Tissue factor-dependent coagulation protease signaling in acute lung injury

Critical Care Medicine

Volumn 31, Issue 4 SUPPL., 2003, Pages

  Ruf, Wolfram ^a   Riewald, Matthias ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Endothelial cell protein C receptor; Inflammatory escalation; Protease activated receptors; Tissue factor

Indexed keywords

BLEOMYCIN; PROTEIN C; PROTEINASE; THROMBIN; THROMBOPLASTIN;

BLOOD CLOTTING; CONFERENCE PAPER; EXTRAVASCULAR SPACE; FIBRIN DEPOSITION; HUMAN; INFLAMMATION; LUNG INJURY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION;

EID: 0037394677     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ccm.0000057848.27456.04     Document Type: Conference Paper

References (73)

1. Idell S: Endothelium and disordered fibrin turnover in the injured lung: Newly recognized pathways. Crit Care Med 2002; 30: S274-S280
2. Welty-Wolf KE, Carraway MS, Ortel TL, et al: Coagulation and inflammation in acute lung. injury. Thromb Haemost 2002; 88:17-25
3. Vu T-KH, Hung DT, Wheaton VI, et al: Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 1991; 64:1057-1068
4. Coughlin SR: Thrombin signalling and protease-activated receptors. Nature 2000; 407:258-264
5. O'Brien PJ, Molino M, Kahn M, et al: Protease activated receptors: Theme and variations. Oncogene 2001; 20:1570-1581
6. Connolly AJ, Ishihara H, Kahn ML, et al: Role of the thrombin receptor in development and evidence for a second receptor. Nature 1996; 381:516-519
7. Griffin CT, Srinavasan Y, Zheng YW, et al: A role for thrombin receptor signaling in endothelial cells during embryonic development. Science 2001; 293:1666-1670
8. Sambrano GR, Weiss EJ, Zheng YW, et al: Role of thrombin signalling in platelets in haemostasis and thrombosis. Nature 2001; 413:26-27
9. Nakanishi-Matsui M, Zheng YW, Sulciner DJ, et al: PAR3 is a cofactor for PAR4 activation by thrombin. Nature 2000; 404:609-613
10. Weiss EJ, Hamilton JR, Lease KE, et al: Protection against thrombosis in mice lacking PAR3. Blood 2002; 100:3240-3244
11. Riewald M, Kravchenko VV, Petrovan RJ, et al: Gene induction by coagulation factor Xa is mediated by activation of PAR-1. Blood 2001; 97:3109-3116
12. Camerer E, Kataoka H, Kahn M, et al: Genetic evidence that protease-activated receptors mediate factor Xa signaling in endothelial cells. J Biol Chem 2002; 277:16081-16087
13. Camerer E, Huang W, Coughlin SR: Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa. Proc Natl Acad Sci USA 2000; 97:5255-5260
14. Riewald M, Ruf W: Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor. Proc Natl Acad Sci USA 2001; 98:7742-7747
15. Camerer E, Gjernes E, Wiiger M, et al: Binding of factor VIIa to tissue factor on keratinocytes induces gene expression. J Biol Chem 2000; 275:6580-6585
16. Pendurthi UR, Allen KE, Ezban M, et al: Factor VIIa and thrombin induce the expression of cyr61 and connective tissue growth factor, extracellular matrix signaling proteins that could act as possible downstream mediators in factor VIIa tissue factor-induced signal transduction. J Biol Chem 2000; 275:14632-14641
17. Brummel KE, Paradis SG, Butenas S, et al: Thrombin functions during tissue factor-induced blood coagulation. Blood 2002; 100:148-152
18. Broze GJ Jr: Tissue factor pathway inhibitor and the revised theory of coagulation. Annu Rev Med 1995; 46:103-112
19. van der Poll T, Büller HR, ten Cate H, et al: Activation of coagulation after administration of tumor necrosis factor to normal subjects. N Engl J Med 1990; 322:1622-1627
20. Taylor FB, Haddad PA, Hack E, et al: Two-stage response to endotoxin infusion into normal human subjects: Correlation of blood phagocyte luminescence with clinical and laboratory markers of the inflammatory, hemostatic response. Crit Care Med 2001; 29:326-334
21. Hanson SR, Griffin JH, Harker LA, et al: Antithrombotic effects of thrombin-induced activation of endogenous protein C in primates. J Clin Invest 1993; 92:2003-2012
22. Esmon CT, Xu J, Gu JM, et al: Endothelial protein C receptor. Thromb Haemost 1999; 82:251-258
23. Taylor FB Jr, Peer GT, Lockhart MS, et al: Endothelial cell protein C receptor plays an important role in protein C activation in vivo. Blood 2001; 97:1685-1688
24. Riewald M, Petrovan RJ, Donner A, et al: Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science 2002; 296:1880-1882
25. Grinnell BW, Berg DT: Surface thrombo-modulin modulates thrombin receptor responses on vascular smooth muscle cells. Am J Physiol 1996; 270:H603-H609
26. Taylor FB Jr, Chang A, Hinshaw LB, et al: A model for thrombin protection against endotoxin. Thromb Res 1984; 36:177-185
27. Taylor FB, Chang A, Esmon CT, et al: Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon. J Clin Invest 1987; 79:918-925
28. Bernard GR, Vincent JL, Laterre PF, et al: Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001; 344:759-762
29. Olman MA, Mackman N, Gladson CL, et al: Changes in procoagulant and fibrinolytic gene expression during bleomycin-induced lung injury in the mouse. J Clin Invest 1995; 96:1621-1630
30. Hattori N, Degen JL, Sisson TH, et al: Bleomycin-induced pulmonary fibrosis in fibrinogen-null mice. J Clin Invest 2000; 106:1341-1350
31. Ploplis VA, Wilberding J, McLennan L, et al: A total fibrinogen deficiency is compatible with the development of pulmonary fibrosis in mice. Am J Pathol 2000; 157:703-708
32. Howell DC, Goldsack NR, Marshall RP, et al: Direct thrombin inhibition reduces lung collagen, accumulation, and connective tissue growth factor mRNA levels in bleomycin-induced pulmonary fibrosis. Am J Pathol 2001; 159:1383-1395
33. Chambers RC, Leoni P, Blanc-Brude OP, et al: Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor-1. J Biol Chem 2000; 275:35584-35591
34. Cunningham MA, Rondeau E, Chen X, et al: Protease-activated receptor 1 mediates thrombin-dependent, cell-mediated renal inflammation in crescentic glomerulonephritis. J Exp Med 2000; 191:455-462
35. Drake TA, Cheng J, Chang A, et al: Expression of tissue factor, thrombomodulin, and E-selectin in baboons with lethal E. coli sepsis. Am J Pathol 1993; 142:1458-1470
36. Mackman N, Sawdey MS, Keeton MR, et al: Murine tissue factor gene expression in vivo: Tissue and cell specificity and regulation by lipopolysaccharide. Am J Pathol 1993; 143:76-84
37. Hara S, Asada Y, Hatakeyama K, et al: Expression of tissue factor and tissue factor pathway inhibitor in rat lungs with lipopolysaccharide-induced disseminated intravascular coagulation. Lab Invest 1997; 77:581-589
38. Murakami K, Okajima K, Uchiba M, et al: Activated protein C prevents LPS-induced pulmonary vascular injury by inhibiting cytokine production. Am J Physiol 1997; 272:L197-L202
39. Miller DL, Welty-Wolf K, Carraway MS, et al: Extrinsic coagulation blockade attenuates lung injury and proinflammatory cytokine release after intratracheal lipopolysaccharide. Am J Respir Cell Mol Biol 2002; 26:650-658
40. Welty-Wolf KE, Carraway MS, Miller DL, et al: Coagulation blockade prevents sepsis-induced respiratory and renal failure in baboons. Am J Respir Crit Care Med 2001; 164:1988-1996
41. Franco RF, De Jonge E, Dekkers PE, et al: The in vivo kinetics of tissue factor messenger RNA expression during human endotoxemia: Relationship with activation of coagulation. Blood 2000; 96:554-559
42. Levi M, ten Cate H, Bauer KA, et al: Inhibition of endotoxin-induced activation of coagulation and fibrinolysis by pentoxifylline or by a monoclonal anti-tissue factor antibody in chimpanzees. J Clin Invest 1994; 93:114-120
43. De Jonge E, Dekkers PE, Creasey AA, et al: Tissue factor pathway inhibitor dose-dependently inhibits coagulation activation without influencing the fibrinolytic and cytokine response during human endotoxemia. Blood 2000; 95:1124-1129
44. Ott I, Andrassy M, Zieglgansberger D, et al: Regulation of monocyte procoagulant activity in acute myocardial infarction: Role of tissue factor and tissue factor pathway inhibitor-1. Blood 2001; 97:3721-3726
45. Joyce DE, Gelbert L, Ciaccia A, et al: Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis. J Biol Chem 2001; 276:11199-11203
46. Taylor FB Jr, Chang A, Ruf W, et al: Lethal E. coli septic shock is prevented by blocking tissue factor with monoclonal antibody. Circ Shock 1991; 33:127-134
47. Creasey AA, Chang AC, Feigen L, et al: Tissue factor pathway inhibitor (TFPI) reduces mortality from E. coli septic shock. J Clin Invest 1993; 91:2850-2860
48. 100 Escherichia coli. Blood 1998; 91:1609-1615
49. Taylor FB Jr, Chang AC, Peer GT, et al: DEGR-factor Xa blocks disseminated intravascular coagulation initiated by Escherichia coli without preventing shock or organ damage. Blood 1991; 78:364-368
50. Chi L, Li Y, Stehno-Bittel L, et al: Interleukin-6 production by endothelial cells via stimulation of protease-activated receptors is amplified by endotoxin and tumor necrosis factor-α. J Interferon Cytokine Res 2001; 21:231-240
51. Asokananthan N, Graham PT, Fink J, et al: Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells. J Immunol 2002; 168:3577-3585
52. Levi M, van der Poll T, ten Cate H, et al: Differential effects of anti-cytokine treatment on bronchoalveolar hemostasis in endotoxemic chimpanzees. Am J Respir Crit Care Med 1998; 158:92-98
53. Galdal KS, Lyberg T, Evensen SA, et al: Thrombin induces thromboplastin synthesis in cultured vascular endothelial cells. Thromb Haemost 1985; 54:373-376
54. Alm AK, Norström E, Sundelin J, et al: Stimulation of proteinase activated receptor-2 causes endothelial ceils to promote blood coagulation in vitro. Thromb Haemost 1999; 81:984-988
55. Langer F, Morys-Wortmann C, Küsters B, et al: Endothelial protease-activated receptor-2 induces tissue factor expression and von Willebrand factor release. Br J Haematol 1999; 105:541-550
56. Asakura H, Suga Y, Aoshima K, et al: Marked difference in pathophysiology between tissue factor- and lipopolysaccharide-induced disseminated intravascular coagulation models in rats. Crit Care Med 2002; 30:161-164
57. Ozcan M, Morton CT, Solovey A, et al: Whole blood tissue factor procoagulant activity remains detectable during severe aplasia following bone marrow and peripheral blood stem cell transplantation. Thromb Haemost 2001; 85:250-255
58. Mesters RM, Mannucci PM, Coppola R, et al: Factor VIIa and antithrombin III activity during severe sepsis and septic shock in neutropenic patients. Blood 1996; 88:881-886
59. Sevinsky JR, Rao LV, Ruf W: Ligand-induced protease receptor translocation into caveolae: A mechanism for regulating cell surface proteolysis of the tissue factor-dependent coagulation pathway. J Cell Biol 1996; 133:293-304
60. Mast AE, Higuchi DA, Huang ZF, et al: Glypican-3 is a binding protein on the HepG2 cell surface for tissue factor pathway inhibitor. Biochem J 1997; 327:577-583
61. Lupu C, Goodwin CA, Westmuckett AD, et al: Tissue factor pathway inhibitor in endothelial cells colocalizes with glycolipid microdomains/caveolae. Regulatory mechanism(s) of the anticoagulant properties of the endothelium. Arterioscler Thromb Vasc Biol 1997; 17:2964-2974
62. Petersen LC, Bjorn SE, Nordfang O: Effect of leukocyte proteinases on tissue factor pathway inhibitor. Thromb Haemost 1992; 67:537-541
63. Ott I, Malcouvier V, Schömig A, et al: Proteolysis of tissue factor pathway inhibitor-1 by thrombolysis in acute myocardial infarction. Circulation 2002; 105:279-281
64. Lawson JH, Butenas S, Ribarik N, et al: Complex-dependent inhibition of factor VIIa by antithrombin III and heparin. J Biol Chem 1993; 268:767-770
65. Rao LV, Rapaport SI, Hoang AD: Binding of factor VIIa to tissue factor permits rapid antithrombin III/heparin inhibition of factor VIIa. Blood 1993; 81:2600-2607
66. Marry I, Peclat V, Kirdaite G, et al: Amelioration of collagen-induced arthritis by thrombin inhibition. J Clin Invest 2001; 107:631-640
67. Cirino G, Cicala C, Bucci MR, et al: Thrombin functions as an inflammatory mediator through activation of its receptor. J Exp Med 1996; 183:821-827
68. Erlich JH, Boyle EM, Labriola J, et al: Inhibition of the tissue factor-thrombin pathway limits infarct size after myocardial ischemia-reperfusion injury by reducing inflammation. Am J Pathol 2000; 157:1849-1862
69. Golino P, Ragni M, Cirillo P, et al: Recombinant human, active site-blocked factor VIIa reduces infarct size and no-reflow phenomenon in rabbits. Am J Physiol Heart Circ Physiol 2000; 278:H1507-H1516
70. Taylor FB Jr, Stearns-Kurosawa DJ, Kurosawa S, et al: The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis. Blood 2000; 95:1680-1686
71. Taylor FB Jr, Dahlback B, Chang AC, et al: Role of free protein S and C4b binding protein in regulating the coagulant response to Escherichia coli. Blood 1995; 86:2642-2652
72. Taylor F, Chang A, Ferrell G, et al: C4b-binding protein exacerbates the host response to Escherichia coli. Blood 1991; 78:357-363
73. Sandset PM, Warn-Cramer BJ, Rao LV, et al: Depletion of extrinsic pathway inhibitor (EPI) sensitizes rabbits to disseminated intravascular coagulation induced with tissue factor: Evidence supporting a physiologic role for EPI as a natural anticoagulant. Proc Natl Acad Sci USA 1991; 88:708-712