Pharmacological control of gastric acid secretion for the treatment of acid-related peptic disease: Past, present, and future

Pharmacology and Therapeutics

Volumn 98, Issue 1, 2003, Pages 109-127

  Aihara, Takeshi ^a   Nakamura, Eiji ^a   Amagase, Kikuko ^a   Tomita, Kazuyoshi ^a   Fujishita, Teruaki ^a   Furutani, Kazuharu ^a   Okabe, Susumu ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Gastric acid secretion; Gastrin CCK2 receptor; H2 receptor; Histidine decarboxylase; M3 receptor; Ulcer disease

Indexed keywords

1 (2,3 DIHYDRO 1 METHYL 2 OXO 5 PHENYL 1H 1,4 BENZODIAZEPIN 3 YL) 3 (3 METHYLPHENYL)UREA; 1 [2,3 DIHYDRO 1 (2' METHYLPHENACYL) 2 OXO 5 PHENYL 1H 1,4 BENZODIAZEPIN 3 YL] 3 (3 METHYLPHENYL)UREA; 1 [2,3 DIHYDRO 2 OXO 1 PIVALOYLMETHYL 5 (2 PYRIDYL) 1H 1,4 BENZODIAZEPIN 3 YL] 3 [3 (METHYLAMINO)PHENYL]UREA; ACID PUMP INHIBITOR; ANTACID AGENT; ANTIULCER AGENT; BENACTIDINE METHOBROMIDE; CALCIUM CARBONATE; CHOLECYSTOKININ RECEPTOR BLOCKING AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; FASUDIL; HA 100; HISTAMINE H2 RECEPTOR ANTAGONIST; LEMINOPRAZOLE; ME 3407; METIAMIDE; MYOSIN LIGHT CHAIN KINASE INHIBITOR; OMEPRAZOLE; PD 136450; PIRENZEPINE; PROPANTHELINE BROMIDE; S 0509; STOMACH SECRETION INHIBITOR; TERENZEPINE; UNCLASSIFIED DRUG; WORTMANNIN; Z 360;

ATROPHY; CANCER; CLINICAL TRIAL; CYTOPLASM; GASTRODUODENAL ULCER; GENE TARGETING; GENETIC PROCEDURES; HUMAN; HYPERPLASIA; KNOCKOUT MOUSE; NONHUMAN; PEPTIC ULCER; PRIORITY JOURNAL; REFLUX ESOPHAGITIS; REVIEW; SIGNAL TRANSDUCTION; STOMACH ACID SECRETION; STOMACH PARIETAL CELL; TRANSGENIC MOUSE;

EID: 0037377569     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0163-7258(03)00015-9     Document Type: Review

References (114)

1. Aihara T., Fujishita T., Kataoka N., Kanatani K., Amagase K., Okabe S., Matsui M., Taketo M.M., Chen D. Role of muscarinic acetylcholine M3- and M1-receptors in gastric acid secretion in mice; studies with receptor knockout mice. Gastroenterology. 122:2002;A-252.
2. Amagase K., Ikeda K., Okabe S. Antisecretory and ulcer healing effects of S-0509, a novel CCK-B/gastrin receptor antagonist, in rats. Dig Dis Sci. 44:1999;879-888.
3. 2-receptors. Nature. 236:1972;385-390.
4. + channel KvLQT1 and epithelial function. Pflügers Arch. 440:2000;202-206.
5. + channel blocker 293B. Pflügers Arch. 434:1997;499-501.
6. Bond A., Hunt J. The effects of sodium fluoride on the output of some electrolytes from the gastric mucosa of cats. J Physiol. 133:1956;317-329.
7. 2-receptors. J Int Med Res. 3:1975;86-92.
8. Canfield S.P., Curwain B.P. Inhibition of gastric acid secretion in the conscious dog by the mast-cell stabilizing agent, FPL 52694. Br J Pharmacol. 80:1983;27-32.
9. Canfield V., West A.B., Goldenring J.R., Levenson R. Genetic ablation of parietal cells in transgenic mice: a new model for analyzing cell lineage relationships in the gastric mucosa. Proc Natl Acad Sci USA. 93:1996;2431-2435.
10. Carlsson E., Havu N., Mattsson H., Ekman L. Gastrin and gastric enterochromaffin-like cell carcinoids in the rat. Digestion. 47(suppl. 1):1990;17-23. (discussion 49-52).
11. Caulfield M.P., Birdsall N.J. International Union of Pharmacology: XVII. Classification of muscarinic acetylcholine receptors. Pharmacol Rev. 50:1998;279-290.
12. Chari S., Teyssen S., Singer M.V. Alcohol and gastric acid secretion in humans. Gut. 34:1993;843-847.
13. 2 receptor-deficient mice. Gastroenterology. 123:2002;577-585.
14. + channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias. EMBO J. 16:1997;5472-5479.
15. Crabtree J., Figura N. Mechanism of Helicobacter pylori-induced Mucosal Damage. vol. 11:1999;21-43 Karger, Basel.
16. Curwain B.P., Canfield S.P. Inhibition of gastric acid secretion in conscious dog with fistula following intragastric administration of FPL 52694. Int J Tissue React. 5:1983;245-247.
17. Danesh J. Helicobacter pylori infection and gastric cancer: systematic review of the epidemiological studies. Aliment Pharmacol Ther. 13:1999;851-856.
18. Davenport H. A history of gastric acid secretion and digestion. 1992;1-75 Oxford University Press, Oxford.
19. +)ATPase. Nature. 290:1981;159-161.
20. Fellenius E., Elander B., Wallmark B., Helander H.F., Berglindh T. Inhibition of acid secretion in isolated gastric glands by substituted benzimidazoles. Am J Physiol. 243:1982;G505-G510.
21. Feurle G.E. Effect of rising intragastric pH induced by several antacids on serum gastrin concentrations in duodenal ulcer patients and in a control group. Gastroenterology. 68:1975;1-7.
22. +-ATPase beta-subunit- and gastrin-deficient mice. Am J Physiol Gastrointest Liver Physiol. 281:2001;G1502-G1511.
23. Friis-Hansen L., Sundler F., Li Y., Gillespie P.J., Saunders T.L., Greenson J.K., Owyang C., Rehfeld J.F., Samuelson L.C. Impaired gastric acid secretion in gastrin-deficient mice. Am J Physiol. 274:1998;G561-G568.
24. +-pump. J Physiol. 540:2002;85-92.
25. 2-blocker, cimetidine. Curr Med Res Opin. 5:1978;376-382.
26. 2+ concentration in parietal cells depends on adenosine 3′,5′-cyclic monophosphate levels. Gastroenterology. 109:1995;1060-1067.
27. + channel KCNQ1 is essential for gastric acid secretion. Gastroenterology. 120:2001;1363-1371.
28. + channels at the apical surface of rat parietal cells: implications for the regulation of gastric acid secretion. Gastroenterology. 120:2001;A-155.
29. Hagishita S., Murakami Y., Seno K., Kamata S., Haga N., Konoike T., Kanda Y., Kiyama R., Shiota T., Ishihara Y., Ishikawa M., Shimamura M., Abe K., Yoshimura K. Synthesis and pharmacological properties of ureidomethylcarbamoylphenylketone derivatives. A new potent and subtype-selective nonpeptide CCK-B/gastrin receptor antagonist, S-0509. Bioorganic Med Chem. 5:1997;1695-1714.
30. Hakanson R., Bottcher G., Sundler F., Vallgren S. Activation and hyperplasia of gastrin and enterochromaffin-like cells in the stomach. Digestion. 35(suppl. 1):1986;23-41.
31. Helander K.G., Bamberg K., Sachs G., Melle D., Helander H.F. Localization of mRNA for the muscarinic M1 receptor in rat stomach. Biochim Biophys Acta. 1312:1996;158-162.
32. Higashi H., Tsutsumi R., Muto S., Sugiyama T., Azuma T., Asaka M., Hatakeyama M. SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein. Science. 295:2002;683-686.
33. Hinkle K.L., Samuelson L.C. Lessons from genetically engineered animal models: III. Lessons learned from gastrin gene deletion in mice. Am J Physiol. 277:1999;G500-G505.
34. Hinkle K.L., Bane G.C., Jazayeri A., Samuelson L.C. Enhanced calcium signaling and acid secretion in parietal cells isolated from gastrin-deficient mice. Am J Physiol Gastrointest Liver Physiol. 284:2003;G145-G153.
35. Hirschowitz B.I., Keeling D., Lewin M., Okabe S., Parsons M., Sewing K., Wallmark B., Sachs G. Pharmacological aspects of acid secretion. Dig Dis Sci. 40:1995;3S-23S.
36. Hirst B.H., Elliott K.J., Ryder H., Szelke M. Inhibition of gastrin- and histamine-stimulated gastric acid secretion by gastrin and cholecystokinin antagonists in the rat. Aliment Pharmacol Ther. 5:1991;31-39.
37. 2-receptor antagonists and proton pump inhibitors for the practising physician. Best Pract Res Clin Gastroenterol. 15:2001;355-370.
38. Huang S.C., Zhang L., Chiang H.C., Wank S.A., Maton P.N., Gardner J.D., Jensen R.T. Benzodiazepine analogues L365,260 and L364,718 as gastrin and pancreatic CCK receptor antagonists. Am J Physiol. 257:1989;G169-G174.
39. Huang J.Q., Sridhar S., Chen Y., Hunt R.H. Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer. Gastroenterology. 114:1998;1169-1179.
40. Keto Y., Takahashi S., Okabe S. Healing of Helicobacter pylori-induced gastric ulcers in Mongolian gerbils: combined treatment with omeprazole and clarithromycin. Dig Dis Sci. 44:1999;257-265.
41. Keto Y., Ebata M., Okabe S. Gastric mucosal changes induced by long term infection with Helicobacter pylori in Mongolian gerbils: effects of bacteria eradication. J Physiol (Paris). 95:2001;429-436.
42. 2 receptor-deficient mice. J Clin Invest. 105:2000;1741-1749.
43. Koh T.J., Goldenring J.R., Ito S., Mashimo H., Kopin A.S., Varro A., Dockray G.J., Wang T.C. Gastrin deficiency results in altered gastric differentiation and decreased colonic proliferation in mice. Gastroenterology. 113:1997;1015-1025.
44. 2-receptor blockade in dogs. Agents Actions. 11:1981;437-441.
45. Konturek S.J., Cieszkowski M., Kwiecien N., Konturek J., Tasler J., Bilski J. Effects of omeprazole, a substituted benzimidazole, on gastrointestinal secretions, serum gastrin, and gastric mucosal blood flow in dogs. Gastroenterology. 86:1984;71-77.
46. Konturek P.C., Bielanski W., Konturek S.J., Hahn E.G. Helicobacter pylori associated gastric pathology. J Physiol Pharmacol. 50:1999;695-710.
47. Langhans N., Rindi G., Chiu M., Rehfeld J.F., Ardman B., Beinborn M., Kopin A.S. Abnormal gastric histology and decreased acid production in cholecystokinin-B/gastrin receptor-deficient mice. Gastroenterology. 112:1997;280-286.
48. Larsson H., Carlsson E., Junggren U., Olbe L., Sjostrand S.E., Skanberg I., Sundell G. Inhibition of gastric acid secretion by omeprazole in the dog and rat. Gastroenterology. 85:1983;900-907.
49. Larsson H., Carlsson E., Mattsson H., Lundell L., Sundler F., Sundell G., Wallmark B., Watanabe T., Hakanson R. Plasma gastrin and gastric enterochromaffinlike cell activation and proliferation. Studies with omeprazole and ranitidine in intact and antrectomized rats. Gastroenterology. 90:1986;391-399.
50. Lee H., Hakanson R., Karlsson A., Mattsson H., Sundler F. Lansoprazole and omeprazole have similar effects on plasma gastrin levels, enterochromaffin-like cells, gastrin cells and somatostatin cells in the rat stomach. Digestion. 51:1992;125-132.
51. Lenz H.J., Ferrari-Taylor J., Isenberg J.I. Wine and five percent ethanol are potent stimulants of gastric acid secretion in humans. Gastroenterology. 85:1983;1082-1087.
52. Li Q., Karam S.M., Gordon J.I. Diphtheria toxin-mediated ablation of parietal cells in the stomach of transgenic mice. J Biol Chem. 271:1996;3671-3676.
53. Lindstrom E., Bjorkqvist M., Boketoft A., Chen D., Zhao C.M., Kimura K., Hakanson R. Neurohormonal regulation of histamine and pancreastatin secretion from isolated rat stomach ECL cells. Regul Pept. 71:1997;73-86.
54. + conductance. Pflügers Arch. 429:1995;517-530.
55. +-ATPase): structure and gene regulation through GATA DNA-binding protein(s). J Biochem (Tokyo). 115:1994;6-14.
56. Makhlouf G.M., Schubert M.L. Gastric somatostatin: a paracrine regulator of acid secretion. Metabolism. 39:1990;138-142.
57. Marshall B.J., Warren J.R. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet. i:1984;1311-1315.
58. Martinez V., Curi A.P., Torkian B., Schaeffer J.M., Wilkinson H.A., Walsh J.H., Tache Y. High basal gastric acid secretion in somatostatin receptor subtype 2 knockout mice. Gastroenterology. 114:1998;1125-1132.
59. Matsui M., Motomura D., Karasawa H., Fujikawa T., Jiang J., Komiya Y., Takahashi S., Taketo M.M. Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype. Proc Natl Acad Sci USA. 97:2000;9579-9584.
60. Matsuno K., Sasaki N., Okabe S. Gastric acid secretion in dogs in response to combinations of beer, ethanol and peptone meal - the role of endogenous gastrin. Aliment Pharmacol Ther. 14(Suppl. 1):2000;109-115.
61. Modlin I., Sachs G. Acid Related Diseases. 1998;39-111 Schnetztor-Verlag, Konstanz.
62. Nagata A., Ito M., Iwata N., Kuno J., Takano H., Minowa O., Chihara K., Matsui T., Noda T. G protein-coupled cholecystokinin-B/gastrin receptors are responsible for physiological cell growth of the stomach mucosa in vivo. Proc Natl Acad Sci USA. 93:1996;11825-11830.
63. Nagaya H., Satoh H., Kubo K., Maki Y. Possible mechanism for the inhibition of gastric (H+ + K+)-adenosine triphosphatase by the proton pump inhibitor AG-1749. J Pharmacol Exp Ther. 248:1989;799-805.
64. Nicol A.K., Thomas M., Wilson J. Inhibition of gastric acid secretion by sodium cromoglycate and FPL 52694. J Pharm Pharmacol. 33:1981;554-556.
65. Nishida A., Takinami Y., Yuki H., Kobayashi A., Akuzawa S., Kamato T., Ito H., Yamano M., Nagakura Y., Miyata K. YM022 [(R)-1-[2,3-dihydro-1-(2′-methylphenacyl)-2-oxo-5-phenyl-1H-1,4- benzodiazepin-3-yl]-3-(3-methylphenyl)urea], a potent and selective gastrin/cholecystokinin-B receptor antagonist, prevents gastric and duodenal lesions in rats. J Pharmacol Exp Ther. 270:1994;1256-1261.
66. 2-receptors in Menetrier's disease. J Pharmacol Sci. 91:2003;61-70.
67. Okabe S. Hypothesis-origin of the parietal cell: microorganism? J Clin Gastroenterol. 25(suppl. 1):1997;S141-S148.
68. +-ATPase gene from parasitic microorganisms to Cnidaria? Chin J Physiol. 42:1999;121-128.
69. Okabe S., Tsukimi Y. Does omeprazole-induced hypergastrinemia contribute to the enhanced healing of acetic acid-induced gastric ulcers in rats? Inflammopharmacology. 4:1996;267-277.
70. Okabe S., Shimosako K., Harada H. Antisecretory effect of leminoprazole on histamine-stimulated gastric acid secretion in dogs: potent local effect. Jpn J Pharmacol. 69:1995;91-100.
71. Okabe S., Nozue C., Amagase K. Mechanism by which omeprazole and leminoprazole enhance healing of acetic acid gastric ulcers in rats: role of circulating gastrin. 1997;169-182 Mediserve, Milan.
72. 2 receptor-deficient mice: role of gastrin. Gastroenterology. 120:1999;A-19.
73. Okabe S., Maeda K., Ogawa T., Kataoka T., Furutani K., Watanabe T., Tanaka S., Ichikawa A. Comparative studies of gastric mucosal changes in histamine H2R-KO and histidine decarboxylase (HDC)-KO mice. Gastroenterology. 122:2002;A-252.
74. Okabe S., Shimosako K., Amagase K., Fujishita T. Pharmacological control of gastric acid secretion via the apical membrane of parietal cells in dogs. 2002;305-315 Kluwer Academic Publishing, Boston.
75. Osato M., Graham D. Clinical Spectrum of Helicobacter pylori Infection. vol. 11:1999;2-20 Karger, Basel.
76. Patel Y.C., Greenwood M., Panetta R., Hukovic N., Grigorakis S., Robertson L.A., Srikant C.B. Molecular biology of somatostatin receptor subtypes. Metabolism. 45:1996;31-38.
77. Powell K.R., Barrett J.E. Evaluation of the effects of PD 134308 (CI-988), a CCK-B antagonist, on the punished responding of squirrel monkeys. Neuropeptides. 19(suppl.):1991;75-78.
78. Reed J.D., Smy J.R. The effects of sodium fluoride on gastric acid and electrolyte output in the anaesthetized cat. J Physiol. 301:1980;39-48.
79. 2-receptor antagonists involving cytochrome P450 (CYPs) enzymes: from the laboratory to the clinic. Croat Med J. 40:1999;357-367.
80. Robert A., Nezamis J.E., Lancaster C., Hanchar A.J. Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury. Gastroenterology. 77:1979;433-443.
81. Robinson M., Maton P.N., Rodriguez S., Greenwood B., Humphries T.J. Effects of oral rabeprazole on oesophageal and gastric pH in patients with gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 11:1997;973-980.
82. +-ATPase: the site of action of omeprazole. Scand J Gastroenterol Suppl. 166:1989;3-11.
83. Sachs G., Prinz C.K., Hersey S.J. Acid related disorders. 1995;Sashu, Palm Beach.
84. Sandvik A.K., Cui G., Bakke I., Munkvold B., Waldum H.L. PACAP stimulates gastric acid secretion in the rat by inducing histamine release. Am J Physiol. 281:2001;G997-G1003.
85. Sasaki N., Matsuno K., Okabe S. Selective action of a CCK-B/gastrin receptor antagonist, S-0509, on pentagastrin-, peptone meal- and beer-stimulated gastric acid secretion in dogs. Aliment Pharmacol Ther. 14:2000;479-488.
86. Satoh H., Inatomi N., Nagaya H., Inada I., Nohara A., Nakamura N., Maki Y. Antisecretory and anti-ulcer activities of a novel proton pump inhibitor AG-1749 in dogs and rats. J Pharmacol Exp Ther. 248:1989;806-815.
87. +-adenosine triphosphatase beta subunit is required for normal function, development, and membrane structure of mouse parietal cells. Gastroenterology. 117:1999;605-618.
88. Semple G., Ryder H., Rooker D.P., Batt A.R., Kendrick D.A., Szelke M., Ohta M., Satoh M., Nishida A., Akuzawa S., Miyata K. (3R)-N-(1-(tert-butylcarbonylmethyl)-2,3-dihydro-2-oxo-5-(2-pyridyl)-1H-1, 4-benzodiazepin-3-yl)-N′-(3-(methylamino)phenyl)urea (YF476): a potent and orally active gastrin/CCK-B antagonist. J Med Chem. 40:1997;331-341.
89. 2+-ATPases. Nature. 319:1986;689-693.
90. 2 receptor antagonist, in rats and dogs. Eur J Pharmacol. 235:1993;245-253.
91. Shieh C.C., Coghlan M., Sullivan J.P., Gopalakrishnan M. Potassium channels: molecular defects, diseases, and therapeutic opportunities. Pharmacol Rev. 52:2000;557-594.
92. Shiratsuchi K., Fuse H., Hagiwara M., Mikami T., Miyasaka K., Sakuma H. Cytoprotective action of roxatidine acetate HCl. Arch Int Pharmacodyn Ther. 294:1988;295-304.
93. Spicer Z., Miller M.L., Andringa A., Riddle T.M., Duffy J.J., Doetschman T., Shull G.E. Stomachs of mice lacking the gastric H,K-ATPase alpha-subunit have achlorhydria, abnormal parietal cells, and ciliated metaplasia. J Biol Chem. 275:2000;21555-21565.
94. + recycling pathway in the gastric gland. Gastroenterology. 120:2001;A-102.
95. Tanaka S., Hamada K., Yamada N., Sugita Y., Tonai S., Hunyady B., Palkovits M., Falus A., Watanabe T., Okabe S., Ohtsu H., Ichikawa A., Nagy A. Gastric acid secretion in L-histidine decarboxylase-deficient mice. Gastroenterology. 122:2002;145-155.
96. 2-receptor antagonistic action of N-(3-[3-(1-piperidinylmethyl)phenoxy]propyl)acetoxyacetamide hydrochloride (TZU-0460). Arzneim-Forsch. 35:1985;703-706.
97. 2-receptor antagonist, on gastric acid secretion and ulcer formation. Arzneim-Forsch. 35:1985;844-848.
98. Teyssen S., Lenzing T., Gonzalez-Calero G., Korn A., Riepl R.L., Singer M.V. Alcoholic beverages produced by alcoholic fermentation but not by distillation are powerful stimulants of gastric acid secretion in humans. Gut. 40:1997;49-56.
99. Uemura N., Okamoto S., Yamamoto S., Matsumura N., Yamaguchi S., Yamakido M., Taniyama K., Sasaki N., Schlemper R.J. Helicobacter pylori infection and the development of gastric cancer. N Engl J Med. 345:2001;784-789.
100. 2-receptor antagonist, on monochloramine-induced gastric lesions in rats: role of capsaicin-sensitive sensory neurons. J Gastroenterol Hepatol. 14:1999;859-865.
101. Urushidani T., Muto Y., Nagao T., Yao X., Forte J.G. ME-3407, a new antiulcer agent, inhibits acid secretion by interfering with redistribution of H(+)-K(+)-ATPase. Am J Physiol. 272:1997;G1122-G1134.
102. Vanetti M., Vogt G., Hollt V. The two isoforms of the mouse somatostatin receptor (mSSTR2A and mSSTR2B) differ in coupling efficiency to adenylate cyclase and in agonist-induced receptor desensitization. FEBS Lett. 331:1993;260-266.
103. Vucic E., Radebold K., MacGregor G., Shull G.E., Spicer Z., Wang T., Hebert S., Geibel J.P. ROMK is the apical potassium regulatory channel in the parietal cell. Gastroenterology. 122:2002;A-244.
104. Wang T.C., Dockray G.J. Lessons from genetically engineered animal models: I. Physiological studies with gastrin in transgenic mice. Am J Physiol. 277:1999;G6-G11.
105. Wang T.C., Dangler C.A., Chen D., Goldenring J.R., Koh T., Raychowdhury R., Coffey R.J., Ito S., Varro A., Dockray G.J., Fox J.G. Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer. Gastroenterology. 118:2000;36-47.
106. Watanabe T., Tada M., Nagai H., Sasaki S., Nakao M. Helicobacter pylori infection induces gastric cancer in Mongolian gerbils. Gastroenterology. 115:1998;642-648.
107. Williams M.P., Pounder R.E. Review article: the pharmacology of rabeprazole. Aliment Pharmacol Ther. 13(suppl. 3):1999;3-10.
108. Yamada M., Inanobe A., Kurachi Y. G protein regulation of potassium ion channels. Pharmacol Rev. 50:1998;723-760.
109. Yamada M., Miyakawa T., Duttaroy A., Yamanaka A., Moriguchi T., Makita R., Ogawa M., Chou C.J., Xia B., Crawley J.N., Felder C.C., Deng C.X., Wess J. Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean. Nature. 410:2001;207-212.
110. Yamamoto O., Okada Y., Okabe S. Effects of a proton pump inhibitor, omeprazole, on gastric secretion and gastric and duodenal ulcers or erosions in rats. Dig Dis Sci. 29:1984;394-401.
111. Yang W.P., Levesque P.C., Little W.A., Conder M.L., Shalaby F.Y., Blanar M.A. KvLQT1, a voltage-gated potassium channel responsible for human cardiac arrhythmias. Proc Natl Acad Sci USA. 94:1997;4017-4021.
112. Zavros Y., Rieder G., Ferguson A., Samuelson L.C., Merchant J.L. Genetic or chemical hypochlorhydria is associated with inflammation that modulates parietal and G-cell populations in mice. Gastroenterology. 122:2002;119-133.
113. Zavros Y., Rieder G., Ferguson A., Samuelson L.C., Merchant J.L. Hypergastrinemia in response to gastric inflammation suppresses somatostatin. Am J Physiol Gastrointest Liver Physiol. 282:2002;G175-G183.
114. Zeng N., Athmann C., Kang T., Lyu R.M., Walsh J.H., Ohning G.V., Sachs G., Pisegna J.R. PACAP type 1 receptor activation regulates ECL cells and gastric acid secretion. J Clin Invest. 104:1999;1383-1391.