Methylphenidate and cocaine have a similar in vivo potency to block dopamine transporters in the human brain

Life Sciences

Volumn 65, Issue 1, 1999, Pages

  Volkow, Nora D ^a,b   Wang, Gene Jack ^a   Fowler, Joanna S ^a   Fischman, Marian ^c   Foltin, Richard ^c   Abumrad, Naji N ^d   Gatley, Samuel J ^a   Logan, Jean ^a   Wong, Cristopher ^a   Gifford, Andrew ^a   Ding, Yu Shin ^a   Hitzemann, Robert ^b   Pappas, Naomi ^a  

^a BROOKHAVEN NATIONAL LABORATORY   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

^d Northshore University Hospital   (United States)

Author keywords

Addiction; ADHD; Imaging; PET; Reinforcement

Indexed keywords

COCAINE; DOPAMINE TRANSPORTER; METHYLPHENIDATE;

ADULT; ARTICLE; BINDING AFFINITY; BLOOD PRESSURE; BRAIN REGION; CARDIOVASCULAR EFFECT; CEREBELLUM; CLINICAL ARTICLE; COCAINE DEPENDENCE; CONTROLLED STUDY; CORPUS STRIATUM; DOSE RESPONSE; DRUG DISTRIBUTION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG UPTAKE; FEMALE; HEART RATE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LIGAND BINDING; MALE; POSITRON EMISSION TOMOGRAPHY; SUBSTANCE ABUSE;

ADULT; BINDING SITES; BLOOD PRESSURE; BRAIN; CARRIER PROTEINS; COCAINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEART RATE; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; METHYLPHENIDATE; NERVE TISSUE PROTEINS; TIME FACTORS; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0033612351     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(99)00225-8     Document Type: Article

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