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Volumn 3, Issue 1, 2003, Pages 57-65

The prodigiosins: A new family of anticancer drugs

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BAFILOMYCIN A1; CALCINEURIN INHIBITOR; CYCLOPRODIGIOSIN; CYCLOSPORIN A; METACYCLOPRODIGIOSIN; METACYCLOPROGIDIOSIN; NONYLPRODIGIOSIN; NUCLEASE; PNU 156804; PRODIGIOSIN; PRODIGIOSIN DERIVATIVE; PROGIDIOSIN; PROGIDIOSINE; TACROLIMUS; UNCLASSIFIED DRUG; UNDECYLPRODIGIOSIN;

EID: 0037303304     PISSN: 15680096     EISSN: None     Source Type: Journal    
DOI: 10.2174/1568009033333772     Document Type: Article
Times cited : (103)

References (79)
  • 2
    • 0026602628 scopus 로고
    • Coley's toxins in perspective
    • Starnes, C. O. Coley's Toxins in Perspective. Nature 1992, 357, 11-12.
    • (1992) Nature , vol.357 , pp. 11-12
    • Starnes, C.O.1
  • 3
    • 0026625803 scopus 로고
    • Tumours and Coley's toxins
    • Rook, G. Tumours and Coley's toxins. Nature 1992, 357, 545.
    • (1992) Nature , vol.357 , pp. 545
    • Rook, G.1
  • 4
    • 84889115296 scopus 로고
    • Uber das prodigiosin, den roten farbstoff des bacillus prodigiosus
    • Wrede, F.; Rothhass, A. Uber das Prodigiosin, den Roten Farbstoff des Bacillus prodigiosus. Hoppe Seyler's Z. Chem. Ber. 1934, 226, 95.
    • (1934) Hoppe Seyler's Z. Chem. Ber. , vol.226 , pp. 95
    • Wrede, F.1    Rothhass, A.2
  • 5
    • 0021832315 scopus 로고
    • Droplet enrichment factors of pigmented and nonpigmented serratia marcescens: Possible selective function for prodigiosin
    • Burger, S. R.; Bennett, J. W. Droplet Enrichment Factors of Pigmented and Nonpigmented Serratia marcescens: Possible Selective Function for Prodigiosin. Appl. Environ. Microbiol. 1985, 50, 487-490.
    • (1985) Appl. Environ. Microbiol. , vol.50 , pp. 487-490
    • Burger, S.R.1    Bennett, J.W.2
  • 6
    • 0022650332 scopus 로고
    • Extracellular vesicle formation and biosurfactant production by serratia marcescens
    • Matsuyama, T; Murakami, T.; Fujita, M.; Fujita, S.; Yano, I. Extracellular Vesicle Formation and Biosurfactant Production by Serratia marcescens. J. Gen. Microbiol. 1986, 132, 865-875.
    • (1986) J. Gen. Microbiol. , vol.132 , pp. 865-875
    • Matsuyama, T.1    Murakami, T.2    Fujita, M.3    Fujita, S.4    Yano, I.5
  • 7
    • 0014192444 scopus 로고
    • Antimalarial activity of prodigiosin
    • Castro, A. J. Antimalarial Activity of Prodigiosin. Nature 1967, 213, 903-904.
    • (1967) Nature , vol.213 , pp. 903-904
    • Castro, A.J.1
  • 8
    • 33845279106 scopus 로고
    • Total synthesis of prodigiosin, prodigiosene, and desmethoxyprodigiosin: Diels-alder reactions of heterocyclic azadienes and development of an effective palladium (II)-promoted 2,2′-bipyrrole coupling procedure
    • Boger, D. L.; Patel, M. Total Synthesis Of Prodigiosin, Prodigiosene, and Desmethoxyprodigiosin: Diels-Alder Reactions of Heterocyclic Azadienes and Development of an Effective Palladium (II)-Promoted 2,2′-Bipyrrole Coupling Procedure. J. Org. Chem. 1988, 53, 1405-1415.
    • (1988) J. Org. Chem. , vol.53 , pp. 1405-1415
    • Boger, D.L.1    Patel, M.2
  • 10
    • 0034674887 scopus 로고    scopus 로고
    • Cytotoxicity of prodigiosin and benznidazole on V79 cells
    • Melo, P. S.; Durán, N.; Haun, M. Cytotoxicity of Prodigiosin and Benznidazole on V79 Cells. Toxicol. Lett. 2000, 116, 237-242.
    • (2000) Toxicol. Lett. , vol.116 , pp. 237-242
    • Melo, P.S.1    Durán, N.2    Haun, M.3
  • 11
    • 0001750476 scopus 로고    scopus 로고
    • Short synthesis of undecylprodigiosine. A new route to 2,2′-bipyrrolyl-pyrromrthene systems
    • D'alessio, R.; Rossi, A. Short Synthesis of Undecylprodigiosine. A New Route to 2,2′-Bipyrrolyl-Pyrromrthene Systems. Synlett 1996, 513-514.
    • (1996) Synlett , pp. 513-514
    • D'alessio, R.1    Rossi, A.2
  • 12
    • 0032904568 scopus 로고    scopus 로고
    • Equilibrium and kinetics of rotamer interconversion in immunosuppressant prodigiosin derivatives in solution
    • Rizzo, V.; Morelli, A.; Pinciroli, V.; Sciangula, D.; D'alessio, R. Equilibrium and Kinetics of Rotamer Interconversion in Immunosuppressant Prodigiosin Derivatives in Solution. J. Pharm. Sci. 1999, 88, 73-78.
    • (1999) J. Pharm. Sci. , vol.88 , pp. 73-78
    • Rizzo, V.1    Morelli, A.2    Pinciroli, V.3    Sciangula, D.4    D'alessio, R.5
  • 15
    • 0022462121 scopus 로고
    • Selective suppression by prodigiosin of the mitogenic response of murine splenocytes
    • Nakamura, A.; Nagai, K.; Ando, K.; Tamura, G. Selective Suppression by Prodigiosin of the Mitogenic Response of Murine Splenocytes. J. Antibiot. 1986, 8, 1155-1159.
    • (1986) J. Antibiot. , vol.8 , pp. 1155-1159
    • Nakamura, A.1    Nagai, K.2    Ando, K.3    Tamura, G.4
  • 16
    • 0024475176 scopus 로고
    • Suppression of cytotoxic T cell induction in vivo by prodigiosin 25-C
    • Nakamura, A.; Magae, J.; Tsuji, R. F.; Yamasaki, M.; Nagai, K. Suppression of Cytotoxic T Cell Induction In Vivo by Prodigiosin 25-C. Transplantation 1989, 47, 1013-1016.
    • (1989) Transplantation , vol.47 , pp. 1013-1016
    • Nakamura, A.1    Magae, J.2    Tsuji, R.F.3    Yamasaki, M.4    Nagai, K.5
  • 18
    • 0026458225 scopus 로고
    • Immunomodulating properties of prodigiosin 25-C, an antibiotic which preferentially suppresses of cytotoxic T cells
    • Tsuji, R. F.; Magae, J.; Jamashita, M.; Nagai, K.; Yamasaki, M. Immunomodulating Properties of Prodigiosin 25-C, An Antibiotic which Preferentially Suppresses of Cytotoxic T Cells. J. Antibiot. 1992, 45, 1295-1302.
    • (1992) J. Antibiot. , vol.45 , pp. 1295-1302
    • Tsuji, R.F.1    Magae, J.2    Jamashita, M.3    Nagai, K.4    Yamasaki, M.5
  • 20
    • 0030050684 scopus 로고    scopus 로고
    • Effect of metacycloprodigiosin, an inhibitor of killer T cells on murine skin and heart transplants
    • Magae, J.; Miller, M. W.; Nagai, K.; Shearer, G. M. Effect of Metacycloprodigiosin, an Inhibitor of Killer T Cells on Murine Skin and Heart Transplants. J. Antibios. 1996, 49, 86-90.
    • (1996) J. Antibios. , vol.49 , pp. 86-90
    • Magae, J.1    Miller, M.W.2    Nagai, K.3    Shearer, G.M.4
  • 24
    • 0031889170 scopus 로고    scopus 로고
    • Suppression of T cell stimulating function of allogeneic antigen presenting cells by prodigiosin 25-C
    • Lee, M. H.; Yamashita, M.; Tsuji, R. F.; Yamasaki, M.; Kataoka, T.; Magae, J.; Nagai, K. Suppression of T Cell Stimulating Function of Allogeneic Antigen Presenting Cells by Prodigiosin 25-C. J. Antibiot. 1998, 51, 92-94.
    • (1998) J. Antibiot. , vol.51 , pp. 92-94
    • Lee, M.H.1    Yamashita, M.2    Tsuji, R.F.3    Yamasaki, M.4    Kataoka, T.5    Magae, J.6    Nagai, K.7
  • 26
    • 0033974672 scopus 로고    scopus 로고
    • + mature cytotoxic T cells by inhibitors of acidification of intracellular organelles, prodigiosin 25-C and concanamycin B
    • + Mature Cytotoxic T Cells by Inhibitors of Acidification of Intracellular Organelles, Prodigiosin 25-C and Concanamycin B. Immunology 2000, 99, 243-248.
    • (2000) Immunology , vol.99 , pp. 243-248
    • Lee, M.H.1    Kataika, T.2    Honjo, N.3    Magae, J.4    Nagai, K.5
  • 27
    • 0033985810 scopus 로고    scopus 로고
    • Induction of apoptosis of activated murine splenic T cells by cycloprodigiosin hydrochloride, a novel immunosuppressant
    • Azuma, T.; Watanabe, N.; Yagisawa, H.; Hirata, H.; Iwamura, M.; Kobayashi, Y. Induction of Apoptosis of Activated Murine Splenic T Cells by Cycloprodigiosin Hydrochloride, a Novel Immunosuppressant. Immunopharmacol. 2000, 46, 29-37.
    • (2000) Immunopharmacol. , vol.46 , pp. 29-37
    • Azuma, T.1    Watanabe, N.2    Yagisawa, H.3    Hirata, H.4    Iwamura, M.5    Kobayashi, Y.6
  • 28
    • 0033833183 scopus 로고    scopus 로고
    • Cycloprodigiosin hydrocloride as an immunosuppressant in rat small bowel transplantation
    • Nakai, K.; Hamada, Y.; Kato, Y.; Yamamoto, D.; Hirata, H.; Hioki, K. Cycloprodigiosin Hydrocloride as an Immunosuppressant in Rat Small Bowel Transplantation. Transplant. Proc. 2000, 32, 1324-1325.
    • (2000) Transplant. Proc. , vol.32 , pp. 1324-1325
    • Nakai, K.1    Hamada, Y.2    Kato, Y.3    Yamamoto, D.4    Hirata, H.5    Hioki, K.6
  • 29
    • 0035825485 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of nonylprodigiosin and macrocyclic prodigiosin analogues
    • Fürstner, A.; Grabowski, J.; Lehmann, C. W.; Kataola, T.; Nagai, K. Synthesis and Biological Evaluation of Nonylprodigiosin and Macrocyclic Prodigiosin Analogues. Chem. BioChem. 2001, 2, 60-68.
    • (2001) Chem. BioChem. , vol.2 , pp. 60-68
    • Fürstner, A.1    Grabowski, J.2    Lehmann, C.W.3    Kataola, T.4    Nagai, K.5
  • 30
    • 0034757614 scopus 로고    scopus 로고
    • Prodigiosin blocks T cell activation by inhibiting interleukin-2Rα expression and delays progression of autoimmune diabetes and collagen-induced arthritis
    • Han, S. B.; Park, S. H.; Jeon, Y. J.; Kim, Y. K.; Kim, H. M.; Yang, K. H. Prodigiosin Blocks T Cell Activation by Inhibiting Interleukin-2Rα Expression and Delays Progression of Autoimmune Diabetes and Collagen-Induced Arthritis. J. Pharm. Exp. Ther. 2001, 299, 415-425.
    • (2001) J. Pharm. Exp. Ther. , vol.299 , pp. 415-425
    • Han, S.B.1    Park, S.H.2    Jeon, Y.J.3    Kim, Y.K.4    Kim, H.M.5    Yang, K.H.6
  • 31
    • 0037079735 scopus 로고    scopus 로고
    • Selective inhibitor of janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin
    • Stepkowski, S. M.; Erwin-Cohen, R. A.; Behbod, F.; Wang, M. E.; Qu, X.; Tejpal, N.; Nagy, Z. S.; Kahan, B. D.; Kirken, R. A. Selective Inhibitor of Janus Tyrosine Kinase 3, PNU156804, Prolongs Allograft Survival and Acts Synergistically with Cyclosporine but Additively with Rapamycin. Blood 2002, 99, 680-689.
    • (2002) Blood , vol.99 , pp. 680-689
    • Stepkowski, S.M.1    Erwin-Cohen, R.A.2    Behbod, F.3    Wang, M.E.4    Qu, X.5    Tejpal, N.6    Nagy, Z.S.7    Kahan, B.D.8    Kirken, R.A.9
  • 32
    • 0032406162 scopus 로고    scopus 로고
    • The regulation of apoptosis by microbial pathogens
    • Moss, J. E.; Aliprantis, A. O.; Zychlinsky, A. The Regulation of Apoptosis by Microbial Pathogens. Int. Rev. Cytol. 1999, 187, 203-259.
    • (1999) Int. Rev. Cytol. , vol.187 , pp. 203-259
    • Moss, J.E.1    Aliprantis, A.O.2    Zychlinsky, A.3
  • 35
    • 0035896188 scopus 로고    scopus 로고
    • Prodigiosin-induced apoptosis in human colon cancer cells
    • Montaner, B.; Pérez-Tomás, R. Prodigiosin-Induced Apoptosis in Human Colon Cancer Cells. Life Sci. 2001, 68, 2025-2036.
    • (2001) Life Sci. , vol.68 , pp. 2025-2036
    • Montaner, B.1    Pérez-Tomás, R.2
  • 36
    • 0035071851 scopus 로고    scopus 로고
    • Prodigiosin induces cell death and morphological changes indicative of apoptosis in gastric cancer cell line HGT-1
    • Díaz-Ruíz, C.; Montaner, B.; Pérez-Tomás, R. Prodigiosin Induces Cell Death and Morphological Changes Indicative of Apoptosis In Gastric Cancer Cell Line HGT-1. Histol. Histophatol. 2001, 16, 415-421.
    • (2001) Histol. Histophatol. , vol.16 , pp. 415-421
    • Díaz-Ruíz, C.1    Montaner, B.2    Pérez-Tomás, R.3
  • 42
    • 0030698096 scopus 로고    scopus 로고
    • Role of intracellular pH in proliferation, transformation, and apoptosis
    • Shrode, L. D.; Tapper, H.; Grinstein, S. Role of Intracellular pH in Proliferation, Transformation, and Apoptosis. J. Bioenerg. Biomembr. 1997, 29, 393-399.
    • (1997) J. Bioenerg. Biomembr. , vol.29 , pp. 393-399
    • Shrode, L.D.1    Tapper, H.2    Grinstein, S.3
  • 43
    • 0027373117 scopus 로고
    • Vacuolar-type H-ATPases are functionally expressed in plasma membranes of human tumor cells
    • Martinez-Zaguilan, R.; Lynch, R. M.; Martinez, G. M.; Gillies, R. J. Vacuolar-Type H-ATPases are Functionally Expressed in Plasma Membranes of Human Tumor Cells. Am. J. Physiol. 1993, 265, 1015-1029.
    • (1993) Am. J. Physiol. , vol.265 , pp. 1015-1029
    • Martinez-Zaguilan, R.1    Lynch, R.M.2    Martinez, G.M.3    Gillies, R.J.4
  • 44
    • 0024389333 scopus 로고
    • Structure and function of vacuolar class of ATP-driven proton pumps
    • Forgac, M. Structure and Function of Vacuolar Class of ATP-Driven Proton Pumps. Physiol. Rev. 1989, 69, 765-796.
    • (1989) Physiol. Rev. , vol.69 , pp. 765-796
    • Forgac, M.1
  • 45
    • 0026563170 scopus 로고
    • Evolution of organellar proton-ATPases
    • Nelson, N. Evolution of Organellar Proton-ATPases. Biochim. Biophys. Acta 1992, 1100, 109-124.
    • (1992) Biochim. Biophys. Acta , vol.1100 , pp. 109-124
    • Nelson, N.1
  • 46
    • 0025932984 scopus 로고
    • Apoptosis: Mechanisms and roles in pathology
    • Arends, M. J.; Wyllie, A. H. Apoptosis: Mechanisms and Roles in Pathology. Int. Rev. Esp. Pathol. 1991, 32, 223-256.
    • (1991) Int. Rev. Esp. Pathol. , vol.32 , pp. 223-256
    • Arends, M.J.1    Wyllie, A.H.2
  • 47
    • 0033119834 scopus 로고    scopus 로고
    • Interdependent regulation of intracellular acidification and SHP-1 in apoptosis
    • Thangaraju, M.; Sharma, K.; Liu, D.; Shen, S. H.; Srikant, C. B. Interdependent Regulation of Intracellular Acidification and SHP-1 in Apoptosis. Cancer Res. 1999, 59, 1649-1654.
    • (1999) Cancer Res. , vol.59 , pp. 1649-1654
    • Thangaraju, M.1    Sharma, K.2    Liu, D.3    Shen, S.H.4    Srikant, C.B.5
  • 48
    • 0033776271 scopus 로고    scopus 로고
    • Changes in intramitochondrial and cytosolic pH: Early events that modulate caspase activation during apoptosis
    • Matsuyama, S.; Llopis, J.; Deveraux, Q. L.; Tsien, R. Y.; Reed, J. C. Changes in Intramitochondrial and Cytosolic pH: Early Events that Modulate Caspase Activation During Apoptosis. Nat. Cell Biol. 2000, 2, 318-325.
    • (2000) Nat. Cell Biol. , vol.2 , pp. 318-325
    • Matsuyama, S.1    Llopis, J.2    Deveraux, Q.L.3    Tsien, R.Y.4    Reed, J.C.5
  • 50
    • 0030013044 scopus 로고    scopus 로고
    • The chronic administration of drugs that inhibit the regulation of intracellular pH: In vitro and anti-tumour effects
    • Yamagata, M.; Tannock, I. F. The Chronic Administration of Drugs that Inhibit the Regulation of Intracellular pH: In Vitro and Anti-Tumour Effects. Br. J. Cancer 1996, 73, 1328-1334.
    • (1996) Br. J. Cancer , vol.73 , pp. 1328-1334
    • Yamagata, M.1    Tannock, I.F.2
  • 56
    • 0033258120 scopus 로고    scopus 로고
    • Bcl-2 proteins: Regulators of apoptosis or of mitochondrial homeostasis?
    • Vander Heiden, M. G.; Thompson, C. B. Bcl-2 Proteins: Regulators of Apoptosis or of Mitochondrial Homeostasis? Nat. Cell. Biol. 1999, 1, 209-216.
    • (1999) Nat. Cell. Biol. , vol.1 , pp. 209-216
    • Vander Heiden, M.G.1    Thompson, C.B.2
  • 57
    • 0032530215 scopus 로고    scopus 로고
    • Molecular epidemiology of human cancer: Contribution of mutation spectra studies for tumor suppressor genes
    • Hussain, S. P.; Harris, C. C. Molecular Epidemiology of Human Cancer: Contribution of Mutation Spectra Studies for Tumor Suppressor Genes. Cancer Res. 1998, 58, 4023-4037.
    • (1998) Cancer Res. , vol.58 , pp. 4023-4037
    • Hussain, S.P.1    Harris, C.C.2
  • 58
    • 0031717905 scopus 로고    scopus 로고
    • Tumor suppressor p53: Implications for tumor development and prognosis
    • Kirsch, D. G.; Kastan, M. B. Tumor Suppressor p53: Implications for Tumor Development and Prognosis. J. Clin. Oncol. 1998, 16, 3158-3168.
    • (1998) J. Clin. Oncol. , vol.16 , pp. 3158-3168
    • Kirsch, D.G.1    Kastan, M.B.2
  • 60
    • 0033118475 scopus 로고    scopus 로고
    • Apoptosis, p53, and tumor cell sensitivity to anticancer agents
    • Brown, J. M.; Wouters, B. G. Apoptosis, p53, and Tumor Cell Sensitivity to Anticancer Agents. Cancer Res. 1999, 59, 1391-1399.
    • (1999) Cancer Res. , vol.59 , pp. 1391-1399
    • Brown, J.M.1    Wouters, B.G.2
  • 62
    • 0028880006 scopus 로고
    • Opposing effects of ERK and JNK-P38 MAP kinases on apoptosis
    • Xia, Z.; Dickens, M.; Raingeaud, J.; Davis, R. J.; Greenberg, M. E. Opposing Effects of ERK and JNK-P38 MAP Kinases on Apoptosis. Science 1995, 270, 1326-1331.
    • (1995) Science , vol.270 , pp. 1326-1331
    • Xia, Z.1    Dickens, M.2    Raingeaud, J.3    Davis, R.J.4    Greenberg, M.E.5
  • 63
    • 0030712182 scopus 로고    scopus 로고
    • The protein kinase C activators phorbol esters and phosphatidylserine inhibit neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin
    • Mansat, V.; Laurent, G.; Levade, T.; Bettaieb, A.; Jaffrezou, J. P. The Protein Kinase C Activators Phorbol Esters and Phosphatidylserine Inhibit Neutral Sphingomyelinase Activation, Ceramide Generation, and Apoptosis Triggered by Daunorubicin. Cancer Res. 1997, 57, 5300-5304.
    • (1997) Cancer Res. , vol.57 , pp. 5300-5304
    • Mansat, V.1    Laurent, G.2    Levade, T.3    Bettaieb, A.4    Jaffrezou, J.P.5
  • 64
    • 0029865419 scopus 로고    scopus 로고
    • ++ dependent endonuclease with protein kinase C as a possible mechanism for cytokine resistance in human renal carcinoma cells
    • ++ Dependent Endonuclease With Protein Kinase C as a Possible Mechanism for Cytokine Resistance in Human Renal Carcinoma Cells. J. Urol. 1996, 155, 1779-1783.
    • (1996) J. Urol. , vol.155 , pp. 1779-1783
    • Woo, K.R.1    Shu, W.P.2    Kong, L.3    Liu, B.C.4
  • 65
    • 0023750235 scopus 로고
    • Inhibition of radiation-induced apoptosis in vitro by tumor promoters
    • Tomei, L. D.; Kanter, P.; Wenner, C. E. Inhibition of Radiation-Induced Apoptosis In Vitro by Tumor Promoters. Biochem. Biophys. Res. Commun. 1988, 155, 324-331.
    • (1988) Biochem. Biophys. Res. Commun. , vol.155 , pp. 324-331
    • Tomei, L.D.1    Kanter, P.2    Wenner, C.E.3
  • 66
    • 0032126479 scopus 로고    scopus 로고
    • Death of tumor cells after intracellular acidification is dependent on stress-activated protein kinases (SAPK/JNK) pathway activation and cannot be inhibited by Bcl-2 expression or interleukin 1B-converting enzyme inhibition
    • Zanke, B. W.; Lee, C.; Arab, S.; Tannock, I. F. Death of Tumor Cells after Intracellular Acidification is Dependent on Stress-Activated Protein Kinases (SAPK/JNK) Pathway Activation and Cannot Be Inhibited by Bcl-2 Expression or Interleukin 1B-Converting Enzyme Inhibition. Cancer Res. 1998, 58, 2801-2808.
    • (1998) Cancer Res. , vol.58 , pp. 2801-2808
    • Zanke, B.W.1    Lee, C.2    Arab, S.3    Tannock, I.F.4
  • 67
    • 0036471026 scopus 로고    scopus 로고
    • Activation of protein kinase C is required for protection of cells against apoptosis induced by the immunossuppresor prodigiosin
    • Montaner, B.; Pérez-Tomás, R. Activation of Protein Kinase C is Required for Protection of Cells Against Apoptosis Induced by the Immunossuppresor Prodigiosin. Biochem. Pharmacol. 2002, 63, 463-469.
    • (2002) Biochem. Pharmacol. , vol.63 , pp. 463-469
    • Montaner, B.1    Pérez-Tomás, R.2
  • 68
    • 0031883140 scopus 로고    scopus 로고
    • The c-Jun N-terminal kinase cascade plays a role in stress-induced apoptosis in jurkat cells by up-regulating Fas ligand expression
    • Faris, M.; Kokot, N.; Latinis, K.; Kasibhatla, S.; Green, D. R.; Koretzky, G. A.; Nel, A. The c-Jun N-Terminal Kinase Cascade Plays a Role In Stress-Induced Apoptosis in Jurkat Cells by Up-Regulating Fas Ligand Expression. J. Immunol. 1998, 160, 134-144.
    • (1998) J. Immunol. , vol.160 , pp. 134-144
    • Faris, M.1    Kokot, N.2    Latinis, K.3    Kasibhatla, S.4    Green, D.R.5    Koretzky, G.A.6    Nel, A.7
  • 69
    • 0032478798 scopus 로고    scopus 로고
    • p38 mitogen-activated protein kinase-dependent and -independent intracellular signal transduction pathways leading to apoptosis in human neutrophils
    • Frasch, S. C.; Nick, J. A.; Fadok, V. A.; Bratton, D. L.; Worthen, G. S.; Henson, P. M. p38 Mitogen-Activated Protein Kinase-Dependent and -Independent Intracellular Signal Transduction Pathways Leading to Apoptosis in Human Neutrophils. J. Biol. Chem. 1998, 273, 8389-8397.
    • (1998) J. Biol. Chem. , vol.273 , pp. 8389-8397
    • Frasch, S.C.1    Nick, J.A.2    Fadok, V.A.3    Bratton, D.L.4    Worthen, G.S.5    Henson, P.M.6
  • 70
    • 0037165497 scopus 로고    scopus 로고
    • The cytotoxic prodigiosin induces phosphorylation of p38-MAPK but not of SAPK/JNK
    • Montaner, B.; Pérez-Tomás, R. The Cytotoxic Prodigiosin Induces Phosphorylation of p38-MAPK but not of SAPK/JNK. Toxicol. Lett. 2002, 129, 93-98.
    • (2002) Toxicol. Lett. , vol.129 , pp. 93-98
    • Montaner, B.1    Pérez-Tomás, R.2
  • 71
    • 0035802124 scopus 로고    scopus 로고
    • Studies on DNA cleavage by cytotoxic pyrrole alkaloids reveal the distinctly different behavior of roseophilin and prodigiosin derivatives
    • Fürstner, A.; Grabowski, E. J. Studies on DNA Cleavage by Cytotoxic Pyrrole Alkaloids Reveal the Distinctly Different Behavior of Roseophilin and Prodigiosin Derivatives. Chem. BioChem. 2001, 9, 706-709.
    • (2001) Chem. BioChem. , vol.9 , pp. 706-709
    • Fürstner, A.1    Grabowski, E.J.2
  • 72
    • 0032885667 scopus 로고    scopus 로고
    • DNA binding by 4-methoxypurrolic natural products. Preference for intercalation at AT sites by tambjamine E and prodigiosin
    • Melvin, M. S.; Ferguson, D. C.; Lindquist, N.; Manderville, R. A. DNA Binding by 4-Methoxypurrolic Natural Products. Preference for Intercalation at AT Sites by Tambjamine E and Prodigiosin. J. Org. Chem. 1999, 64, 6861-6869.
    • (1999) J. Org. Chem. , vol.64 , pp. 6861-6869
    • Melvin, M.S.1    Ferguson, D.C.2    Lindquist, N.3    Manderville, R.A.4
  • 73
    • 0035093737 scopus 로고    scopus 로고
    • DNA double-strand breaks: Signaling, repair and the cancer connection
    • Khanna, K. K; Jackson, S. P. DNA Double-Strand Breaks: Signaling, Repair and the Cancer Connection. Nat. Genet. 2001, 27, 247-254.
    • (2001) Nat. Genet. , vol.27 , pp. 247-254
    • Khanna, K.K.1    Jackson, S.P.2
  • 74
    • 0021732164 scopus 로고
    • The relevance of tumor pH to the treatment of malignant disease
    • Wike-Hooley, J. L.; Haveman, J.; Reinhold, J. S. The Relevance of Tumor pH to the Treatment of Malignant Disease. Radiother. Oncol. 1984, 2, 343-366.
    • (1984) Radiother. Oncol. , vol.2 , pp. 343-366
    • Wike-Hooley, J.L.1    Haveman, J.2    Reinhold, J.S.3
  • 75
    • 0035874951 scopus 로고    scopus 로고
    • The cell transmembrane pH gradient in tumors enhances cytotoxicity of specific weak acid chemotherapeutics
    • Kozin, S.; Shkarin, P.; Gerweck, L. The cell Transmembrane pH Gradient in Tumors Enhances Cytotoxicity of Specific Weak Acid Chemotherapeutics. Cancer Res. 2001, 61, 4740-4743.
    • (2001) Cancer Res. , vol.61 , pp. 4740-4743
    • Kozin, S.1    Shkarin, P.2    Gerweck, L.3
  • 76
    • 0017583940 scopus 로고
    • Effects of bacterial extracts on chinese hamster cells and rat neoplasms
    • Fullan, N. P.; Lynch, D. L; Ostrow, D. H. Effects of Bacterial Extracts on Chinese Hamster Cells and Rat Neoplasms. Microbios Lett. 1977, 5, 157-161.
    • (1977) Microbios Lett. , vol.5 , pp. 157-161
    • Fullan, N.P.1    Lynch, D.L.2    Ostrow, D.H.3
  • 77
    • 0028823396 scopus 로고
    • A kinase-deficient splice variant of the human Jak3 is expressed in hematopoietic and epithelial cancer cells
    • Lai, K. S.; Jin, Y.; Graham, D. K.; Witthuhn, B. A.; Ihle, J. N.; Liu, E. T. A Kinase-Deficient Splice Variant of the Human Jak3 is Expressed in Hematopoietic and Epithelial Cancer Cells. J. Biol. Chem. 1995, 270, 25028-25036.
    • (1995) J. Biol. Chem. , vol.270 , pp. 25028-25036
    • Lai, K.S.1    Jin, Y.2    Graham, D.K.3    Witthuhn, B.A.4    Ihle, J.N.5    Liu, E.T.6
  • 78
    • 0030999750 scopus 로고    scopus 로고
    • Apoptosis and the dilemma of cancer chemotherapy
    • Hannun, Y. A. Apoptosis and the Dilemma of Cancer Chemotherapy. Blood 1997, 89, 1845-1853.
    • (1997) Blood , vol.89 , pp. 1845-1853
    • Hannun, Y.A.1
  • 79
    • 0030832842 scopus 로고    scopus 로고
    • The NCI anti-cancer drug screen: A smart screen to identify effectors of novel targets
    • Monks, A.; Scudiero, D. A.; Johnson, G. S.; Paull, K. D.; Sausville, E. A. The NCI Anti-Cancer Drug Screen: A Smart Screen to Identify Effectors of Novel Targets. Anticancer Drug Des. 1997, 12, 533-541.
    • (1997) Anticancer Drug Des. , vol.12 , pp. 533-541
    • Monks, A.1    Scudiero, D.A.2    Johnson, G.S.3    Paull, K.D.4    Sausville, E.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.