

GLUTAMIC ACID; GLUTAMINE;

AMINO ACID METABOLISM; AMINO ACID SYNTHESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CARBON DIOXIDE FIXATION; CARBOXYLATION; CONTROLLED STUDY; ENZYME ANALYSIS; GLIA CELL; NONHUMAN; PRIORITY JOURNAL; RADIOACTIVITY; RAT; RETINA; TRANSAMINATION;

ANIMALS; ASTROCYTES; BICARBONATES; BRAIN; CARBON DIOXIDE; CARBON RADIOISOTOPES; GLUTAMIC ACID; GLUTAMINE; KETO ACIDS; MODELS, CHEMICAL; MODELS, NEUROLOGICAL; NEUROGLIA; NEURONS; NITROGEN; PYRUVATE CARBOXYLASE; PYRUVATES; RADIOISOTOPE DILUTION TECHNIQUE; RATS; RATS, SPRAGUE-DAWLEY; RETINA;

ANIMALIA;

EID: 0035100128     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00156.x     Document Type: Article

References (40)

1. Cellular distribution of branched-chain amino acid aminotransferase isoenzymes among rat brain glial cells in culture
2. Distribution of key enzymes of branched chain amino acids in glial and neuronal cells in culture
3. Biochemistry and physiology of brain ammonia
4. Tissue specific effects of in vivo adenosine receptor blockade on glucose uptake in Zucker rats
5. Ontogeny and cellular localization of the pyruvate cycling system in rat brain
6. Overexpression and characterization of the human mitochondrial and cytosolic branched-chain aminotransferases
7. Role of pyruvate carboxylase in facilitation of synthesis of glutamate and glutamine in cultured astrocytes
8. Delayed labelling of brain glutamate after an intra-arterial [13C]glucose bolus: Evidence for aerobic metabolism of guinea pig brain glycogen store
9. Localized in vivo 13C-NMR of glutamate metabolism in the human brain: Initial results at 4 tesla
10. 13C-NMR spectroscopy studies of pyruvate recycling in brain
11. Cerebral metabolism of lactate in vivo: Evidence for neuronal pyruvate carboxylation
12. Neuronal pyruvate carboxylation supports formation of transmitter glutamate
13. Cloning and expression of the mammalian cytosolic branched chain aminotransferase isoenzyme
14. Role of branched-chain aminotransferase isoenzymes and gabapentin in neurotransmitter metabolism
15. 15N-NMR
16. Carbon dioxide fixation in neuronal and astroglial cells in culture
17. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
18. Cerebral metabolic compartmentation. Estimation of glucose flux via pyruvate carboxylase/pyruvate dehydrogenase by 13C NMR isotopomer analysis of D-[U-13C]glucose metabolites
19. Metabolic compartmentation of glutamate and glutamine: Morphological evidence obtained by quantitative immunocytochemistry in rat cerebellum
20. 2-fixing enzymes
21. Glutamate in some retinal neurons is derived solely from glia
22. Present status and significance of the glutamine cycle in neural tissues
23. Pyruvate carboxylase: An astrocyte-specific enzyme implicated in the replenishment of amino acid neurotransmitter pools
24. Cerebral metabolic compartmentation as revealed by nuclear magnetic resonance analysis of D-[1-13C]glucose metabolism
25. Determination of the rate of the glutamate/ glutamine cycle in the human brain by in vivo 13C NMR
26. In vivo 13C NMR measurements of cerebral glutamine synthesis as evidence for glutamate-glutamine cycling
27. Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity
28. 13C NMR spectroscopy: Incorporation of more label into lactate than into glutamine demonstrates the importance of the tricarboxylic acid cycle
29. Metabolism of [U-13C5] glutamine in cultured astrocytes studied by NMR spectroscopy: First evidence of astrocytic pyruvate recycling
30. Processing of prothrombin in the secretory pathway
31. Effect of phenylephrine on pyruvate dehydrogenase in fasting rat livers
32. 2 fixation in mammalian brain in vivo
33. Purification of branched chain aminotransferase from rat heart mitochondria
34. Potential treatment of amyotrophic lateral sclerosis with gabapentin: A hypothesis
35. Development of mitochondrial pyruvate metabolism in rat brain
36. Assays of intermediates of the citric acid cycle and related compounds by fluorometric enzyme methods
37. Effects of inhibiting glutamine synthetase and blocking glutamate uptake on B-wave generation in the isolated rat retina
38. Pyruvate carboxylase activity in primary cultures of astrocytes and neurons
39. Brain metabolism of branched-chain amino acids
40. Astrocyte leucine metabolism: Significance of branched-chain amino acid transamination