Steady-state pharmacokinetics and tolerability of modafinil given alone or in combination with methylphenidate in healthy volunteers

Journal of Clinical Pharmacology

Volumn 41, Issue 8, 2001, Pages 895-904

  Hellriegel, Edward T ^a   Arora, Sanjay ^a   Nelson, Michael ^a   Robertson, Philmore ^a  

^a CEPHALON INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHYLPHENIDATE; MODAFINIL;

ABDOMINAL PAIN; ADULT; ANOREXIA; AREA UNDER THE CURVE; ARTICLE; CHIRALITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG DISPOSITION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG SAFETY; DRUG TOLERABILITY; DYSPEPSIA; ENANTIOMER; FEMALE; HEADACHE; HUMAN; HUMAN EXPERIMENT; INSOMNIA; MALE; NAUSEA; RANDOMIZED CONTROLLED TRIAL; RHINITIS; STATISTICAL ANALYSIS; STEADY STATE; XEROSTOMIA;

ADULT; BENZHYDRYL COMPOUNDS; CENTRAL NERVOUS SYSTEM STIMULANTS; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; MALE; METHYLPHENIDATE; MIDDLE AGED;

EID: 0034916291     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1177/00912700122010690     Document Type: Article

References (19)

1. Narcolepsy
2. Narcolepsy and its treatment with stimulants: ASDA standards of practice
3. Practice parameters for the use of stimulants in the treatment of narcolepsy
4. Evaluation of the abuse liability of modafinil and other drugs for excessive daytime sleepiness associated with narcolepsy
5. Treatment modalities for narcolepsy
6. Pharmacokinetics and clinical effectiveness of methylphenidate
7. Pharmacokinetic profile of modafinil
8. Single-dose pharmacokinetics of modafinil and methylphenidate given alone or in combination to healthy male volunteers
9. Randomized trial of modafinil for the treatment of pathological somnolence in narcolepsy
10. Randomized trial of modafinil as a treatment for the excessive daytime somnolence of narcolepsy
11. Subjective effects of modafinil, a new central adrenergic stimulant in healthy volunteers: A comparison with amphetamine, caffeine and placebo
12. Long-term efficacy and safety of modafinil (PROVIGIL) for the treatment of excessive daytime sleepiness associated with narcolepsy
13. Use of modafinil in the treatment of narcolepsy: A long term follow-up study
14. A double-blind, placebo-controlled, ascending-dose evaluation of the pharmacokinetics and tolerability of modafinil tablets in healthy male volunteers
15. Nonlinear kinetics of threo-methylphenidate enantiomers in a patient with narcolepsy and in healthy volunteers
16. Enantioselective pharmacokinetics of dl-threo-methylphenidate in humans
17. Pharmacology of the enantiomers of threo-methylphenidate