MK-954 (losartan potassium) exerts endothelial protective effects against reperfusion injury: Evidence of an e-NOS mRNA overexpression after global ischemia

Atherosclerosis

Volumn 155, Issue 1, 2001, Pages 53-59

  Barsotti, Antonio ^a   Di Napoli, Pericle ^a   Taccardi, Alfonso A ^a   Spina, Rita ^a   Stuppia, Liborio ^a   Palka, Giandomenico ^a   Barbacane, Renato C ^a   De Caterina, Raffaele ^a   Conti, Pio ^a  

^a UNIVERSITY OF CHIETI   (Italy)

Author keywords

Endothelium; Losartan; Nitric oxide; Reperfusion damage

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; CREATINE KINASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; ISOENZYME; LOSARTAN POTASSIUM; NITRIC OXIDE SYNTHASE; RNA;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; CELL DEATH; CELL PROTECTION; CELL ULTRASTRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DRUG EFFECT; ENZYME RELEASE; GENE OVEREXPRESSION; HEART WEIGHT; ISCHEMIA; MALE; MICROCIRCULATION; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY;

ANIMALS; CAPILLARY PERMEABILITY; CORONARY CIRCULATION; CREATINE KINASE; ENDOTHELIUM, VASCULAR; LOSARTAN; MALE; MYOCARDIAL CONTRACTION; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; RATS; RATS, WISTAR; RECEPTORS, ANGIOTENSIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0035113001     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(00)00533-5     Document Type: Article

References (32)

1. Cell biology and genetics of angiotensin in cardiovascular disease
2. Effect of angiotensin-converting enzyme inhibitors on myocardial ischemia/reperfusion injury: An overview
3. Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction
4. Comparison of the effects of angiotensin converting enzyme inhibition with those of angiotensin II receptor antagonism on functional and metabolic recovery in the post-ischemic working rat heart as studied by 31P nuclear magnetic resonance
5. Increase in angiotensin II type 1 receptor expression immediately after ischemia-reperfusion in isolated rat hearts
6. Identification of angiotensin II receptor subtype
7. Effects of an Angiotensin II antagonist on ischemic and nonischemic isolated rat hearts
8. Angiotensin II receptor subtypes: Selective antagonist and functional correlates
9. Opposite effects of Angiotensin AT1 and AT2 receptor antagonism on recovery of mechanical function after ischemia-reperfusion in isolated working rat hearts
10. Effect of pressure development on oxygen consumption by isolated working rat heart
11. The ligand binding site of the angiotensin AT1 receptor
12. Platelet activating factor modulates microvascular permeability through nitric oxide synthesis
13. Clinical and pathological changes of the heart in the brain death maintained with vasopressin and epinephrine
14. v mice
15. 2 release in polymorphonuclear leukocytes, macrophages and platelets: Effects of IL-1 receptor antagonist
16. Pharmacokinetic-pharmacodynamic profile of Angiotensin II receptor antagonists
17. Angiotensin deteriorates but bradykinin improves cardiac function following ischemia in isolated rat hearts
18. Cardioprotective effects of the angiotensin II type 1 receptor antagonist TCV-116 on ischemia-reperfusion injury
19. Endothelial function in health and disease: New insights into the genesis of cardiovascular disease
20. Endothelial dysfunction: Does it matter? Is it reversible?
21. Nitric oxide synthases and cardiac muscle: Autocrine and paracrine influences
22. Inflammatory alterations in the myocardial microcirculation
23. Effects of nitric oxide synthase inhibition on myocardial capillary permeability and reactive hyperaemic response
24. Mechanisms of nitric oxide release from the vascular endothelium
25. Endothelial function: General considerations
26. Nitric oxide modulates microvascular permeability
27. Abnormal vascular function following ischemia-reperfusion injury
28. Angiotensin II stimulates the production of NO and peroxynitrite in endothelial cells
29. Endothelial nitric oxide gene knockout mice: Cardiac phenotypes and the effect of angiotensin-converting enzyme inhibitor on myocardial ischemia-reperfusion injury
30. Myocardial ischemia-reperfusion injury is exacerbated in absence of endothelial cell nitric oxide synthase
31. Angiotensin II-elicited signal transduction via AT1 receptors in endothelial cells
32. Peroxinitrite-induced apoptosis in HL-60 cells