Group III metabotropic glutamate receptors as autoreceptors in the cerebellar cortex

British Journal of Pharmacology

Volumn 138, Issue 4, 2003, Pages 614-625

  Lorez, Matthias ^a,b   Humbel, Urs ^a   Pflimlin, Marie Claire ^a   Kew, James N C ^a,c  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Autoreceptor; Brain slice; Cerebellum; L AP4; Metabotropic glutamate receptor; MSOP; Presynaptic inhibition; Purkinje cell

Indexed keywords

2 AMINO 4 PHOSPHONOBUTYRIC ACID; ALPHA METHYLSERINE O PHOSPHATE; AUTORECEPTOR; BRAIN RECEPTOR; GLUTAMIC ACID; L AP4; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR AGONIST;

ANIMAL TISSUE; ARTICLE; BRAIN DEPTH STIMULATION; BRAIN SLICE; CEREBELLUM CORTEX; CONTROLLED STUDY; EVOKED RESPONSE; EXCITATORY POSTSYNAPTIC POTENTIAL; IC 50; LATENT PERIOD; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; RAT; SYNAPSE; VOLTAGE CLAMP;

ANIMALS; AUTORECEPTORS; CEREBELLAR CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY POSTSYNAPTIC POTENTIALS; PROPIONIC ACIDS; RATS; RATS, WISTAR; RECEPTORS, AMPA; RECEPTORS, GLUTAMATE;

EID: 0037293570     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705099     Document Type: Article

References (55)

1. ANWYL, R. (1999). Metabotropic glutamate receptors: electrophysiological properties and role in plasticity. Brain Res. Rev., 29, 83-120.
2. BARBOUR, B., KELLER, B.U., LLANO, I. & MARTY, A. (1994). Prolonged presence of glutamate during excitatory synaptic transmission to cerebellar Purkinje cells. Neuron, 12, 1331-1343.
3. BATCHELOR, A.M. & GARTHWAITE, J. (1993). Novel synaptic potentials in cerebellar Purkinje cells: probable mediation by metabotropic glutamate receptors. Neuropharmacology, 32, 11-20.
4. BERTHELE, A., PLATZER, S., LAURIE, D.J., WEIS, S., SOMMER, B., ZIEGLGANSBERGER, W., CONRAD, B. & TOLLE, T.R. (1999). Expression of metabotropic glutamate receptor subtype mRNA (mGluR1-8) in human cerebellum. Neuro Report, 10, 3861-3867.
5. BRADLEY, S.R., STANDAERT, D.G., RHODES, K.J., REES, H.D., TESTA, C.M., LEVEY, A.I. & CONN, P.J. (1999). Immunohistochemical localization of subtype 4a metabotropic glutamate receptors in the rat and mouse basal ganglia. J. Comp. Neurol., 407, 33-46.
6. BRASNJO, G. & OTIS, T.S. (2001). Neuronal glutamate transporters control activation of postsynaptic metabotropic glutamate receptors and influence cerebellar long-term depression. Neuron, 31, 607-616.
7. BRODY, D.L. & YUE, D.T. (2000). Relief of G-protein inhibition of calcium channels and short-term synaptic facilitation in cultured hippocampal neurons. J. Neurosci., 20, 889-898.
8. CHEN, C.Y., LING EH, E.H., HOROWITZ, J.M. & BONHAM, A.C. (2002). Synaptic transmission in nucleus tractus solitarius is depressed by Group II and III but not Group I presynaptic metabotropic glutamate receptors in rats. J. Physiol., 538, 773-786.
9. CONQUET, F., BASHIR, Z.I., DAVIES, C.H., DANIEL, H., FERRAGUTI, F., BORDI, F., FRANZ-BACON, K., REGGIANI, A., MATARESE, V., CONDE, F., COLLINGRIDGE, G.L. & CREPEL, L. (1994). Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1. Nature, 372, 237-243.
10. CORTI, C., ALDEGHERI, L., SOMOGYI, P. & FERRAGUTI, F. (2002). Distribution and synaptic localisation of the metabotropic glutamate receptor 4 (mGluR4) in the rodent CNS. Neuroscience, 110, 403-420.
11. CORTI, C., RESTITUITO, S., RIMLAND, J.M., BRABET, I., CORSI, M., PIN, J.P. & FERRAGUTI, F. (1998). Cloning and characterization of alternative mRNA forms for the rat metabotropic glutamate receptors mGluR7 and mGluR8. Eur. J. Neurosci., 10, 3629-3641.
12. DANIEL, H. & CREPEL, F. (2001). Control of Ca2+ influx by cannabinoid and metabotropic glutamate receptors in rat cerebellar cortex requires K+ channels. Journal of Physiology, 537, 793-800.
13. DAVARE, M.A., AVDONIN, V., HALL, D.D., PEDEN, E.M., BURETTE, A., WEINBERG, R.J., HORNE, M.C., HOSHI, T. & HELL, J.W. (2001). A beta2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav1.2. Science, 293, 98-101.
14. DE BLASI, A., CONN, P.J., PIN, J.P. & NICOLETTI, F. (2001). Molecular determinants of metabotropic glutamate receptor signaling. Trends Pharmacol. Sci., 22, 114-120.
15. DEBANNE, D., GUERINEAU, N.C., GAHWILER, B.H. & THOMPSON, S.M. (1997). Action-potential propagation gated by an axonal I(A)-like K+ conductance in hippocampus [published erratum appears in Nature 1997 Dec 4;390(6659):536]. Nature, 389, 286-289.
16. DITTMAN, J.S. & REGEHR, W.G. (1996). Contributions of calcium-dependent and calcium-independent mechanisms to presynaptic inhibition at a cerebellar synapse. J. Neurosci., 16, 1623-1633.
17. DUBE, G.R. & MARSHALL, K.C. (2000). Activity-dependent activation of presynaptic metabotropic glutamate receptors in locus coeruleus. J. Neurophysiol., 83, 1141-1149.
18. DUVOISIN, R.M., ZHANG, C. & RAMONELL, K. (1995). A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb. J. Neurosci., 15, 3075-3083.
19. HAMPSON, D.R., HUANG, X.-P., PEKHLETSKI, R., PELTEKOVA, V., HORNBY, G., THOMSEN, C. & THOGERSEN, H. (1999). Probing the ligand-binding domain of the mGluR4 subtype of metabotropic glutamate receptor. J. Biol. Chem., 274, 33488-33495.
20. HARTELL, N.A. (1996). Strong activation of parallel fibers produces localized calcium transients and a form of LTD that spreads to distant synapses. Neuron, 16, 601-610.
21. IACOVELLI, L., BRUNO, V., SALVATORE, L., MELCHIORRI, D., GRADINI, R., CARICASOLE, A., BARLETTA, E., DEBLASI, A. & NICOLETTI, F. (2002). J. Neurochem., 82, 216-223.
22. ILOUZ, N., BRANSKI, L., PARNIS, J., PARNAS, H. & LINIAL, M. (1999). Depolarization affects the binding properties of muscarinic acetylcholine receptors and their interaction with proteins of the exocytic apparatus. J. Biol. Chem., 274, 29519-29528.
23. KEW, J.N., DUCARRE, J.M., PFLIMLIN, M.C., MUTEL, V. & KEMP, J.A. (2001). Activity-dependent presynaptic autoinhibition by group II metabotropic glutamate receptors at the perforant path inputs to the dentate gyrus and CA1. Neuropharmacology, 40, 20-27.
24. KEW, J.N., PFLIMLIN, M.C., KEMP, J.A. and MUTEL, V. (2002). Differential regulation of synaptic transmission by mGlu2 and mGlu3 at the perforant path inputs to the dentate gyrus and CA1 revealed in mGlu2 -/- mice. Neuropharmacology, 43, 215-221.
25. KINOSHITA, A., OHISHI, H., NOMURA, S., SHIGEMOTO, R., NAKANISHI, S. & MIZUNO, N. (1996). Presynaptic localization of a metabotropic glutamate receptor, mGluR4a, in the cerebellar cortex: a light and electron microscope study in the rat. Neurosci. Lett., 207, 199-202.
26. KLUNK, W.E., MCCLURE, R.J. & PETTEGREW, J.W. (1991). L-phosphoserine, a metabolite elevated in Alzheimer's disease, interacts with specific L-glutamate receptor subtypes. J. Neurochem., 56, 1997-2003.
27. LITSCHIG, S., GASPARINI, F., RUEEGG, D., STOEHR, N., FLOR, P.J., VRANESIC, I., PREZEAU, L., PIN, J.P., THOMSEN, C. & KUHN, R. (1999). CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding. Mol. Pharmacol., 55, 453-461.
28. LLINAS, R.R. & WALTON, K.D. (1998). Cerebellum. New York, Oxford: Oxford University Press.
29. LUJAN, R., ROBERTS, J.D., SHIGEMOTO, R., OHISHI, H. & SOMOGYI, P. (1997). Differential plasma membrane distribution of metabotropic glutamate receptors mGluR1 alpha, mGluR2 and mGluR5, relative to neurotransmitter release sites. J. Chem. Neuroanat., 13, 219-241.
30. MATEOS, J.M., AZKUE, J., SARRIA, R., KUHN, R., GRANDES, P. & KNOPFEL, T. (1998). Localization of the mGlu4a metabotropic glutamate receptor in rat cerebellar cortex. Histochem. Cell Biol., 109, 135-139.
31. MATEOS, J.M., ELEZGARAI, I., BENITEZ, R. OSORIO, A., BILBAO, A., AZKUE, J.J., KUHN, R., KNOPFEL, T. & GRANDES, P. (1999). Clustering of the group III metabotropic glutamate receptor 4a at parallel fiber synaptic terminals in the rat cerebellar molecular layer. Neurosci. Res., 35, 71-74.
32. MITCHELL, S.J. & SILVER, R.A. (2000). Glutamate spillover suppresses inhibition by activating presynaptic mGluRs. Nature, 404, 498-502.
33. MONASTYRSKAIA, K., LUNDSTROM, K., PLAHL, D., ACUNA, G., SCHWEITZER, C., MALHERBE, P. & MUTEL, V. (1999). Effect of the umami peptides on the ligand binding and function of rat mGlu4a receptor might implicate this receptor in the monosodium glutamate taste transduction. Br. J. Pharmacol., 128, 1027-1034.
34. NEALE, S.A., GARTHWAITE, J.M. & BATCHELOR, A. (2001). Metabotropic glutamate receptor subtypes modulating neurotransmission at parallel fibre-Purkinje cell synapses in rat cerebellum. Neuropharmacology, 41, 42-49.
35. OHISHI, H., AKAZAWA, C., SHIGEMOTO, R., NAKANISHI, S. & MIZUNO, N. (1995). Distributions of the mRNAs for L-2-amino-4-phosphonobutyrate-sensitive metabotropic glutamate receptors, mGluR4 and mGluR7, in the rat brain. J. Comp. Neurol., 360, 555-570.
36. O'LEARY, D.M., CASSIDY, E.M. & O'CONNOR, J.J. (1997). Group II and III metabotropic glutamate receptors modulate paired pulse depression in the rat dentate gyrus in vitro. Eur. J. Pharmacol., 340, 35-44.
37. OLIET, S.H.R., PIET, R. & POULAIN, D.A. (2001). Control of glutamate clearance and synaptic efficacy by glial coverage of neurons. Science, 292, 923-926.
38. PAMIDIMUKKALA, J. & HAY, M. (2001). Frequency dependence of endocytosis in aortic baroreceptor neurons and role of group III mGluRs. Am. J. Physiol., 281, H387-H395.
39. PEKHLETSKI, R., GERLAI, R., OVERSTREET, L.S., HUANG, X.P., AGOPYAN, N., SLATER, N.T., ABRAMOW-NEWERLY, W., RODER, J.C. & HAMPSON, D.R. (1996). Impaired cerebellar synaptic plasticity and motor performance in mice lacking the mGluR4 subtype of metabotropic glutamate receptor. J. Neurosci., 16, 6364-6373.
40. PERROY, J., RICHARD, S., NARGEOT, J., BOCKAERT, J. & FAGNI, L. (2002). Permissive effect of voltage on mGlu 7 receptor subtype signaling in neurons. Journal of Biological Chemistry, 277, 1223-1228.
41. PIN, J.P., DE COLLE, C., BESSIS, A.S. & ACHER, F. (1999). New perspectives for the development of selective metabotropic glutamate receptor ligands. Eur. J. Pharmacol., 375, 277-294.
42. SALIN, P.A., MALENKA, R.C. & NICOLL, R.A. (1996). Cyclic AMP mediates a presynaptic form of LTP at cerebellar parallel fiber synapses. Neuron, 16, 797-803.
43. SCANZIANI, M., SALIN, P.A., VOGT, K.E., MALENKA, R.C. & NICOLL, R.A. (1997). Use-dependent increases in glutamate concentration activate presynaptic metabotropic glutamate receptors. Nature, 385, 630-634.
44. SCHOEPP, D.D. (2001). Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system. J. Pharmacol. Exp. Ther., 299, 12-20.
45. SCHOEPP, D.D., JANE, D.E. & MONN, J.A. (1999). Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacology, 38, 1431-1476.
46. SCHRADER, L.A. & TASKER, J.G. (1997). Presynaptic modulation by metabotropic glutamate receptors of excitatory and inhibitory synaptic inputs to hypothalamic magnocellular neurons. J. Neurophysiol., 77, 527-536.
47. SEMYANOV, A. & KULLMANN, D.M. (2000). Modulation of GABAergic signaling among interneurons by metabotropic glutamate receptors. Neuron, 25, 663-672.
48. SHIGEMOTO, R., KINOSHITA, A., WADA, E., NOMURA, S., OHISHI, H., TAKADA, M., FLOR, P.J., NEKI, A., ABE, T., NAKANISHI, S. & MIZUNO, N. (1997). Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus. J. Neurosci., 17, 7503-7522.
49. STEFANI, A., SPADONI, F. & BERNARDI, G. (1998). Group III metabotropic glutamate receptor agonists modulate high voltage-activated Ca2+ currents in pyramidal neurons of the adult rat. Exp. Brain Res., 119, 237-244.
50. TABATA, T., AIBA, A. & KANO, M. (2002). Extracellular calcium controls the dynamic range of neuronal metabotropic glutamate receptor responses. Mol. Cell Neurosci., 20, 56-68.
51. TAKAHASHI, M., KOVALCHUK, Y. & ATTWELL, D. (1995). Pre- and postsynaptic determinants of EPSC waveform at cerebellar climbing fiber and parallel fiber to Purkinje cell synapses. J. Neurosci., 15, 5693-5702.
52. THOMAS, N.K., JANE, D.E., TSE, H.W. & WATKINS, J.C. (1996). alpha-Methyl derivatives of serine-O-phosphate as novel, selective competitive metabotropic glutamate receptor antagonists. Neuropharmacology, 35, 637-642.
53. THOMSEN, C., PEKHLETSKI, R., HALDEMAN, B., GILBERT, T.A., O'HARA, P. & HAMPSON, D.R. (1997). Cloning and characterization of a metabotropic glutamate receptor, mGluR4b. Neuropharmacology, 36, 21-30.
54. VON GERSDORFF, H., SCHNEGGENBURGER, R., WEIS, S. & NEHER, E. (1997). Presynaptic depression at a calyx synapse: the small contribution of metabotropic glutamate receptors. J. Neurosci., 17, 8137-8146.
55. YUZAKI, M., FORREST, D., CURRAN, T. & CONNOR, J.A. (1996). Selective activation of calcium permeability by aspartate in Purkinje cells. Science, 273, 1112-1114.