Effect of modafinil on the pharmacokinetics of ethinyl estradiol and triazolam in healthy volunteers

Clinical Pharmacology and Therapeutics

Volumn 71, Issue 1, 2002, Pages 46-56

  Robertson Jr , Philmore ^a   Hellriegel, Edward T ^a   Arora, Sanjay ^a   Nelson, Michael ^a  

^a CEPHALON INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; ETHINYLESTRADIOL PLUS NORGESTIMATE; MODAFINIL; ORAL CONTRACEPTIVE AGENT; PLACEBO; TRIAZOLAM;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME INDUCTION; FEMALE; HUMAN; HUMAN CELL; LONG TERM CARE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE;

ADULT; AREA UNDER CURVE; BENZHYDRYL COMPOUNDS; BIOLOGICAL MARKERS; CENTRAL NERVOUS SYSTEM STIMULANTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DRUG INTERACTIONS; ESTRADIOL CONGENERS; ETHINYL ESTRADIOL; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HALF-LIFE; HUMANS; HYPNOTICS AND SEDATIVES; MASS SPECTROMETRY; MIXED FUNCTION OXYGENASES; SINGLE-BLIND METHOD; SPECTROPHOTOMETRY, ULTRAVIOLET; TRIAZOLAM;

EID: 0036161693     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1067/mcp.2002.121217     Document Type: Article

References (28)

1. Modafinil in obstructive sleep apnea-hypopnea syndrome: A pilot study in 6 patients
2. Modafinil improves alertness and performance during simulated night work
3. Long-term efficacy and safety of modafinil (Provigil) for the treatment of excessive daytime sleepiness associated with narcolepsy
4. Randomized trial of modafinil for the treatment of pathological somnolence in narcolepsy
5. Randomized trial of modafinil as a treatment for the excessive daytime somnolence of narcolepsy
6. A double-blind, placebo-controlled, ascending-dose evaluation of the pharmacokinetics and tolerability of modafinil tablets in healthy male volunteers
7. Pharmacokinetic profile of modafinil
8. In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil
9. Cytochrome P-450 3A4: Regulation and role in drug metabolism
10. Metabolism of 17 alpha-ethynylestradiol in humans
11. Oral contraceptive steroids: Pharmacological issues of interest to the prescribing physician
12. Pharmacokinetic drug interactions with oral contraceptives
13. Interindividual variation and drug interactions with hormonal steroid contraceptives
14. Interaction with the pharmacokinetics of ethinylestradiol and progestogens contained in oral contraceptives
15. Ketoconazole inhibition of triazolam and alprazolam clearance: Differential kinetic and dynamic consequences
16. Triazolam pharmacokinetics after intravenous, oral, and sublingual administration
17. Triazolam biotransformation by human liver microsomes in vitro: Effects of metabolic inhibitors and clinical confirmation of a predicted interaction with ketoconazole
18. Metabolism of norgestimate by human gastrointestinal mucosa and liver microsomes in vitro
19. Pharmacologic and pharmacokinetic characteristics of norgestimate and its metabolites
20. Noncompartmental analysis based on statistical moment theory
21. Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction
22. Cytochrome P450 3A: Ontogeny and drug disposition
23. Effect of modafinil at steady state on the single-dose pharmacokinetic profile of warfarin in healthy volunteers
24. Human P450 metabolism of warfarin
25. Pharmacokinetic and pharmacodynamic consequences of metabolism-based drug interactions with alprazolam, midazolam, and triazolam
26. Oral contraceptives. Are drug interactions of clinical significance?
27. The effects of rifampin and rifabutin on the pharmacokinetics and pharmacodynamics of a combination oral contraceptive
28. Induction of ethinylestradiol and levonorgestrel metabolism by oxcarbazepine in healthy women