Benzimidazole derivatives. Part 1: Synthesis and structure-activity relationships of new benzimidazole-4-carboxamides and carboxylates as potent and selective 5-HT4 receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 11, 1999, Pages 2271-2281

  López Rodríguez, María L ^a   Benhamú, Bellinda ^a   Viso, Alma ^a   Morcillo, M José ^b   Murcia, Marta ^a   Orensanz, Luis ^c   Alfaro, M José ^a   Martín, M Isabel ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b UNIVERSIDAD NACIONAL DE EDUCACIÓN A DISTANCIA   (Spain)

^c HOSPITAL RAMÓN Y CAJAL   (Spain)

Author keywords

5 HT4 antagonist; Benzimidazole; Pharmacophore; Serotonin

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; N [(1 BUTYL 4 PIPERIDYL)METHYL] 6 CHLOROBENZIMIDAZOLE 4 CARBOXAMIDE; N [(1 PENTYL 4 PIPERIDYL)METHYL] 6 CHLOROBENZIMIDAZOLE 4 CARBOXAMIDE; N [1 ISOBUTYL 4 PIPERIDYL)METHYL] 6 CHLOROBENZIMIDAZOLE 4 CARBOXAMIDE; N [[1 [2 [(METHYLSULFONYL)AMINO]ETHYL] 4 PIPERIDYL]METHYL] 6 CHLOROBENZIMIDAZOLE 4 CARBOXAMIDE; SEROTONIN 4 ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; BRAIN TISSUE; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; GUINEA PIG; ILEUM; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

AMIDES; ANIMALS; BENZIMIDAZOLES; BRAIN; CARBOXYLIC ACIDS; DRUG DESIGN; GUINEA PIGS; ILEUM; MALE; MODELS, MOLECULAR; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT4; SEROTONIN ANTAGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0343503009     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00172-8     Document Type: Article

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