Presynaptic localization of a metabotropic glutamate receptor, mGluR4a, in the cerebellar cortex: A light and electron microscope study in the rat

Neuroscience Letters

Volumn 207, Issue 3, 1996, Pages 199-202

  Kinoshita, Ayae ^a   Ohishi, Hitoshi ^a   Nomura, Sakashi ^a   Shigemoto, Ryuichi ^a   Nakanishi, Shigetada ^a   Mizuno, Noboru ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Antibody; Cerebellum; Granule cells; Immunohistochemistry; L 2 Amino 4 phosphonobutyrate; Metabotropic glutamate receptor; mGluR4; Parallel fibers

Indexed keywords

GLUTAMATE RECEPTOR; METABOTROPIC RECEPTOR;

ANIMAL TISSUE; ARTICLE; CEREBELLUM; CONTROLLED STUDY; ELECTRON MICROSCOPY; GRANULE CELL; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SYNAPSE VESICLE;

EID: 0029873054     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(96)12519-2     Document Type: Article

References (20)

1. Akazawa, C., Ohishi, H., Nakajima, Y., Okamoto, N., Shigemoto, R., Nakanishi, S. and Mizuno, N., Expression of mRNAs of L-AP4-sensitive metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7) in the rat retina, Neurosci. Lett., 171 (1994) 52-54.
2. Conquet, F., Bashir, Z.I., Davies, C.H., Daniel, H., Ferraguti, F., Bordi, F., Franz-Bacon, K., Reggiani, A., Matarese, V., Condé, F., Collingridge, G.L. and Crépel, F., Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1, Nature, 372 (1994) 237-243.
3. Duvoisin, R.M., Zhang, C. and Ramonell, K., A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb, J. Neurosci., 15 (1995) 3075-3083.
4. Ito, M., Glutamate as a neurotransmitter in the cerebellar cortex, Biomed. Res., 5 (1984) 63-66.
5. Iversen, L., Mulvihill, E., Haldeman, B., Diemer N.H., Kaiser, F., Sheardown, M. and Kristensen, P., Changes in metabotropic glutamate receptor mRNA levels following global ischemia: increase of a putative presynaptic subtype (mGluR4) in highly vulnerable rat brain areas, J. Neurochem., 63 (1994) 625-633.
6. Kinoshita, A., Ohishi, H., Neki, A., Nomura, S., Shigemoto, R., Takada, M., Nakanishi, S. and Mizuno, N., Presynaptic localization of a metabotropic glutamate receptor, mGluR8, in the rhinen-cephalic areas: a light and electron microscope study in the rat, Neurosci. Lett., 207 (1996) 61-64.
7. Kinzie, J.M., Saugstad, J.A., Westbrook, G.L. and Segerson, T.P., Distribution of metabotropic glutamate receptor 7 messenger RNA in the developing and adult rat brain, Neuroscience, 69 (1995) 167-176.
8. Kristensen, P., Suzdak, P.D. and Thomsen, C., Expression pattern and pharmacology of the rat type IV metabotropic glutamate receptor, Neurosci. Lett., 155 (1993) 159-162.
9. Nakajima, Y., Iwakabe, H., Akazawa, C., Nawa, H., Shigemoto, R., Mizuno, N. and Nakanishi, S., Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate, J. Biol. Chem., 268 (1993) 11868-11873.
10. Nakanishi, S. and Masu, M., Molecular diversity and functions of glutamate receptors, Annu. Rev. Biophys. Biomol. Struct., 23 (1994) 319-348.
11. Ohishi, H., Akazawa, C., Shigemoto, R., Nakanishi, S. and Mizuno, N., Distributions of the mRNAs for L-2-amino-4-phosphonobutyrate-sensitive metabotropic glutamate receptors, mGluR4 and mGluR7, in the rat brain, J. Comp. Neurol., 360 (1995) 555-570.
12. Ohishi, H., Nomura, S., Ding, Y.-Q., Shigemoto, R., Wada, E., Kinoshita, A., Li, J.-L., Neki, A., Nakanishi, S. and Mizuno, N., Presynaptic localization of a metabotropic glutamate receptor, mGluR7, in the primary afferent neurons: an immunohistochemical study in the rat, Neurosci. Lett., 202 (1995) 85-88.
13. Okamoto, N., Hori, S., Akazawa, C., Hayashi, Y., Shigemoto, R., Mizuno, N. and Nakanishi, S., Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction, J. Biol. Chem., 269 (1994) 1231-1236.
14. Palay, S.L. and Chan-Palay, V., Cerebellar Cortex: Cytology and Organization, Springer, New York, 1974.
15. Pin, J.-P. and Duvoisin, R., The metabotropic glutamate receptors: structure and functions, Neuropharmacology, 34 (1995) 1-26.
16. Ross, C.A., Bredt, D. and Snyder, S.H., Messenger molecules in the cerebellum, Trends Neurosci., 13 (1990) 216-222.
17. Saugstad, J.A., Kinzie, J.M., Mulvihill, E.R., Segerson, T.P. and Westbrook, G.L., Cloning and expression of a new member of the L-2-amino-4-phosphonobutyric acid-sensitive class of metabotropic glutamate receptors, Mol. Pharmacol., 45 (1994) 367-372.
18. Tanabe, Y., Masu, M., Ishii, T., Shigemoto, R. and Nakanishi, S., A family of metabotropic glutamate receptors, Neuron, 8 (1992) 169-179.
19. Tanabe, Y., Nomura, A., Masu, M., Shigemoto, R., Mizuno, N. and Nakanishi, S., Signal transduction, pharmacological properties and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4, J. Neurosci., 13 (1993) 1372-1378.
20. Thomsen, C., Kristensen, P., Mulvihill, E., Haldeman, B. and Suzdak, P.D., L-2-Amino-4-phosphonobutyrate (L-AP4) is an agonist at the type IV metabotropic glutamate receptor which is negatively coupled to adenylate cyclase, Eur. J Pharmacol., 227 (1992) 361-362.