Studies on DNA cleavage by cytotoxic pyrrole alkaloids reveal the distinctly different behavior of roseophilin and prodigiosin derivatives

ChemBioChem

Volumn 2, Issue 9, 2001, Pages 706-709

  Fürstner, Alois ^a   Grabowski, Eric Jarek ^a  

^a MAX PLANCK INSTITUT FÜR KOHLENFORSCHUNG   (Germany)

Author keywords

Alkaloids; Antitumor agents; DNA cleavage; Prodigiosins; Pyrroles

Indexed keywords

ALKALOID; ANTIINFECTIVE AGENT; DNA; FUSED HETEROCYCLIC RINGS; PRODIGIOSIN; PYRROLE DERIVATIVE; ROSEOPHILIN;

AGAR GEL ELECTROPHORESIS; ARTICLE; CHEMISTRY; DRUG EFFECT; STREPTOMYCES;

ALKALOIDS; ANTI-BACTERIAL AGENTS; DNA; ELECTROPHORESIS, AGAR GEL; HETEROCYCLIC COMPOUNDS, 3-RING; PRODIGIOSIN; PYRROLES; STREPTOMYCES;

EID: 0035802124     PISSN: 14394227     EISSN: None     Source Type: Journal    
DOI: 10.1002/1439-7633(20010903)2:9<706::AID-CBIC706>3.0.CO;2-J     Document Type: Article

References (6)

1. Y. Hayakawa, K. Kawakami, H. Seto, K. Furihata, Tetrahedron Lett. 1992, 33, 2701-2704.
2. Information concerning the cytotoxicity of 1-HCI (NCI number 650718) against various human cancer cell lines in vitro is available from the NCI database on the Internet at http://www.dtp.nci.nih.gov.
3. a) A. Fürstner, H. Szillat, B. Gabor, R. Mynott, J. Am. Chem. Soc. 1998, 120, 8305-8314;
4. b) A. Fürstner, J. Grabowski, C.W. Lehmann, J. Org. Chem. 1999, 64, 8275-8280;
5. c) A. F̈rstner, H. Krause, J. Org. Chem. 1999, 64, 8281-8286.
6. A. Fürstner, J. Grabowski, CW. Lehmann, T. Kataoka, K. Nagai, Chem-BioChem 2001, 2, 60-68.