The roles of Hedgehogs and Fibroblast growth factors in eye development and retinal cell rescue

Vision Research

Volumn 43, Issue 8, 2003, Pages 899-912

  Russell, Claire ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Development; FGF; Hh; Neuroprotection; Retina

Indexed keywords

FIBROBLAST GROWTH FACTOR; ISOPROTEIN; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CONFERENCE PAPER; EXPERIMENTAL MODEL; EYE DEVELOPMENT; HUMAN; LENS; NERVE ENDING; NONHUMAN; PHOTORECEPTOR CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; RETINA CELL; RETINA GANGLION CELL; SIGNAL TRANSDUCTION; ZEBRA FISH;

EID: 0037382284     PISSN: 00426989     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0042-6989(02)00416-9     Document Type: Conference Paper

References (112)

1. Ando H., Furuta T., Tsien R.Y., Okamoto H. Photo-mediated gene activation using caged RNA/DNA in zebrafish embryos. Nature Genetics. 28:2001;317-325.
2. Araki I., Brand M. Morpholino induced knockdown of fgf8 efficiently phenocopies the acerebellar (ace) phenotype. Genesis. 30:2001;157-159.
3. Baier H. Zebrafish on the move: towards a behaviour-genetic analysis of vertebrate vision. Current Opinion in Neurobiology. 10:2000;451-455.
4. Bernhardt R.R., Tongiorgi E., Anzini P., Schachner M. Increased expression of specific recognition molecules by retinal ganglion cells and by optic pathway glia accompanies the successful regeneration of retinal axons in adult zebrafish. Journal Comparative Neurology. 376:1996;253-264.
5. Bingham S., Nasevicius A., Ekker S.C., Chandrasekhar A. Sonic hedgehog and tiggy-winkle hedgehog cooperatively induce zebrafish branchiomotor neurons. Genesis. 30:2001;170-174.
6. Bormann P., Roth L.W.A., Andel D., Ackermann M., Reinhard E. ZfNLRR, a novel leucine-rich repeat protein is preferentially expressed during regeneration in zebrafish. Molecular and Cellular Neuroscience. 13:1999;167-179.
7. Brewster R., Mullor J.L., Altaba A. Gli2 functions in FGF signalling during antero-posterior patterning. Development. 127:2000;4395-4405.
8. Carl M., Wittbrodt J. Graded interference with FGF signalling reveals its dorsoventral asymmetry at the mid-hindbrain boundary. Development. 126:1999;5659-5667.
9. Chader G.J. Animal models in research on retinal degenerations: past progress and future hope. Vision Research. 42:2002;393-399.
10. Chai L., Morris J.E. Heparan sulphate in the inner limiting membrane of embryonic chicken retina binds basic fibroblast growth factor to promote axonal outgrowth. Experimental Neurology. 160:1999;175-185.
11. Chen W., Burgess S., Hopkins N. Analysis of the zebrafish smoothened mutant reveals conserved and divergent functions of hedgehog activity. Development. 128:2001;2385-2396.
12. Chiang C., Litingtung Y., Lee E., Young K.E., Corden J.L., Westphal H., Beachy P.A. Cyclopia and defective axial patterning in mice lacking sonic hedgehog gene function. Nature. 383:1996;407-413.
13. Crossley P.H., Martin G.R. The mouse fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo. Development. 121:1995;439-451.
14. Crossley P.H., Martinez S., Ohkubo Y., Rubenstein J.L.R. Coordinate expression of fgf8, otx2, bmp4 and shh in the rostral prosencephalon during development of the telencephalic and optic vesicles. Neuroscience. 108:2001;183-206.
15. Dahmane N., Sanchez P., Gitton Y., Palma V., Sun T., Beyna M., Weiner H., Ruiz i Altaba A. The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis. Development. 128:2001;5201-5212.
16. Doerre G., Malicki J. Genetic analysis of photoreceptor cell development in the zebrafish retina. Mechanisms of Development. 110:2002;125-138.
17. Doherty P., Williams G., Williams E.-J. CAMs and axonal growth: a critical evaluation of the role of calcium and the MAPK cascade. Molecular and Cellular Neuroscience. 16:2000;283-295.
18. Draper B.W., Morcos P.A., Kimmel C.B. Inhibition of zebrafish fgf8 pre-mRNA splicing with morpholino oligos: a quantifiable method for gene knockdown. Genesis. 30:2001;154-156.
19. Ekker S.C., Ungar A.R., Greenstein P., von Kessler D.P., Porter J.A., Moon R.T., Beachy P.A. Patterning activities of vertebrate hedgehog proteins in the developing eye and brain. Current Biology. 5:1995;944-955.
20. Faktorovich E.G., Steinberg R.H., Yasumura D., Matthes M.T., LaVail M.M. Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor. Nature. 347:1990;83-86.
21. Ford-Perriss M., Abud H., Murphy M. Fibroblast growth factors in the developing central nervous system. Clinical and Experimental Pharmacology and Physiology. 28:2001;493-503.
22. García-Alonso L., Romani S., Jiménez F. The EGF and FGF receptors mediate Neuroglian function to control growth cone decisions during sensory axon guidance in Drosophila. Neuron. 28:2000;742-752.
23. Goldfarb M. Functions of Fibroblast Growth Factors in vertebrate development. Cytokine and Growth factor Reviews. 7:1996;311-325.
24. Govindarajan V., Overbeek P.A. Secreted FGFR3, but not FGFR1, inhibits lens fiber differentiation. Development. 128:2001;1617-1627.
25. Guillemot F., Cepko C.L. Retinal fate and ganglion cell differentiation are potentiated by acidic FGF in an in vitro assay of early retinal development. Development. 114:1992;743-754.
26. Heisenberg C.-P., Brennan C., Wilson S.W. Zebrafish aussicht mutant embryos exhibit widespread overexpression of ace (fgf8) and coincident defects in CNS development. Development. 126:1999;2129-2140.
27. Helms J.A., Kim C.H., Eichele G., Thaller C. Retinoic acid signalling is required during early chick limb development. Development. 122:1996;1385-1394.
28. Hicks D. Putative functions of fibroblast growth factors in retinal development, maturation and survival. Seminars in Cell and Developmental Biology. 9:1998;263-269.
29. Hicks D., Courtois Y. Fibroblast growth factor stimulates photoreceptor differentiation in vitro. Journal of Neuroscience. 12:1992;2022-2033.
30. Hyer J., Mima T., Mikawa T. Fgf1 patterns the optic vesicle by directing the placement of the neural retina domain. Development. 125:1998;869-877.
31. Huang Z., Kunes S. Hedgehog, transmitted along retinal axons, triggers neurogenesis in the developing visual centers of the Drosophila brain. Cell. 86:1996;411-422.
32. Huang Z., Kunes S. Signals transmitted along retinal axons in Drosophila: hedgehog signal reception and the cell circuitry of lamina cartridge assembly. Development. 125:1998;3753-3764.
33. Huh S., Hatini V., Marcus R.C., Li S.C., Lai E. Dorsal-ventral patterning defects in the eye of BF-1-deficient mice associated with a restricted loss of shh expression. Developmental Biology. 211:1999;53-63.
34. Hutson L.D., Chien C.-B. Wiring the zebrafish: axon guidance and synaptogenesis. Current Opinion in Neurobiology. 12:2002;87-92.
35. Ingham P.W., McMahon A.P. Hedgehog signalling in animal development: paradigms and principles. Genes and Development. 15:2001;3059-3087.
36. Jarman A.P. Developmental genetics: vertebrates and insects see eye to eye. Current Biology. 10:2000;R857-R859.
37. Jensen A.M., Wallace V.A. Expression of Sonic hedgehog and its putative role as a precursor cell mitogen in the developing mouse retina. Development. 124:1997;363-371.
38. Johnson R.L., Tabin C.J. Molecular models for vertebrate limb development. Cell. 90:1997;979-990.
39. Keifer P., Strähle U., Dickson C. The zebrafish Fgf3 gene: cDNA sequence, transcript structure and genomic organisation. Gene. 168:1996;211-215.
40. Koebernick K., Pieler T. Gli-type zinc finger proteins as bipotential transducers of Hedgehog signalling. Differentiation. 70:2002;69-76.
41. Launay C., Fromentoux V., Thery C., Shi D.L., Boucaut J.C. Comparative analysis of the tissue distribution of three fibroblast growth factor receptor mRNAs during amphibian morphogenesis. Differentiation. 58:1994;101-111.
42. Layman L.C. Genetics of human hypogonadotropic hypogonadism. American Journal Medical Genetics. 89:1999;240-248.
43. Levine E.M., Roelink H., Turner J., Reh T.A. Sonic Hedgehog promotes rod photoreceptor differentiation in mammalian retinal cells in vitro. Journal of Neuroscience. 17:1997;6277-6288.
44. Lillien L., Cepko C. Control of proliferation in the retina: temporal changes in responsiveness to FGF and TGFα Development. 115:1992;253-266.
45. Litingtung Y., Chiang C. Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3. Nature Neuroscience. 3:2000;979-985.
46. Livesey F.J., Cepko C.L. Vertebrate neural cell fate determination: lessons from the retina. Nature Reviews. 2:2001;109-118.
47. Lu H.-C., Swindell E.C., Sierralta W.D., Eichele G., Thaller C. Evidence for a role of protein kinase C in FGF signal transduction in the developing chick limb bud. Development. 128:2001;2451-2460.
48. Macdonald R., Barth K.A., Xu Q., Holder N., Mikkola I., Wilson S.W. Midline signalling is required for Pax gene regulation and patterning of the eyes. Development. 121:1995;3267-3278.
49. Macdonald R., Scholes J., Strähle U., Brennan C., Holder N., Brand M., Wilson S.W. The Pax protein Noi is required for commissural axon pathway formation in the rostral forebrain. Development. 124:1997;2397-2408.
50. Malicki J. Harnessing the power of forward genetics - analysis of neuronal diversity and patterning in the zebrafish retina. TINS. 23:2000;531-541.
51. Malicki J., Driever W. oko meduzy mutations affect neuronal patterning in the zebrafish retina and reveal cell-cell interactions of the retinal neuroepithelial sheet. Development. 126:1999;1235-1246.
52. Malicki J.J., Pujic Z., Thisse C., Thisse B., Wei X. Forward and reverse genetic approaches to the analysis of eye development in zebrafish. Vision Research. 42:2002;527-533.
53. Marcus R.C., Delaney C.L., Easter S.S. Jr. Neurogenesis in the visual system of embryonic and adult zebrafish (Danio rerio). Visual Neuroscience. 16:1999;417-424.
54. Masai I., Stemple D.L., Okamoto H., Wilson S.W. Midline signals regulate retinal neurogenesis in zebrafish. Neuron. 27:2000;251-263.
55. Mason C.A., Sretevan D.W. Glia, neurons and axon pathfinding during optic chiasm development. Current Opinion in Neurobiology. 7:1997;647-653.
56. McCabe K.L., Gunther E.C., Reh T.A. The development of the pattern of retinal ganglion cells in the chick retina: mechanisms that control differentiation. Development. 126:1999;5713-5724.
57. McFarlane S., Cornel E., Amaya E., Holt C.E. Inhibition of FGF Receptor activity in retinal ganglion cell axons causes errors in target recognition. Neuron. 17:1996;245-254.
58. McFarlane S., McNeill L., Holt C.E. FGF signalling and target recognition in the developing Xenopus visual system. Neuron. 15:1995;1017-1028.
59. McFarlane S., Zuber M.E., Holt C.E. A role for the fibroblast growth factor receptor in cell fate decisions in the developing vertebrate retina. Development. 125:1998;3967-3975.
60. Meyers E.N., Lewandoski M., Martin G.R. An fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination. Nature Genetics. 18:1998;136-141.
61. Ming J.E., Roessler E., Muenke M. Human developmental disorders and the Sonic hedgehog pathway. Molecular Medicine Today. 4:1998;343-349.
62. Nasevicius A., Ekker S.C. Effective targeted gene 'knockdown' in zebrafish. Nature Genetics. 26:2000;216-220.
63. Neumann C.J., Nüsslein-Volhard C. Patterning of the zebrafish retina by a wave of sonic hedgehog activity. Science. 289:2000;2137-2139.
64. Nguyen M., Arnheiter H. Signalling and transcriptional regulation in early mammalian eye development: a link between FGF and MITF. Development. 127:2000;3581-3591.
65. Ogilvie J.M., Speck J.D., Lett J.M. Growth factors in combination, but not individually, rescue rd mouse photoreceptors in organ culture. Experimental Neurology. 161:2000;676-685.
66. Park C.M., Hollenberg M.J. Basic fibroblast growth factor induces retinal regeneration in vivo. Developmental Biology. 134:1989;201-205.
67. Park C.M., Hollenberg M.J. Induction of retinal regeneration in vivo by growth factors. Developmental Biology. 148:1991;322-333.
68. Patel A., McFarlane S. Overexpression of FGF-2 alters cell fate specification in the developing retina of Xenopus laevis. Developmental Biology. 222:2000;170-180.
69. Perron J.C., Bixby J.L. Distinct neurite outgrowth signalling pathways converge on ERK activation. Molecular and Cellular Neuroscience. 13:1999;362-378.
70. Picker A., Brennan C., Reifers F., Clarke J.D.W., Holder N., Brand M. Requirement for the zebrafish mid-hindbrain boundary in midbrain polarisation, mapping and confinement of the retinotectal projection. Development. 126:1999;2967-2978.
71. Pittack C., Grunwald G.B., Reh T.A. Fibroblast growth factors are necessary for neural retina but not pigmented epithelium differentiation in chick embryos. Development. 124:1997;805-816.
72. Pittack C., Jones M., Reh T.A. Basic fibroblast growth factor induces retinal pigment epithelium to generate neural retina in vitro. Development. 113:1991;577-588.
73. Pujic Z., Malicki J. Mutation of the zebrafish glass onion locus causes early cell-nonautonomous loss of neuroepithelial integrity followed by severe neuronal patterning defects in the retina. Developmental Biology. 234:2001;454-469.
74. Raible F., Brand M. Tight transcriptional control of the ETS domain factors Erm and Pea3 by Fgf signalling during early zebrafish development. Mechanisms of Development. 107:2001;105-117.
75. Ramalho-Santos M., Melton D.A., McMahon A.P. Hedgehog signals regulate multiple aspects of gastrointestinal development. Development. 127:2000;2763-2772.
76. Raymond P.A., Hitchcock P.F. How the neural retina regenerates. Results and Problems in Cell Differentiation. 31:2000;197-218.
77. Reifers F., Adams J., Mason I.J., Schulte-Merker S., Brand M. Overlapping and distinct functions provided by fgf17, a new zebrafish member of the Fgf8/17/18 subgroup of Fgfs. Mechanisms of Development. 99:2000;39-49.
78. Reifers F., Bohli H., Walsh E.C., Crossley P.H., Stainier D.Y., Brand M. fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis. Development. 125:1998;2381-2395.
79. Roth L.W.A., Bormann P., Wiederkehr C., Reinhard E. β-thymosin, a modulator of the actin cytoskeleton is increased in regenerating retinal ganglion cells. European Journal of Neuroscience. 11:1999;3488-3498.
80. Rousseau B., Dubayle D., Sennlaub F., Jeanny J.-C., Costet P., Bikfalvi A., Javerzat S. Neural and angiogenic defects in eyes of transgenic mice expressing a dominant-negative FGF receptor in the pigmented cells. Experimental Eye Research. 71:2000;395-404.
81. Saffell J.L., Williams E.J., Mason I.J., Walsh F.S., Doherty P. Expression of a dominant negative FGF Receptor inhibits axonal growth and FGF Receptor phosphorylation stimulated by CAMs. Neuron. 18:1997;231-242.
82. Schauerte H.E., van Eeden F.J., Fricke C., Odenthal J., Strähle U., Haffter P. Sonic hedgehog is not required for the induction of medial floor plate cells in the zebrafish. Development. 125:1998;2983-2993.
83. Schneider R.A., Hu D., Rubenstein J.L.R., Maden M., Helms J.A. Local retinoid signalling coordinates forebrain and facial morphogenesis by maintaining FGF8 and SHH. Development. 128:2001;2755-2767.
84. Sener R.N. Septo-optic dysplasia associated with cerebral cortical dysplasia (cortico-septo-optic dysplasia). Journal of Neuroradiology. 23:1996;245-247.
85. Shanmugalingam S., Houart C., Picker A., Reifers F., Macdonald R., Barth A., Griffin K., Brand M., Wilson S.W. Ace/Fgf8 is required for forebrain commissure formation and patterning of the telencephalon. Development. 127:2000;2549-2561.
86. Sleptsova-Friedrich I., Li Y., Emelyanov A., Ekker M., Korzh V., Ge R. fgfr3 and regionalization of anterior neural tube in zebrafish. Mechanisms of Development. 102:2001;213-217.
87. Stenkamp D.L., Cameron D.A. Cellular pattern formation in the retina: retinal regeneration as a model system. Molecular Vision. 8:2002;280-293.
88. Stenkamp D.L., Frey R.A., Prabhudesai S.N., Raymond P.A. Function for Hedgehog genes in zebrafish retinal development. Developmental Biology. 220:2000;238-252.
89. Stratford T., Logan C., Zile M., Maden M. Abnormal anteroposterior and dorsoventral patterning of the limb bud in the absence of retinoids. Mechanisms of Development. 81:1999;115-125.
90. Streichert L.C., Birnbach C.D., Reh T.A. A diffusible factor from normal retinal cells promotes rod photoreceptor survival in an in vitro model of Retinitis Pigmentosa. Journal of Neurobiology. 39:1999;475-490.
91. Tanihara H., Inatani M., Honda Y. Growth factors and their receptors in the retina and pigment epithelium. Progress in Retinal and Eye Research. 16:1997;271-301.
92. Tcheng M., Fuhrmann G., Hartmann M.-P., Courtois Y., Jeanny J.-C. Spatial and temporal expression patterns of Fgf receptor genes type 1 and type 2 in the developing chick retina. Experimental Eye Research. 58:1994;351-358.
93. Traiffort E., Moya K.L., Faure H., Hässig R., Ruat M. High expression and anterograde axonal transport of aminoterminal Sonic hedgehog in the adult hamster brain. European Journal of Neuroscience. 14:2001;839-850.
94. Treisman J.E., Heberlein U. Eye development in Drosophila: formation of the eye field and control of differentiation. Current Topics in Developmental Biology. 39:1998;119-158.
95. Trousse F., Marti E., Gruss P., Torres M., Bovolenta P. Control of retinal ganglion cell axon growth: a new role for Sonic hedgehog. Development. 128:2001;3927-3936.
96. Tsang M., Friesel R., Kudoh T., Dawid I.B. Identification of Sef, a novel modulator of FGF signalling. Nature Cell Biology. 4:2002;165-169.
97. Unoki K., LaVail M.M. Protection of the rat retina from ischemic injury by brain-derived neurotrophic factor, ciliary neurotrophic factor, and basic fibroblast growth factor. Investigative Opthalmology and Visual Science. 35:1994;907-915.
98. Varga Z.M., Amores A., Lewis K.E., Yan Y.L., Postlethwait J.H., Eisen J.S., Westerfield M. Zebrafish smoothened functions in ventral neural tube specification and axon tract formation. Development. 128:2001;3497-3509.
99. Varga Z.M., Wegner J., Westerfield M. Anterior movement of ventral diencephalic precursors separates the primordial eye field in the neural plate and requires cyclops. Development. 126:1999;5533-5546.
100. Vihitelic T.S., Hyde D.R. Zebrafish mutagenesis yields eye morphological mutants with retinal and lens defects. Vision Research. 42:2002;535-540.
101. Vogel-Höpker A., Momose T., Rohrer H., Yasuda K., Ishihara L., Rapaport D.H. Multiple functions of fibroblast growth factor-8 (FGF-8) in chick eye development. Mechanisms of Development. 94:2000;25-36.
102. Wallace V.A., Raff M.C. A role for Sonic hedgehog in axon-to-astrocyte signalling in the rodent optic nerve. Development. 126:1999;2901-2909.
103. Wallis D., Muenke M. Mutations in holoprosencephaly. Human Mutation. 16:2000;99-108.
104. Walz A., McFarlane S., Brickman Y.G., Nurcombe V., Bartlett P.F., Holt C.E. Essential role of heparan sulphates in axon navigation and targeting in the developing visual system. Development. 124:1997;2421-2430.
105. Wei X., Malicki J. nagie oko, encoding an MAGUK-family protein, is essential for cellular patterning of the retina. Nature Genetics. 31:2002;150-157.
106. Wild A., Kalff-Suske M., Vortkamp A., Bornholdt D., Konig R., Grzeschik K.H. Point mutations in human Gli3 cause Greig syndrome. Human Molecular Genetics. 6:1998;1979-1984.
107. Ye W., Shimamura K., Rubenstein J.L.R., Hynes M.A., Rosenthal A. FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate. Cell. 93:1998;755-766.
108. Zhang X.-M., Yang X.-J. Regulation of retinal ganglion cell production by Sonic hedgehog. Development. 128:2001;943-957.
109. Zhang X.-M., Yang X.-J. Temporal and spatial effects of Sonic hedgehog signalling in chick eye morphogenesis. Developmental Biology. 233:2001;271-290.
110. Zhang C., Takahashi K., Lam T.T., Tso M.O.M. Effects of basic fibroblast growth factor on retinal ischemia. Investigative Opthalmology and Visual Science. 35:1994;3163-3168.
111. Zhao S., Barnstable C.J. Differential effects of bFGF on development of the rat retina. Brain Research. 723:1996;169-176.
112. Zhao S., Hung F.-C., Colvin J.S., White A., Dai W., Lovicu F.J., Ornitz D.M., Overbeek P.A. Patterning the optic neuroepithelium by FGF signalling and Ras activation. Development. 128:2001;5051-5060.