Expression of endothelial nitric oxide synthase in the ischemic penumbra: Relationship to expression of neuronal nitric oxide synthase and vascular endothelial growth factor

Brain Research

Volumn 909, Issue 1-2, 2001, Pages 1-7

  Leker, Ronen R ^a   Teichner, Angella ^a   Ovadia, Haim ^a   Keshet, Eli ^a   Reinherz, Esther ^a   Ben Hur, Tamir ^a  

^a HEBREW UNIVERSITY   (Israel)

Author keywords

Free radical; Nitric oxide synthase; Permanent middle cerebral artery occlusion; Stroke; Vascular endothelial growth factor

Indexed keywords

NITRIC OXIDE SYNTHASE; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; CYTOPLASM; ENDOTHELIUM CELL; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MEMBRANE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOTOR PERFORMANCE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; BRAIN ISCHEMIA; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; IMMUNOHISTOCHEMISTRY; INFARCTION, MIDDLE CEREBRAL ARTERY; LYMPHOKINES; MALE; NEURONS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; RATS; RATS, INBRED SHR; RNA, MESSENGER; TIME FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0035800586     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)02561-6     Document Type: Article

References (39)

1. Core and penumbral nitric oxide synthase activity during cerebral ischemia and reperfusion
2. Role of nitric oxide in the angiogenic response in vitro to basic fibroblast growth factor
3. Ischemic preconditioning and brain tolerance: Temporal histological and functional outcomes, protein synthesis requirement, and interleukin-1 receptor antagonist and early gene expression
4. The complex role of nitric oxide in the pathophysiology of focal cerebral ischemia
5. A novel neuronal messenger molecule in brain: The free radical, nitric oxide
6. Endothelial nitric oxide synthase localized to hippocampal pyramidal cells: Implications for synaptic plasticity
7. Localization of neuronal and endothelial nitric oxide synthase isoforms in human hippocampus
8. Nitric oxide-dependent production of cGMP supports the survival of rat embryonic motor neurons cultured with brain-derived neurotrophic factor
9. Regulation of the cerebral circulation: Role of endothelium and potassium channels
10. Expressional control of the 'constitutive' isoforms of nitric oxide synthase (NOS I and NOS III)
11. Nitric oxide synthase isozymes. Characterization, purification, molecular cloning, and functions
12. VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells
13. Enlarged infarcts in endothelial nitric oxide synthase knockout mice are attenuated by nitro-L-arginine
14. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase
15. Bright and dark sides of nitric oxide in ischemic brain injury
16. Nitric oxide synthase inhibition and cerebrovascular regulation
17. Effects of nitric oxide synthase gene knockout on neurotransmitter release in vivo
18. A role for endothelial NO synthase in LTP revealed by adenovirus-mediated inhibition and rescue
19. Nitric oxide modulates microvascular permeability
20. Expression of vascular endothelial growth factor (VEGF) and its receptors (Flt-1 and Flk-1) following permanent and transient occlusion of the middle cerebral artery in the rat
21. Temporal correlation mapping analysis of the hemodynamic penumbra in mutant mice deficient in endothelial nitric oxide synthase gene expression
22. Nitric oxide: Physiology, pathophysiology, and pharmacology
23. Nitric oxide synthase modulates angiogenesis in response to tissue ischemia
24. Endothelial NOS and the blockade of LTP by NOS inhibitors in mice lacking neuronal NOS
25. Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells
26. Cell type specific upregulation of vascular endothelial growth factor in an MCA-occlusion model of cerebral infarct
27. The anti-aggregating properties of vascular endothelium: Interactions between prostacyclin and nitric oxide
28. The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium
29. Inhibition of endothelial cell proliferation and bFGF-induced phenotypic modulation by nitric oxide
30. Nitric oxide synthase in models of focal ischemia
31. Differential expression of neuronal and endothelial nitric oxide synthase in blood vessels of the rat brain
32. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
33. The role of nitric oxide in the pathophysiology of thromboembolic stroke in the rat
34. Distribution of the endothelial constitutive nitric oxide synthase in the developing rat brain: An immunohistochemical study
35. Vascular endothelial growth factor-C (VEGF-C/VEGF-2) promotes angiogenesis in the setting of tissue ischemia
36. Inhibition of nitric oxide synthesis increases focal ischemic infarction in rat
37. Cerebral endothelial nitric oxide synthase expression after focal cerebral ischemia in rats
38. ARL 17477, a potent and selective neuronal NOS inhibitor decreases infarct volume after transient middle cerebral artery occlusion in rats
39. Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis