Solution structure of the catalytic domain of human collagenase-3 (MMP-13) complexed to a potent non-peptidic sulfonamide inhibitor: Binding comparison with stromelysin-1 and collangenase-1

Journal of Molecular Biology

Volumn 301, Issue 2, 2000, Pages 513-524

  Zhang, Xiaolu ^a   Gonnella, Nina C ^a   Koehn, James ^a   Pathak, Naveen ^b   Ganu, Vishwas ^a   Melton, Richard ^a   Parker, David ^a   Hu, Shu Ih ^a   Nam, Ki Yean ^c  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b DSM RESOLVE   (Netherlands)

^c UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

Author keywords

Collagenase 3; Enzyme inhibitor complex; Matrix metalloproteinase; NMR structure; Sulfonamide inhibitor

Indexed keywords

CARBON 13; COLLAGENASE 3; ENZYME INHIBITOR; HYDROXAMIC ACID; MATRIX METALLOPROTEINASE; NITROGEN 15; PROTON; STROMELYSIN; SULFONAMIDE;

ARTICLE; CATALYSIS; ENZYME INHIBITOR COMPLEX; ENZYME STRUCTURE; HUMAN; ISOTOPE LABELING; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

EID: 0034636992     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.3988     Document Type: Article

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