Deficiency in a mitochondrial aldehyde dehydrogenase increases vulnerability to oxidative stress in PC12 cells

Journal of Neurochemistry

Volumn 84, Issue 5, 2003, Pages 1110-1117

  Ohsawa, Ikuroh ^a   Nishimaki, Kiyomi ^a   Yasuda, Chie ^a   Kamino, Kouzin ^a,b   Ohta, Shigeo ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

4 Hydroxy 2 nonenal; Aldehyde dehydrogenase; Alzheimer's disease; Mitochondria; Oxidative stress

Indexed keywords

4 HYDROXYNONENAL; ALDEHYDE DEHYDROGENASE ISOENZYME 2; ANTIMYCIN A1; COMPLEMENTARY DNA; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; UNSATURATED FATTY ACID;

ALZHEIMER DISEASE; ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL DEATH; CELL STRAIN; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME DEFICIENCY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ALDEHYDE DEHYDROGENASE; ALDEHYDES; ANIMALS; ANTI-BACTERIAL AGENTS; ANTIMYCIN A; CELL DEATH; GENES, DOMINANT; MICE; MITOCHONDRIA; OXIDATIVE STRESS; PC12 CELLS; PHEOCHROMOCYTOMA; RATS; REACTIVE OXYGEN SPECIES; TRANSFECTION;

ANIMALIA;

EID: 0037342862     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.01619.x     Document Type: Article

References (47)

1. Asoh S., Mori T., Hayashi J. and Ohta S. (1996) Expression of the apoptosis-mediator Fas is enhanced by dysfunctional mitochondria. J. Biochem. 120, 600-607.
2. Asoh S., Ohtsu T. and Ohta S. (2000) The super anti-apoptotic factor Bcl-xFNK constructed by disturbing intramolecular polar interactions in rat Bcl-xL. J. Biol. Chem. 275, 37240-37245.
3. Bosron W. F. and Li T. K. (1986) Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism and alcoholism. Hepatology 6, 502-510.
4. Chan P. H. (2001) Reactive oxygen radicals in signaling and damage in the ischemic brain. J. Cereb. Blood Flow Metab. 21, 2-14.
5. Comporti M. (1998) Lipid pexoxidation and biogenic aldehydes: from the identification of 4-hydroxynonenal to further achievements in biopathology. Free Rad. Res. 28, 623-635.
6. Crabb D. W. (1990) Biological markers for increased risk of alcoholism and for quantitation of alcohol consumption. J. Clin. Invest. 85, 311-315.
7. Crabb D. W., Edenberg H. J., Borson W. F. and Li T. K. (1989) Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2 (2) allele is dominant. J. Clin. Invest. 83, 314-316.
8. Dexter D. T., Holley A. E., Flitter W. D., Slater T. F., Wells F. R., Daniel S. E., Lees A. J., Jennet P. and Marsden C. D. (1994) Increased levels of lipid hydroperoxides in the parkinsonian substantia nigra: an HPLC and ESR study. Mov. Disord. 9, 92-97.
9. Farres J., Wang X., Takahashi K., Cunningham S. J., Wang T. T. and Weiner H. (1994) Effects of changing glutamate 487 to lysine in rat and human liver mitochondrial aldehyde dehydrogenase. A model to study human (Oriental type) class 2 aldehyde dehydrogenase. J. Biol. Chem. 269, 13854-13860.
10. Ferrante R. J., Browne S. E., Shinobu L. A., Bowling A. C., Baik M. J., MacGarvey U., Kowall N. W., Brown R. H. Jr and Beal M. F. (1997) Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis. J. Neurochem. 69, 2064-2074.
11. Goedde H. W., Harada S. and Agarwal D. P. (1979) Racial differences in alcohol sensitivity: a new hypothesis. Hum. Genet. 51, 331-334.
12. Haines J. L., Pritchard M. L., Saunders A. M., Schildkraut J. M., Growdon J. H., Gaskell P. C., Farrer L. A., Auerbach S. A., Gusella J. F., Locke P. A., Rosi B. L., Yamaoka L., Small G. W., Conneally P. M., Roses A. D. and Pericak-Vance M. A. (1996) No genetic effect of α1-antichymotrypsin in Alzheimer disease. Genomics 33, 53-56.
13. Hartley D. P., Ruth J. A. and Petersen D. R. (1995) The hepatocellular metabolism of 4-hydroxynonenal by alcohol dehydrogenase, aldehyde dehydrogenase, and glutathione S-transferase. Arch. Biochem. Biophys. 316, 197-205.
14. Itoh T., Matsumoto M., Nakamura M., Okada A., Shirahashi N., Hougaku H., Hashimoto H., Sakaguchi M., Handa N., Takeshita T., Morimoto K. and Hori M. (1997) Effects of daily alcohol intake on the blood pressure differ depending on an individual's sensitivity to alcohol: oriental flushing as a sign to stop drinking fur health reasons. J. Hypertens. 15, 1211-1217.
15. Kamino K., Nagasaka K., Imagawa M., Yamamoto H., Yoneda H., Ueki A., Kitamura S., Namekata K., Miki T. and Ohm S. (2000) Deficiency in mitochondrial aldehyde dehydrogenase increases the risk for late-onset Alzheimer's disease in the Japanese population. Biochem. Biophys. Res. Commun. 273, 192-196.
16. Kawamoto T., Matsnno K, Kodama Y, Murata K. and Matsuda S. (1994) ALDH2 polymorphism and biological monitoring of toluene. Arch. Environ. Health. 49, 332-336.
17. Keller J. N., Pang Z., Geddes J. W., Begley J. G., Germeyer A., Waeg G. and Mattson M. P. (1997) Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid β-peptide: role of the lipid peroxidation product 4-hydroxynonenal. J. Neurochem. 69, 273-284.
18. Kruman I. and Mattson M. P. (1999) Pivotal role of mitochondrial calcium uptake in neural cell apoptosis and necrosis. J. Neurochem. 72, 529-540.
19. Kruman I., Bruce-Keller A. J., Bredesen D., Waeg G. and Mattson M. P. (1997) Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis. J. Neurosci. 17, 5089-5100.
20. Liu W., Kato M., Akhand A. A., Hayakawa A., Suzuki H., Miyata T., Kurokawa K., Hotta Y., Ishikawa N. and Nakashima I. (2000) 4-hydroxynonenal induces a cellular redox status-related activation of the caspase cascade for apoptotic cell death. J Cell Sci. 113, 635-641.
21. Lovell M. A., Ehmann W. D., Mattson M. P. and Markesbery W. R. (1997) Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease. Neurobiol. Aging 18, 457-461.
22. Mark R. J., Pang Z., Geddes J. W., Uchida K. and Mattson M. P. (1997) Amyloid β-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation. Neurosci. 17, 1046-1054.
23. Mitchell D. Y. and Petersen D. R. (1987) The oxidation of α-β unsaturated aldehydic products of lipid peroxidation by rat liver aldehyde dehydrogenases. Toxicol. Appl. Pharmacol. 87, 403-410.
24. Montine K. S., Olson S. J., Amarnath V., Whetsell W. O. Jr, Graham D. G. and Montine T. J. (1997) Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer's disease is associated with inheritance of APOF4. Am. J. Pathol. 150, 437-443.
25. Niwa H., Yamamura K. and Miyazaki J. (1991) Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108, 193-199.
26. Ohsawa I., Takamura C., Morimoto T., Ishiguro M. and Kohsaka S. (1999) Amino-terminal region of secreted form of amyloid precursor protein stimulates proliferation of neural stem cells. Eur. J. Neurosci. 11, 1907-1913.
27. Pedersen W. A., Fu W., Keller J. N., Markesbery W. R., Appel S., Smith R. G., Kasarskis E. and Mattson M. P. (1998) Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients. Ann. Neurol. 44, 819-824.
28. Pedersen W. A., Chan S. L. and Mattson M. P. (2000) A mechanism for the neuroprotective effect of apolipoprotein E: isoform-specific modification by the lipid peroxidation product 4-hydroxynonenal. J. Neurochem. 74, 1426-1433.
29. Picklo M. J., Olson S. J., Markesbery W. R. and Montine T. J. (2001) Expression and activities of aldo-keto oxidoreductases in Alzheimer's disease. J. Neuropathol. Exp. Neurol. 60, 686-695.
30. Reichard J. F., Vasiliou V. and Petersen D. R. (2000) Characterization of 4-hydroxy-2-nonenal metabolism in stellate cell lines derived from normal and cirrhotic rat liver. Biochim. Biophys. Acta. 1487, 222-232.
31. Sayre L. M., Zelasko D. A., Harris P. L., Perry G., Salomon R. G. and Smith M. A. (1997) 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease. J. Neurochem. 68, 2092-2097.
32. Schulze-Osthoff K., Bakker A. C., Vanhaesebroeck B., Beyaert R., Jacob W. A. and Fiers W. (1992) Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation. J. Biol. Chem. 267, 5317-5323.
33. Seims W. G., Hapner S. J. and van Kuijk F. J. (1996) 4-hydroxynonenal inhibits Na(+)-K(+)-ATPase. Free Radic. Biol. Med. 20, 215-223.
34. Siew C., Deitrich R. A. and Erwin V. G. (1976) Localization and characteristics of rat liver mitochondrial aldehyde dehydrogenases. Arch. Biochem. Biophys. 176, 638-649.
35. Singh S., Fritze G., Fang B. L., Harada S., Paik Y. K., Eckey R., Agarwal D. P. and Goedde H. W. (1989) Inheritance of mitochondrial aldehyde dehydrogenase: genotyping in Chinese, Japanese and South Korean families reveals dominance of the mutant allele. Hum. Genet. 83, 119-121.
36. Stewart M. J., Malek K. and Crabb D. W. (1996) Distribution of messenger RNAs for aldehyde dehydrogenase 1, aldehyde dehydrogenase 2, and aldehyde dehydrogenase 5 in human tissues. J. Invest. Med. 44, 42-46.
37. Suzuki Y., Muramatsu T., Taniyama M., Atsumi Y., Kawaguchi R., Higuchi S., Hosokawa K., Asahina T., Murata C. and Matsuoka K. (1996a) Association of aldehyde dehydrogenase with inheritance of NIDDM. Diabetologia 39, 1115-1118.
38. (leu (UUR)) mutation at position 3243. Diabetes Care 19, 1423-1425.
39. Tjalkens R. B., Cook L. W. and Petersen D. R. (1999) Formation and export of the glutathione conjugate of 4-hydroxy-2,3-E-nonenal (4-HNE) in hepatoma cells. Arch. Biochem. Biophys. 361,113-119.
40. Turrens J. F., Alexandre A. and Lehninger A. L. (1985) Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria. Arch. Biochem. Biophys. 237, 408-414.
41. Uchida K. and Stadtman E. R. (1992) Modification of histidine residues in proteins by reaction with 4-hydroxynonenal. Proc. Natl Acad. Sci. USA 89, 4544-4548.
42. Xiao Q., Weiner H. and Crabb D. W. (1996) The mutation in the mitochondrial aldehyde dehydrogenase (ALDH2) gene responsible for alcohol-induced flushing increases turnover of the enzyme tetramers in a dominant fashion. J. Clin. Invest. 98, 2027-2032.
43. Yasukawa T., Suzuki T., Ishii N., Ohta S. and Watanabe K. (2001) Wobble modification defect in tRNA disturbs codon-anticodon interaction in a mitochondrial disease. EMBO J. 20, 4794-4802.
44. Yokoyama A., Muramatsu T., Ohmori T., Makuuchi H., Higuchi S., Matsushita S., Yoshino K., Maruyama K., Nakano M. and Ishii H. (1996) Multiple primary esophageal and concurrent upper aerodigestive tract cancer and the aldehyde dehydrogenase-2 genotype of Japanese alcoholics. Cancer. 77, 1986-1990.
45. Yokoyama A., Muramatsu T., Ohmori T., Yokoyama T., Okuyama K., Takahashi H., Hasegawa Y., Higuchi S., Maruyama K., Shirakura K. and Ishii H. (1998) Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics. Carcinogenesis 19, 1383-1387.
46. Yoritaka A., Hattori N., Uchida K, Tanaka M., Stadtman E. R. and Mizuno Y. (1996) Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease. Proc. Natl Acad. Sci. USA 93, 2696-2701.
47. Yoshida A., Huang I. Y. and Ikawa M. (1984) Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals. Proc. Natl Acad Sci. USA 81, 258-261.