메뉴 건너뛰기




Volumn 29, Issue 6 SUPPL. 21, 2002, Pages 3-11

Preclinical pharmacology of zoledronic acid

Author keywords

[No Author keywords available]

Indexed keywords

ALENDRONIC ACID; AMINO TERMINAL TELOPEPTIDE; CALCITRIOL; CLODRONIC ACID; DEOXYPYRIDINOLINE; ETIDRONIC ACID; GERANYLTRANSFERASE; HYDROXYPROLINE; IBANDRONIC ACID; NERIDRONIC ACID; OLPADRONIC ACID; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PAMIDRONIC ACID; PEPTIDE DERIVATIVE; PYRIDINOLINE; RISEDRONIC ACID; UNCLASSIFIED DRUG; ZOLEDRONIC ACID;

EID: 0037279873     PISSN: 00937754     EISSN: None     Source Type: Journal    
DOI: 10.1053/sonc.2002.37421     Document Type: Conference Paper
Times cited : (36)

References (51)
  • 1
    • 0036148405 scopus 로고    scopus 로고
    • Development of bisphosphonates
    • Fleisch H: Development of bisphosphonates. Breast Cancer Res 4:30-34, 2002
    • (2002) Breast Cancer Res , vol.4 , pp. 30-34
    • Fleisch, H.1
  • 2
    • 0023891046 scopus 로고
    • Bisphosphonates inhibit 1,25-dihydroxyvitamin D3-induced increase of osteocalcin in plasma of rats in vivo and in culture medium of rat calvaria in vitro
    • Stronski SA, Bettschen-Camin L, Wetterwald A, et al: Bisphosphonates inhibit 1,25-dihydroxyvitamin D3-induced increase of osteocalcin in plasma of rats in vivo and in culture medium of rat calvaria in vitro. Calcif Tissue Int 42:248-254, 1988
    • (1988) Calcif Tissue Int , vol.42 , pp. 248-254
    • Stronski, S.A.1    Bettschen-Camin, L.2    Wetterwald, A.3
  • 3
    • 0032942599 scopus 로고    scopus 로고
    • Bisphosphonates: Pharmacology, mechanisms of action and clinical uses
    • Russell RGG, Croucher PI, Rogers MJ: Bisphosphonates: pharmacology, mechanisms of action and clinical uses. Osteoporos Int 9:S66-S80, 1999 (suppl 2)
    • (1999) Osteoporos Int , vol.9 , Issue.SUPPL. 2
    • Russell, R.G.G.1    Croucher, P.I.2    Rogers, M.J.3
  • 4
    • 0026329441 scopus 로고
    • Inhibition of bone resorption by bisphosphonates: Interactions between bisphosphonates, osteoclasts, and bone
    • Flanagan AM, Chambers TJ: Inhibition of bone resorption by bisphosphonates: Interactions between bisphosphonates, osteoclasts, and bone. Calcif Tissue Int 49:407-415, 1991
    • (1991) Calcif Tissue Int , vol.49 , pp. 407-415
    • Flanagan, A.M.1    Chambers, T.J.2
  • 5
    • 0034659773 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of action of bisphosphonates
    • Rogers MJ, Gordon S, Benford HL, et al: Cellular and molecular mechanisms of action of bisphosphonates. Cancer 88:2961-2978, 2000 (suppl)
    • (2000) Cancer , vol.88 , Issue.SUPPL. , pp. 2961-2978
    • Rogers, M.J.1    Gordon, S.2    Benford, H.L.3
  • 6
    • 0026320852 scopus 로고
    • Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure
    • Sato M, Grasser W, Endo N, et al: Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure. J Clin Invest 88:2095-2105, 1991
    • (1991) J Clin Invest , vol.88 , pp. 2095-2105
    • Sato, M.1    Grasser, W.2    Endo, N.3
  • 7
    • 0021328378 scopus 로고
    • Focal osteomalacia due to low-dose diphosphonate therapy in Paget's disease
    • Boyce BF, Smith L, Fogelman I, et al: Focal osteomalacia due to low-dose diphosphonate therapy in Paget's disease. Lancet 1:821-824, 1984
    • (1984) Lancet , vol.1 , pp. 821-824
    • Boyce, B.F.1    Smith, L.2    Fogelman, I.3
  • 8
    • 0020696938 scopus 로고
    • Renal failure associated with intravenous diphosphonates
    • Bounameaux HM, Schifferli J, Montani JP, et al: Renal failure associated with intravenous diphosphonates. Lancet 1:471, 1983
    • (1983) Lancet , vol.1 , pp. 471
    • Bounameaux, H.M.1    Schifferli, J.2    Montani, J.P.3
  • 9
    • 1842405434 scopus 로고    scopus 로고
    • Clodronate and liposome-encapsulated clodronate are metabolized to a toxic ATP analog, adenosine 5′-(beta, gamma-dichloromethylene) triphosphate, by mammalian cells in vitro
    • Frith JC, Monkkonen J, Blackburn GM, et al: Clodronate and liposome-encapsulated clodronate are metabolized to a toxic ATP analog, adenosine 5′-(beta, gamma-dichloromethylene) triphosphate, by mammalian cells in vitro. J Bone Miner Res 12:1358-1367, 1997
    • (1997) J Bone Miner Res , vol.12 , pp. 1358-1367
    • Frith, J.C.1    Monkkonen, J.2    Blackburn, G.M.3
  • 10
    • 0035460134 scopus 로고    scopus 로고
    • The molecular mechanism of action of the antiresorptive and antiinflammatory drug clodronate: Evidence for the formation in vivo of a metabolite that inhibits bone resorption and causes osteoclast and macrophage apoptosis
    • Frith JC, Monkkonen J, Auriola S, et al: The molecular mechanism of action of the antiresorptive and antiinflammatory drug clodronate: Evidence for the formation in vivo of a metabolite that inhibits bone resorption and causes osteoclast and macrophage apoptosis. Arthritis Rheum 44:2201-2210, 2001
    • (2001) Arthritis Rheum , vol.44 , pp. 2201-2210
    • Frith, J.C.1    Monkkonen, J.2    Auriola, S.3
  • 11
    • 0026438993 scopus 로고
    • Cytotoxicity of dichloromethane diphosphonate and of 1-hydroxyethane-1,1-diphosphonate in the amoebae of the slime mould Dictyostelium discoideum. A 31P NMR study
    • Pelorgeas S, Martin JB, Satre M: Cytotoxicity of dichloromethane diphosphonate and of 1-hydroxyethane-1,1-diphosphonate in the amoebae of the slime mould Dictyostelium discoideum. A 31P NMR study. Biochem Pharmacol 44:2157-2163, 1992
    • (1992) Biochem Pharmacol , vol.44 , pp. 2157-2163
    • Pelorgeas, S.1    Martin, J.B.2    Satre, M.3
  • 12
    • 0027055851 scopus 로고
    • Metabolism of halogenated bisphosphonates by the cellular slime mould Dictyostelium discoideum
    • Rogers MJ, Russell RG, Blackburn GM, et al: Metabolism of halogenated bisphosphonates by the cellular slime mould Dictyostelium discoideum. Biochem Biophys Res Commun 189:414-423, 1992
    • (1992) Biochem Biophys Res Commun , vol.189 , pp. 414-423
    • Rogers, M.J.1    Russell, R.G.2    Blackburn, G.M.3
  • 13
    • 0028059006 scopus 로고
    • Incorporation of bisphosphonates into adenine nucleotides by amoebae of the cellular slime mould Dictyostelmm discoideum
    • Rogers MJ, Ji X, Russell RG, et al: Incorporation of bisphosphonates into adenine nucleotides by amoebae of the cellular slime mould Dictyostelmm discoideum. Biochem J 303: 303-311, 1994
    • (1994) Biochem J , vol.303 , pp. 303-311
    • Rogers, M.J.1    Ji, X.2    Russell, R.G.3
  • 14
    • 0030749322 scopus 로고    scopus 로고
    • Overview of bisphosphonates
    • Rogers MJ, Watts DJ, Russell RG: Overview of bisphosphonates. Cancer 80:1652-1660, 1997 (suppl)
    • (1997) Cancer , vol.80 , Issue.SUPPL. , pp. 1652-1660
    • Rogers, M.J.1    Watts, D.J.2    Russell, R.G.3
  • 15
    • 0035051719 scopus 로고    scopus 로고
    • Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoctasts in vitro
    • Benford HL, McGowan NWA, Helfrich MH, et al: Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoctasts in vitro. Bone 28:465-473, 2001
    • (2001) Bone , vol.28 , pp. 465-473
    • Benford, H.L.1    McGowan, N.W.A.2    Helfrich, M.H.3
  • 16
    • 0029133135 scopus 로고
    • Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo
    • Hughes DE, Wright KR, Uy HL, et al: Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo. J Bone Miner Res 10:1478-1487, 1995
    • (1995) J Bone Miner Res , vol.10 , pp. 1478-1487
    • Hughes, D.E.1    Wright, K.R.2    Uy, H.L.3
  • 17
    • 0029829704 scopus 로고    scopus 로고
    • Characteristics of clodronate-induced apoptosis in osteoclasts and macrophages
    • Selander KS, Monkkonen J, Karhukorpi EK, et al: Characteristics of clodronate-induced apoptosis in osteoclasts and macrophages. Mol Pharmacol 50:1127-1138, 1996
    • (1996) Mol Pharmacol , vol.50 , pp. 1127-1138
    • Selander, K.S.1    Monkkonen, J.2    Karhukorpi, E.K.3
  • 18
    • 0020687209 scopus 로고
    • Structure-activity relationships of various bisphosphonates
    • Shinoda H, Adamek G, Felix R, et al: Structure-activity relationships of various bisphosphonates. Calcif Tissue Int 35: 87-99, 1983
    • (1983) Calcif Tissue Int , vol.35 , pp. 87-99
    • Shinoda, H.1    Adamek, G.2    Felix, R.3
  • 19
    • 0028202499 scopus 로고
    • Preclinical pharmacology of CGP 42,446, a new, potent, heterocyclic bisphosphonate compound
    • Green JR, Müller K, Jaeggi KA: Preclinical pharmacology of CGP 42,446, a new, potent, heterocyclic bisphosphonate compound. J Bone Miner Res 9:745-751, 1994
    • (1994) J Bone Miner Res , vol.9 , pp. 745-751
    • Green, J.R.1    Müller, K.2    Jaeggi, K.A.3
  • 20
    • 0030829844 scopus 로고    scopus 로고
    • Effects of short-term treatment with the bisphosphonates zoledronate and pamidronate on rat bone: A comparative histomorphometric study on the cancellous bone formed before, during, and after treatment
    • Pataki A, Müller K, Green JR, et al: Effects of short-term treatment with the bisphosphonates zoledronate and pamidronate on rat bone: A comparative histomorphometric study on the cancellous bone formed before, during, and after treatment. Anat Rec 249:458-468, 1997
    • (1997) Anat Rec , vol.249 , pp. 458-468
    • Pataki, A.1    Müller, K.2    Green, J.R.3
  • 21
    • 0000039252 scopus 로고    scopus 로고
    • Zoledronate (CGP 42,446) suppresses turnover without affecting mineralization in cancellous bone of the ovariectomized non-human primate
    • abstr
    • Bare S, Kimmel D, Binkley N, et al: Zoledronate (CGP 42,446) suppresses turnover without affecting mineralization in cancellous bone of the ovariectomized non-human primate. J Bone Miner Res 12:S473, 1997 (suppl 1) (abstr)
    • (1997) J Bone Miner Res , vol.12 , Issue.SUPPL. 1
    • Bare, S.1    Kimmel, D.2    Binkley, N.3
  • 22
    • 0031754524 scopus 로고    scopus 로고
    • Zoledronate prevents the development of absolute osteopenia following ovariectomy in adult rhesus monkeys
    • Binkley N, Kimmel D, Bruner J, et al: Zoledronate prevents the development of absolute osteopenia following ovariectomy in adult rhesus monkeys. J Bone Miner Res 13: 1775-1782, 1998
    • (1998) J Bone Miner Res , vol.13 , pp. 1775-1782
    • Binkley, N.1    Kimmel, D.2    Bruner, J.3
  • 23
    • 0002074991 scopus 로고    scopus 로고
    • The bisphosphonate zoledronate prevents vertebral bone loss in mature estrogen-deficient rats as assessed by micro-computed tomography
    • Glatt M: The bisphosphonate zoledronate prevents vertebral bone loss in mature estrogen-deficient rats as assessed by micro-computed tomography. Eur Cells Materials 1:18-26, 2001
    • (2001) Eur Cells Materials , vol.1 , pp. 18-26
    • Glatt, M.1
  • 24
    • 0000595642 scopus 로고    scopus 로고
    • Effect of 1-year treatment with zoledronate (CGP 42446) on bone mineral density, bone mechanical properties and biochemical markers in the ovariectomized rat
    • abstr
    • Green JR, Hornby SB, Evans GP, et al: Effect of 1-year treatment with zoledronate (CGP 42446) on bone mineral density, bone mechanical properties and biochemical markers in the ovariectomized rat. J Bone Miner Res 11:S339, 1996 (suppl 1) (abstr)
    • (1996) J Bone Miner Res , vol.11 , Issue.SUPPL. 1
    • Green, J.R.1    Hornby, S.B.2    Evans, G.P.3
  • 25
    • 4243545340 scopus 로고    scopus 로고
    • Effects of 16-month zoledronate treatment on bone mechanical properties in the ovariectomized adult rhesus monkey
    • abstr
    • Grynpas MD, Kasra M, Binkley N: Effects of 16-month zoledronate treatment on bone mechanical properties in the ovariectomized adult rhesus monkey. Bone 22:47S, 1998 (suppl) (abstr)
    • (1998) Bone , vol.22 , Issue.SUPPL.
    • Grynpas, M.D.1    Kasra, M.2    Binkley, N.3
  • 26
    • 0000039252 scopus 로고    scopus 로고
    • Zoledronate (CGP 42,446) suppresses turnover in cortical bone of the ovariectomized non-human primate
    • abstr
    • O'Rourke C, Bare S, Kimmel D, et al: Zoledronate (CGP 42,446) suppresses turnover in cortical bone of the ovariectomized non-human primate. J Bone Miner Res 12: S473, 1997 (abstr) (suppl 1)
    • (1997) J Bone Miner Res , vol.12 , Issue.SUPPL. 1
    • O'Rourke, C.1    Bare, S.2    Kimmel, D.3
  • 27
    • 0002951471 scopus 로고    scopus 로고
    • Zoledronic acid prevents the development of osteolytic bone disease and increases survival in a murine model of multiple myeloma
    • abstr
    • Croucher P, De Raeve H, Perry M, et al: Zoledronic acid prevents the development of osteolytic bone disease and increases survival in a murine model of multiple myeloma. Bone 30:39S, 2002 (suppl) (abstr)
    • (2002) Bone , vol.30 , Issue.SUPPL.
    • Croucher, P.1    De Raeve, H.2    Perry, M.3
  • 28
    • 0002099766 scopus 로고    scopus 로고
    • Zoledronic acid potently inhibits tumour-induced osteolysis in two models of breast cancer metastasis to bone
    • abstr
    • Green J, Gschaidmeier H, Yoneda T, et al: Zoledronic acid potently inhibits tumour-induced osteolysis in two models of breast cancer metastasis to bone. Ann Oncol 11:14, 2000 (suppl 4) (abstr)
    • (2000) Ann Oncol , vol.11 , Issue.SUPPL. 4 , pp. 14
    • Green, J.1    Gschaidmeier, H.2    Yoneda, T.3
  • 29
    • 0034783467 scopus 로고    scopus 로고
    • Early detection of bone metastases in a murine model using fluorescent human breast cancer cells: Application to the use of the bisphosphonate zoledronic acid in the treatment of osteolytic lesions
    • Peyruchaud O, Winding B, Pécheur I, et al: Early detection of bone metastases in a murine model using fluorescent human breast cancer cells: Application to the use of the bisphosphonate zoledronic acid in the treatment of osteolytic lesions. J Bone Miner Res 16:2027-2034, 2001
    • (2001) J Bone Miner Res , vol.16 , pp. 2027-2034
    • Peyruchaud, O.1    Winding, B.2    Pécheur, I.3
  • 30
    • 0036181668 scopus 로고    scopus 로고
    • Myeloma interacts with the bone marrow microenvironment to induce osteoclastogenesis and is dependent on osteoclast activity
    • Yaccoby S, Pearse RN, Johnson CL, et al: Myeloma interacts with the bone marrow microenvironment to induce osteoclastogenesis and is dependent on osteoclast activity. Br J Haematol 116:278-290, 2002
    • (2002) Br J Haematol , vol.116 , pp. 278-290
    • Yaccoby, S.1    Pearse, R.N.2    Johnson, C.L.3
  • 31
    • 0036138783 scopus 로고    scopus 로고
    • Ibandronate treatment decreases the effects of tumor-associated lesions on bone density and strength in the rat
    • Kurth AA, Kim SZ, Sedlmeyer I, et al: Ibandronate treatment decreases the effects of tumor-associated lesions on bone density and strength in the rat. Bone 30:300-306, 2002
    • (2002) Bone , vol.30 , pp. 300-306
    • Kurth, A.A.1    Kim, S.Z.2    Sedlmeyer, I.3
  • 32
    • 0035146537 scopus 로고    scopus 로고
    • Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates
    • Dunford JE, Thompson K, Coxon FP, et al: Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J Pharmacol Exp Ther 296:235-242, 2001
    • (2001) J Pharmacol Exp Ther , vol.296 , pp. 235-242
    • Dunford, J.E.1    Thompson, K.2    Coxon, F.P.3
  • 33
    • 0036359076 scopus 로고    scopus 로고
    • Alendronate disturbs vesicular trafficking in osteoclasts
    • Alakangas A, Selander K, Mulari M, et al: Alendronate disturbs vesicular trafficking in osteoclasts. Calcif Tissue Int 70:40-47, 2002
    • (2002) Calcif Tissue Int , vol.70 , pp. 40-47
    • Alakangas, A.1    Selander, K.2    Mulari, M.3
  • 34
    • 0034520352 scopus 로고    scopus 로고
    • In vivo effects of bisphosphonates on the osteoclast mevalonate pathway
    • Fisher JE, Rodan GA, Reszka AA: In vivo effects of bisphosphonates on the osteoclast mevalonate pathway. Endocrinology 141:4793-4796, 2000
    • (2000) Endocrinology , vol.141 , pp. 4793-4796
    • Fisher, J.E.1    Rodan, G.A.2    Reszka, A.A.3
  • 35
    • 0034773199 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinases and calcium channels are involved in the proliferative effect of bisphosphonates on osteoblastic cells in vitro
    • Mathov I, Plotkin LI, Sgarlata CL, et al: Extracellular signal-regulated kinases and calcium channels are involved in the proliferative effect of bisphosphonates on osteoblastic cells in vitro. J Bone Miner Res 16:2050-2056, 2001
    • (2001) J Bone Miner Res , vol.16 , pp. 2050-2056
    • Mathov, I.1    Plotkin, L.I.2    Sgarlata, C.L.3
  • 36
    • 0034326253 scopus 로고    scopus 로고
    • Bisphosphonates directly regulate cell proliferation, differentiation, and gene expression in human osteoblasts
    • Reinholz GG, Getz B, Pederson L, et al: Bisphosphonates directly regulate cell proliferation, differentiation, and gene expression in human osteoblasts. Cancer Res 60:6001-6007, 2000
    • (2000) Cancer Res , vol.60 , pp. 6001-6007
    • Reinholz, G.G.1    Getz, B.2    Pederson, L.3
  • 37
    • 0034926222 scopus 로고    scopus 로고
    • Pamidronate decreases tumor-induced osteoclastogenesis in osteopetrotic mice
    • Clohisy DR, O'Keefe PF, Ramnaraine ML: Pamidronate decreases tumor-induced osteoclastogenesis in osteopetrotic mice. J Orthop Res 19:554-558, 2001
    • (2001) J Orthop Res , vol.19 , pp. 554-558
    • Clohisy, D.R.1    O'Keefe, P.F.2    Ramnaraine, M.L.3
  • 38
    • 0036138734 scopus 로고    scopus 로고
    • Bisphosphonates suppress bone resorption by a direct effect on early osteoclast precursors without affecting the osteoclastogenic capacity of osteogenic cells: The role of protein geranylgeranylation in the action of nitrogen-containing bisphosphonates on osteoclast precursors
    • Van Beek ER, Lowik CW, Papapoulos SE: Bisphosphonates suppress bone resorption by a direct effect on early osteoclast precursors without affecting the osteoclastogenic capacity of osteogenic cells: The role of protein geranylgeranylation in the action of nitrogen-containing bisphosphonates on osteoclast precursors. Bone 30:64-70, 2002
    • (2002) Bone , vol.30 , pp. 64-70
    • Van Beek, E.R.1    Lowik, C.W.2    Papapoulos, S.E.3
  • 39
    • 0036295812 scopus 로고    scopus 로고
    • Bisphosphonates pamidronate and zoledronic acid stimulate osteoprotegerin production by primary human osteoblasts
    • Viereck V, Emons G, Lauck V, et al: Bisphosphonates pamidronate and zoledronic acid stimulate osteoprotegerin production by primary human osteoblasts. Biochem Biophys Res Commun 291:680-686, 2002
    • (2002) Biochem Biophys Res Commun , vol.291 , pp. 680-686
    • Viereck, V.1    Emons, G.2    Lauck, V.3
  • 41
    • 0032540319 scopus 로고    scopus 로고
    • Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    • Lacey DL, Timms E, Tan HL, et al: Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93:165-176, 1998
    • (1998) Cell , vol.93 , pp. 165-176
    • Lacey, D.L.1    Timms, E.2    Tan, H.L.3
  • 42
    • 0032584208 scopus 로고    scopus 로고
    • Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
    • Yasuda H, Shima N, Nakagawa N, et al: Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci U S A 95:3597-3602, 1998
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 3597-3602
    • Yasuda, H.1    Shima, N.2    Nakagawa, N.3
  • 43
    • 0035360265 scopus 로고    scopus 로고
    • Osteoprotegerin inhibits osteolysis and decreases skeletal tumor burden in syngeneic and nude mouse models of experimental bone metastasis
    • Morony S, Capparelli C, Sarosi I, et al: Osteoprotegerin inhibits osteolysis and decreases skeletal tumor burden in syngeneic and nude mouse models of experimental bone metastasis. Cancer Res 61:4432-4436, 2001
    • (2001) Cancer Res , vol.61 , pp. 4432-4436
    • Morony, S.1    Capparelli, C.2    Sarosi, I.3
  • 44
    • 10144241022 scopus 로고    scopus 로고
    • Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis
    • Guise TA, Yin JJ, Taylor SD, et al: Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis. J Clin Invest 98:1544-1549, 1996
    • (1996) J Clin Invest , vol.98 , pp. 1544-1549
    • Guise, T.A.1    Yin, J.J.2    Taylor, S.D.3
  • 45
    • 0035174823 scopus 로고    scopus 로고
    • A phase I, open label, dose ranging trial of intravenous bolus zoledronic acid, a novel bisphosphonate, in cancer patients with metastatic bone disease
    • Berenson JR, Vescio R, Henick K, et al: A phase I, open label, dose ranging trial of intravenous bolus zoledronic acid, a novel bisphosphonate, in cancer patients with metastatic bone disease. Cancer 91:144-154, 2001
    • (2001) Cancer , vol.91 , pp. 144-154
    • Berenson, J.R.1    Vescio, R.2    Henick, K.3
  • 46
    • 0034906503 scopus 로고    scopus 로고
    • A phase I dose-ranging trial of monthly infusions of zoledronic acid for the treatment of osteolytic bone metastases
    • Berenson JR, Vescio RA, Rosen LS, et al: A phase I dose-ranging trial of monthly infusions of zoledronic acid for the treatment of osteolytic bone metastases. Clin Cancer Res 7:478-485, 2001
    • (2001) Clin Cancer Res , vol.7 , pp. 478-485
    • Berenson, J.R.1    Vescio, R.A.2    Rosen, L.S.3
  • 47
    • 0035312469 scopus 로고    scopus 로고
    • Zoledronic acid reduces skeletal-related events in patients with osteolytic metastases: A double-blind, randomized dose-response study
    • published erratum appears in Cancer 91:1956, 2001
    • Berenson JR, Rosen LS, Howell A, et al: Zoledronic acid reduces skeletal-related events in patients with osteolytic metastases: A double-blind, randomized dose-response study (published erratum appears in Cancer 91:1956, 2001) Cancer 91: 1191-1200, 2001
    • (2001) Cancer , vol.91 , pp. 1191-1200
    • Berenson, J.R.1    Rosen, L.S.2    Howell, A.3
  • 48
    • 0035863508 scopus 로고    scopus 로고
    • Zoledronic acid is superior to pamidronate in the treatment of hypercalcemia of malignancy: A pooled analysis of two randomized, controlled clinical trials
    • Major P, Lortholary A, Hon J, et al: Zoledronic acid is superior to pamidronate in the treatment of hypercalcemia of malignancy: A pooled analysis of two randomized, controlled clinical trials. J Clin Oncol 19:558-567, 2001
    • (2001) J Clin Oncol , vol.19 , pp. 558-567
    • Major, P.1    Lortholary, A.2    Hon, J.3
  • 49
    • 0035463593 scopus 로고    scopus 로고
    • Zoledronic acid versus pamidronate in the treatment of skeletal metastases in patients with breast cancer or osteolytic lesions of multiple myeloma: A phase III, double-blind, comparative trial
    • Rosen LS, Gordon D, Kaminski M, et al: Zoledronic acid versus pamidronate in the treatment of skeletal metastases in patients with breast cancer or osteolytic lesions of multiple myeloma: A phase III, double-blind, comparative trial. Cancer J 7:377-387, 2001
    • (2001) Cancer J , vol.7 , pp. 377-387
    • Rosen, L.S.1    Gordon, D.2    Kaminski, M.3
  • 50
    • 0003233542 scopus 로고    scopus 로고
    • Zoledronic acid (Zol) significantly reduces skeletal-related events (SREs) in patients with bone metastases from solid tumors
    • abstr
    • Rosen L, Gordon D, Tchekmedyian S, et al: Zoledronic acid (Zol) significantly reduces skeletal-related events (SREs) in patients with bone metastases from solid tumors. Proc Am Soc Clin Oncol 21:295a, 2002 (abstr)
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Rosen, L.1    Gordon, D.2    Tchekmedyian, S.3
  • 51
    • 0037009822 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial of zoledronic acid in patients with hormone-refractory metastatic prostate carcinoma
    • Saad F, Gleason DM, Murray R, et al: A randomized, placebo-controlled trial of zoledronic acid in patients with hormone-refractory metastatic prostate carcinoma. J Natl Cancer Inst 94:1458-1468, 2002
    • (2002) J Natl Cancer Inst , vol.94 , pp. 1458-1468
    • Saad, F.1    Gleason, D.M.2    Murray, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.