Equilibrium and kinetics of rotamer interconversion in immunosuppressant prodigiosin derivatives in solution

Journal of Pharmaceutical Sciences

Volumn 88, Issue 1, 1999, Pages 73-78

  Rizzo, Vincenzo ^a   Morelli, Amedea ^a   Pinciroli, Vittorio ^a   Sciangula, Domenico ^a   D'Alessio, Roberto ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETONITRILE; CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT; PNU 156737; PNU 156804; PRODIGIOSIN; PRODIGIOSIN DERIVATIVE; UNCLASSIFIED DRUG; WATER;

ARTICLE; DRUG CONFORMATION; IMMUNE RESPONSE; ISOMERISM; NUCLEAR MAGNETIC RESONANCE; PH; PROTON TRANSPORT;

EID: 0032904568     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js980225w     Document Type: Article

References (8)

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3. Tsuji, R. F.; Yamamoto, M.; Nakamura, A.; Kataoka, T.; Magae, J.; Nagai, K.; Jamasaky, M. Selective Immunosuppression of Prodigiosin 25-C and FK506 in the Murine Immune System. Antibiotics 1990, 13, 1293-1301.
4. Liu, J. FK506 and Cyclosporin, Molecular Probes for Studying Intracellular Signal Transduction. Immunol. Today 1993, 14, 290-295.
5. D'Alessio, R.; Rossi A. Short Synthesis of Undecylprodigiosin. A new Route to 2, 2′-Bipyrrolyl-pyrromethylene Systems. Synlett 1996, 513-514.
6. Bernasconi, C. F. Relaxation Kinetics; Academic: New York, 1976; Chapter 4.
7. Blake, A. J.; Hunter, G. A.; McNab, H. A Short Synthesis of Prodigiosin Analogues. J. Chem. Soc., Chem. Commun. 1990, 734-736.
8. Stamnes, M. A.; Rutherford, S. L.; Zucker, C. S. Cyclophilins: A New Family of Proteins Involved in Intracellular Folding. Trends Cell. Biol. 1992, 2, 272-276.