Randomized, double-blind, placebo-controlled crossover trial of modafinil in the treatment of excessive daytime sleepiness in narcolepsy

Neurology

Volumn 49, Issue 2, 1997, Pages 444-451

  Broughton, R J ^a   Fleming, J A E ^b   George, C F P ^c   Hill, J D ^d   Kryger, M H ^e   Moldofsky, H ^f   Montplaisir, J Y ^g   Morehouse, R L ^h   Moscovitch, A ⁱ   Murphy, W F ^j  

^a UNIVERSITY OF OTTAWA   (Canada)

^b VANCOUVER GENERAL HOSPITAL   (Canada)

^c LONDON HEALTH SCIENCES CENTRE   (Canada)

^d Draxis Health Inc   (Canada)

^e ST BONIFACE GENERAL HOSPITAL   (Canada)

^f TORONTO WESTERN HOSPITAL   (Canada)

^g HÔPITAL DU SACRÉ COEUR DE MONTRÉAL   (Canada)

^h Camphill Medical Centre   (Canada)

ⁱ Canadian Sleep Institute   (Canada)

^j Calgary General Hospital   (Canada)

more..

Author keywords

[No Author keywords available]

Indexed keywords

MODAFINIL;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; HUMAN; MAJOR CLINICAL STUDY; NARCOLEPSY; NAUSEA; PATIENT SELECTION; PRIORITY JOURNAL; SLEEP; SOMNOLENCE;

EID: 0030816557     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.49.2.444     Document Type: Article

References (20)

1. de Sereville JE, Boer C, Rambert F, Duteil J. Lack of presynaptic dopaminergic involvement in modafinil activity in anesthetized mice: in vivo voltammetry studies. Neuropharmacology 1994;33:755-761.
2. Warot D, Corruble E, Payan C, Weil JS, Puech AJ. Subjective effects of modafinil, a new central adrenergic stimulant in health volunteers: a comparison with amphetamine, caffeine, and placebo. Eur Psychiatry 1993;8:201-208.
3. Laffont F, Agar N, Mayer G, Minz M. Effet du modafinil chez des patients narcoleptiques: études électrophysiologiques et psychométriques. Neurophysiol Clin 1995;25:84-95.
4. Hermant JF, Rambert FA, Duteil J. Lack of cardiovascular effects after administration of modafinil in conscious monkeys [abstract]. Fundam Clin Pharmacol 1991;5:825.
5. Bastugi H, Jouvet M. Successful treatment of idiopathic hypersomnia and narcolepsy with modafinil. Prog Neuropsychopharmacol Biol Psychiatry 1988;12:695-700.
6. Boivin DB, Montplaisir J, Petit D, Lambert C, Lubin S. Effects of modafinil on symptomatology of human narcolepsy. Clin Neuropharmacol 1993;16:46-53.
7. Besset A, Tafti M, Villemin E, Billiard M. Effet du modafinil (300 mg) sur le sommeil, la somnolence et la vigilance du narcoleptique. Neurophysiol Clin 1993;23:47-60.
8. Billiard M, Besset A, Montplaisir J. Modafinil: a double-blind multicenter study. Sleep 1994;17(suppl):107-112.
9. Laffont F, Mayer G, Minz M. Modafinil in diurnal sleepiness: a study of 123 patients. Sleep 1994;17(suppl.):113-115.
10. Diagnostic Steering Committee, Thorpy M. International classification of sleep disorders: diagnostic and coding manual. Rochester, MN: American Sleep Disorders Association, 1990.
11. Richardson GS, Carskadon M, Flagg W, van den Hoed J, Dement W, Mitler M. Excessive daytime sleepiness in man: multiple sleep latency measurements in narcoleptic and control subjects. Electroencephalogr Clin Neurophysiol 1982;45: 621-627.
12. Mitler MM, Gujavarty KS, Browman CP. Maintenance of wakefulness test: a polysomnographic technique for evaluating treatment efficacy in patients with excessive somnolence. Electroencephalogr Clin Neurophysiol 1982;53:658-661.
13. Mitler MM, Shafor R, Hajdukovich R, Timms RM, Browman CP. Treatment of narcolepsy: objective studies on methylphenidate, pemoline and protriptyline. Sleep 1986;9:260-264.
14. Johns M. New method for measuring daytime sleepiness: the Epworth Sleepiness Scale. Sleep 1991;14:540-545.
15. Wilkinson RT, Houghton D. Portable four-choice reaction time test with magnetic tape memory. Behav Res Meth Instrum 1975;7:441-446.
16. McNair DM, Lorr M, Droppleman LF. Profile of mood states manual. San Diego, CA: Educational and Industrial Testing Service, 1992.
17. Rechtschaffen A, Kales A, eds. A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. Bethesda, MD: US Department of Health, Education and Welfare, 1968.
18. Ratkowsky DA, Evans MA, Alldredge JR, eds. Cross-over experiments: design, analysis and application. New York: Marcel Dekker, 1993.
19. George CF. Standards for polysomnography in Canada. The Standards Committees of the Canadian Sleep Society and the Canadian Thoracic Society. Can Med Assoc J 1996;155:1673-1678.
20. Zwicker J, Bruck D, Parkes JD, Broughton RJ. Acute mood improvement after amphetamine and methylphenidate in narcolepsy. J Sleep Res 1995;4:252-255.