Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice

Journal of Hepatology

Volumn 38, Issue 2, 2003, Pages 179-187

  Storto, Marianna ^a   Teke Ngomba, Richard ^a   Battaglia, Giuseppe ^a   Freitas, Isabel ^b   Griffini, Patrizia ^b   Richelmi, Plinio ^c   Nicoletti, Ferdinando ^a,d   Vairetti, Mariapia ^b  

^a IRCCS NEUROMED   (Italy)

^b UNIVERSITY OF PAVIA   (Italy)

^c UNIVERSITY OF INSUBRIA   (Italy)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Acetaminophen; Cell damage; Hepatotoxicity; Liver; mGlu5 receptor antagonist; Oxidative stress

Indexed keywords

2 METHYL 6 (2 PHENYLVINYL)PYRIDINE; 2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 6 METHYL 2 PHENYLAZO 3 PYRIDINOL; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR ANTAGONIST; PARACETAMOL; REACTIVE OXYGEN METABOLITE; TERT BUTYL HYDROPEROXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; LIVER CELL; LIVER INJURY; LIVER NECROSIS; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING;

EID: 0037310893     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(02)00384-7     Document Type: Article

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