Determination of the D- and L-enantiomers of modafinil in human plasma utilizing liquid-liquid extraction and high-performance liquid chromatography

Journal of Chromatography B: Biomedical Sciences and Applications

Volumn 730, Issue 1, 1999, Pages 1-7

  Gorman, Steven H ^a  

^a CEPHALON INC   (United States)

Author keywords

Enantiomer separation; Modafinil

Indexed keywords

BETA CYCLODEXTRIN; MODAFINIL;

ARTICLE; BLOOD ANALYSIS; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STABILITY; ENANTIOMER; HUMAN; LIQUID LIQUID EXTRACTION; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; REPRODUCIBILITY; STEREOSPECIFICITY;

BENZHYDRYL COMPOUNDS; CENTRAL NERVOUS SYSTEM STIMULANTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROPHOTOMETRY, ULTRAVIOLET; STEREOISOMERISM;

EID: 0033063439     PISSN: 13872273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(99)00149-8     Document Type: Article

References (9)

1. Boivin D.B., Montplaisir J., Petit D., Lambert C., Lubin S. Clin. Neuropharm. 16:1993;46-53.
2. Besset A., Tafti M., Villemin E., Billiard M. Neurophysiol. Clin. 23:1993;47-60.
3. Moachon G., Matinier D. J. Chromatogr. B. 654:1994;91-96.
4. Burnat P., Robles F., Do B. J. Chromatogr. B. 706:1997;295-304.
5. Drouin J.E., Broquaire M. J. Chromatogr. 605:1992;19-31.
6. S.H. Gorman, Pharm. Res. 12 (1995) S-22.
7. Raynal H., Barthous N., Millet P., Moachon G. ISSX Proceedings. 3:1993;27.
8. Dappen R., Arm H., Myer V.R. J. Chromatogr. 373:1986;1-20.
9. Hinze W.L., Reihl T.E. Anal. Chem. 57:1985;237-242.