Synthesis of NF-κB activation inhibitors derived from epoxyquinomicin C

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 9, 2000, Pages 865-869

  Matsumoto, Naoki ^a   Ariga, Akiko ^b   To E, Sakino ^b   Nakamura, Hikaru ^a   Agata, Naoki ^c   Hirano, Shin Ichi ^c   Inoue, Jun Ichiro ^d   Umezawa, Kazuo ^b  

^a INSTITUTE OF MICROBIAL CHEMISTRY   (Japan)

^b KEIO UNIVERSITY   (Japan)

^c MERCIAN CORPORATION   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 CYCLOHEXENONE DERIVATIVE; EPOXYQUINOMICIN C DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; ANTIRHEUMATIC AGENT; BENZAMIDE DERIVATIVE; EPOXYQUINOMICIN C; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; QUINONE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL MODIFICATION; DRUG DESIGN; DRUG STRUCTURE; HUMAN; HUMAN CELL; INHIBITION KINETICS; MOUSE; NONHUMAN; PARTIAL DRUG SYNTHESIS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; ANIMAL; BIOTRANSFORMATION; CHEMICALLY INDUCED DISORDER; CHEMISTRY; CIRCULAR DICHROISM; DRUG ANTAGONISM; DRUG EFFECT; LEUKEMIA CELL LINE; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION REDUCTION REACTION; RHEUMATOID ARTHRITIS; STEREOISOMERISM; SYNTHESIS;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; BENZAMIDES; BIOTRANSFORMATION; CIRCULAR DICHROISM; HUMANS; JURKAT CELLS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; NF-KAPPA B; OXIDATION-REDUCTION; QUINONES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034178264     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00114-1     Document Type: Article

References (10)

1. Baeuerle P.A., Baichwal V.R. Adv. Immunol. 65:1997;111.
2. Erkel G., Anke T., Sterner O. Biochem. Biophys. Res. Commun. 226:1996;214.
3. Gehrt A., Erkel G., Anke Timm, Sterner O. J. Antibiotics. 51:1998;455.
4. Matsumoto N., Tsuchida T., Umekita M., Kinoshita N., Iinuma H., Sawa T., Hamada M., Takeuchi T. J. Antibiotics. 50:1997;900.
5. Matsumoto N., Iinuma H., Sawa T., Takeuchi T., Hirano S., Yoshioka T., Ishizuka M. J. Antibiotics. 50:1997;906.
6. Wipf, P.; Kim, Y.; Jahn, H. Synthesis 1995, 1549.
7. Altomare A., Burla M.C., Camalli M., Cascarano M., Giacovazzo C., Guagliardi A., Polidori G. J. Appl. Crystallogr. 27:1994;435.
8. Beurskens, P. T.; Admiraal, G.; Beurskens, G.; Bosman, W. P.; de Gelder, R.; Israel, R.; Smits, J. M. M. The DIRDIF-94 program system, Technical Report of the Crystallography Laboratory, University of Nijmegen, The Netherlands, 1994.
9. Crosse A., Mauli R., Sigg H.P. Helv. Chim. Acta. 49:1966;204.
10. Sakamura, S.; Niki, H.; Obata, Y.; Sakai, R.; Matsumoto, T. Agr. Biol. Chem., 1969, 698.