Activation patterns of hindlimb motor units in the awake rat and their relation to motoneuron intrinsic properties

Journal of Neurophysiology

Volumn 82, Issue 2, 1999, Pages 709-717

  Gorassini, Monica ^a,c   Bennett, David J ^a,c   Kiehn, Ole ^a   Eken, Torsten ^b   Hultborn, Hans ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF OSLO   (Norway)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GASTROCNEMIUS MUSCLE; HINDLIMB; LOCOMOTION; MALE; MOTONEURON; MOTOR UNIT; MUSCLE STRETCHING; NERVE CELL EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; RAT; TIBIALIS ANTERIOR MUSCLE;

EID: 0032783675     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1999.82.2.709     Document Type: Article

References (41)

1. BENNETT, D. J., HULTBORN, H., FEDIRCHUCK, B., AND GORASSINI, M. Synaptic activation of plateaus in hindlimb motoneurons of decerebrate cats. J. Neurophysiol. 80: 2023-2037, 1998a.
2. BENNETT, D. J., HULTBORN, H., FEDIRCHUCK, B., AND GORASSINI, M. Short-term plasticity in hindlimb motoneurons of decerebrate cats. J. Neurophysiol. 80: 2038-2045, 1998b.
3. BINDER, M. D., HECKMAN, C. J., AND POWERS, R. K. The physiological control of motoneuron activity. In: Handbook of Physiology. Neuronal Control of Movement. Bethesda, MD: Am. Physiol. Soc., 1996, sect. 12, p. 3-53.
4. BURKE, R. E., RUDOMIN, P., AND ZAJAC, F. E. Catch property in single mammalian motor units. Science 168: 122-124, 1969.
5. CLOSE, R. Properties of motor units in fast and slow skeletal muscles of the rat. J. Physiol. (Lond.) 193: 45-55, 1967.
6. CONWAY, B. A., HULTBORN, H., KIEHN, O., AND MINTZ, I. Plateau potentials in α-motoneurones induced by intravenous injection of L-DOPA and clonidine in the spinal cat. J. Physiol. (Lond.) 405: 369-384, 1988.
7. CRONE, C., HULTBORN, H., KIEHN, O., MAZIERES, L., AND WIOSTRÖM, H. Maintained changes in motoneuronal excitability by short-lasting synaptic inputs in the decerebrate cat. J. Physiol. (Lond.) 405: 321-343, 1988.
8. DELUCA, C. J., LEFEVER, R. S., MCCUE, M. P., AND XENAKIS, A. P. Behaviour of human motor units in different muscles during linearly varying contractions. J. Physiol. (Lond.) 329: 113-128, 1982.
9. DELUCA, C. J. AND ERIM, Z. Common drive of motor units in regulation of muscle force. Trends Neurosci. 17: 299-305, 1994.
10. EKEN, T. Spontaneous electromyographic activity in adult rat soleus muscle. J. Neurophysiol. 80: 365-376, 1998.
11. EKEN, T., ELDER, G., AND LØMO, T. Motor unit activity patterns in the developing rat soleus muscle. Soc. Neurosci. Abstr. 16: 331, 1990.
12. EKEN, T. AND KIEHN, O. Bistable firing properties of SOL motor units in unrestrained rats. Acta Physiol. Scand. 136: 383-394, 1989.
13. FREUND, H. J. Motor unit and muscle activity in voluntary motor control. Physiol. Rev. 63: 387-436, 1983.
14. FULTON, B. P. AND WALTON, K. Electrophysiological properties of neonatal rat motoneurons studied in vitro. J. Physiol. (Lond.) 370: 651-678, 1986.
15. GRILLNER, S. AND UDO, M. Recruitment in the tonic stretch reflex. Acta Physiol. Scand. 81: 571-573, 1971.
16. GORASSINI, M., BENNETT, D. J., SIU, M., AND YANG, J. F. Reduction in recruitment threshold of human motor units by repeated muscle activation. Soc. Neurosci. Abstr. 23: 814.7, 1997.
17. GORASSINI, M., BENNETT, D. J., AND YANG, J. F. Self-sustained activation of human motor units. Neurosci. Lett. 247: 13-16, 1998.
18. GORASSINI, M., KIEHN, O., BENNETT, D., AND HULTBORN, H. Hindlimb motor unit activity during locomotion in the awake rat. Soc. Neurosci. Abstr. 20: 173.18, 1995.
19. GRANIT, R., KERNELL, D., AND SMITH, R. S. Delayed depolarization and the repetitive response to intracellular stimulation of mammalian motoneurones. J. Physiol. (Lond.) 168: 890-910, 1963.
20. HENNIG, R. AND LØMO, T. Firing patterns of motor units in normal rats. Nature 314: 164-166, 1985.
21. HOCHMAN, S. AND SCHMIDT, B. J. Whole cell recordings of lumbar motoneurons during locomotor-like activity in the in vitro neonatal spinal cord. J. Neurophysiol. 79: 743-752, 1998.
22. HOFFER, J. A., SUGANO, N., LOEB, G. E., AND MARKS, W. B., O'DONOVAN, M. J., AND PRATT, C. A. Cat hindlimb motoneurons during locomotion. II. Normal activity patterns. J. Neurophysiol. 57: 530-553, 1987.
23. HOUNSGAARD, J., HULTBORN, H., JESPERSON, B., AND KIEHN, O. Bistability of α-motoneurones in the decerebrate cat and the acute spinal cat after intravenous injection of 5-hydroxytryptophan. J. Physiol. (Lond.) 405: 345-367, 1988.
24. HULLIGER, M., MATTHEWS, P.B.C., AND NOTH, J. Effects of combining static and dynamic fusimotor stimulation on the response of the muscle spindle primary ending to sinusoidal stretching. J. Physiol. (Lond.) 267: 839-856, 1977.
25. HULTBORN, H. AND KIEHN, O. Neuromodulation of vertebrate motor neuron membrane properties. Curr. Opin. Neurobiol. 2: 770-775, 1992.
26. JACOBS, B. L. AND FORNAL, C. A. 5-HT and motor control: a hypothesis. Trends Neurosci. 6: 346-352, 1993.
27. JONES, K. E. AND BAWA, P. Responses of human motoneurons to Ia inputs: effects of background firing rate. Can. J. Physiol. Pharmacol. 73: 1224-1234, 1995.
28. KIEHN, O. Plateau potentials and active integration in the "final common pathway" for motor behaviour. Trends Neurosci. 14: 68-73, 1991.
29. KIEHN, O. AND EKEN, T. Prolonged firing in motor units - evidence of plateau potentials in human motoneurons? J. Neurophysiol. 78: 3061-3068, 1997.
30. KIEHN, O., ERDAL, J., EKEN, T., AND BRUHN, T. Selective depletion of spinal monoamines changes the rat soleus EMG from a tonic to a more phasic pattern. J. Physiol. (Lond.) 492: 173-184, 1996.
31. LEE, R. H. AND HECKMAN, C. J. Characteristics of persistent inward currents underlying dendritic plateau potentials in spinal motoneurons. Soc. Neurosci. Abstr. 23: 512.15, 1997.
32. MATTHEWS, P.B.C. AND STEIN, R. B. The sensitivity of muscle spindle afferents to small sinusoidal changes in length. J. Physiol. (Lond.) 200: 723-743, 1969.
33. PRATT, C. A. AND LOEB, G. E. Functionally complex muscles of the cat hindlimb. I. Patterns of activation across sartorius. Exp. Brain Res. 85: 243-56, 1991.
34. PROCHAZKA, A. Sensorimotor gain control: a basic strategy of motor systems. Prog. Neurobiol 33: 281-307, 1989.
35. ROMAIGUERE, P., VEDEL, J. P., AND PAGNI, S. Effects of tonic vibration reflex on motor unit recruitment in human wrist extensor muscles. Brain Res. 602: 32-40, 1993.
36. 2+ channels. Neuroscience 61: 191-197, 1994.
37. STEIN, R. B. AND PARMIGGIANI, F. Optimal motor patterns for activating mammalian muscle. Brain Res. 175: 372-376, 1979.
38. SUZUKI, S., HAYAMI, A., SUZUKI, M., WATANABE, S., AND HUTTON, R. S. Reductions in recruitment force thresholds in human single motor units by successive voluntary contractions. Exp. Brain Res. 82: 227-230, 1990.
39. SVIRSKIS, G. AND HOUNSGAARD, J. Depolarization-induced facilitation of plateau generating currents in ventral horn neurons in the turtle spinal cord. J. Neurophysiol. 78: 1740-1742, 1997.
40. TÖTÖSY DE ZEPETNEK, J., ZUNG, H. V., ERDEBIL, S., AND GORDON, T. Motor-unit categorization based on contractile and histochemical properties: a glycogen depletion analysis of normal and reinnervated rat tibialis anterior muscle. J. Neurophysiol. 67: 1404-1415, 1992.
41. WESTERGA, J. AND GRAMSBERGEN, A. Development of the EMG of the soleus muscle in the rat. Brain Res. 80: 233-243, 1994.