Role of nitric oxide in down-regulation of CYP2B1 protein, but not RNA, in primary cultures of rat hepatocytes

Molecular Pharmacology

Volumn 60, Issue 1, 2001, Pages 209-216

  Ferrari, Luc ^a,b   Peng, Ning ^a   Halpert, James R ^c   Morgan, Edward T ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INSERM   (France)

^c University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 ANILINO 5,8 QUINOLINEQUINONE; ARGININE; CYTOCHROME P450 2B1; CYTOCHROME P450 ISOENZYME; ENDOTOXIN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; MATRIGEL; MESSENGER RNA; N ACETYL S NITROSOPENICILLAMINE; NITRATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; NITRITE; PENTOXYRESORUFIN DEALKYLASE; RECOMBINANT INTERLEUKIN 1BETA; S NITROSOGLUTATHIONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ASSAY; INFLAMMATION; LIVER CELL; LIVER MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; WESTERN BLOTTING;

EID: 0034958357     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.60.1.209     Document Type: Article

References (40)

1. A role for inducible nitric oxide biosynthesis in the liver in inflammation and in the allogeneic immune response
2. Role of nitric oxide in the cytokine-mediated regulation of cytochrome P-450
3. Single-stop method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
4. Nitric oxide-mediated inhibition of cytochrome P450 by interferon-gamma in human hepatocytes
5. Purification and characterization of the dog hepatic cytochrome P-450 isozyme responsible for the metabolism of 2,2′,4,4′,5,5′-hexachlorobiphenyl
6. Cloning and expression of inducible nitric oxide synthase from rat astrocytes
7. Cyclic GMP and cGMP-binding phosphodiesterase are required for interleukin-1-induced nitric oxide synthesis in human articular chondrocytes
8. Regulation of hepatic cytochrome P450 2C11 by glucocorticoids
9. Nitric oxide differentially affects constitutive cytochrome P450 isoforms in rat liver
10. Evidence for nitric oxide participation in down-regulation of CYP2B1/2 gene expression at the pretranslational level
11. Nitric oxide is a mediator of the decrease in cytochrome P45O-dependent metabolism caused by immunostimulants
12. Control of transferrin receptor expression via nitric oxide-mediated modulation of iron-regulatory protein 2
13. Loss and degradation of enzyme-bound heme induced by cellular nitric oxide synthase
14. Expression of CD14 by hepatocytes: Upregulation by cytokines during endotoxemia
15. Protein measurement with the Folin phenol reagent
16. Dealkylation of pentoxyresorufin: A rapid and sensitive assay for measuring induction of cytochrome(s) P-450 by phenobarbital and other xenobiotics in the rat
17. Kupffer cell-mediated differential down-regulation of cytochrome P450 metabolism in rat hepatocytes
18. Irreversible inhibition of cytochrome P450 by nitric oxide
19. Suppression of cytochrome P450- and UDP glucuronosyl transferase-dependent enzyme activities by proinflammatory cytokines and possible role of nitric oxide in primary cultures of pig hepatocytes
20. Regulation of cytochromes P450 during inflammation and infection
21. Nitric oxide mediates hepatic cytochrome P450 dysfunction induced by endotoxin
22. Phenobarbital induction of rat liver cytochromes P-450b and P-450e. Quantitation of specific mRNAs by hybridization to synthetic oligodeoxyribonucleotide probes
23. Inhibition of P450 cytochromes by reactive intermediates
24. Biological aspects of reactive nitrogen species
25. Evidence of proteasome-mediated cytochrome P-450 degradation
26. Peroxynitrite-mediated nitration of tyrosine and inactivation of the catalytic activity of cytochrome P450 2B1
27. Hepatocyte-derived interleukin-6 and tumor-necrosis factor α mediate the lipopolysaccharide-induced acute-phase response and nitric oxide release by cultured rat hepatocytes
28. Evaluation of the Limulus test for endotoxemia in neonates with suspected sepsis
29. Regulation of gene expression in adult rat hepatocytes cultured on a basement membrane matrix
30. Down-regulation of cytochrome P450 mRNAs and proteins in mice lacking a functional NOS2 gene
31. Differential inductive and suppressive effects of endotoxin and particulate irritants on hepatic and renal cytochrome P-450 expression
32. Nitric oxide-independent suppression of P450 2C11 expression by interleukin-1β and endotoxin in primary rat hepatocytes
33. Down-regulation of the expression of three major rat liver cytochrome P450S by endotoxin in vivo occurs independently of nitric oxide production
34. Turnover of membrane proteins: Kinetics of induction and degradation of seven forms of rat liver microsomal cytochrome P-450, NADPH-cytochrome P-450 reductase, and epoxide hydrolase
35. Modulation of xenobiotic-inducible cytochrome P450 gene expression by dexamethasone in primary rat hepatocytes
36. Inhibition of cytochromes P4501A by nitric oxide
37. Hepatic cytochrome P450 is directly inactivated by nitric oxide, not by inflammatory cytokines, in the early phase of endotoxemia
38. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin
39. Inhibition of cytochromes P450 by nitric oxide and a nitric oxide-releasing agent
40. Interleukin 1beta decreases prostacyclin synthase activity in rat mesangial cells via endogenous peroxynitrite formation