Immunophilin ligands as a novel treatment for neurological disorders

Trends in Pharmacological Sciences

Volumn 21, Issue 1, 2000, Pages 3-5

  Herdegen, Thomas ^a   Fischer, Gunter ^b   Gold, Bruce G ^c  

^a UNIVERSITY OF KIEL   (Germany)

^b MAX PLANCK RESEARCH UNIT FOR ENZYMOLOGY OF PROTEIN FOLDING   (Germany)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3,3 DIMETHYL 1,2 DIOXOPENTYL) 2 PYRROLIDINECARBOXYLIC ACID 3 (3 PYRIDYL)PROPYL ESTER; ADENINE; CAFFEINE; CALCINEURIN; CALCIUM ION; CIS TRANS ISOMERASE; COLLAGEN; CYCLOSPORIN A; EPIDERMAL GROWTH FACTOR RECEPTOR; FK 506 BINDING PROTEIN; HEAT SHOCK PROTEIN 90; IMMUNOPHILIN; LIGAND; NEUROPROTECTIVE AGENT; RYANODINE RECEPTOR; TACROLIMUS; TIMCODAR; UNCLASSIFIED DRUG; VX 853;

ANTIINFLAMMATORY ACTIVITY; BRAIN ISCHEMIA; CLINICAL TRIAL; CONFERENCE PAPER; DEGENERATIVE DISEASE; DIABETES MELLITUS; DIABETIC NEUROPATHY; HUMAN; LYMPHOCYTE DEPLETION; NERVE REGENERATION; NEUROLOGIC DISEASE; NEUROPROTECTION; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; HUMANS; IMMUNOPHILINS; LIGANDS; NERVOUS SYSTEM DISEASES; TACROLIMUS BINDING PROTEINS;

EID: 0033963487     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-6147(99)01407-8     Document Type: Conference Paper

References (9)

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8. Winter C.et al. The immunophilin-ligand FK506, but not GPI-1046, protects against neuronal death and inhibits c-Jun expression in substantia nigra pars compacta folllowing transection of the rat medial forebrain bundle. Neuroscience. 1999;. in press.
9. Martin-Villalba A.et al. CD95-Ligand (Fas-Ligand/APO-1L) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mediate ischemia-induced apoptosis in neurons. J. Neurosci. 19:1999;3809-3817.