Insulin and IGF-1 induce different patterns of gene expression in mouse fibroblast NIH-3T3 cells: Identification by cDNA microarray analysis

Endocrinology

Volumn 142, Issue 11, 2001, Pages 4969-4975

  Dupont, Joelle ^a   Khan, Javed ^b   Qu, Bao He ^a   Metzler, Paul ^b   Helman, Lee ^c   LeRoith, Derek ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; INSULIN RECEPTOR; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DNA MICROARRAY; FIBROBLAST; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; MITOGENESIS; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

EID: 0034751597     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.142.11.8476     Document Type: Article

References (60)

1. IGF binding proteins: Regulation of cellular actions
2. How distinct are the insulin and insulin-like growth factor I signalling systems?
3. Insulin action and the insulin signaling network
4. Molecular and cellular aspects of the insulin-like growth factor I receptor
5. Insulin-like growth factors and their binding proteins: Biological actions
6. Early neonatal death in mice homozygous for a null allele of the insulin receptor gene
7. Hypoglycemic effect of insulin-like growth factor-1 in mice lacking insulin receptors
8. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)
9. Effect of a mutation at tyrosine 950 of the insulin-like growth factor I receptor on the growth and transformation of cells
10. Molecular analysis of signal transduction by growth factors
11. Signal transduction by receptors with tyrosine kinase activity
12. Insulin-like growth factor I receptor primary structure: Comparison with insulin receptor suggests structural determinants that define functional specificity
13. Structure-function relationship of the insulin-like growth factor-I receptor tyrosine kinase
14. Essential role of tyrosine residues 1131, 1135, and 1136 of the insulin-like growth factor-I (IGF-I) receptor in IGF-I action
15. IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3′-kinase
16. Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
17. Role of IRS-2 in insulin and cytokine signalling
18. 4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice
19. Characterization of a 60-kilodalton substrate of the insulin receptor kinase
20. The insulin-elicited 60-kDa phosphotyrosine protein in rat adipocytesis associated with phosphatidylinositol 3-kinase
21. Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells
22. Identification of major tyrosine phosphorylation sites in the human insulin receptor substrate Gab-1 by insulin receptor kinase in vitro
23. Gab-1-mediated IGF-1 signaling in IRS-1-deficient 3T3 fibroblasts
24. Insulin-induced phosphorylation of the 46- and 52-kDa Shc proteins
25. A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction
26. The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1
27. The SH2/SH3 domain-containing protein GRB2 interacts with IRS1 and Shc: Implications for insulin control of ras signalling
28. Regulation by insulin of phosphatidylinositol 3′-kinase bound to α- and β-isoforms of p85 regulatory subunit
29. Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation
30. Involvement of Src-homology/collagen (SHC) proteins in signaling through the insulin receptor and the insulin-like-growth-factor-I-receptor
31. Mutation of a conserved amino acid residue (tryptophan 1173) in the tyrosine kinase domain of the IGF-I receptor abolishes autophosphorylation but does not eliminate biologic function
32. Signaling via the insulin-like growth factor-I receptor: Does it differ from insulin receptor signaling?
33. Deletion of C-terminal 113 amino acids impairs processing and internalization of human insulin receptor: Comparison of receptors expressed in CHO and NIH-3T3 cells
34. Gene expression profiling of alveolar rhabdomyosarcoma with cDNA microarrays
35. DNA microarray technology: The anticipated impact on the study of human disease
36. Thyroid hormone regulation of hepatic genes in vivo detected by complementary DNA microarray
37. Leptin-specific patterns of gene expression in white adipose tissue
38. Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes
39. Insulin-like growth factor-I stimulates c-fos and c-jun transcription in PC12 cells
40. Insulin-like growth factor I stimulates transcription of the c-jun proto-oncogene in Balb/C 3T3 cells
41. Insulin-like growth factor-1 (IGF-1) specifically binds to bovine lens epithelial cells and increases the number of fibronectin receptor sites
42. Signal transduction pathways leading to insulin-induced early gene induction
43. NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli
44. Tel induces a G1 arrest and suppresses ras-induced transformation
45. Essential roles of the winged helix transcription factor MFH-1 in aortic arch patterning and skeletogenesis
46. The cDNA sequence and chromosomal location of the human SOX2 gene
47. The myogenic regulatory gene Mef2 is a direct target for transcriptional activation by Twist during Drosophila myogenesis
48. Muscle develops a specific form of small heat shock protein complex composed of MKBP/HSPB2 and HSPB3 during myogenic differentiation
49. Calponin phosphorylation in vitro and in intact muscle
50. Insulin and IGF-I receptors signaling in protection from apoptosis
51. High insulin-like growth factor 1 (IGF-1) and insulin concentrations trigger apoptosis in the mouse blastocyst via down-regulation of the IGF-1 receptor
52. Differential roles of insulin receptor and insulin-like growth factor-1 receptor in differentiation of murine skin keratinocytes
53. Insulin-like growth factor I and insulin regulate delta-crystallin gene expression in developing lens
54. Differential phosphorylation of pp120 by insulin and insulin-like growth factor-1 receptors: Role for the C-terminal domain of the β-subunit
55. The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-1 receptor in mouse fibroblasts
56. Is insulin a growth factor?
57. Increased expression of insulin/insulin-like growth factor-I hybrid receptors in skeletal muscle of noninsulin-dependent diabetes mellitus subjects
58. Spatial determinants of specificity in insulin action
59. Role of the time factor in signaling specificity: Application to mitogenic and metabolic signaling by the insulin and insulin-like growth factor-I receptor tyrosine kinases
60. IGF-1-induced Twist expression is involved in the anti-apoptotic effects of the IGF-1 receptor