Adult stem cell therapy for heart failure

Expert Opinion on Biological Therapy

Volumn 3, Issue 2, 2003, Pages 215-225

  Chiu, Ray Chu Jeng ^a,b  

^a MONTREAL GENERAL HOSPITAL   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Adult stem cells; Bone marrow cells; Heart failure therapy; Myoblasts; Myocardial infarction

Indexed keywords

ADOPTIVE IMMUNOTHERAPY; ANGIOGENESIS; BIOSAFETY; BONE MARROW CELL; CELL DIFFERENTIATION; CLINICAL TRIAL; CORONARY ARTERY; EMBRYO CELL; ENDOCARDIUM; EPICARDIUM; HEART FAILURE; HEART MUSCLE; HEART VENTRICLE FUNCTION; HUMAN; IMMUNOLOGICAL TOLERANCE; MICROENVIRONMENT; MYOBLAST; NONHUMAN; PHENOTYPE; REVIEW; STEM CELL; TISSUE INJURY; TISSUE REPAIR; TREATMENT OUTCOME;

ANIMALS; BONE MARROW CELLS; CELL TRANSPLANTATION; CLINICAL TRIALS; HEART FAILURE, CONGESTIVE; HUMANS; IMMUNE TOLERANCE; MYOCYTES, CARDIAC; STEM CELL TRANSPLANTATION;

ANIMALIA;

EID: 0037391748     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.3.2.215     Document Type: Review

References (105)

1. FRIEDENSTEIN AJ: Precursor cells of mechanocytes. Int. Rev. Cytol. (1976) 47:327-359.
2. WATT FM: Epidermal stem cells: markers, patterning and the control of stem cell fate. Philosophical Transactions of the Royal Society of London - Series B: Biological Sciences (1998) 353(1370):831-837.
3. PETERSEN BE, BOWEN WC, PATRENE KD et al.: Bone marrow as a potential source of hepatic oval cells. Science (1999) 284:1168-1170.
4. MCKAY R: Stem cell in the central nervous system. Science (1997) 274:69-71.
5. THOMSON JA, ITSKOVITZ-ELDOR J, SHAPIRO SS et al.: Embryonic stem cell lines derived from human blastocysts. Science (1998) 282:1145-1147.
6. KEHAT I, KENYAGIN-KARSENTI D, SNIR M et al.: Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes. J. Clin. Invest. (2001) 108:407-414.
7. XU C, POLICE S, RAO N, CARPENTER MK: Characterization and enrichment of cardiomyocytes derived from human embryonic stem cells. Circ. Res. (2002) 91:501-508.
8. EDELMAN GM: Topobiology: An introduction to molecular embryology. Basic books, HarperCollins Publishers, Inc., New York, USA (1988):18-21.
9. LIECHTY KW, MACKENZIE TC, SHAABAN AF et al.: Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep. Nat. Med. (2000) 11:1282-1286.
10. PROCKOP DJ: Marrow stromal cells as stem cells for nonhematopoietic tissues. Science (1997) 276(5309):71-74.
11. POTTEN CS: Stem cells in gastrointestinal epithelium: numbers, characteristics and death. Philosophical Transactions of the Royal Society of London - Series B: Biological Sciences (1998) 353(1370):821-830.
12. BITTIRA B, KUANG JQ, PIQUER S, SHUM-TIM D, AL-KHALDI A, CHIU RCJ: The pathophysiological roles of bone marrow stromal cells (MSCs) in myocardial infarction. Circulation (2001) 104(Suppl.):II-523.
13. HOECHT E, KAHNERT H, GUAN K et al.: Cardiac regeneration by stem cells after myocardial infarction in transplanted human hearts. Circulation (2002) 106(Suppl.):II-132.
14. TERADA N, HAMAZAKI T, OKA M et al.: Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature (2002) 416(6880):542-545.
15. YING QL, NICHOLS J, EVANS EP, SMITH AG: Changing potency by spontaneous fusion. Nature (2002) 416(6880):545-548.
16. VERFAILLIE CM: Stem cell plasticity. Graft (2000) 3(6):296-299.
17. WAGERS AJ, SHERWOOD RI, CHRISTENSEN JL, WEISSMANN IL: Little evidence for developmental plasticity of adult hematopoietic stem cells. Science (2002) 297:2256-2259.
18. REYES M, VERFAILLIE CM: Characterization of multipotent adult progenitor cells, a subpopulation of mesenchymal stem cells. Ann NY Acad. Sci. (2001) 938:231-233.
19. CAPLAN AI: Mesenchymal stem cells. J. Orthop. Res. (1991) 9:641-650.
20. PEREIRA RF, HALFORD KW, O'HARA MD et al.: Cultured adherent cells from marrow can serve as long-lasting precursor cells for bone, cartilage and lung in irradiated mice. Proc. Natl. Acad. Sci. USA (1995) 92:4857-4861.
21. WANG JS, SHUM-TIMD, GALIPEAU J et al.: Marrow stromal cells for cellular cardiomyoplasty: feasibility and clinical advantages. J. Thorac. Cardiovasc. Surg. (2000) 120:999-1006.
22. COLTER DC, CLASS R, DIGIROLAMO CM, PROCKOP DJ: Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow. Proc. Natl. Acad. Sci. USA (2000) 97(7):3213-3218.
23. PITTENGER MF, MACKAY AM, BECK SC et al.: Multilineage potential of adult human mesenchymal stem cells. Science (1999) 284:143-147.
24. PITTENGER MF, MACKAY AM: Multipotential human mesenchymal stem cells. Graft (2000) 3:288-295.
25. ORLIC D, KAJSTURA J, CHIMENTL S et al.: Bone marrow cells regenerate infracted myocardium. Nature (2001) 410:701-705.
26. RINGES-LICHTENBERG SM, JAEGER MD, FUCHS M et al.: Sustained improvement of left ventricular (LV) function after myocardial infarction by intravenous application of Sca-1 + Lin-/c-Kit+ bone marrow derived stem cells (Bmc). Circulation (2002) 106(Suppl.):II-14.
27. MANGI AA, KONG D, HE H: Genetically modified mesenchymal stem cells perform in vivo repair of damaged myocardium. Circulation (2002) 106(Suppl.):II-131.
28. SAW JW, QAYUMI K, HAMBURGER JN et al.: Transplantation of highly purified lentiviral transduced SP cells from bone marrow in a porcine myocardial model. Circulation (2002) 106(Suppl.):II-131.
29. GALINANES M, LOUBANI M, DAVIES J et al.: Safety and efficacy of transplantation of autologous bone marrow into scarred myocardium for the enhancement of cardiac function in man. Circulation (2002) 106(Suppl.):II-463.
30. JIANG Y, JAHAGIRDAR BN, REINHARDT RL et al.: Pluriporency of mesenchymal stem cells derived from adult marrow. Nature (2002) 418(6893):41-49.
31. CAMPION DR: The muscle satellite cell: a review. Int. Rev. Cytol. (1984) 87:225-251.
32. NATHANSON MA, HILFER SR, SEARLS RL: Formation of cartilage by non-chondrogenic cell types. Dev. Biol. (1978) 64:99-117,
33. MARELLI D, DESROSIERS C, ALFY M, KAO RL, CHIU RC: Cell transplantation for myocardial repair: an experimental approach. Cell Transplant. (1992) 1(6):383-390.
34. CHIU RCJ, ZIBAITIS A, KAO RL: Cellular cardiomyoplasty: myocardial regeneration with satellite cell implantation. Ann. Thorac. Surg. (1995) 60:12-18.
35. CHIU RCJ: Cardiac cell transplantation: the autologous skeletal myoblast implantation for myocardial regeneration. In: Advances in Cardiac Surgery, RB Karp, H Laks, AS Wechsler (Eds) (1999) 11:69-98.
36. DORFMAN J, DUONG M, ZIBAITIS A et al.: Myocardial tissue engineering with autologous myoblast implantation. J. Thorac. Cardiovasc. Surg. (1998) 116:744-751.
37. REINECKE H, MACDONALD GH, HAUSCHKA SD, MURRY CE: Electromechanical coupling between skeletal and cardiac muscle: implications for infarct repair. J. Cell. Biol. (2000) 149:731-740.
38. TAYLOR DA, ATKINS BZ, HUNGSPREUGS P et al.: Regenerating functional myocardium: improved performance after skeletal myoblast transplantation. Nat. Med. (1998) 4:929-933.
39. MENASCHE P, HAGEGE AA, SCORSIN M et al.: Myoblast transplantation for heart failure. Lancet (2001) 357:279-280.
40. CHIU RCJ: Therapeutic cardiac angiogenesis and myogenesis: the promises and challenges on a new frontier (Editorial). J. Thorac. Cardiovasc. Surg. (2001) 122:851-856.
41. ATKINS BZ, LEWIS CW, KRAUS WE, HUTCHESON KA, GLOWER DD, TAYLOR DA: Intracardiac transplantation of skeletal myoblasts yields two populations of striated cells in situ. Ann. Thorac. Surg. (1999) 67:124-129.
42. REINECKE H POPPA V, MURRY CE: Skeletal muscle stem cells do not transdifferentiate into cardiomyocytes after cardiac grafting. J. Mol. Cell. Cardiology (2002) 34:241-249.
43. MACKINNEY-FREEMAN S, JACKSON KA, OAMARGO FD, FERRARI G, MAVILIO F, GOODELL MA: Muscle-derived hematopoietic stem cells are hematopoietic in origin. Proc. Natl. Acad. Sci. USA (2002) 99:1341-1346.
44. CASCIO WE, BRACKHAN J, MULLERBORER BJ et al.: adult-derived stem cells from the liver respond to signals from the microenvironment and transdifferentiate into cardiac myocytes in culture. Circulation (2002) 106(Suppl.):II-220.
45. BITTNER RE, SCHOFER C, WEIPOLTSHAMMER K et al.: Recruitment of bone-marrow-derived. cells by skeletal and cardiac muscle in adult dystropic mdx mice. Anat. Embryol. (1999) 199:391-396.
46. CHEN J, LI Y, WANG L, ZHANG Z et al.: Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischaemia in rats. Stroke (2001) 32:1005-1011.
47. ORLIC D, KAJSTURA J, CHIMENTI S et al.: Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc. Natl. Acad. Sci. USA (2001) 98(18):10344-10349.
48. SORGER JM, DESPRES D, HILL J et al.: MRI tracking of intravenous magnetically labelled mesenchymal stem cells following myocardial infarction in rats. Circulation (2002) 106(Suppl.):II-16.
49. FUJITA J, SUZUKI Y, ANDO K et al.: Transplanted bone marrow stem cells move to the infracted myocardium and differentiate into smooth muscle cells and cardiomyocytes. Circulation (2002) 106(Suppl.):II-132.
50. MIKI T, SAKAMOTO J, NAKANO A et al.: Mobilization of bone marrow cells by G-CSF/M-CSF improves ventricular function in the heart undergoing postinfarct remodeling. Circulation (2002) 106(Suppl.):II-15.
51. MINATOGUCHI S, TAKAMURA G, CHEN XH et al.: Myocardial infarction itself induces cardiomyocyte regeneration from bone marrow cells and postischemic G-CSF treatment improves cardiac dysfunction via acceleration of the process. Circulation (2002) 106(Suppl.):II-132.
52. FUKUHARA S, TOMITA S, OHTSU Y et al.: G-CSF promoted bone marrow cells to migrate into infracted heart and differentiate into cardiomyocytes. Circulation (2002) 106(Suppl.):II-376.
53. FUJITA J, SUZUKI Y, ANDO K et al.: G-CSF improves postinfarcfion heart failure by mobilizing bone marrow stem cells but GM-CSF increases the mortality by deteriorating heart function in mice. Circulation (2002) 106(Suppl.):II-15.
54. DEVINE SM, BARTHOLOMEW AM, MAHMUD N et al.: Mesenchymal stem cells are capable of homing to the bone marrow of non-human primates following systemic infusion. Exp. Hematol. (2001) 29:244-255.
55. BRADSTOCK K: Wanderings of the bone-marrow stem cell. Lancet (2001) 358:5-6.
56. CHIMENTI S, BARLUCCHI L, LIMANA F et al.: Local mobilization of resident cardiac primitive cells by growth factors repairs the infracted heart. Circulation (2002) 106(Suppl.):II-14.
57. CHIU RCJ: Cellular cardiomyoplasty: the biology and clinical importance of amilieu dependent differentiation. In: Handbook of Cardiac Cell Transplantation, N Kipshidzen, PW Serruys (Eds), Martin Dunitz Ltd, London, UK (2003) (in press).
58. CAHILL KS, PITTENGER MF, BYRNE BJ: Differentiation of human mesenchymal cells to cardiomyocytes by co-culture. Circulation (2002) 106(Suppl.):II-198.
59. RANGAPPA S, ENTWISTLE JWC, WECHSLER AS: Cardiomyocytes can induce human mesenchymal stem cells to express cardiac phenotype and genotype. Circulation (2002) 106(Suppl.):II-235.
60. TOMITA S, NAKATANI T, FUKUHARA S et al.: Bone marrow stromal cells can differentiate into cardiac lineage and contract synchronously with cardiomyocytes by direct cell-to-cell interaction in vitro. Presented at the 82nd Annual Meeting of the American Association for Thoracic Surgery, Washington, DC, (May 5, 2002).
61. AL-KHALDI A, ELIOPOULOS N, LACHAPELLE K, GALIPEAU J: VEGF-dependent angiogenic response induced by ex-vivo cultured marrow stromal cells. Circulation (2001) 104(Suppl.):II-123.
62. CHEDRAWY EG, WANG JS, NGUYEN DM et al.: Incorporation and integration of implanted myogenic and stem cells into native myocardial fibres: anatomical basis for functional improvement. J Thorac. Cardiovasc. Surg. (2002) 124:584-590.
63. NIKLASON LE, GAO J, ABBOTT WM et al.: Functional arteries grown in vitro. Science (1999) 284:489-493.
64. WILSON E, SUDHIR K, IVES HE: Mechanical strain of rat vascular smooth muscle cells is sensed by specific extracellular matrix/integrin interactions. J. Clin. Invest. (1995) 96:2364-2372.
65. DEWEY CF, BUSSOLAFI SR, GIMBRONE MA et al.: The dynamic response of vascular endothelial cells to fluid shear stress. J. Biomech. Eng. (1981) 103:177-188.
66. KANDA K, MATSUDA T: Mechanical stress-induced orientation and ultrastructural change of smooth muscle cells cultured in three-dimensional collagen lattices. Cell Transplant. (1994) 3:481-492.
67. DOUGLAS PS, MORROW R, IOLO A, REICHEK N: Left ventricular shape, afterload and survival in idiopathic dilated cardiomyopathy. J. Am. Coll. Cardiol. (1989) 13:311-315.
68. GRIESE DP, GRUMBECK B, KUNZSCHUGRARDT L et al.: Genetic engineering of postnatal hematopoietic stem cells for gene and cell-based therapy of ischemic heart disease in rars. Circulation (2002) 106(Suppl.)II-15.
69. YAU TM, FUNG K, FUJII T et al.: Enhanced myocardial angiogenesis by gene transfer using transplanted cells. Circulation (2001) 104:1218-1222.
70. WAKITANI S, SAITO T, CAPLAN AI: Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. Muscle Nerve (1995) 18:1417-1426.
71. MAKINO S, FUKUDA K, MIYOSHI S et al.: Cardiomyocytes can be generated from marrow stromal cells in vitro. J. Clin. Invest. (1999) 103:697-705.
72. TOMITA S, LI RK, WEISEL RD et al.: Autologous transplantation of bone marrow cells improves damaged heart function. Circulation (1999) 100(Suppl. II):247-256.
73. BITTIRA B, KUANG JQ, AL-KHALDI A, SHUM-TIM D, CHIU RCJ: In vitro preprogramming of marrow stromal cells for myocardial regeneration. Ann. Thorac. Surg. (2002) 74:1154-1160.
74. ROBINSON SW, CHO PW, LEVITSKY HI et al.: Arterial delivery of genetically labelled skeletal myoblasts to the murine heart: long-term survival and phenotypic modification of implanted myoblasts. Cell Transplant. (1996) 5(1):77-91.
75. TANGY, ZHAO Q, WANG K et al.: The in vivo differentiation and attribution of bone marrow derived mesenchymal stem cell in infracted myocardium in rats. Circulation (2002) 106(Suppl.):II-199.
76. WANG JS, SHUM-TIM D, CHEDRAWY E, CHIU RCJ: The coronary delivery of marrow stromal cells for myocardial regeneration: pathophysiologic and therapeutic implications. J. Thorac. Cardiovasc. Surg. (2001) 122:699-705.
77. SAITO T, KUANG JQ, LIN CCH, CHIU RCJ: Transcoronary implantation of bone marrow stromal cells ameliorates cardiac function after myocardial infarction. J. Thorac. Cardiovasc. Surg. (2003) (in press).
78. GAO J, DENNIS JE, MUZIC RF, LUNDBERG M, CAPLAN AL: The dynamic in vivo distribution of bone-marrow derived mesenchymal stem cells after infusion. Cells Tissues Organs (2001) 169:12-20.
79. TANG Y, ZHAO Q, CHENG L: Autologous marrow stromal cell transplantation improves cardiac function after myocardial infarction in rats. Circulation (2002) 106(Suppl.):II-52.
80. THOMPSON RB, EMANI S, COLGROVE S et al.: A direct functional comparison of autologous bone marrow-derived multipotent progenitor cells and autologous skeletal myoblasts in repairing cryoinjured rabbit myocardium. Circulation (2002) 106(Suppl.):II-463.
81. YOON YS, MURAYAMA T, TKEBUCHAVA T et al.: Clonally expanded bone marrow derived stem cells differentiate into multiple lineages in vitro and can attenuate myocardial dysfunction post myocardial infarction. Circulation (2002) 106(Suppl.):II-11.
82. SIMINIAK T, KALAWSKI R, JERZYKOWSKA O et al.: Transplantation of autologous skeletal myoblasts in the treatment of patients with postinfarction heart failure. Early results of Phase I clinical trial. Circulation (2002) 106(Suppl.):II-636.
83. MENACHE P, HAGEGE AA, VILQUIN JT et al.: Transplantation of autologous skeletal myoblasts in patients with severe left ventricular dysfunction. A medium-term appraisal. Circulation (2002) 106(Suppl.):II-462.
84. STAMM C, WESTPHAL B, KLEINE HD et al.: Bone marrow stem cell transplantation for myocardial regeneration in post infarction CABG patients. Circulation (2002) 106(Suppl.):II-375.
85. BELA, AGBULUTO, SAMUEL JL et al.: Transplantation of autologous fresh bone marrow into infracted myocardium: a word of caution. Circulation (2002) 106(Suppl.):II-463.
86. ASSMUS B, SCHACHINGER V, TEUPE C et al.: Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction. Circulation (2002) 106:3009-3017.
87. STAMM C, WESTPHAL B, KLEIN H-D et al.: Autologous bone-marrow stem-cell transplantation for myocardial regeneration. Lancet (2003) 361:45-46.
88. STRAUER BE, BREHM M, ZEUS T et al.: Repair of infracted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation (2002) 106:1913-1918.
89. TSE HT, KWONG Y-L, CHAN JKF et al.: Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation. Lancet (2003) 361:47-49.
90. 125I-labelled basic fibroblast growth factor (bFGF) favor intramyocardial delivery. J. Am. Col. Cardiol. (2000) 35:10A.
91. ISNER JM, VALE PR, SYMES JF, LOSORDO DW: Assessment of risks associated with cardiovascular gene therapy in human subjects. Circ. Res. (2001) 89(5):389-400.
92. HAMANO K: Preliminary result of clinical trial of therapeutic angiogenesis achieved by the implantation of self bone marrow cells for ischemic heart disease. Circulation (2001) 104(Suppl.):II-17, II-69.
93. FUJI H, TOMITA S, HANATANI A et al.: Bone marrow cell transplantation improved regional perfusion after infarction: measurement of myocardial perfusion by myocardial contrast echocardiography and histological study Circulation (2002) 106(Suppl.):II-375.
94. DAVANI S, MARANDIN A, KANTELIP B et al.: Transplanted mesenchymal stem cells induce angiogenesis in infracted myocardium. Circulation (2002) 106(Suppl.):II-549.
95. SIMONS M, BONOW RO, CHRONOS NA et al.: Clinical trial in coronary angiogenesis: issues, problems, consensus. An expert panel summary. Circulation (2000) 102:73-86.
96. LEE RJ, SPRINGER ML, BLANCOBOSE WE, SHAW R, URSELL PC, BLAU HM: VEGF gene delivery to myocardium: deleterious effects of unregulated expression. Circulation (2000) 102(8):898-901.
97. CAPARELLI DJ, CATTANEO S, SHAKE JG et al.: Cellular cardiomyoplasty with allogeneic mesenchymal STEM cells results in improved cardiac performance in a swine model of myocardial infarction. Circulation (2001) 104(Suppl.):II-599.
98. MAKKAR RR, PRICE M, LILL M et al.: Multilineage differentiation of transplanted allogenic mesenchymal stem cells in a porcine model of recent myocardial infarction improves left ventricular function. Circulation (2002) 106(Suppl.):II-34.
99. SAITO T, KUANG JQ, BITTIRA B, ALKHALDI A, CHIU RCJ: Xenotransplant cardiac chimaera: immune tolerance of adult stem cells. Ann. Thorac. Surg. (2002) 74:19-24.
100. MCINTOSH K, BARTHOLOMEW A: Stromal cell modulation of the immune system. A potential role for mesenchymal stem cells. Graft (2000) 3:324-328.
101. MATZINGER P: The danger model: a renewed sense of self. Science (2002) 296:301-305.
102. NARULA J, HAIDER N, VIRMANI R et al.: Apoptosis in myocytes in end stage heart failure. N. Engl. J. Med. (1996) 335(16):1182-1189.
103. YOO K-J, LI R-K WEISEL RD, MICKLE DAG, LI G, YAU TM: Autologous smooth muscle cell transplantation improved heart function in dilated cardiomyopathy. Ann. Thorac. Surg. (2000) 70:859-865.
104. LEOBON B, GARCIN I, VILQUIN JT et al.: Do engrafted skeletal myoblasts contract in infracted myocardium? Circulation (2002) 106(Suppl.):II-549.
105. TAMBARAK, SAKAKIBARA Y, SAKAGUCHI G et al.: Transplanted skeletal myoblasts can fully replace the infracted myocardium when they survive in the host in large numbers. Circulation (2002) 106(Suppl.):II-549.