Normalizing the expression of nitric oxide synthase by low-dose AT1 receptor antagonism parallels improved vascular morphology in hypertensive rats

Journal of the American Society of Nephrology

Volumn 10, Issue 1 SUPPL. 11, 1999, Pages

  Bennai, Fatima ^a   Morsing, Peter ^b   Paliege, Alexander ^a   Ketteler, Markus ^c   Mayer, Bernd ^e   Tapp, Rosemarie ^a   Bachmann, Sebastian ^a,d  

^a HUMBOLDT UNIVERSITY   (Germany)

^b ASTRAZENECA R AND D   (Sweden)

^c FREIE UNIVERSITÄT BERLIN   (Germany)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^e NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; CANDESARTAN; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN BLOOD FLOW; BRAIN BLOOD VESSEL; DOSE RESPONSE; DRUG EFFECT; DRUG RECEPTOR BINDING; ENZYME ACTIVITY; ENZYME INDUCTION; GENE EXPRESSION REGULATION; HYPERTENSION; KIDNEY BLOOD FLOW; NONHUMAN; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; STROKE;

EID: 0032938013     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Ross R: The pathogenesis of atherosclerosis: A perspective for the 1990s. Nature 362: 801-809, 1993
2. Kalimo H, Kaste M, Haltia M: Vascular diseases. In: Greenfield's Neuropathology, edited by Graham DI, Lantos PL, London, Arnold, 1997, pp 315-396
3. Rubattu S, Volpe M, Kreutz R, Ganten U, Ganten D, Lindpaintner K: Chromosomal mapping of quantitative trait loci contributing to stroke in a rat model of complex human disease. Nat Genet 13: 429-434, 1996
4. Kontos HA, Wei EP, Dalton Dietrich W, Navari RM, Povlishock JT, Ghatak NR, Ellis EF, Patterson JL: Mechanisms of cerebral arteriolar abnormalities after acute hypertension. Am J Physiol 240: H511-H527, 1981
5. Baumbach GL, Ghoneim S: Vascular remodeling in hypertension. Scann ing Microsc1: 137-143, 1993
6. Fredriksson K, Auer RN, Kalimo H, Nordborg C, Olsson Y, Johansson BB: Cerebrovascular lesions in stroke-prone spontaneously hypertensive rats. Acta Neuropathol 68: 284-294, 1985
7. Fredriksson K, Nordborg C, Kalimo H, Olsson Y, Johansson BB: Cerebral microangiopathy in stroke-prone spontaneously hypertensive rats. Acta Neuropathol 75: 241-252, 1988
8. Abumiya T, Masuda J, Kawai J, Suzuki T, Ogata J: Heterogeneity in the appearance and distribution of macrophage subsets and their possible involvement in hypertensive vascular lesions in rats. Lab Invest 75: 125-136, 1996
9. Tagami M, Nara Y, Kubota A, Sunaga T, Maezawa H, Fujino H, Yamori Y: Ultrastructural characteristics of occluded perforating arteries in stroke-prone spontaneously hypertensive rats. Stroke 18: 733-740, 1987
10. Kriz W, Hosser H, Hähnel B, Simons JL, Provoost AP: Development of vascular pole-associated glomerulosclerosis in the fawn-hooded rat. J Am Soc Nephrol 9: 381-396, 1998
11. Shibota M, Nagaoka A, Shino A, Fujita T: Renin-angiotensin system in stroke-prone spontaneously hypertensive rats. Am J Physiol 263: H409-H416, 1979
12. Tapia E, Gabbai FB, Calleja C, Franco M, Cermeno JL, Bobadilla NA, Pérez JM, Alvarado JA, Herrera-Acosta J: Determinants of renal damage in rats with systemic hypertension and partial renal ablation. Kidney Int 38: 642-648, 1990
13. Cai Y, Sich M, Beziau A, Kleppel MM, Gubler MC: Collagen distribution in focal and segmental glomerulosclerosis: An immunofluorescence and ultrastructural immunogold study. J Pathol 179: 188-196, 1996
14. Floege J, Alpers CE, Burns MW, Pritzl P, Gordon K, Couser WG, Johnson RJ: Glomerular cells, extracellular matrix accumulation, and the development of glomerulosclerosis in the remnant kidney model. Lab Invest 66: 485-497, 1992
15. Johnson RJ, Alpers CE, Yoshimura A, Lombardi D, Pritzl P, Floege J, Schwartz SM: Renal injury from angiotensin-II mediated hypertension. Hypertension 19: 464-474, 1992
16. Bidani AK, Griffin KA, Plott W, Schwartz MM: Renal ablation acutely transforms "benign" hypertension to "malignant" nephrosclerosis in hypertensive rats. Hypertension 24: 309-316, 1994
17. Fornes P, Richer C, Vacher E, Bruneval P, Giudicelli JF: Losartan's protective effects in stroke-prone spontaneously hypertensive rats persist durably after treatment withdrawal. J Cardiovasc Pharmacol 22: 305-313, 1993
18. Obata JE, Nakamura T, Kuroyanagi R, Yoshida Y, Guo DF, Inagami T: Candesartan prevents the progression of glomerulosclerosis in genetic hypertensive rats. Kidney Int 52[Suppl 63]: 229-231, 1997
19. Ahmad S: Angiotensin receptor antagonists delay nitric oxide-deficient stroke in stroke-prone rats. Eur J Pharmacol 333: 39-45, 1997
20. Oberbäumer I, Moser D, Bachmann S: Nitric oxide synthase 1 mRNA: Tissue-specific variants from rat with alternative first exons. Biol Chem 379: 913-919, 1998
21. Michel T, Feron O: Nitric oxide synthases: Which, where, how, and why? J Clin Invest 100: 2146-2152, 1997
22. Cuevas P, Garcia-Calvo M, Carceller F, Reimers D, Dazo M, Cuevas B, Munoz-Willery I, Martinez-Coso F, Lamas S, Gimenez-Gallego G: Correction of hypertension by normalization of endothelial level of fibroblast growth factor and nitric oxide synthase in spontaneously hypertensive rats. Proc Natl Acad Sci USA 93: 11996-12001, 1996
23. Malinsky T, Kapturczak M, Dayharsh J, Bohr D: Nitric oxide synthase activity in genetic hypertension. Biochem Biophys Res Commun 194: 654-658, 1993
24. Crabos M, Coste P, Paccalin M, Tariosse L, Daret D, Besse D, Bonoron-Adele S: Reduced basal NO-mediated dilation and decreased NO-synthase expression in coronary vessels of spontaneously hypertensive rats. J Mol Cell Cardiol 29: 55-65, 1997
25. Clavier N, Tobin JR, Kirsch JR, Izuta M, Traystman RJ: Brain nitric oxide synthase activity in normal, hypertensive, and strokeprone rats. Stroke 25: 1674-1678, 1994
26. Hayakawa H, Raij L: Nitric oxide synthase activity and renal injury in genetic hypertension. Hypertension 31: 266-270, 1998
27. Wu CC, Hong HJ, Chou TC, Ding YA, Yen MH: Evidence for inducible nitric oxide synthase in spontaneously hypertensive rats. Biochem Biophys Res Commun 228: 459-466, 1996
28. Vaziri ND, Ni Z, Oveisi F: Upregulation of renal and vascular nitric oxide synthase in young spontaneously hypertensive rats. Hypertension 31: 1248-1254, 1998
29. McIntyre M, Hamilton CA, Rees DD, Reid JL, Dominiczak AF: Sex differences in the abundance of endothelial nitric oxide in a model of genetic hypertension. Hypertension 30: 1517-1524, 1997
30. Moreau P, Takase H, Küng CF, van Rooijen MM, Schaffner T, Lüscher TF: Structure and function of the rat basilar artery during chronic nitric oxide synthase inhibition. Stroke 26: 1922-1929, 1995
31. Samdani AF, Dawson TM, Dawson VL: Nitric oxide synthase in models of focal ischemia. Stroke 28: 1283-1288, 1997
32. Furusu A, Miyazaki M, Abe K, Tsukasaki S, Shioshita K, Sasaki O, Miyazaki K, Ozono Y, Koji T, Harada T, Sakai H, Kohno S: Expression of endothelial and inducible nitric oxide synthase in human glomerulonephritis. Kidney Int 53: 1760-1768, 1998
33. Iadecola C, Zhang F, Casey R, Clark HB, Ross E: Inducible nitric oxide synthase gene expression in vascular cells after transient focal cerebral ischemia. Stroke 27: 1373-1380, 1996
34. Harrison DG: Cellular and molecular mechanisms of endothelial cell dysfunction. J Clin Invest 100: 2153-2157, 1997
35. Hennington BS, Zhang H, Miller MT, Granger JP, Reckelhoff JF: Angiotensin II stimulates synthesis of endothelial nitric oxide synthase. Hypertension 31: 283-288, 1998
36. Bosse HM, Böhm R, Resch S, Bachmann S: Parallel regulation of constitutive NO synthase and renin at JGA of rat kidney under various stimuli. Am J Physiol 269: F793-F805, 1995
37. Ramasubbu K, Gretz N, Bachmann S: Increased epithelial cell proliferation and abnormal extracellular matrix in rat polycystic kidney disease. J Am Soc Nephrol 9: 937-945, 1998
38. Bachmann S, Peters J, Engler E, Ganten D, Mullins J: Transgenic rats carrying the mouse renin gene: Morphological characterization of a low-renin hypertension model. Kidney Int 41: 24-36, 1992
39. Yamori Y, Horie R, Handa H, Sato M, Fukase M: Pathogenetic similarity of strokes in stroke-prone spontaneously hypertensive rats and humans. Stroke 7: 46-53, 1976
40. Inada Y, Wada T, Ojima M, Sanada T, Shibouta Y, Kanagawa R, Ishimura Y, Fujisawa Y, Nishikawa K: Protective effects of candesartan cilexetil (TCV-116) against stroke, kidney dysfunction and cardiac hypertrophy in stroke-prone spontaneously hypertensive rats. Clin Exp Hypertens 19: 1079-1099, 1997
41. + feeding in stroke-prone hypertensive rats. Hypertension 15: 318-326, 1990
42. Gahnem F, Camargo MJF, von Lutterotti N, Laragh JH, Sealey JE: Angiotensinogen depletion by high renin levels in hypertensive rats: No evidence for tonic stimulation of angiotensinogen by angiotensin II. J Hypertens 13: 91-96, 1995
43. Schnermann J: Juxtaglomerular cell complex in the regulation of renal salt excretion. Am J Physiol 274: R263-R279, 1998
44. Bachmann S: Distribution of NOSs in the kidney. In: Nitric Oxide and the Kidney: Physiology and Pathophysiology, edited by Goligorsky MS, Gross SS, New York, Chapman and Hall, 1997, pp 133-160
45. Izuta M, Clavier N, Kirsch JR, Traystman RJ: Cerebral blood flow during inhibition of brain nitric oxide synthase activity in normal, hypertensive, and stroke-prone rats. Stroke 26: 1079-1085, 1995
46. Nava E, Noll G, Lüscher TF: NO and hypertension. In: Nitric Oxide and the Kidney: Physiology and Pathophysiology, edited by Goligorsky MS, Gross SS, New York, Chapman and Hall, 1997, pp 368-383
47. ω-nitro-L-arginine methyl ester during delayed hypoperfusion in cats. Am J Physiol 267: H174-H181, 1994
48. Cabrera CL, Bealer SL, Bohr DF: Central depressor action of nitric oxide is deficient in genetic hypertension. Am J Hypertens 9: 237-241, 1996
49. Sigmon DH, Beierwaltes WH: Nitric oxide influences blood flow distribution in renovascular hypertension. Hypertension 23: 134-139, 1994
50. Miyata N, Tsuchida K, Tanaka M, Otomo S: Impairment of endothelium-dependent relaxation and changes in levels of cyclic GMP in carotid arteries from stroke-prone spontaneously hypertensive rats. J Pharm Pharmacol 42: 763-766, 1990
51. Grunfeld S, Hamilton CA, Mesaros S, McClain SW, Dominiczak AF, Bohr DF, Malinski T: Role of superoxide in the depressed nitric oxide production by the endothelium of genetically hypertensive rats. Hypertension 26: 854-857, 1995
52. Nakazono K, Watanabe N, Matsuno K, Sasaki J, Sato T, Inoue M: Does superoxide underlie the pathogenesis of hypertension? Proc Natl Acad Sci USA 88: 10045-10048, 1991
53. Kanno K, Hirata Y, Imai T, Iwashina M, Marumo F: Regulation of inducible nitric oxide synthase gene by interleukin-1b in rat vascular endothelial cells. Am J Physiol 267: H2318-H2324, 1994
54. Pfeilschifter J, Mühl H: NOS in mesangial cells: Physiological and pathophysiological roles. In: Nitric Oxide and the Kidney: Physiology and Pathophysiology, edited by Goligorsky MS, Gross SS, New York, Chapman and Hall, 1997, pp 198-215
55. Mayer B, Klatt P, Werner ER, Schmidt K: Kinetics and mechanism of tetrahydrobiopterin-induced oxidation of nitric oxide. J Biol Chem 270: 655-659, 1995
56. Cattell V, Cook HT, Ebrahim H, Waddington SN, Wei XG, Assmann KJM, Liew FY: Anti-GBM glomerulonephritis in mice lacking nitric oxide synthase type 2. Kidney Int 53: 932-936, 1998
57. Griendling K, Ollerenshaw JD, Minieri CA, Alexander RW: Angiotensin II stimulates NADH and NADPH activity in cultured vascular smooth muscle cells. Circ Res 74: 1141-1148, 1994