Aged-rodent models of long-term growth hormone therapy: Lack of deleterious effect on longevity

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 53, Issue 6, 1998, Pages

  Kalu, Dike N ^a   Orhii, Paul B ^a   Chen, Cang ^a   Lee, Doug Yoon ^a   Hubbard, Gene B ^b   Lee, Shuko ^a   Olatunji Bello, Yemi ^a,c  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^c UNIVERSITY OF LAGOS   (Nigeria)

Author keywords

[No Author keywords available]

Indexed keywords

SOMATOMEDIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY COMPOSITION; BODY MASS; BODY WEIGHT; CALORIC INTAKE; CONTROLLED STUDY; CONVALESCENCE; GROWTH HORMONE RELEASE; GROWTH REGULATION; HORMONAL REGULATION; HORMONAL THERAPY; LIFESPAN; NONHUMAN; PRIORITY JOURNAL; RAT; STATISTICAL ANALYSIS;

ANIMALIA; RODENTIA;

EID: 0031758513     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/53A.6.B452     Document Type: Article

References (8)

1. Copras E, Harman SM, Blackman MR. Human growth hormone and human aging. Endoc Rev. 1993:14:20-39.
2. Sonntag WE, Steger RW, Forman LJ, Meites J. Decreased pulsatile release of growth hormone in old male rats. Endocrinology. 1980; 107:1875-1879.
3. Sonntag WE, Hylka VW, Meites J. Impaired ability of male rats to secrete growth hormone in vivo but not in vitro in response to hpGRF(1-44). Endocrinology. 1983;113:2305-2307.
4. Shimokawa I, Higami Y, Okimoto T, Ideda T. The growth hormone releasing hormone-cyclic adenosine-3′,5′-monophosphate signal pathway in somatotropes is practically intact during aging. Neuroendocrinology. 1994;60:575-580.
5. Rudman D, Feller AG, Nagraj HS, et al. Effect of human growth hormone in men over 60 years old. N Engl J Med. 1990;323:1-6.
6. Wise B, Case B. Recombinant human growth hormone. ANNA J. 1994;21:87-89.
7. Crist DM, Peake GT, Egan PA, Waters DL. Body composition response to exogenous GH during training in highly conditioned adults. J Appl Physiol. 1988:62:579-584.
8. Synder DK, Clemmons DR, Underwood LE. Treatment of obese, diet restricted subjects with growth hormone for 11 weeks: effects on anabolism, lipolysis, and body composition. J Clin Endocrinol Metab. 1988:67:54-61.