Nitration and inactivation of cytochrome P450(BM-3) by peroxynitrite: Stopped-flow measurements prove ferryl intermediates

European Journal of Biochemistry

Volumn 267, Issue 23, 2000, Pages 6729-6739

  Daiber, Andreas ^a   Herold, Susanna ^b   Schoand̈neich, Christian ^c   Namgaladze, Dmitry ^a   Peterson, Julian A ^d   Ullrich, Volker ^a  

^a UNIVERSITY OF KONSTANZ   (Germany)

^b ETH ZURICH   (Switzerland)

^c UNIVERSITY OF KANSAS   (United States)

^d UNIVERSITY OF TEXAS   (United States)

Author keywords

Bacterial monooxygenase; Iron catalysis; P450 proteins; Peroxynitrite; Tyrosine nitration

Indexed keywords

3 NITROTYROSINE; CYTOCHROME P450; DITHIOTHREITOL; GLUTATHIONE; HEMOPROTEIN; IRON DERIVATIVE; NITRIC OXIDE; PEROXYNITRITE; PHENOL DERIVATIVE; PROSTACYCLIN SYNTHASE; SUPEROXIDE; URIC ACID;

ARTICLE; BLOOD VESSEL TONE; CATALYSIS; CHEMICAL REACTION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INACTIVATION; NITRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN;

ANIMALS; BACILLUS; BACTERIAL PROTEINS; BINDING SITES; BLOTTING, WESTERN; CATTLE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DITHIOTHREITOL; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; GLUTATHIONE; INHIBITORY CONCENTRATION 50; IRON; MASS SPECTROMETRY; MIXED FUNCTION OXYGENASES; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLSIDOMINE; NITRATES; NITRIC OXIDE DONORS; NITROGEN; OXYGEN; SUPEROXIDE DISMUTASE; TEMPERATURE; TIME FACTORS; TYROSINE; URIC ACID;

BACTERIA (MICROORGANISMS);

EID: 0033678831     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2000.01768.x     Document Type: Article

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