Characterization of calcium currents in functionally mature mouse spinal motoneurons

European Journal of Neuroscience

Volumn 12, Issue 5, 2000, Pages 1624-1634

  Carlin, K P ^a   Jiang, Z ^a   Brownstone, R M ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

agatoxin; conotoxin; Dihydropyridines; Locomotion; Spinal cord

Indexed keywords

CALCIUM CHANNEL; CHOLINE ACETYLTRANSFERASE; CONOTOXIN; DIHYDROPYRIDINE;

ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CHOLINERGIC NERVE; CONTROLLED STUDY; LOCOMOTION; LUMBAR SPINAL CORD; MOTONEURON; MOUSE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; SPINAL CORD VENTRAL HORN;

ANIMALS; CADMIUM; CALCIUM; CALCIUM CHANNEL AGONISTS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CALCIUM CHANNELS, L-TYPE; CALCIUM CHANNELS, P-TYPE; CALCIUM CHANNELS, Q-TYPE; CALCIUM CHANNELS, T-TYPE; MEMBRANE POTENTIALS; MICE; MICE, INBRED BALB C; MOTOR NEURONS; NIFEDIPINE; PATCH-CLAMP TECHNIQUES; PYRROLES; SPINAL CORD;

EID: 0034019154     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2000.00050.x     Document Type: Article

References (82)

1. Aghajanian, G.K. & Rasmussen, K. (1989) Intracellular studies in the facial nucleus illustrating a simple new method for obtaining viable motoneurons in adult rat brain slices. Synapse, 3, 331-338.
2. Akaike, N., Kostyuk, P.G. & Osipchuk, Y.V. (1989) Dihydropyridinesensitive low-threshold calcium channels in isolated rat hypothalamic neurones. J. Physiol. (Lond), 412, 181-195.
3. Avery, R.B. & Johnston, D. (1996) Multiple channel types contribute to the low-voltage-activated calcium current in hippocampal CA3 pyramidal neurons. J. Neurosci., 16, 5567-5582.
4. Bean, B.P. (1989) Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence. Nature, 340, 153-156.
5. Berger, A.J. & Takahashi, T. (1990) Serotonin enhances a low-voltage-activated calcium current in rat spinal motoneurons, J. Neurosci., 10, 1922-1928.
6. Bourinet, E., Soong, T.W., Sutton, K., Slaymaker, S., Mathews, E., Monteil, A., Zamponi, G.W., Nargeot, J. & Snutch, T.P. (1999) Splicing of alpha 1A subunit gene generates phenotypic variants of P- and Q-type calcium channels. Nature Neurosci, 2, 407-415.
7. 2+ channels in nerve terminals of the neurohypophysis. J. Neurosci, 17, 5772-5781.
8. Brownstone, R.M., Jordan, L.M., Kriellaars, D.J., Noga, B.R. & Shefchyk, S.J. (1992) On the regulation of repetitive firing in lumbar motoneurones during fictive locomotion in the cat. Exp. Brain Res., 90, 441-455.
9. Brownstone, R.M., Gossard, J.P. & Hultborn, H. (1994) Voltage-dependent excitation of motoneurones from spinal locomotor centres in the cat. Exp. Brain Res., 102, 34-44.
10. Burke, R.E., Cullheim, S., Fleshman, J.W. & Glenn, L.L. (1988) Dendritic morphology of type-identified alpha motoneurons in the cat. In Lasek, R. & Black, M., (eds), Intrinsic Determinants of Neuronal Form and Function. Allan R. Liss, Inc., New York, pp. 167-176.
11. Byerly, L. & Hagiwara, S. (1982) Calcium currents in internally perfused nerve cell bodies of Limnea stagnalis. J. Physiol. (Lond), 322, 503-528.
12. Carbone, E. & Lux, H.D. (1987) Kinetics and selectivity of a low-voltage-activated calcium current in chick and rat sensory neurones. J. Physiol. (Lond), 386, 547-570.
13. Carlin, K.P., Jones, K.E., Jiang, Z., Jordan, L.M. & Brownstone, R.M. (2000) Dendritic L-type calcium currents in mouse spinal motoneurones: implications for bistability. Eur. J. Neurosci, 12, 1635-1646.
14. de Weille, J.R., Schweitz, H., Maes, P., Tartar, A. & Lazdunski, M. (1991) Calciseptine, a peptide isolated from black mamba venom, is a specific blocker of the L-type calcium channel. Proc. Natl Acad. Sci. USA, 88, 2437-2440.
15. Delgado-Lezama, R. & Hounsgaard, J. (1999) Adapting motoneurons for motor behavior. In Binder, M.D., (ed.), Peripherial and Spinal Mechanisms in the Neural Control. of Movement. Prog. Brain Res., 123, 57-63.
16. Diochot, S., Richard, S., Baldy-Moulinier, M., Nargeot, J. & Valmier, J. (1995) Dihydropyridines, phenylalkylamines and benzothiazepines block N-, P/Q- and R-type calcium currents. Pflugers Arch., 431, 10-19.
17. Dodt, H.U. & Zieglgansberger, W. (1990) Visualizing unstained neurons in living brain slices by infrared DIC-videomicroscopy. Brain Res., 537, 333-336.
18. El Manira, A. & Bussieres, N. (1997) Calcium channel subtypes in lamprey sensory and motor neurons. J. Neurophysiol., 78, 1334-1340.
19. Feldman, D.H., Olivera, B.M. & Yoshikami, D. (1987) Omega Conus geographus toxin: a peptide that blocks calcium channels. FEBS Lett., 214, 295-300.
20. Fisher, T.E. & Bourque, C.W. (1995) Voltage-gated calcium currents in the magnocellular neurosecretory cells of the rat supraoptic nucleus. J. Physiol. (Lond), 486, 571-580.
21. Ganong, A.H., Lanthorn, T.H. & Cotman, C.W. (1983) Kynurenic acid inhibits synaptic and acidic amino acid-induced responses in the rat hippocampus and spinal cord. Brain Res., 273, 170-174.
22. Gao, B.-X. & Ziskind-Conhaim, L. (1998) Development of ionic currents underlying changes in action potential waveforms in rat spinal motoneurons. J. Neurophysiol., 80, 3047-3061.
23. Ghosh, A. & Greenberg, M.E. (1995) Calcium signaling in neurons: molecular mechanisms and cellular consequences. Science, 268, 239-247.
24. Greenberg, M.E., Ziff, E.B. & Greene, L.A. (1986) Stimulation of neuronal acetylcholine receptors induces rapid gene transcription. Science, 234, 80-83.
25. 2+ conductance. J. Neurosci, 17, 3334-3342.
26. Hille, B. (1992). Ionic Channels of Excitable Membranes. Sinauer Associates Inc., Sunderland, Mass, USA.
27. Hivert, B., Bouhanna, S., Diochot, S., Camu, W., Dayanithi, G., Henderson, C.E. & Valmier, J. (1995) Embryonic rat motoneurons express a functional P-type voltage-dependent calcium channel. Int. J. Dev. Neurosci., 13, 429-436.
28. 2+-channel currents in bovine adrenal chromaffin cells. Proc. Natl Acad. Sci. USA, 81, 5871-5875.
29. Hounsgaard, J. & Kiehn, O. (1989) Serotonin-induced bistability of turtle motoneurones caused by a nifedipine-sensitive calcium plateau potential. J. Physiol. (Lond.), 414, 265-282.
30. Hsiao, C.F., Del Negro, C.A., Trueblood, P.R. & Chandler, S.H. (1998) Ionic basis for serotonin-induced bistable membrane properties in guinea pig trigeminal motoneurons. J. Neurophysiol., 79, 2847-2856.
31. Ikeda, S.R. (1991) Double-pulse calcium channel current facilitation in adult rat sympathetic neurones. J. Physiol. (Lond.), 439, 181-214.
32. Jacob, T.J.C., Stelling, J.W., Gooch, A. & Zhang, J.J. (1993) Transport mechanisms in ocular epithelia. In Wallis, D.I. (ed.), Electrophysiology: a Practical Approach. Oxford Univeristy Press Inc, New York, pp. 29-48.
33. Jeong, S.W. & Wurster, R.D. (1997) Calcium channel currents in acutely dissociated intracardiac neurons from adult rats. J. Neurophysiol., 77, 1769-1778.
34. Jiang, Z., Rempel, J., Li, J., Sawchuck, M., Carlin, K.P. & Brownstone, R.M. (1999a) Development of L-type calcium channels and a nifedipine-sensitive motor activity in the postnatal mouse spinal cord. Eur. J. Neurosci, 11, 3481-3487.
35. Jiang, Z., Carlin, K.P. & Brownstone, R.M. (1999b) An in vitro functionally mature mouse spinal cord preparation for the study of spinal motor networks. Brain Res., 816, 493-499.
36. Jonas, P., Bischofberger, J. & Sandkuhler, J. (1998) Corelease of two fast neurotransmitters at a central synapse. Science, 281, 419-424.
37. Jones, S.W. & Jacobs, L.S. (1990) Dihydropyridine actions on calcium currents of frog sympathetic neurons. J. Neurosci, 10, 2261-2267.
38. Kammermeier, P.J. & Jones, S.W. (1998) Facilitation of L-type calcium current in thalamic neurons. J. Neurophysiol., 79, 410-417.
39. Kasai, H. (1991) Tonic inhibition and rebound facilitation of a neuronal calcium channel by a GTP-binding protein. Proc. Natl Acad. Sci. USA, 88, 8855-8859.
40. 2+ channels by intracellular pH in chick sensory neurons. J. Neurophysiol., 81, 1839-1847.
41. Krawitz, S., Brownstone, R.M., Noga, B.R. & Jordan, L.M. (1996) Can the nervous system overcome a possible central fatigue process - late adaptation? Muscle Nerve Supplement, 4, S52.
42. Krawitz, S. & Brownstone, R.M. (1994) Late adaptation in cat motoneurones during fictive locomotion. Soc. Neurosci. Abstr., 20, 241.
43. 2+ channel activator, FPL 64176, in GH3 cells. Mol Pharmacol., 42, 666-670.
44. 2+ channels. Naunyn Schmiedebergs Arch. Pharmacol., 360, 122-128.
45. Lee, R.H. & Heckman, C.J. (1998) Bistability in spinal motoneurons in vivo: systematic variations in persistent inward currents. J. Neurophysiol., 80, 583-593.
46. McCobb, D.P., Best, P.M. & Beam, K.G. (1989) Development alters the expression of calcium currents in chick limb motoneurons. Neuron, 2, 1633-1643.
47. McHanwell, S. & Biscoe, T.J. (1981) The sizes of motoneurons supplying hindlimb muscles in the mouse. Proc. R Soc. Lond B Biol. Sci., 213, 201-216.
48. Meir, A., Ginsburg, S., Butkevich, A., Kachalsky, S.G., Kaiserman, I., Ahdut, R., Demirgoren, S. & Rahamimoff, R. (1999) Ion channels in presynaptic nerve terminals and control of transmitter release. Physiol. Rev., 79, 1019-1088.
49. Mills, J.D. & Pitman, R.M. (1997) Electrical properties of a cockroach motor neuron soma depend on different characteristics of individual Ca components. J. Neurophysiol., 78, 2455-2466.
50. Mintz, I.M., Venema, V.J., Swiderek, K.M., Lee, T.D., Bean, B.P. & Adams, M.E. (1992) P-type calcium channels blocked by the spider toxin omega-Aga-IVA. Nature, 355, 827-829.
51. Morisset, V. & Nagy, F. (1999) Ionic basis for plateau potentials in deep dorsal horn neurons of the rat spinal cord. J. Neurosci, 19, 7309-7316.
52. Muller, W. & Lux, H.D. (1993) Analysis of voltage-dependent membrane currents in spatially extended neurons from point-clamp data. J. Neurophysiol., 69, 241-247.
53. Murphy, T.H., Worley, P.F. & Baraban, J.M. (1991) L-type voltage-sensitive calcium channels mediate synaptic activation of immediate early genes. Neuron, 7, 625-635.
54. + and cyclic AMP in the presence or absence of NGF. Eur. J. Neurosci, 5, 1261-1272.
55. Mynlieff, M. & Beam, K.G. (1992a) Developmental expression of voltage-dependent calcium currents in identified mouse motoneurons. Dev. Biol., 152, 407-410.
56. Mynlieff, M. & Beam, K.G. (1992b) Characterization of voltage-dependent calcium currents in mouse motoneurons. J. Neurophysiol., 68, 85-92.
57. Newman, G.C., Hospod, F.E., Qi, H. & Patel, H. (1995) Effects of dextran on hippocampal brain slice water, extracellular space, calcium kinetics and histology. J. Neurosci. Meth., 61, 33-46.
58. Parsley, C.P., Cheng, K.W., Song, L. & Hochman, S. (1998) Thin slice CNS explants maintained on collagen-coated culture dishes. J. Neurosci. Meth., 80, 65-74.
59. Rampe, D. & Lacerda, A.E. (1991) A new site for the activation of cardiac calcium channels defined by the nondihydropyridine FPL 64176. J. Pharmacol. Exp. Ther., 259, 982-987.
60. 2+ channel currents in rat cerebellar granule neurons. J. Neurosci., 15, 2995-3012.
61. Scamps, F., Valentin, S., Dayanithi, G. & Valmier, J. (1998) Calcium channel subtypes responsible for voltage-gated intracellular calcium elevations in embryonic rat motoneurons. Neuroscience, 87, 719-730.
62. Schurr, A., West, C.A. & Rigor, B.M. (1988) Lactate-supported synaptic function in the rat hippocampal slice preparation. Science, 240, 1326-1328.
63. Schwindt, P.C. & Crill, W.E. (1980) Properties of a persistent inward current in normal and TEA-injected motoneurons. J. Neurophysiol., 43, 1700-1724.
64. Schwindt, P.C. & Crill, W.E. (1984) Membrane properties of cat spinal motoneurons. In Davidoff, R. (ed.). Handbook of the Spinal Cord, pp. 199.
65. Somjen, G.G. & Czeh, G. (1989) Pathophysiology of the spinal cord studied in vitro. J. Neurosci. Meth., 28, 35-46.
66. Takahashi, T. & Berger, A.J. (1990) Direct excitation of rat spinal motoneurones by serotonin. J. Physiol. (Lond.), 423, 63-76.
67. Takahashi, T. (1990) Membrane currents in visually identified motoneurones of neonatal rat spinal cord. J. Physiol. (Lond.), 423, 27-46.
68. Talley, E.M., Cribbs, L.L., Lee, J.H., Daud, A., Perez-Reyes, E. & Bayliss, D.A. (1999) Differential distribution of three members of a gene family encoding low voltage-activated (T-type) calcium channels. J. Neurosci, 19, 1895-1911.
69. Teramoto, T., Niidome, T., Miyagawa, T., Nishizawa, Y., Katayama, K. & Sawada, K. (1995) Two types of calcium channels sensitive to omega-agatoxin-TK in cultured rat hippocampal neurones. Neuroreport., 6, 1684-1688.
70. Thurbon, D., Luscher, H.R., Hofstetter, T. & Redman, S.J. (1998) Passive electrical properties of ventral horn neurons in rat spinal cord slices [corrected and republished in J. Neurophysiol., 1998, 80, 2485-2502]. J. Neurophysiol., 79, 2485-2502.
71. 2+ channels in hypoglossal motoneurons. J. Neurosci, 14, 5652-5660.
72. Usowicz, M.M., Gigg, M., Jones, L.M., Cheung, C.W. & Hartley, S.A. (1995) Allosteric interactions at L-type calcium channels between FPL 64176 and the enantiomers of the dihydropyridine Bay K 8644. J. Pharmacol. Exp. Ther., 275, 638-645.
73. Viana, F., Bayliss, D.A. & Berger, A.J. (1993a) Multiple potassium conductances and their role in action potential repolarization and repetitive firing behavior of neonatal rat hypoglossal motoneurons. J. Neurophysiol., 69, 2150-2163.
74. Viana, F., Bayliss, D.A. & Berger, A.J. (1993b) Calcium conductances and their role in the firing behavior of neonatal rat hypoglossal motoneurons. J. Neurophysiol., 69, 2137-2149.
75. 2+ channel subtypes on rat spinal motor neurons, interneurons, and nerve terminals. J. Neurosci., 18, 6319-6330.
76. White, M.G., Crumling, M.A. & Meriney, S.D. (1997) Developmental changes in calcium current pharmacology and somatostatin inhibition in chick parasympathetic neurons. J. Neurosci, 17, 6302-6313.
77. Wikström, M.A. & El Manira, A. (1998) Calcium influx through N- and P/Q-type channels activate apamin-sensitive calcium-dependent potassium channels generating the late afterhyperpolarization in lamprey spinal neurons. Eur. J. Neurosci., 10, 1528-1532.
78. Yu, B. & Shinnick-Gallagher, P. (1997) Dihydropyridine-and neurotoxin-sensitive and -insensitive calcium currents in acutely dissociated neurons of the rat central amygdala. J. Neurophysiol., 77, 690-701.
79. 2+ channels and their possible counterparts in mammalian CNS neurons. Neuropharmacology, 32, 1075-1088.
80. 2+ channel activator, in cardiac and vascular preparations. Mol. Pharmacol., 40, 734-741.
81. 2+ currents by various G protein-coupled receptors in sympathetic neurons of male rat pelvic ganglia. J. Neurophysiol., 78, 780-789.
82. Zygmunt, A.C. & Maylie, J. (1990) Stimulation-dependent facilitation of the high threshold calcium current in guinea-pig ventricular myocytes. J. Physiol. (Lond.), 428, 653-671.