Modafinil induces wakefulness without intensifying motor activity or subsequent rebound hypersomnolence in the rat

Journal of Pharmacology and Experimental Therapeutics

Volumn 283, Issue 2, 1997, Pages 757-769

  Edgar, Dale M ^a   Seidel, Wesley F ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHAMPHETAMINE; MODAFINIL;

ALERTNESS; ANIMAL EXPERIMENT; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; ELECTROENCEPHALOGRAM; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOTOR ACTIVITY; NONHUMAN; NONREM SLEEP; PRIORITY JOURNAL; RAT; REM SLEEP; SLEEP WAKING CYCLE; WAKEFULNESS;

ANIMALS; BENZHYDRYL COMPOUNDS; BODY TEMPERATURE; CENTRAL NERVOUS SYSTEM STIMULANTS; ELECTROENCEPHALOGRAPHY; MALE; METHAMPHETAMINE; MOTOR ACTIVITY; RATS; RATS, WISTAR; SLEEP, REM; WAKEFULNESS;

EID: 0030775911     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. AKAOKA, H., ROUSSEL, B., LIN, J. S., CHOUVET, G. AND JOUVET, M.: Effect of modafinil and amphetamine on the rat catecholaminergic neuron activity. Neurosci. Lett. 123: 20-22, 1991.
2. BASTUJI, H. AND JOUVET, M.: Successful treatment of idiopathic hypersomnia and narcolepsy with modafinil. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 12: 695-700, 1988.
3. BENINGTON, J. H. AND HELLER H. C.: REM-sleep timing is controlled homeostatically by accumulation of REM-sleep propensity in non-REM sleep. Am. J. Physiol. 266: R1992-R2000, 1994.
4. BOIVIN, D. B., MONTPLAISIR, J., PETIT, D., LAMBERT, C. AND LUBIN, S.: Effects of modafinil on symptomatology of human narcolepsy. Clin. Neuropharmacol. 16: 46-53, 1993.
5. BORBÉLY, A. A. AND NEUHAUS, H. U.: Sleep-deprivation: Effects on sleep and EEG in the rat. J. Comp. Physiol. 133: 71-87, 1979.
6. BRACEWELL, R. N.: The Hartley Transform, Appendix 1, pp. 115-144, Oxford, New York, 1986.
7. BUGUET, A., MONTMAYEUR, A., PIGEAU, R. AND NAITOH, P.: Modafinil, damphetamine and placebo during 64 hours of sustained mental work. II. Effects on two nights of recovery sleep. J. Sleep Res. 4: 229-241, 1995.
8. CARSKADON, M. A. AND DEMENT, W. C.: Effects of total sleep loss on sleep tendency. Percept. Motor Skills 48: 495-506, 1979.
9. CZEISLER, C. A., WEITZMAN, E. D., MOORE-EDE, M. C., ZIMMERMAN, J. C. AND KNAUER, R. S.: Human sleep: Its duration and organization depend on its circadian phase. Science 210: 1264-1267, 1980.
10. DAAN, S., BEERSMA, D. G. M. AND BORBÉLY, A. A.: Timing of human sleep: Recovery process gated by a circadian pacemaker. Am. J. Physiol. 246: R161-R178, 1984.
11. DE SEREVILLE, J. E., BOER, C., RAMBERT, F. A. AND DUTEIL, J.: Lack of pre-synaptic dopaminergic involvement in modafinil activity in anaesthetized mice: In vivo voltammetry studies. Neuropharmacology 33: 755-761, 1994.
12. DIJK, D. J., BRUNNER, D. P., BEERSMA, D. G. AND BORBÉLY, A. A.: Electrogram power density and slow wave sleep as a function of prior waking and circadian phase. Sleep 13: 430-440, 1990.
13. DUTEIL, J., RAMBERT, F. A., PESSONNIER, J., HERMANT, J. F., GOMBERT, R. AND ASSOUS, E.: Central alpha 1-adrenergic stimulation in relation to the behaviour stimulating effect of modafinil: Studies with experimental animals. Eur. J. Pharmacol. 180: 49-58, 1990.
14. EDGAR, D. M.: Control of sleep/wakefulness: Implications in shift work and therapeutic strategies. In Physiological Basis of Occupational Health: Stressful Environments, ed. by K. Shiraki, S. Sagawa, M. K. Yousef, vol. 11, pp. 253-265, SPB Academic Publishing, Amsterdam. Serial: Progress in Biometry, 1996.
15. EDGAR, D. M., DEMENT, W. C. AND FULLER, C. A.: Effect of SCN lesions on sleep in squirrel monkeys: Evidence for opponent processes in sleep-wake regulation. J. Neurosci. 13: 1065-1079, 1993.
16. EDGAR, D. M., SEIDEL, W. F. AND DEMENT, W. C.: Triazolam-induced sleep in the rat: influence of prior sleep, circadian time, and light/dark cycles. Psychopharmacology 105: 374-380, 1991.
17. EDGAR, D. M., SEIDEL, W. F., GEE, K. W., LAN, N. C., FIELD, G., XIA, H. HAWKINSON, J. E., WIELAND, S., CARTER, R. B. AND WOOD, P. L.: CCD-3693: An orally bioavailable analog of the endogenous neuroactive steroid, pregnanolone, demonstrates potent sedative hypnotic actions in the rat. J. Pharmacol. Exp. Ther. 282: 420-429, 1997.
18. FERRARO, L., TANGANELLI, S., O'CONNOR, W. T., ANTONELLI, T., RAMBERT, F. AND FUXE, K.: The vigilance promoting drug modafinil increases dopamine release in the rat nucleus accumbens via the involvement of a local GABAergic mechanism. Eur. J. Pharmacol. 306: 33-39, 1996.
19. GOLD, L. H. AND BALSTER, R. L.: Evaluation of the cocaine-like discriminative stimulus effects and reinforcing effects of modafinil. Psychopharmacology 126: 286-292, 1996.
20. HERMANT, J-L., RAMBERT, F. A. AND DUTEIL, J.: Awakening properties of modafinil: effect on nocturnal activity in monkeys (Macaca mulatta) after acute and repeated administration. Psychopharmacology 103: 28-32, 1991.
21. KOOB, G. F. AND BLOOM, F. E.: Cellular and molecular mechanisms of drug dependence. Science 242: 715-723, 1988.
22. LAGARDE, D. AND MILHAUD, C.: Electroencephalographic effects of modafinil, an alpha-1-adrenergic psychostimulant, on the sleep of rhesus monkeys. Sleep 13: 441-448, 1990.
23. LAGARDE, D., BATEJAT, D., VAN BEERS, P., SARAFIAN, D. AND PRADELLA, S.: Interest of modafinil, a new psychostimulant, during a sixty-hour sleep deprivation experiment. Fundam. Clin. Pharmacol. 9: 271-279, 1995.
24. LEITH, N. J. AND BARRETT, R. J.: Amphetamine and the reward system: evidence for tolerance and post-drug depression.. Psychopharmacology 46: 19-25, 1976.
25. LIN, J. S., ROUSSEL, B., AKAOKA, H., FORT, P., DEBILLY, G. AND JOUVET, M.: Role of catecholamine in the modafinil and amphetamine induced wakefulness, a comparative pharmacological study in the cat. Brain Res. 591: 319-326, 1992.
26. LIN, J. S., HOU, Y. AND JOUVET, M.: Potential brain neuronal targets for amphetamine-, methylphenidate-, and modafinil-induced wakefulness, evidenced by c-fos immunocytochemistry in the cat. Proc. Natl Acad. Sci. U.S.A. 93: 14128-14133, 1996.
27. LYONS, T. J. AND FRENCH, J.: Modafinil: The unique properties of a new stimulant. Aviat. Space Environ. Med. 62: 432-435, 1991.
28. MIGNOT, E., NISHINO, S., GUILLEMINAULT, C. AND DEMENT, W. C.: Modafinil binds to the dopamine uptake carrier site with low affinity. Sleep 17: 436-437, 1994.
29. MISTLBERGER, R. E., BERGMANN, B. M., WALDNER, W. AND RECHTSCHAFFEN, A.: Recovery sleep following sleep deprivation in intact and suprachiasmatic nuclei-lesioned rats. Sleep 6: 217-233, 1983.
30. NATIONAL COMMISSION ON SLEEP DISORDERS RESEARCH: Wake Up America: A National Sleep Alert. Vol. 1 Submitted to the United States Congress, W. C. Dement, chairman, January 1993.
31. NICKELL, P. V. AND UHDE, T. W.: Dose-response effects of caffeine in normal volunteers. Anxiety 1: 161-169, 1994.
32. PIGEAU, R., NAITOH, P., BUGUET, A., MCCANN, C., BARANSKI, J., TAYLOR, M., THOMPSON, M. AND MACK, I.: Modafinil, d-amphetamine and placebo during 64 hours of sustained mental work. I. Effects on mood, fatigue, cognitive performance and body temperature. J. Sleep Res. 4: 212-218, 1995.
33. ROEHRS, T., ZWYGHUIZEN-DIIRENBOS, A., TIMMS, V., ZORICK, F. AND ROTH, T.: Sleep extension, enhanced alertness and the sedating effects of ethanol. Pharmacol. Biochem. Behav. 34: 321-324, 1989.
34. SEIDEL, W. F., MAZE, M., DEMENT W. C. AND EDGAR, D. M.: Alpha-2 adrenergic modulation of sleep: Time-of-day-dependent pharmacodynamic profiles of dexmedetomidine and clonidine in the rat. J. Pharmacol. Exp. Ther. 275: 263-273, 1995.
35. SHELTON, J., NISHINO, S., VAUGHT, J., DEMENT, W. C. AND MIGNOT, E.: Comparative effects of modafinil and amphetamine on daytime sleepiness and cataplexy of narcoleptic dogs. Sleep 18: 817-826, 1995.
36. SIMON, P., PANISSAUD, C. AND COSTENTIN, J.: The stimulant effect of modafinil on wakefulness is not associated with an increase in anxiety in mice. A comparison with dexamphetamine. Psychopharmacology 114: 597-600, 1994.
37. SIMON, P., HEMET, C., RAMASSAMY, C. AND COSTENTIN, J.: Non-amphetaminic mechanism of stimulant locomotor effect of modafinil in mice. Eur. Neuropsychopharmacology 5: 509-514, 1995.
38. SIMON, P., HEMET, C. AND COSTENTIN, J.: Analysis of stimulant locomotor effects of modafinil in various strains of mice and rats. Fundam. Clin. Pharmacol. 10: 431-435, 1996.
39. TANGANELLI, S., PEREZ DE LA MORA, M., FERRARO, L., MENDEZ-FRANCO, J., BEANI, L., RAMBERT, F. A. AND FUXE, K.: Modafinil and cortical gamma-aminobutyric acid outflow. Modulation by 5-hydroxytryptamine neurotoxins. Eur. J. Pharmacol. 273: 63-71, 1995.
40. TOURET, M., SALLANON-MOULIN, M. AND JOUVET, M.: Awakening properties of modafinil without paradoxical sleep rebound: Comparative study with amphetamine in the rat. Neurosci. Lett. 189: 43-46, 1995.
41. TRACHSEL, L., EDGAR, D. M., SEIDEL, W. F. AND DEMENT, W. C.: Sleep homeostasis in suprachiasmatic nuclei-lesioned rats: effects of sleep deprivation and triazolam administration. Brain Res. 589: 253-261, 1992.
42. VAN GELDER, R. N., EDGAR, D. M. AND DEMENT, W. C.: Real-time automated sleep scoring: validation of a microcomputer-based system for mice. Sleep 14: 48-55, 1991.
43. WELSH, D. K., RICHARDSON, G. S. AND DEMENT, W. C.: A circadian rhythm of hippocampal theta activity in the mouse. Physiol. Behav. 35: 533-538, 1985.