Single-dose pharmacokinetics of modafinil and methylphenidate given alone or in combination in healthy male volunteers

Journal of Clinical Pharmacology

Volumn 38, Issue 3, 1998, Pages 276-282

  Wong, Y Nancy ^a   King, S Peter ^a,b   Laughton, Watson B ^a   McCormick, George C ^a   Grebow, Peter E ^a  

^a CEPHALON INC   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHYLPHENIDATE; MODAFINIL;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CENTRAL NERVOUS SYSTEM; CLINICAL TRIAL; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE TIME EFFECT RELATION; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG EFFECT; DRUG SAFETY; HUMAN; HUMAN EXPERIMENT; MALE; NARCOLEPSY; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; RANDOMIZED CONTROLLED TRIAL;

EID: 0031943018     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1552-4604.1998.tb04425.x     Document Type: Article

References (22)

1. Boivin DB, Montplaisir J, Petit D, Lambert C, Lubin S: Effects of modafinil on symptomatology of human narcolepsy. Clin Neuropharmacol 1993;16:46-53.
2. Besset A, Tafti M, Villemin E, Billiard M: Effects of modafinil (300 mg) on sleep, somnolence, and alertness of narcoleptic patients. Neurophysiol Clin 1993;23:47-60.
3. Akaoka H, Roussel B, Lin J-S. Chouvet G, Jouvet M: Effect of modafinil and amphetamine on the rat catecholaminergic neuron activity. Neurosci Lett 1991;123:20-23.
4. Mignot E, Nishino S, Guilleminault C, Dement WC: Modafinil binds to the dopamine uptake carrier site with low affinity. Sleep 1994;17:436-437.
5. Lin J-S, Roussel B, Akaoka H, Fort P, Debilly G, Jouvet M: Role of catecholamines in modafinil and amphetamine induced wakefulness: a comparative pharmacological study in the cat. Brain Res 1992;591:319-326.
6. Duteil J, Rambert FA, Pessonnier J, Hermant J-F, Gombert R: Central α1-adrenergic stimulation in relation to the behaviour stimulating effect of modafinil: studies with experimental animals. Eur J Pharmacol 1990;180:49-58.
7. Shelton J, Nishino S, Vaught J, Dement WC, Mignot E: Comparative effects of modafinil and amphetamine on daytime sleepiness and cataplexy of narcoleptic dogs. Sleep 1995;18:817-826.
8. Parkes J: Amphetamines and alertness. In, Guilleminault C, Dement W, Passouant P (eds.): Narcolepsy. New York: Spectrum, 1976;643-658.
9. Takahaski S: The action of tricyclics (alone or in combination with methylphenidate) upon several symptoms of narcolepsy. In, Guilleminault C, Dement W, Passouant P (eds.): Narcolepsy. New York: Spectrum, 1976;303-310.
10. Zung WWK: Antidepressant drugs and sleep. Exp Med Surg 1969;27:124-137.
11. Cadilhac J: Tricyclics and REM sleep. In, Guilleminault C, Dement W, Passouant P (eds.): Narcolepsy. New York: Spectrum, 1976;605-623.
12. Guilleminault C, Raynal D, Takahashi S, Carskadon M, Dement W: Evaluation of short-term and long-term treatment of the narcolepsy syndrome with clomipramine hydrochloride. Acta Neural Scand 1976;54:71-87.
13. Hoffman BB, Lefkowitz RJ: Catecholamines, sympathomimetic drugs, and adrenergic receptor antagonists. In, Molinoff PB, Ruddon RW (eds.): The Pharmacological Basis of Therapeutics. New York: MacMillan, 1996;225-232.
14. Billiard M, Besset A, Montplaisir J, Laffont F, Goldenberg F, Weill SS, Lubin S: Modafinil: a double-blind multicentric study (abstract). J Sleep Res 1994;3(suppl 1):24.
15. Warot D, Corruble E, Payan C, Weil JS, Puech AJ: Subjective effects of modafinil, a new central adrenergic stimulant in healthy volunteers: a comparison with amphetamine, caffeine and placebo. Eur Psychiatry 1993;8:201-208.
16. Moachon G, Kanmacher I, Clenet M, Matinier D: Pharmacokinetic profile of modafinil. Drugs Today 1996;32:327-337.
17. Patrick KS, Caldwell RW, Ferris RM, Breese GR: Pharmacology of the enantiomers of threo-methylphenidate. J Pharmacol Exp Ther 1987;241:152-158.
18. Patrick KS, Straughn AB, Jarvi EJ, Breese GR, Meyer MC: The absorption of sustained-release methylphenidate formulations compared to an immediate-release formulation. Biopharm Drug Dispos 1989;10:165-171.
19. Srinivas NR, Hubbard JW, Korchinski ED, Midha KK: Enantio-selective pharmacokinetics of dl-threo methylphenidate in humans. Pharm Res 1993;10:14-21.
20. Gibaldi M, Perrier D (eds.): Noncompartmental analysis based on statistical moment theory. In, Pharmacokinetics. Second edition. New York: Marcel Dekker, 1982;409-417.
21. Aoyama T, Sasaki T, Kotaki H, Sawada Y, Sudoh Y, Honda Y, Iga T: Pharmacokinetics and pharmacodynamics of (+)-threomethylphenidate enantiomer in patients with hypersomnia. Clin Pharmacol Ther 1994;55:270-276.
22. Laffont F: Clinical assessment of modafinil. Drugs Today 1996;32:339-347.