Pharmacokinetic profile of modafinil

Drugs of Today

Volumn 32, Issue SUPPL. I, 1996, Pages 23-33

  Moachon, G ^a   Kanmacher, I ^a   Clenet, M ^a   Matinier, D ^a  

^a Ctr de Rech du Lab L Lafon   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; MODAFINIL;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; BIOAVAILABILITY; DOG; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG URINE LEVEL; HUMAN; KIDNEY FAILURE; LIVER FAILURE; MOUSE; NONHUMAN; PHARMACOKINETICS; RABBIT; RAT; REVIEW;

EID: 0030479311     PISSN: 16993993     EISSN: 16994019     Source Type: Journal    
DOI: None     Document Type: Review

References (9)

1. Moachon, G., Matinier, D. Simultaneous determination of modafinil and its acid metabolite by high-performance liquid chromatography in human plasma. J Chromatogr 1994, B 654: 91-6.
2. Kanmacher, I., Barthoux, N., Millet, P., Moachon, G. Metabolism of modafinil in mice, rats, guinea pigs and rabbits. 1st Eur Gong Pharmacol (June 16-19, Milan) 1995, Abst 48.
3. Kanmacher, I., Barthoux, N., Millet, P., Moachon, G. Kinetics of tissue distribution of modafinil in mice and rats. 1st Eur Cong Pharmacol (June 16-19, Milan) 1995, Abst 40.
4. Rambert, F.A., Moachon, G., Multon, M.F. et al. Correlation of modafinil plasma levels to pharmacological activity in mice. 5th Int Cong Sleep Res (June 28-July 3, Copenhagen) 1987.
5. Moachon, G., Rambert, F.A., Matinier, D., Pessonnier, J., Clenet, M., Duteil, J. Modafinil plasma levels are correlated to locomotor effects in mice. Fundam Clin Pharmacol 1989, 4(4): 452.
6. Benel, L., Matinier, D., Raynal, H., Moachon, G. Effects of modafinil, phenobarbital or diazepam on cytochrome P-450-dependent enzyme activities in the rat. 14th Eur Workshop Drug Metab (July 3-9, Paris) 1994, Abst A75.
7. Gorman, S.H., Neidlinger, S.K., Stong, D.B., Grebow, P.E. Pharmacokinetic profiles of modafinil and modafinil acid during a double-blind, ascending dose, seven-day administration of modafinil tablets in normal male subjects. 6th North Amer ISSX Meet (Oct 23-27, Raleigh) 1994, Abst 75.
8. Moachon, G., Matinier, D., Lubin, S., Rautureau, J. Pharmacokinetics of multiple doses of modafinil in hepatic insufficiency. Can J Physiol Pharmacol 1994, 72 (Suppl. 1): AbSt P12.2.36.
9. Chesne, C., Kanmacher, I., Benel, L., Lubin, S., Moachon, G. Effects of modafinil on cytochrome P-450-dependent enzyme activities in cultured human hepatocytes. 14th Eur Workshop Drug Metab (July 3-9, Paris) 1994, Abst B23.