Interleukin-6 production by endothelial cells via stimulation of protease-activated receptors is amplified by endotoxin and tumor necrosis factor-α

Journal of Interferon and Cytokine Research

Volumn 21, Issue 4, 2001, Pages 231-240

  Chi, L ^a   Li, Y ^a   Stehno Bittel, L ^a   Gao, J ^a   Morrison, D C ^a   Stechschulte, D J ^a   Dileepan, K N ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CALCIUM ION; GUANINE NUCLEOTIDE BINDING PROTEIN; HEXAPEPTIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; PERTUSSIS TOXIN; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; SERYLLEUCYLISOLEUCYLGLYCYLLYSYLVALINE; THROMBIN RECEPTOR ACTIVATING PEPTIDE 6; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CELL LEVEL; CONCENTRATION RESPONSE; CONSENSUS SEQUENCE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

CALCIUM; CALCIUM SIGNALING; CELL LINE; ENDOTHELIUM, VASCULAR; ENDOTOXINS; GTP-BINDING PROTEINS; HUMANS; INTERLEUKIN-6; NF-KAPPA B; PEPTIDES; RECEPTOR, PAR-1; RECEPTOR, PAR-2; RECEPTORS, THROMBIN; TUMOR NECROSIS FACTOR-ALPHA;

BACTERIA (MICROORGANISMS); RICKETTSIA SP. PAR;

EID: 0034917224     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/107999001750169871     Document Type: Article

References (38)

1. Endothelial cell thrombin receptors and PAR-2. Two protease-activated receptors located in a single cellular environment
2. The biology of interleukin-6
3. Interleukin-6 in biology and medicine
4. Human endothelial cells produce IL-6. Lack of responses to exogenous IL-6
5. Cytokine regulation of interleukin-6 production by human endothelial cells
6. IL-1 stimulates IL-6 production in endothelial cells
7. Interleukin-6 gene expression in human endothelial cells
8. BSF-2/IL-6 is co-stimulant for human thymocytes
9. Complementary DNA for novel human interleukin (BSF-2) that induces B-lymphocytes to produce immunoglobulin
10. Antitumor activity of recombinant interleukin-6 in mice
11. IFN-β2/IL-6 augments the activity of human natural killer cells
12. Interferon β2/BSF-2 shares identity with monocyte-derived hepatocyte stimulating factor (HSF) and regulates the major acute phase protein response in liver cells
13. C-reactive protein and its relation to cardiovascular risk factors: A population-based cross-sectional study
14. Production of C-reactive protein and risk of coronary events in stable and unstable angina
15. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
16. Elevated levels of interlukin-6 in unstable angina
17. IL-6 gene transcripts are expressed in human atherosclerotic lesions
18. Mast cell granules potentiate endotoxin-induced IL-6 production by en-dothelial cells
19. Endotoxin and mast cell granule proteases synergistically activate human coronary artery endothelial cells to generate interleukin-6 and interleukin-8
20. Exercise training depletes sarcoplastic reticulum calcium in coronary smooth muscle
21. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
22. Transient degradation of NF-κB proteins in macrophages after interaction with mast cell granules
23. Role of protein kinase A in activation of NF-κB proteins of a mouse macrophage-like cell line, J774
24. Influence of 3′ half-site sequence of NF-κB motifs on the binding of lipopolysaccharide-activatable macrophage NF-κB proteins
25. Mechanism of lipopolysaccharide-triggered junB activation in a mouse macrophage-like cell line (J774)
26. The binding of immobilized IgG2a to Fcκ2a receptor activates NF-κB via reactive oxygen intermediates and tumor necrosis factor
27. Molecular cloning of a functional thrombin receptor reveals a proteolytic mechanism of receptor activation
28. Involvement of NF-κB in the activation of IL-6 gene by inflammatory lymphokines
29. Activation of interleukin 6 gene expression through the NF-κB transcription factor
30. The PAR-2 is induced by inflammatory mediators in human endothelial cells. Comparison with the thrombin receptor
31. Lipopolysaccharide response is linked to the GTP binding protein Gi2, in the premonocytic cell line U937
32. Pertussis toxin inhibition of B cell and macrophage responses to bacterial lipopolysaccharide
33. Pertussis toxin-sensitive factor differentially regulates lipopolysaccharide-induced tumor necrosis factor-alpha and nitric oxide production in mouse peritoneal macrophages
34. The cloned thrombin receptor is necessary and sufficient for activation of mitogen-activated protein kinase and mitogenesis in mouse lung fibroblasts. Loss of responses in fibroblasts from receptor knockout mice
35. Function and activation of NF-κB in the immune system
36. NF-κB: Ten years after
37. Thrombin induces endothelial cell type II activation in vitro. IL-1 and TNF-α independent IL-8 secretion and E-selectin expression
38. Thrombin receptor mediated signals induce expressions of interleukin-6 and granulocyte colony-stimulating factor via NF-κB activation in synovial fibroblasts