메뉴 건너뛰기




Volumn 36, Issue 4, 2003, Pages 171-182

Inhibition of proteasome-dependent degradation of Wee1 in G2-arrested Hep3B cells by TGFβ1

Author keywords

CDC2; Cell cycle; Cyclin; MG132; p21cip1; PD0166285

Indexed keywords

CELL CYCLE PROTEIN; CYCLIN B1; CYCLIN DEPENDENT KINASE 2; DNA; MESSENGER RNA; PD 0166285; PHOSPHATASE; PHOSPHOTRANSFERASE; PROTEASOME; PROTEIN INHIBITOR; PROTEIN P21; PROTEIN P27; RETINOBLASTOMA PROTEIN; RNA; TRANSFORMING GROWTH FACTOR BETA1; TYROSINE; UNCLASSIFIED DRUG;

EID: 0037387152     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/mc.10111     Document Type: Article
Times cited : (39)

References (50)
  • 2
    • 0028959114 scopus 로고
    • Transforming growth factor-beta 1 (TGFβ1) and TGFβ1 receptors in normal, cirrhotic, and neoplastic human livers
    • Bedossa P, Peltier E, Terris B, Franco D, Poynard T. Transforming growth factor-beta 1 (TGFβ1) and TGFβ1 receptors in normal, cirrhotic, and neoplastic human livers. Hepatology 1995;21:760-766.
    • (1995) Hepatology , vol.21 , pp. 760-766
    • Bedossa, P.1    Peltier, E.2    Terris, B.3    Franco, D.4    Poynard, T.5
  • 3
    • 0028301747 scopus 로고
    • Plasma transforming growth factor β1 in patients with hepatocellular carcinoma
    • Shirai Y, Kawata S, Tamura S, et al. Plasma transforming growth factor β1 in patients with hepatocellular carcinoma. Cancer 1994;73:2275-2279.
    • (1994) Cancer , vol.73 , pp. 2275-2279
    • Shirai, Y.1    Kawata, S.2    Tamura, S.3
  • 4
    • 16044369574 scopus 로고    scopus 로고
    • MADR2 maps to 18q21 and encodes a TGFβ-regulated MAD-related protein that is functionally mutated in colorectal carcinoma
    • Eppert K, Scherer SW, Ozcelik H, et al. MADR2 maps to 18q21 and encodes a TGFβ-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. Cell 1996;86:543-552.
    • (1996) Cell , vol.86 , pp. 543-552
    • Eppert, K.1    Scherer, S.W.2    Ozcelik, H.3
  • 5
    • 0032981837 scopus 로고    scopus 로고
    • Acceleration of c-myc-induced hepatocarcinogenesis by coexpression of transforming growth factor (TGF)α in transgenic mice is associated with TGFβ1 signaling disruption
    • Santoni-Rugiu E, Jensen MR, Factor VM, Thorgeirsson SS. Acceleration of c-myc-induced hepatocarcinogenesis by coexpression of transforming growth factor (TGF)α in transgenic mice is associated with TGFβ1 signaling disruption. Am J Pathol 1999;154:1693-1700.
    • (1999) Am J Pathol , vol.154 , pp. 1693-1700
    • Santoni-Rugiu, E.1    Jensen, M.R.2    Factor, V.M.3    Thorgeirsson, S.S.4
  • 6
    • 9344223357 scopus 로고    scopus 로고
    • DPC4 gene in various tumor types
    • Schutte M, Hruban RH, Hedrick L, et al. DPC4 gene in various tumor types. Cancer Res 1996;56:2527-2530.
    • (1996) Cancer Res , vol.56 , pp. 2527-2530
    • Schutte, M.1    Hruban, R.H.2    Hedrick, L.3
  • 7
    • 0032544448 scopus 로고    scopus 로고
    • Smad3 mutant mice develop metastatic colorectal cancer
    • Zhu Y, Richardson JA, Parada LF, Graff JM. Smad3 mutant mice develop metastatic colorectal cancer. Cell 1998;94:703-714.
    • (1998) Cell , vol.94 , pp. 703-714
    • Zhu, Y.1    Richardson, J.A.2    Parada, L.F.3    Graff, J.M.4
  • 8
    • 0034644472 scopus 로고    scopus 로고
    • TGFβ signaling in growth control, cancer, and heritable disorders
    • Massague J, Blain SW, Lo RS. TGFβ signaling in growth control, cancer, and heritable disorders. Cell 2000;103:295-309.
    • (2000) Cell , vol.103 , pp. 295-309
    • Massague, J.1    Blain, S.W.2    Lo, R.S.3
  • 9
    • 0027374766 scopus 로고
    • TGFβ inhibition of CDK4 synthesis is linked to cell cycle arrest
    • Ewen ME, Sloss HK, Whitehouse LL, Livingston DM. TGFβ inhibition of CDK4 synthesis is linked to cell cycle arrest. Cell 1993;74:1009-1020.
    • (1993) Cell , vol.74 , pp. 1009-1020
    • Ewen, M.E.1    Sloss, H.K.2    Whitehouse, L.L.3    Livingston, D.M.4
  • 10
    • 0030978315 scopus 로고    scopus 로고
    • Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGFβ in cells lacking the CDK inhibitor p15
    • Iavarone A, Massague J. Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGFβ in cells lacking the CDK inhibitor p15. Nature 1997;387:417-422.
    • (1997) Nature , vol.387 , pp. 417-422
    • Iavarone, A.1    Massague, J.2
  • 11
    • 0029147796 scopus 로고
    • 1 independent of effects on gene transcription
    • 1 independent of effects on gene transcription. Cancer Res 1995;55:1452-1457.
    • (1995) Cancer Res , vol.55 , pp. 1452-1457
    • Alexandrow, M.G.1    Moses, H.L.2
  • 12
    • 10244232854 scopus 로고    scopus 로고
    • Sensitivity to transforming growth factor β1-induced growth arrest is common in human squamous cell carcinoma cell lines: c-MYC downregulation and p21waf1 induction are important early events
    • Malliri A, Yeudall WA, Nikolic M, Crouch DH, Parkinson EK, Ozanne B. Sensitivity to transforming growth factor β1-induced growth arrest is common in human squamous cell carcinoma cell lines: c-MYC downregulation and p21waf1 induction are important early events. Cell Growth Differ 1996;7:1291-1304.
    • (1996) Cell Growth Differ , vol.7 , pp. 1291-1304
    • Malliri, A.1    Yeudall, W.A.2    Nikolic, M.3    Crouch, D.H.4    Parkinson, E.K.5    Ozanne, B.6
  • 13
    • 0032803878 scopus 로고    scopus 로고
    • Myc down-regulation by transforming growth factor β required for activation of the p15 (Ink4b) G (1) arrest pathway
    • Warner BJ, Blain SW, Seoane J, Massague J. Myc down-regulation by transforming growth factor β required for activation of the p15 (Ink4b) G (1) arrest pathway. Mol Cell Biol 1999;19:5913-5922.
    • (1999) Mol Cell Biol , vol.19 , pp. 5913-5922
    • Warner, B.J.1    Blain, S.W.2    Seoane, J.3    Massague, J.4
  • 14
    • 0034644653 scopus 로고    scopus 로고
    • Different sensitivity of the transforming growth factor β cell cycle arrest pathway to c-Myc and MDM-2
    • Blain SW, Massague J. Different sensitivity of the transforming growth factor β cell cycle arrest pathway to c-Myc and MDM-2. J Biol Chem 2000;275:32066-32070.
    • (2000) J Biol Chem , vol.275 , pp. 32066-32070
    • Blain, S.W.1    Massague, J.2
  • 15
    • 0031466305 scopus 로고    scopus 로고
    • Cyclin-dependent kinases: Engines, clocks, and microprocessors
    • Morgan DO. Cyclin-dependent kinases: Engines, clocks, and microprocessors. Annu Rev Cell Dev Biol 1997;13:261-291.
    • (1997) Annu Rev Cell Dev Biol , vol.13 , pp. 261-291
    • Morgan, D.O.1
  • 16
    • 0025246110 scopus 로고
    • Checkpoint pathways come of age
    • Nurse P. Checkpoint pathways come of age. Nature 1990;344:503-508.
    • (1990) Nature , vol.344 , pp. 503-508
    • Nurse, P.1
  • 17
    • 0031470835 scopus 로고    scopus 로고
    • Universal control mechanism regulating onset of M-phase
    • Nurse P. Universal control mechanism regulating onset of M-phase. Cell 1997;91:865-867.
    • (1997) Cell , vol.91 , pp. 865-867
    • Nurse, P.1
  • 18
    • 0030665150 scopus 로고    scopus 로고
    • The role of Cdc2 feedback loop control in the DNA damage checkpoint in mammalian cells
    • Poon RY, Chau MS, Yamashita K, Hunter T. The role of Cdc2 feedback loop control in the DNA damage checkpoint in mammalian cells. Cancer Res 1997;57:5168-5178.
    • (1997) Cancer Res , vol.57 , pp. 5168-5178
    • Poon, R.Y.1    Chau, M.S.2    Yamashita, K.3    Hunter, T.4
  • 19
    • 0030803797 scopus 로고    scopus 로고
    • Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity
    • Booher RN, Holman PS, Fattaey A. Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity. J Biol Chem 1997;272:22300-22306.
    • (1997) J Biol Chem , vol.272 , pp. 22300-22306
    • Booher, R.N.1    Holman, P.S.2    Fattaey, A.3
  • 20
    • 0028978205 scopus 로고
    • Mouse p87wee1 kinase is regulated by M-phase specific phosphorylation
    • Honda R, Tanaka H, Ohba Y, Yasuda H. Mouse p87wee1 kinase is regulated by M-phase specific phosphorylation. Chromosome Res 1995;3:300-308.
    • (1995) Chromosome Res , vol.3 , pp. 300-308
    • Honda, R.1    Tanaka, H.2    Ohba, Y.3    Yasuda, H.4
  • 21
    • 0033067558 scopus 로고    scopus 로고
    • 2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexes
    • 2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexes. Mol Cell Biol 1999;19:5113-5123.
    • (1999) Mol Cell Biol , vol.19 , pp. 5113-5123
    • Liu, F.1    Rothblum-Oviatt, C.2    Ryan, C.E.3    Piwnica-Worms, H.4
  • 22
    • 0027510249 scopus 로고
    • Human Wee1 kinase inhibits cell division by phosphorylating p34CDC2 exclusively on Tyr15
    • McGowan CH, Russell P. Human Wee1 kinase inhibits cell division by phosphorylating p34CDC2 exclusively on Tyr15. EMBO J 1993;12:75-85.
    • (1993) EMBO J , vol.12 , pp. 75-85
    • McGowan, C.H.1    Russell, P.2
  • 23
    • 0028998865 scopus 로고
    • Cell cycle regulation of a Xenopus Wee1-like kinase
    • Mueller PR, Coleman TR, Dunphy WG. Cell cycle regulation of a Xenopus Wee1-like kinase. Mol Biol Cell 1995;6:119-134.
    • (1995) Mol Biol Cell , vol.6 , pp. 119-134
    • Mueller, P.R.1    Coleman, T.R.2    Dunphy, W.G.3
  • 24
    • 0026616796 scopus 로고
    • Inactivation of the p34CDC2-cyclin B complex by the human WEE1 tyrosine kinase
    • Parker LL, Piwnica-Worms H. Inactivation of the p34CDC2-cyclin B complex by the human WEE1 tyrosine kinase. Science 1992;257:1955-1957.
    • (1992) Science , vol.257 , pp. 1955-1957
    • Parker, L.L.1    Piwnica-Worms, H.2
  • 25
    • 0029048491 scopus 로고
    • Regulation of the human WEE1 Hu CDK tyrosine 15-kinase during the cell cycle
    • Watanabe N, Broome M, Hunter T. Regulation of the human WEE1 Hu CDK tyrosine 15-kinase during the cell cycle. EMBO J 1995;14:1878-1891.
    • (1995) EMBO J , vol.14 , pp. 1878-1891
    • Watanabe, N.1    Broome, M.2    Hunter, T.3
  • 26
    • 0031758564 scopus 로고    scopus 로고
    • Checkpoints on the road to mitosis
    • Russell P. Checkpoints on the road to mitosis. Trends Biochem Sci 1998;23:399-402.
    • (1998) Trends Biochem Sci , vol.23 , pp. 399-402
    • Russell, P.1
  • 27
    • 0029000155 scopus 로고
    • Cell cycle regulation of human WEE1
    • McGowan CH, Russell P. Cell cycle regulation of human WEE1. EMBO J 1995;14:2166-2175.
    • (1995) EMBO J , vol.14 , pp. 2166-2175
    • McGowan, C.H.1    Russell, P.2
  • 28
    • 0032484097 scopus 로고    scopus 로고
    • Coupling of mitosis to the completion of S phase through Cdc34-mediated degradation of Wee1
    • Michael WM, Newport J. Coupling of mitosis to the completion of S phase through Cdc34-mediated degradation of Wee1. Science 1998;282:1886-1889.
    • (1998) Science , vol.282 , pp. 1886-1889
    • Michael, W.M.1    Newport, J.2
  • 29
    • 0032538796 scopus 로고    scopus 로고
    • Control of Swe1p degradation by the morphogenesis checkpoint
    • Sia RA, Bardes ES, Lew DJ. Control of Swe1p degradation by the morphogenesis checkpoint. EMBO J 1998;17:6678-6688.
    • (1998) EMBO J , vol.17 , pp. 6678-6688
    • Sia, R.A.1    Bardes, E.S.2    Lew, D.J.3
  • 30
    • 0032496322 scopus 로고    scopus 로고
    • Replication checkpoint enforced by kinases Cds1 and Chk1
    • Boddy MN, Furnari B, Mondesert O, Russell P. Replication checkpoint enforced by kinases Cds1 and Chk1. Science 1998;280:909-912.
    • (1998) Science , vol.280 , pp. 909-912
    • Boddy, M.N.1    Furnari, B.2    Mondesert, O.3    Russell, P.4
  • 32
    • 0018718742 scopus 로고
    • Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line
    • Aden DP, Fogel A, Plotkin S, Damjanov I, Knowles BB. Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line. Nature 1979;282:615-616.
    • (1979) Nature , vol.282 , pp. 615-616
    • Aden, D.P.1    Fogel, A.2    Plotkin, S.3    Damjanov, I.4    Knowles, B.B.5
  • 33
    • 0021347915 scopus 로고
    • Phenotypical stability of a human hepatoma cell line, HuH-7, in long-term culture with chemically defined medium
    • Nakabayashi H, Taketa K, Yamane T, Miyazaki M, Miyano K, Sato J. Phenotypical stability of a human hepatoma cell line, HuH-7, in long-term culture with chemically defined medium. Jpn J Cancer Res 1984;75:151-158.
    • (1984) Jpn J Cancer Res , vol.75 , pp. 151-158
    • Nakabayashi, H.1    Taketa, K.2    Yamane, T.3    Miyazaki, M.4    Miyano, K.5    Sato, J.6
  • 34
    • 0026677934 scopus 로고
    • Expression of oncogenes and tumor suppressor genes in human hepatocellular carcinoma and hepatoblastoma cell lines
    • Farshid M, Tabor E. Expression of oncogenes and tumor suppressor genes in human hepatocellular carcinoma and hepatoblastoma cell lines. J Med Virol 1992;38:235-239.
    • (1992) J Med Virol , vol.38 , pp. 235-239
    • Farshid, M.1    Tabor, E.2
  • 35
    • 0040419494 scopus 로고    scopus 로고
    • Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53
    • Muller M, Stand S, Hug H, et al. Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53. J Clin Invest 1997;99:403-413.
    • (1997) J Clin Invest , vol.99 , pp. 403-413
    • Muller, M.1    Stand, S.2    Hug, H.3
  • 37
    • 0033865273 scopus 로고    scopus 로고
    • Regulatory mechanisms for transforming growth factor β as an autocrine inhibitor in human hepatocellular carcinoma: Implications for roles of smads in its growth
    • Matsuzaki K, Date M, Furukawa F, et al. Regulatory mechanisms for transforming growth factor β as an autocrine inhibitor in human hepatocellular carcinoma: Implications for roles of smads in its growth. Hepatology 2000;32:218-227.
    • (2000) Hepatology , vol.32 , pp. 218-227
    • Matsuzaki, K.1    Date, M.2    Furukawa, F.3
  • 38
    • 0035890610 scopus 로고    scopus 로고
    • Radiosensitization of p53 mutant cells by PD0166285, a novel G(2) checkpoint abrogator
    • Wang Y, Li J, Booher RN, et al. Radiosensitization of p53 mutant cells by PD0166285, a novel G(2) checkpoint abrogator. Cancer Res 2001;61:8211-8217.
    • (2001) Cancer Res , vol.61 , pp. 8211-8217
    • Wang, Y.1    Li, J.2    Booher, R.N.3
  • 39
    • 0033515424 scopus 로고    scopus 로고
    • 1 arrest triggered by p16INK4a, TGFβ, and contact inhibition
    • 1 arrest triggered by p16INK4a, TGFβ, and contact inhibition. Cell 1999;97:53-61.
    • (1999) Cell , vol.97 , pp. 53-61
    • Zhang, H.S.1    Postigo, A.A.2    Dean, D.C.3
  • 40
    • 0029880622 scopus 로고    scopus 로고
    • Suppression of apoptosis by dominant negative mutants of cyclin-dependent protein kinases
    • Meikrantz W, Schlegel R. Suppression of apoptosis by dominant negative mutants of cyclin-dependent protein kinases. J Biol Chem 1996;271:10205-10209.
    • (1996) J Biol Chem , vol.271 , pp. 10205-10209
    • Meikrantz, W.1    Schlegel, R.2
  • 41
    • 0345425059 scopus 로고    scopus 로고
    • Cdc2 and Cdk2 kinase activated bytransforming growth factor β1 trigger apoptosis through the phosphorylation of retinoblastoma protein in FaO hepatoma cells
    • Choi KS, Eom YW, Kang Y, et al. Cdc2 and Cdk2 kinase activated bytransforming growth factor β1 trigger apoptosis through the phosphorylation of retinoblastoma protein in FaO hepatoma cells. J Biol Chem 1999;274:31775-31783.
    • (1999) J Biol Chem , vol.274 , pp. 31775-31783
    • Choi, K.S.1    Eom, Y.W.2    Kang, Y.3
  • 42
    • 0029883399 scopus 로고    scopus 로고
    • The retinoblastoma gene product inhibits TGFβ1 induced apoptosis in primary rat hepatocytes and human HuH-7 hepatoma cells
    • Fan G, Ma X, Kren BT, Steer CL. The retinoblastoma gene product inhibits TGFβ1 induced apoptosis in primary rat hepatocytes and human HuH-7 hepatoma cells. Oncogene 1996;12:1909-1919.
    • (1996) Oncogene , vol.12 , pp. 1909-1919
    • Fan, G.1    Ma, X.2    Kren, B.T.3    Steer, C.L.4
  • 43
    • 0031961995 scopus 로고    scopus 로고
    • 2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication
    • 2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol Cell Biol 1998;18:629-643.
    • (1998) Mol Cell Biol , vol.18 , pp. 629-643
    • Niculescu A.B. III1    Chen, X.2    Smeets, M.3    Hengst, L.4    Prives, C.5    Reed, S.I.6
  • 46
    • 0032540280 scopus 로고    scopus 로고
    • RhoB is stabilized by transforming growth factor β and antagonizes transcriptional activation
    • Engel ME, Datta PK, Moses HL. RhoB is stabilized by transforming growth factor β and antagonizes transcriptional activation. J Biol Chem 1998;273:9921-9926.
    • (1998) J Biol Chem , vol.273 , pp. 9921-9926
    • Engel, M.E.1    Datta, P.K.2    Moses, H.L.3
  • 47
    • 0027236688 scopus 로고
    • Two distinct mechanisms for negative regulation of the Wee1 protein kinase
    • Tang Z, Coleman TR, Dunphy WG. Two distinct mechanisms for negative regulation of the Wee1 protein kinase. EMBO J 1993;12:3427-3436.
    • (1993) EMBO J , vol.12 , pp. 3427-3436
    • Tang, Z.1    Coleman, T.R.2    Dunphy, W.G.3
  • 48
    • 0034058071 scopus 로고    scopus 로고
    • Activation of Wee1 by p42 MAPK in vitro and in cycling xenopus egg extracts
    • Walter SA, Guadagno SN, Ferrell JE Jr. Activation of Wee1 by p42 MAPK in vitro and in cycling xenopus egg extracts. Mol Biol Cell 2000;11:887-896.
    • (2000) Mol Biol Cell , vol.11 , pp. 887-896
    • Walter, S.A.1    Guadagno, S.N.2    Ferrell J.E., Jr.3
  • 49
    • 0035158899 scopus 로고    scopus 로고
    • Positive regulation of Wee1 by Chk1 and 14-3-3 proteins
    • Lee J, Kumagai A, Dunphy WG. Positive regulation of Wee1 by Chk1 and 14-3-3 proteins. Mol Biol Cell 2001;12:551-563.
    • (2001) Mol Biol Cell , vol.12 , pp. 551-563
    • Lee, J.1    Kumagai, A.2    Dunphy, W.G.3
  • 50
    • 0035135161 scopus 로고    scopus 로고
    • Roles of the mitotic inhibitors Wee1 and Mik1 in the G(2) DNA damage and replication checkpoints
    • Rhind N, Russell P. Roles of the mitotic inhibitors Wee1 and Mik1 in the G(2) DNA damage and replication checkpoints. Mol Cell Biol 2001;21:1499-1508.
    • (2001) Mol Cell Biol , vol.21 , pp. 1499-1508
    • Rhind, N.1    Russell, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.