Tissue factor pathway inhibitor in endothelial cells colocalizes with glycolipid microdomains/caveolae: Regulatory mechanism(s) of the anticoagulant properties of the endothelium

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 17, Issue 11, 1997, Pages 2964-2974

  Lupu, Cristina ^a   Goodwin, Christopher A ^a   Westmuckett, Andrew D ^a   Emeis, Jeff J ^b   Scully, Michael F ^a   Kakkar, Vijay V ^a   Lupu, Florea ^a  

^a THROMBOSIS RESEARCH INSTITUTE   (United Kingdom)

^b TNO   (Netherlands)

Author keywords

Caveolae; Endothelial cells; Glycolipid microdomains; Tissue factor pathway inhibitor

Indexed keywords

ALKALINE PHOSPHATASE; CAVEOLIN; GLYCOLIPID; GLYCOSPHINGOLIPID; TISSUE FACTOR PATHWAY INHIBITOR; UROKINASE RECEPTOR;

ANIMAL TISSUE; ANTICOAGULATION; ARTICLE; CELL MEMBRANE; CELLULAR DISTRIBUTION; ELECTRON MICROSCOPY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0031439536     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.17.11.2964     Document Type: Article

References (19)

1. Stern D, Handley D, Nawroth PP. Endothelium and the regulation of coagulation. In Simtonescu N, Simionescu M, eds. Endothelial Cell Biology in Health and Disease. NY: Plenum Press; 1988:275-306.
2. Pearson JD. Endothelial cell function and thrombosis. Baillieres Clin Haematol. 1994;7:441-452.
3. Broze GJ Jr. The role of tissue factor pathway inhibitor in a revised coagulation cascade. Semin Hematol. 1992;29:159-169.
4. Bevilacqua MP, Pober JS, Majeau GR, Cotran RS, Gimbrone MA Jr. Interleukin 1(IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells. J Exp Med. 1984;160:618-623.
5. Brox JH, Osterud B, Bjorklid E, Fenton JW II. Production and availability of thromboplastin in endothelial cells: effects of thrombin, endotoxin and platelets. Br J Haematol. 1984;57:239-246.
6. Nawroth PP, Stern DM. Modulation of endothelial cell hemostatic properties by tumor necrosis factor. J Exp Med. 1986;163:740-745.
7. Drake TA, Cheng J, Chang A, Taylor FB Jr. Expression of tissue factor, thrombomodulin, and E-selectin in baboons with lethal E. coli sepsis. Am J Pathol. 1993;142:1458-1470.
8. Contrino J, Hair G, Schmeizl M, Rickles F, Kreutzeur D. In situ characterization of antigenic and functional tissue factor expression in human tumors utilizing monoclonal antibodies and recombinant factor Vila as probes. Am J Pathol. 1994;145:1315-1322.
9. Broze GJ Jr., Warren LA, Novotny WF, Higuchi DA, Girard JJ, Miletich JP. The lipoprotein-associated coagulation inhibitor that inhibits the factor VII-tissue factor complex also inhibits factor Xa: insight into its possible mechanism of action. Blood. 1988;71:335-343.
10. Huang ZF, Wun TC, Braze GJ, Jr. Kinetics of factor Xa inhibition by tissue factor pathway inhibitor. J Biol Chem. 1993;268:26950-26955.
11. Callander NS, Rao LVM, Nordfang O, Sandset PM, Warn-Cramer B, Rapaport SI. Mechanisms of binding of recombinant extrinsic pathway inhibitor (rEPI) to cultured cell surfaces. Evidence that rEPI can bind to and inhibit factor VIIa-tissue factor complexes in the absence of factor Xa. J Biol Chem. 1992;267:876-882.
12. Scvinsky JR, Rao LVM, Ruf W. Ligand-induced protease receptor translocation into caveolae: a mechanism for regulating cell surface proteolysis of the tissue factor-dependent coagulation pathway. J Cell Biol. 1996;133:293-304.
13. Bajaj MS, Kuppuswamy MN, Saito H, Spitzer SG, Bajaj SP. Cultured normal human hepatocytes do not synthesize lipoprotein-associated coagulaton inhibitor: evidence that endothelium is the principal site of its synthesis. Proc Natl Acad Sci U. S. A. 1990;87:8869-8873.
14. Abildgaard U. Heparin/low molecular weight heparin and tissue factor pathway inhibitor. Haemostasis. 1993;23(suppl. 1):103-106.
15. Lupu C, Lupu F, Dennehy U, Kakkar VV, Scully MF. Thrombin induces the redistribution and acute release of tissue factor pathway inhibitor from specific granules within human endothelial cells in culture. Arterioscler Thromb Vasc Biol. 1995;15:2055-2062.
16. Sandset PM, Abildgaard U, Larsen ML. Heparin induces release of extrinsic coagulation pathway inhibitor (EPI). Thromb Res. 1988;50:803-813.
17. Edgwell CJS, McDonald CG, Graham JB. Permanent cell line expressing human factor VIII-related antigen established by hybridization. Proc Natl Acad Sci U. S. A.. 1983;80:3734-3737.
18. Jaffe EA, Nachman RL, Becker CG, Minick CR. Culture of human endothelial cells derived from human umbilical veins: identification by morphologic and immunologic criteria. J Clin Invest. 1973;52:2745-2756.
19. Gleizes PE, Noaillac-Depeyre J, Amalric F, Gas N. Basic fibroblast growth factor (FGF-2) internalization through the heparan sulfate proteoglycans-mediated pathway: an ultrastructural approach. Eur J Cell Biol. 1995;66:47-59.