Prolonged firing in motor units: Evidence of plateau potentials in human motoneurons?

Journal of Neurophysiology

Volumn 78, Issue 6, 1997, Pages 3061-3068

  Kiehn, Ole ^a,c   Eken, Torsten ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF OSLO   (Norway)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; DEPOLARIZATION; FEMALE; HUMAN; MALE; MOTONEURON; MOTOR UNIT; MUSCLE ACTION POTENTIAL; MUSCLE INNERVATION; NORMAL HUMAN; PRIORITY JOURNAL; SOLEUS MUSCLE; TIBIALIS ANTERIOR MUSCLE;

EID: 0031423613     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1997.78.6.3061     Document Type: Article

References (41)

1. BALDISSERA, F., CAVALLARI, P., AND DWORZAK, F. Cramps: a sign of motoneurone "bistability" in a human patient. Neurosci. Lett. 133: 303-306, 1991.
2. BALDISSERA, F., CAVALLARI, P., AND DWORZAK, F. Motor neuron bistability: a pathogenetic mechanism for cramps and myokymia. Brain 117: 929-939, 1994.
3. BASMAJIAN, J. V. AND DE LUCA, C. J. Muscles Alive: Their Functions Revealed by Electromyography. Baltimore, MD: Williams & Wilkins, 1985.
4. BAWA, P. AND CALANCIE, B. Repetitive doublets in human flexor carpi radialis muscle. J. Physiol. (Lond.) 339: 123-132, 1983.
5. BENNETT, D. J., HULTBORN, H., FREDIRCHUK, B., AND GORASSINI, M. A. Some evidence for a dendritic origin of plateau potentials in cat motoneurons. Soc. Neurosci. Abstr. 21: 145, 1995.
6. BOOTH, V. AND RINZEL, J. A minimal, compartmental model for a dendritic origin of bistability of motoneuron firing patterns. J. Comput. Neurosci. 2: 299-312, 1995.
7. 2+-dependent spiking and plateau potentials under pharmacological treatment. J. Neurophysiol. In press.
8. BURKE, D. The fusiomotor innervation of muscle spindle endings in man. Trends Neurosci. 10: 89-92, 1978.
9. CARP, J. S. AND RYMER, W. Z. Enhancement by serotonin of tonic vibration and stretch reflexes in the decerebrate cat. Exp. Brain Res. 62: 111-122, 1986.
10. CONWAY, B. A., HULTBORN, H., KIEHN, O., AND MINTZ, I. Plateau potentials in α-motoneurones induced by intravenous injection of L-DOPA and clonidine in the spinal cat. J. Physiol. (Lond.) 405: 369-384, 1988.
11. CRONE, C., HULTBORN, H., KIEHN, O., MAZIERES, L., AND WIGSTRÖM, H. Maintained changes in motoneuronal excitability by short-lasting inputs in the decerebrate cat. J. Physiol. (Lond.) 405: 321-343, 1988.
12. DE LUCA, C. J, LEFEVER, R. S., MCCUE, M. P., AND XENAKIS, A. P. Behaviour of human motor units in different muscles during linearly varying contractions. J. Physiol. (Lond.) 329: 113-128, 1982.
13. DENIER VAN DER GON, J. J., TER HAR ROMENY, B. M., AND VAN ZUYLEN, E. J. Behaviour of motor units of human arm muscles: differences between isometric contraction and relaxation. J. Physiol. (Lond.) 359: 107-118, 1985.
14. EDIN, B. B., BÄCKSTRÖM, P. A., AND BÄCKSTRÖM, L. O. Single unit retrieval in microneurography: a microprocessor-based device controlled by an operator. J. Neurosci. Methods 24: 137-144, 1988.
15. EKEN, T., ELDER, G.C.B., AND LØMO, T. Spontaneous electromyographic activity in the developing rat soleus muscle. Soc. Neurosci. Abstr. 16: 331, 1990.
16. EKEN, T. AND LØMO, T. Independent recruitment to tonic firing among rat soleus motoneurones during spontaneous activity. Physiologist 36: A-2, 1993.
17. EKEN, T. AND KIEHN, O. Bistable firing properties of soleus motor units in unrestrained rats. Acta Physiol. Scand. 136: 383-394, 1989.
18. FETZ, E. E. AND CHENEY, P. D. Functional properties of primate corticomotoneuronal cells: comparisons with spindle afferents and motor units. In: The Segmental Motor System, edited by M. D. Binder and L. M. Mendell. Oxford: Oxford Univ. Press, 1990, p. 381-392.
19. GORASSINI, M., BENNETT, D. J., SIU, M., AND YANG, J. F. Reduction in recruitment threshold of human motor units by repeated muscle activation. Soc. Neurosci. Abstr. In press.
20. HAGBART, K.-E. The effect of muscle vibration in normal man and in patients with motor disorders. In: New Development in Electromyography and Clinical Neurophysiology, edited by J. E. Desmedt. Basel: Karger, 1973, p. 428-443.
21. HARTLINE D. K., RUSSELL D. F., RAPER, J. A., AND GRAUBARD, K. Special cellular and synaptic mechanisms in motor pattern generation. Comp. Biochem. Physiol. C Pharmacol. Toxicol. Endrocrinol. 91: 115-131, 1988.
22. HOUNSGAARD, J., HULTBORN, H., JESPERSEN, B., AND KIEHN, O. Bistability of α-motoneurones in the decerebrate cat and in the acute spinal cat after intravenous 5-hydroxytryptophan. J. Physiol. (Lond.) 405: 345-367, 1988.
23. 2+-dependent bistability by serotonin in spinal motoneurones. Exp. Brain Res. 57: 422-425, 1985.
24. HOUNSGAARD, J. AND KIEHN, O. Serotonin-induced bistability of turtle motoneurones caused by a nifedipine-sensitive calcium plateau potential. J. Physiol. (Lond.) 414: 265-282, 1989.
25. HOUNSGAARD, J. AND MINTZ, I. Calcium conductance and firing properties of spinal motoneurones in the turtle. J. Physiol. (Lond.) 398: 591-603, 1988.
26. HULTBORN, H. AND KIEHN, O. Neuromodulation of vertebrate motoneurone membrane properties. Curr. Opin. Neurobiol. 2: 770-775, 1992.
27. KANDA, K. Contribution of polysynaptic pathways to the tonic vibration reflex. Jpn. J. Physiol. 22: 367-77, 1972.
28. KIEHN, O. Plateau potentials and active integration in the "final common pathway" for motor behaviour. Trends Neurosci. 14: 68-73, 1991a.
29. KIEHN, O. Electrophysiology of 5-HT on vertebrate motoneurones. In: Aspects of Synaptic Transmission, edited by T. Stone. London: Taylor & Francis, 1991b, vol. 1, p. 527-555.
30. KIEHN, O. Transmitter-modulation and possible function of plateau properties in mammalian motoneurones. Physiol. Soc. Magazine (Lond.) 8: 35-38, 1993.
31. KIEHN, O. AND EKEN, T. Discontinuous changes in discharge pattern of human motor units. J. Physiol. (Lond.) 452: 277 P, 1992.
32. KIEHN, O., ERDAL, J., EKEN, T., AND BRUHN, T. Selective depletion of spinal monoamines changes the rat soleus EMG from a tonic to a more phasic pattern. J. Physiol. (Lond.) 492: 173-184, 1996.
33. KUDINA, L. P. AND ALEXEEVA, N. L. After-potentials and control of repetitive firing in human motoneurones. Electroencephalogr. Clin. Neurophysiol. 85: 345-53, 1992.
34. LANCE, J. W., DE GAIL, P., AND NEILSON, P. D. Tonic and phasic spinal cord mechanisms in man. J. Neurol. Neurosurg. Psychiatry 29: 535-544, 1966.
35. LANG, A. H. AND VALLBO, B. Motoneuron activation by low intensity tetanic stimulation of muscle afferents in man. Exp. Neurol. 18: 383-391, 1967.
36. MILNER-BROWN, H. S., STEIN, R. B., AND YEMM, R. Changes in firing rate of human motor units during linearly changing voluntary contractions. J. Physiol. (Lond.) 230: 371-390, 1973.
37. ROMAIGUERE, P., VEDEL, J.-P., AND PAGNI, S. Comparison of fluctuations of motor unit recruitment and de-recruitment thresholds in man. Exp. Brain Res. 95: 517-522, 1993.
38. SCHWINDT, P. C. AND CRILL, W. E. Role of a persistent inward current in motoneuron bursting during spinal seizures. J. Neurophysiol. 43: 1296-1318, 1980a.
39. SCHWINDT, P. C. AND CRILL, W. E. Properties of a persistent inward current in normal and TEA-injected motoneurons. J. Neurophysiol. 43: 1700-1724, 1980b.
40. SCHWINDT, P. C. AND CRILL, W. E. Effects of barium on cat spinal motoneurons studied by voltage clamp. J. Neurophysiol. 44: 827-846, 1980c.
41. VAN DER LINDEN, D. W., KUKULKA, C. G., AND SODERBERG, G. L. The effect of muscle length on motor unit discharge characteristics in human tibialis anterior muscle. Exp. Brain Res. 84: 210-218, 1991.