Metabotropic glutamate receptor subtypes modulating neurotransmission at parallel fibre-Purkinje cell synapses in rat cerebellum

Neuropharmacology

Volumn 41, Issue 1, 2001, Pages 42-49

  Neale, Stuart A ^a   Garthwaite, John ^a   Batchelor, Andrew M ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Cerebellum; CPCCOEt; DHPG; Metabotropic glutamate receptors; Purkinje cell; Synaptic transmission

Indexed keywords

2 (2,3 DICARBOXYCYCLOPROPYL)GLYCINE; 2 AMINO 4 PHOSPHONOBUTYRIC ACID; 3,5 DIHYDROXYPHENYLGLYCINE; 7 HYDROXYIMINOCYCLOPROPAN[B]CHROMEN 1A CARBOXYLIC ACID ETHYL ESTER; ALPHA METHYL 4 CARBOXYPHENYLGLYCINE; ALPHA METHYL 4 PHOSPHONOPHENYLGLYCINE; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR AGONIST; METABOTROPIC RECEPTOR ANTAGONIST; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; DEPRESSION; DRUG EFFECT; DRUG INHIBITION; DRUG SELECTIVITY; MALE; MICROELECTRODE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; RAT; SYNAPTIC MEMBRANE; SYNAPTIC TRANSMISSION;

AMINOBUTYRIC ACIDS; ANIMALS; ANTICONVULSANTS; CEREBELLUM; CYCLOPROPANES; GLYCINE; MALE; METHOXYHYDROXYPHENYLGLYCOL; NERVE FIBERS; PURKINJE CELLS; RATS; RATS, WISTAR; RECEPTORS, METABOTROPIC GLUTAMATE; SYNAPSES; SYNAPTIC TRANSMISSION;

EID: 0034972568     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(01)00046-6     Document Type: Article

References (57)

1. Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice
2. A novel class of antagonists for metabotropic glutamate receptors, 7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylates
3. Metabotropic glutamate receptors: Electrophysiological properties and role in plasticity
4. Novel synaptic potentials in cerebellar Purkinje cells: Probable mediation by metabotropic glutamate receptors
5. Frequency detection and temporally dispersed synaptic signal association through a metabotropic glutamate receptor pathway
6. Pharmacological characterization of synaptic transmission through mGluRs in rat cerebellar slices
7. Synaptic activation of metabotropic glutamate receptors in the parallel fibre-Purkinje cell pathway in rat cerebellar slices
8. The metabotropic glutamate receptor (mGluR1α) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction
9. Activation of metabotropic glutamate receptors increases extracellular adenosine in vivo
10. Comparative effect of L-CCG-I, DCG IV and gamma carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes
11. Expression and coupling to polyphosphoinositide hydrolysis of group I metabotropic glutamate receptors in early postnatal and adult rat brain
12. Pharmacology and functions of metabotropic glutamate receptors
13. Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1
14. Direct effects of metabotropic glutamate receptor compounds on native and recombinant N-methyl-D-aspartate receptors
15. Effects of ACPD and AP3 on parallel-fibre-mediated EPSPs of Purkinje cells in cerebellar slices in vitro
16. Activity-dependent activation of presynaptic metabotropic glutamate receptors in locus coeruleus
17. Local calcium signalling by inositol-1,4,5-triphosphate in Purkinje cell dendrites
18. Multiple presynaptic metabotropic glutamate receptors modulate excitatory and inhibitory synaptic transmission in hippocampal area CA1
19. Role of metabotropic glutamate (ACPD) receptors at the parallel fiber-Purkinje cell synapse
20. Coupling of metabotropic glutamate receptors 2 and 4 to Gα15, Gα16, and chimeric Gαq/i proteins: Characterization of new antagonists
21. Differential cellular localization of three splice variants of the mGluR1 metabotropic glutamate receptor in the rat cerebellum
22. Effects of the acidic amino acid antagonists on paired-pulse potentiation at the lateral perforant path
23. Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor sub-types
24. A novel metabotropic glutamate receptor agonist: Marked depression of monosynaptic excitation in the newborn rat isolated spinal cord
25. 3,5-Dihydroxyphenylglycine: A potent agonist of metabotropic glutamate receptors
26. Activation of metabotropic glutamate receptor type 2/3 suppresses transmission at rat hippocampal mossy fibre synapses
27. Persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking mGluR1
28. Activity-dependent presynaptic autoinhibition by group II metabotropic glutamate receptors at the perforant path inputs to the dentate gyrus and CA1
29. Presynaptic localisation of a metabotropic glutamate receptor, mGluR4a, in the cerebellar cortex: A light- and electron-microscope study in the rat
30. Modulation of transmission during trains at a cerebellar synapse
31. Cloning, distribution and functional expression of the human mGlu6 metabotropic glutamate receptor
32. Long-term depression of synaptic transmission in the cerebellum: Cellular and molecular mechanisms revisited
33. CPCCOEt, a non-competitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signalling without effecting glutamate binding
34. Metabotropic glutamate receptor-mediated presynaptic depression at corticostriatal synapses involves mGluR2 or 3
35. Metabotropic glutamate receptors inhibiting excitatory synapses in the CA1 area of rat hippocampus
36. Localisation of the mGluR4a metabotropic glutamate receptor in the rat cerebellar cortex
37. Immunolocalization of the mGluR1b splice variant of the metabotropic glutamate receptor 1 at parallel fiber-Purkinje cell synapses in the rat cerebellar cortex
38. Clustering of the group III metabotropic glutamate receptors in the rat cerebellar molecular layer
39. 2+ channels via multiple signal transduction pathways in HEK 293 cells
40. Glutamate spillover suppresses inhibition by activating presynaptic mGluRs
41. Molecular characterisation of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate
42. Metabotropic glutamate receptors mGluR2 and mGluR5 are expressed in two non-overlapping populations of Golgi cells in the rat cerebellum
43. Subsynaptic segregation of metabotropic and ionotropic glutamate receptors as revealed by immunogold localization
44. Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex
45. Impaired cerebellar synaptic plasticity and motor performance in mice lacking the mGluR4 subtype of metabotropic glutamate receptor
46. Immunohistochemical localisation of mGluR7 protein in the rodent and human cerebellar cortex using subtype specific antibodies
47. The metabotropic glutamate receptors: Structure and functions
48. Cloning and expression of rat metabotropic glutamate receptor 8 reveals a distinct pharmacological profile
49. Use-dependent increases in glutamate concentration activate presynaptic metabotropic glutamate receptors
50. 3,5-Dihydroxyphenylglycine is a highly selective agonist for phosphoinositide-linked metabotropic glutamate receptors in the rat hippocampus
51. Pharmacological agents acting at subtypes of metabotropic glutamate receptors
52. A new class of synaptic response involving calcium in dendritic spines
53. Actions of phenylglycine analogues at subtypes of the metabotropic glutamate receptor family
54. (2S,1′S,2′S,3′R)-2-(2′-carboxy-3′- phenylcyclopropyl)glycine, a potent and selective antagonist of type 2 metabotropic glutamate receptors
55. Regulation of synaptic transmission in the mossy fibre-granule cell pathway of rat cerebellum by metabotropic glutamate receptors
56. Metabotropic glutamate receptor agonist DCG-IV as NMDA receptor agonist in immature rat hippocampal neurons
57. Contributions of mGluR1 to the basal activity of a mouse cerebellar Purkinje neuron