Synthesis of conformationally locked carbocyclic nucleosides built on an oxabicyclo[3.1.0]hexane system

Tetrahedron

Volumn 59, Issue 3, 2003, Pages 295-301

  Comin, María J ^a   Rodriguez, Juan B ^a   Russ, Pam ^b   Marquez, Victor E ^b  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

2 deoxyneplanocin C; 6 oxobicyclo 3.1.0 hexane; Antiviral activity, EBV; Carbocyclic nucleosides; Conformationally locked nucleosides

Indexed keywords

2 AMINO 9 [4 HYDROXY 5 (HYDROXYMETHYL) 6 OXABICYCLO[3.1.0]HEX 2 YL]HYDROPURIN 6 ONE; 4 (6 AMINOPURIN 9 YL) 1 (HYDROXYMETHYL) 6 OXABICYCLO[3.1.0]HEXAN 2 OL; 8 HYDROXY 7 (PHENYLMETHOXY) 8 [(PHENYLMETHOXY)METHYL] 5,6,7,8,5A,8A HEXAHYDRO 5AH,8AH CYCLOPENTA[1,2 D]PYRIMIDINO[2,1 B] 1,3 OXAZOLIDIN 2 ONE; ANTIBIOTIC AGENT; BICYCLO COMPOUND; CARBOCYCLIC NUCLEOSIDE; DEOXYGUANOSINE DERIVATIVE; HETEROCYCLIC COMPOUND; NEPLANOCIN C; OXABICYCLO[3.1.0]HEXANE; PURINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG CONFORMATION; DRUG SYNTHESIS; EPSTEIN BARR VIRUS; MITSUNOBU REACTION; PRIORITY JOURNAL; ROTATION;

EID: 0037433987     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(02)01528-4     Document Type: Article

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39. Antiviral activity was obtained through Dr Christopher K.-H. Tseng, NIAID, NIH. These assays were performed according to the standard protocol developed in the laboratory of Dr Earl R. Kern, University of Alabama.