Can we model nitric oxide biotransport? A survey of mathematical models for a simple diatomic molecule with surprisingly complex biological activities

Annual Review of Biomedical Engineering

Volumn 3, Issue , 2001, Pages 109-143

  Buerk, D G ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Blood flow; Endothelium; Mass transport; Nitric oxide synthases; Nitrosohemoglobins; Nitrosothiols; Oxygen transport; Oxyhemoglobin; Peroxynitrite; Reaction kinetics; Soluble guanylate cyclase

Indexed keywords

HEMOGLOBIN; NITRIC OXIDE; VASODILATOR AGENT;

GAS TRANSPORT; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; MOLECULE; OXYGEN TRANSPORT; PRESSURE; REVIEW; SCAVENGING SYSTEM;

ANIMALS; BIOLOGICAL TRANSPORT; HEMOGLOBINS; HUMANS; MODELS, BIOLOGICAL; NITRIC OXIDE; SUPEROXIDES; VASODILATOR AGENTS;

EID: 0034813738     PISSN: 15239829     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.bioeng.3.1.109     Document Type: Review

References (119)

1. Molecule of the year. NO news is good news
2. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
3. Additional evidence that endothelium-derived relaxing factor is nitric oxide
4. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide
5. The discovery of nitric oxide as the endogenous nitrovasodilator
6. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
7. Guanylate cyclase: Activation by azide, nitro compounds, nitric oxide, and hydroxyl radical and inhibition by hemoglobin and myoglobin
8. Biochemistry of nitric oxide and its redoxactivated forms
9. International Union of Pharmacology nomenclature in nitric oxide research
10. Nitric oxide as a secretory product of mammalian cells
11. Effects of pH on the structure and function of neuronal nitric oxide synthase
12. Direct effect of temperature on the catalytic activity of nitric oxide synthases types I, II, and III
13. Interactions of nitric oxide with hemoproteins: Roles of nitric oxide in mitochondria
14. 2 reaction
15. Kinetics of nitric oxide autoxidation in aqueous solutions
16. Kinetics of the reaction of nitric oxide with oxygen in aqueous solutions
17. 2 as studied by a novel approach
18. 2 within the hydrophobic interior of biological membranes
19. The reaction of NO with superoxide
20. 2·: A pulse radiolysis study
21. The kinetics and equilibria of the reactions of nitric oxide with sheep haemoglobin
22. Conformation, co-operativity and ligand binding in human hemoglobin
23. The role of diffusion in limiting the rate of ligand binding to hemoglobin
24. Mechanism of NO-induced oxidation of myoglobin and hemoglobin
25. Arterial blood pressure responses to cell-free hemoglobin solutions and the reaction with nitric oxide
26. The rate of uptake of carbon monoxide and of nitric oxide by normal human erythrocytes and experimentally produced spherocytes
27. Diffusion-limited reaction of free nitric oxide with erythrocytes
28. Erythrocytes possess an intrinsic barrier to nitric oxide consumption
29. Oxidation of nitrogen oxides by bound dioxygen in hemoproteins
30. A molecular basis for nitric oxide sensing by soluble guanylate cyclase
31. Nitric oxide diffusion in membranes determined by fluorescence quenching
32. Apparent hydroxyl radical production by peroxinitrite: Implications for endothelial injury by nitric oxide and superoxide
33. Superoxide radical and superoxide dismutases
34. A vertebrate globin expressed in the brain
35. Effect of nitric oxide on the oxygen transport of human erythrocytes
36. Spectral and kinetic studies on the activation of soluble guanylyl cyclase by nitric oxide
37. Kinetics of nitric oxide dissociation from five- and six-coordinate nitrosyl hemes and heme proteins, including soluble guanylate cyclase
38. Rate of deactivation of nitric oxide-stimulated soluble guanylate cyclase: Influence of nitric oxide scavengers and calcium
39. Rapid desensitization of the nitric oxide receptor, soluble guanylyl cyclase, underlies diversity of cellular cGMP responses
40. Potency and kinetics of nitric oxide-mediated vascular smooth muscle relaxation determined with flash photolysis of ruthenium nitrosyl chlorides
41. The oxyhemoglobin reaction of nitric oxide
42. Reactions between nitric oxide and haemoglobin under physiological conditions
43. S-nitrosohaemoglobin: A dynamic activity of blood involved in vascular control
44. Dynamic state of S-nitrosothiols in human plasma and whole blood
45. Concerted nitric oxide/oxygen delivery by hemoglobin
46. Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient
47. Electron paramagnetic resonance and oxygen binding studies of α-nitrosyl hemoglobin. A novel oxygen carrier having NO-assisted allosteric functions
48. Relative role of heme nitrosylation and -cysteine 93 nitrosation in the transport and metabolism of nitric oxide by hemoglobin in the human circulation
49. Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans
50. Direct observation of trapping and release of nitric oxide by glutathione and cysteine with electron paramagnetic resonance spectroscopy
51. Xanthine oxidase-mediated decomposition of S-nitrosothiols
52. Reduction of nitrite to nitric oxide catalyzed by xanthine oxidoreductase
53. Generation of nitric oxide by a nitrite reductase activity of xanthine oxidase: A potential pathway for nitric oxide formation in the absence of nitric oxide synthase activity
54. Production and storage of nitric oxide in adaptation to hypoxia
55. Simulation of the diffusion and reaction of endogenously produced nitric oxide
56. The diffusion of free nitric oxide
57. A tutorial on the diffusibility and reactivity of free nitric oxide
58. Diffusion coefficients of neon, krypton, xenon, carbon monoxide, and nitric oxide in water at 10-60°C
59. Solubilities of gases in water
60. Kinetic modeling of the nitric oxide gradient generated in vitro by adherent cells expressing inducible nitric oxide synthase
61. Diffusion and reaction of nitric oxide in suspension cell cultures
62. Kinetic analysis of the fate of nitric oxide synthesized by macrophages in vitro
63. Arterial wall oxygen consumption rate varies spatially
64. Spatial variation of aortic wall oxygen diffusion coefficient from transient polarographic measurements
65. Microvascular and tissue oxygen gradients in the rat mesentery
66. Effective diffusion distance of nitric oxide in the microcirculation
67. Estimation of nitric oxide production and reaction rates in tissue by use of a mathematical model
68. Nitric oxide measured by a porphyrinic microsensor in rat brain after transient middle cerebral artery occlusion
69. Diffusion of nitric oxide and scavenging by blood in the vasculature
70. Biochemical aspects of the reaction of hemoglobin and NO: Implications for Hb-based substitutes
71. Intravascular flow decreases erythrocyte consumption of nitric oxide
72. 2 transport model
73. 2-Hb reaction kinetics and the Fähraeus effect during stagnant, hypoxic and anemic supply deficit
74. m for oxygen of nitric oxide synthase isoforms
75. Nitric oxide binding to the heme of neuronal nitric-oxide synthase links its activity to changes in oxygen tension
76. Nitric oxide synthesis in the lung. Regulation by oxygen through a kinetic mechanism
77. 2 on macrophage (RAW 264.7) nitric oxide production
78. Regulation of bovine constitutive nitric oxide synthase by oxygen
79. Regulation of nitric oxide syntesis by oxygen in vascular endothelial cells
80. Physiological role of nitric oxide as an enhancer of oxygen transfer from erythrocytes to tissues
81. Regulation of mitochondrial respiration by adenosine diphosphate, oxygen, and nitric oxide
82. Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase
83. On the mechanism by which vascular endothelial cells regulate their oxygen consumption
84. Nitric oxide. An important signaling mechanism between vascular endothelium and parenchymal cells in the regulation of oxygen consumption
85. Role of endothelium-derived nitric oxide in the regulation of cardiac oxygen metabolism
86. Kinetics of the inhibition of mitochondrial respiration by NO
87. A novel reaction mechanism for the formation of S-nitrosothiol in vivo
88. Kinetics of nitrosation of thiols by nitric oxide in the presence of oxygen
89. Determination of production of nitric oxide by lower airways of humans theory
90. A two-compartment model of pulmonary nitric oxide exchange dynamics
91. 2 in humans: Effect of dynamically changing flow rate
92. Exhaled nitric oxide partitioned into alveolar, lower airways and nasal contributions
93. Nitric oxide: Linking space and time in the brain
94. Endothelium-derived relaxing factor release on activation of NMDA receptors suggest role as intercellular messenger in the brain
95. Nitric oxide, a novel neuronal messenger
96. Locally distributed synaptic potentiation in the hippocampus
97. Models of the diffusional spread of nitric oxide: Implications for neural nitric oxide signaling and its pharmacological properties
98. Four-dimensional neuronal signaling by nitric oxide: A computational analysis
99. Diffusion of nitric oxide can facilitate cerebellar learning: A simulation study
100. Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and ugly
101. Modeling the interaction of peroxynitrite with low density lipoproteins. I. Plasma levels of peroxynitrite
102. Modeling the interaction of peroxynitrite with low density lipoproteins. II. Reaction/diffusion model of peroxynitrite in low-density lipoproteins
103. Modeling the interaction of peroxynitrite with low density lipoproteins. III. The role of antioxidants
104. Transfer and expression of recombinant nitric oxide synthase genes in the cardiovascular system
105. Measurement of nitric oxide in biological models
106. An electrochemical microprobe for detecting nitric oxide release in brain tissue
107. Nitric oxide release from a single cell measured in situ by a porphyrinic-based microsensor
108. Nitric oxide has a vasodilatory role in cat optic nerve head during flicker stimuli
109. Endogenous nitric oxide release required for long-term synaptic depression in the cerebellum
110. Layer-specific NO dependence of long-term potentiation and biased NO release in layer V in the rat auditory cortex
111. Tyrosine confounds xidative electrochemical detection of nitric oxide
112. Diffusion of nitric oxide in the aorta wall monitored in situ by porphyrinic microsensors
113. Vasomotion and spontaneous low frequency oscillations in blood flow and nitric oxide in cat optic nerve head
114. Investigating the role of nitric oxide in regulating blood flow and oxygen delivery from in vivo electrochemical measurements in eye and brain
115. 2 measurements in cat carotid body
116. Mechanism of increased vessel wall nitric oxide concentrations during intestinal absorption
117. Dependence of intestinal arteriolar regulation on flow-mediated nitric oxide formation
118. In vivo nitric oxide detection in the septic rat brain by electron paramagnetic resonance
119. Cerebellar nitric oxide is increased during isoflurane anesthesia compared to halothane anesthesia: A microdialysis study in rats