On the unfolding of α-lytic protease and the role of the pro region

Proteins: Structure, Function and Genetics

Volumn 41, Issue 1, 2000, Pages 21-32

  Inuzuka, Yoshihiko ^a   Lazaridis, Themis ^a  

^a CITY COLLEGE OF NEW YORK   (United States)

Author keywords

Lytic protease; Kinetic control; Proenzymes; Protein folding

Indexed keywords

ENZYME PRECURSOR; MUTANT PROTEIN; PROTEINASE;

ARTICLE; BACTERIUM; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME STRUCTURE; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING;

ELECTROSTATICS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN FOLDING; SERINE ENDOPEPTIDASES; THERMODYNAMICS;

BACTERIA (MICROORGANISMS);

EID: 0034308169     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0134(20001001)41:1<21::AID-PROT50>3.0.CO;2-V     Document Type: Article

References (25)

1. The α-lyric protease pro-region does not require a physical linkage to activate the protease domain in vivo
2. A protein folding reaction under kinetic control
3. Kinetics versus thermodynamics in protein folding
4. Unfolded conformations of α-lytic protease are more stable than its native state
5. Molecular structure of the α-lyric protease from Myxobacter 495 at 2.8 Å resolution
6. Refined structure of α-lytic protease at 1.7 Å resolution
7. Structure of α-lytic protease complexed with its pro region
8. Effective energy function for proteins in solution
9. α-Lytic protease precursor: Characterization of a structured folding intermediate
10. 'New view' of protein folding reconciled with the old through multiple unfolding simulations
11. Energetics of folding subtilisin BPN'
12. Pro region C-terminus: Protease active site interactions are critical in catalyzing the folding of α-lytic protease
13. Metastable states and folding free energy barriers
14. The denatured state (the other half of the folding equation) and its role in protein stability
15. Rapid folding of Ca-free subtilisin by a stabilized pro-domain mutant
16. CHARMM: A program for macromolecular energy minimization and dynamics calculations
17. Simulation of activation free energies in molecular systems
18. Discrimination of the native from misfolded protein models with an energy function including implicit solvation
19. Heat capacity and compactness of denatured proteins
20. Forced unfolding of fibronectin type 3 modules: An analysis by biased MD simulations
21. Understanding β-hairpin folding
22. Polar hydrogen positions in proteins: Empirical energy placement and neutron diffraction comparison
23. Algorithms for macromolecular dynamics and constraint dynamics
24. Deformable stochastic boundaries in molecular dynamics
25. Dynamics and unfolding pathways of a hyperthermophilic and a mesophilic rubredoxin