Impact of mobility on structure-based drug design for the MMPs

Journal of the American Chemical Society

Volumn 124, Issue 43, 2002, Pages 12658-12659

  Moy, Franklin J ^a,b   Chanda, Pranab K ^a,b   Chen, James ^a,b   Cosmi, Scott ^a,b   Edris, Wade ^a,b   Levin, Jeremy I ^a,b   Rush, Thomas S ^a,b   Wilhelm, James ^a,b   Powers, Robert ^a,b  

^a PFIZER INC   (United States)

^b WYETH RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR;

ARTHRITIS; ARTICLE; CANCER; DRUG DESIGN; DRUG STRUCTURE; ENZYME ACTIVITY; NUCLEAR MAGNETIC RESONANCE; PROTEIN TARGETING;

EID: 0037202174     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja027391x     Document Type: Article

References (18)

1. Gubemator, K.; Boehm, H. J. Methods Princ. Med. Chem 1998, 6, 15-36.
2. Kubinyi, H. Curr. Opin. Drug Discovery Dev. 1998, 1, 4-15.
3. Gane, P. J.; Dean, P. M. Curr. Opin. Struct. Biol. 2000, 10, 401-404.
4. Joseph-McCarthy, D. Pharmacol. Ther. 1999, 84, 179-191.
5. Mihelich, E. D.; Schevitz, R. W. Biochim. Biophys. Acta 1999, 1441, 223-228.
6. Sintchak, M. D.; Nimmesgern, E. Immunopharmacology 2000, 47, 163-184.
7. Ajay, Murcko, M. A. J. Med. Chem. 1995, 38, 4953-67.
8. Baker, B. M.; Murphy, K. P. Methods Enzymol. 1998, 295, 294-315.
9. Moy, F. J.; Pisano, M. R.; Chanda, P. K.; Urbano, C.; Killar, L. M.; Sung, M.-L.; Powers, R. J. Biomol. NMR 1997, 10, 9-19.
10. Moy, F. J.; Chanda, P. K.; Cosmi, S.; Pisano, M. R.; Urbano, C.; Wilhelm, J.; Powers, R. Biochemistry 1998, 37, 1495-1504.
11. Moy, F. J.; Chanda, P. K.; Chen, J. M.; Cosmi, S.; Edris, W.; Levin, J. I.; Powers, R. J. Mol. Biol. 2000, 302, 671-689.
12. Lovejoy, B.; Welch, A. R.; Carr, S.; Luong, C.; Broka, C.; Hendricks, R. T.; Campbell, J. A.; Walker, K. A. M.; Martin, R.; Van Wart, H.; Browner, M. F. Nat. Struct. Biol. 1999, 6, 217-221.
13. Zhang, X.; Gonnella, N. C.; Koehn, J.; Pathak, N.; Ganu, V.; Melton, R.; Parker, D.; Hu, S.-I.; Nam, K.-Y. J. Mol. Biol. 2000, 301, 513-524.
14. Skiles, J. W.; Gonnella, N. C.; Jeng, A. Y. Curr. Med. Chem. 2001, 8, 425-474.
15. Zask, A.; Levin, J. I.; Killar, L. M.; Skotnicki, J. S. Curr. Pharm. Des. 1996, 2, 624-661.
16. Moy, F. J.; Chanda, P. K.; Chen, J. M.; Cosmi, S.; Edris, W.; Skotnicki, J. S.; Wilhelm, J.; Powers, R. Biochemistry 1999, 38, 7085-7096.
17. Chen, J. M.; Nelson, F. C.; Levin, J. I.; Mobilio, D.; Moy, F. J.; Nilakantan, R.; Zask, A.; Powers, R. J. Am. Chem. Soc. 2000, 122, 9648-9654.
18. Serrano, L.; Kellis, J. T., Jr.; Cann. P.; Matouschek, A.; Fersht, A. R. J. Mol. Biol. 1992, 224, 783-804.