Metabotropic glutamate receptor agonists stimulate polyphosphoinositide hydrolysis in primary cultures of rat hepatocytes

European Journal of Pharmacology

Volumn 338, Issue 2, 1997, Pages

  Sureda, Francesc ^a   Copani, Agata ^b   Bruno, Valeria ^a   Knöpfel, Thomas ^c   Meltzger, Gainer ^d   Nicoletti, Ferdinando ^a,b  

^a IMN Sanatrix   (Italy)

^b UNIVERSITY OF CATANIA   (Italy)

^c IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^d CellControl Biomed Laboratories AG   (Germany)

Author keywords

Hepatocyte cultured; Metabotropic glutamate receptor; Polyphosphoinositide hydrolysis

Indexed keywords

1 AMINO 1,3 CYCLOPENTANEDICARBOXYLIC ACID; ADENYLATE CYCLASE; ALPHA METHYL 4 CARBOXYPHENYLGLYCINE; METABOTROPIC RECEPTOR; QUISQUALIC ACID; RECEPTOR SUBTYPE;

ANIMAL CELL; ARTICLE; CELL CULTURE; DRUG EFFECT; LIVER CELL; NONHUMAN; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

EID: 0030669195     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)81950-4     Document Type: Article

References (7)

1. Chaudhari N., Yang H., Lamp C., Delay E., Cartford C., Than T. The taste of monosodium glutamate: Membrane receptors in taste buds. J. Neurosci. 16:1996;3817-3828.
2. Guguen-Guillouzo C., Bourel M., Guillouzo A. Human hepatocyte cultures. Prog. Liver Dis. 8:1986;33-50.
3. Inagaki N., Kuromi H., Gonoi T., Okamoto Y., Ishida H., Seino Y., Kaneko T., Iwanaga T., Seino S. Expression and role of ionotropic glutamate receptors in pancreatic islet cells. FASEB J. 9:1995;686-691.
4. Kimball S.R., Horetsky R.L., Jefferson L.S. Hormonal regulation of albumin gene expression in primary cultures of rat hepatocytes. Am. J. Physiol. 268:1995;6-14.
5. Moroni F., Luzzi S., Franchi-Micheli S., Zilletti L. The presence of N-methyl-D-aspartate-type receptors for glutamic acid in the guinea pig myenteric plexus. Neurosci. Lett. 68:1986;57-62.
6. Nicoletti F., Wroblewski J.T., Novelli A., Alho H., Guidotti A., Costa E. The activation of inositol phospholipid metabolism as a signal transduction system for excitatory amino acids in primary cultures of cerebellar granule cells. J. Neurosci. 6:1986;1905-1911.
7. Pin J.-P., Duvoisin R. The metabotropic glutamate receptors: Structure and functions. Neuropharmacology. 34:1995;1-26.