Activation of PI 3-kinase by the hexosamine biosynthesis pathway

Molecular and Cellular Endocrinology

Volumn 194, Issue 1-2, 2002, Pages 29-37

  Filippis, Christine ^a   Filippis, Anthony ^a   Clark, Stella ^a   Proietto, Joseph ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Glucosamine; Insulin resistance; Protein kinase C (Rat adipocytes)

Indexed keywords

2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; GLUCOSAMINE; GLUCOSE; GLUCOSE TRANSPORTER 4; HEXOSAMINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN KINASE C DELTA; PROTEIN KINASE C EPSILON; PROTEIN KINASE C ZETA; WORTMANNIN; GLUCOSE TRANSPORTER; ISOENZYME; MUSCLE PROTEIN; PROTEIN KINASE C; SLC2A4 PROTEIN, RAT;

ADIPOCYTE; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; CELL FRACTIONATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GLUCOSE TRANSPORT; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; RAT; ANIMAL; DRUG EFFECT; ENZYMOLOGY; INSULIN RESISTANCE; METABOLISM; MICROSOME; PROTEIN TRANSPORT; SPRAGUE DAWLEY RAT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADIPOCYTES; ANIMALS; ENZYME ACTIVATION; GLUCOSAMINE; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; HEXOSAMINES; INSULIN RESISTANCE; ISOENZYMES; MALE; MICROSOMES; MONOSACCHARIDE TRANSPORT PROTEINS; MUSCLE PROTEINS; PROTEIN KINASE C; PROTEIN TRANSPORT; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0037200659     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(02)00213-7     Document Type: Article

References (51)

1. Amos A.F., McCarty D.J., Zimmet P. The rising global burden of diabetes and its complications: estimates and projections to the year 2010. Diabetes Med. 14:(Suppl. 5):1997;S1-S85.
2. Bandyopadhyay G., Standaert M.L., Galloway L., Moscat J., Farese R.V. Evidence for involvement of protein kinase C (PKC)-zeta and noninvolvement of diacylglycerol-sensitive PKC's in insulin-stimulated glucose transport in L6 myotubes. Endocrinology. 138:1997;4721-4731.
3. Bandyopadhyay G., Standaert M.L., Kikkawa U., Ono Y., Moscat J., Farese R.V. Effects of transiently expresses atypical (ζ, λ) conventional (α, β) and novel (δ, ε) protein kinase C isoforms on insulin-stimulated translocation of epitope-tagged GLUT4 glucose transporters in rat adipocytes: specific interchangeable effects of protein kinases C-ζ and C-λ Biochem. J. 337:1999;461-470.
4. Baron A.D., Zhu J.S., Weldon H., Maianu L., Garvey W.T. Glucosamine induces insulin resistance in vivo by affecting GLUT4 translocation in skeletal muscle. J. Clin. Invest. 96:1995;2792-2801.
5. Bradford M.M. A rapid and sensitive method for the quantification of microgram quantities of protein utilising the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
6. Braiman L., Alt A., Kuroki T., Ohba M., Bak A., Tennenhaum T., Sampson S.R. Protein kinase C-delta mediates insulin-induced glucose transport in primary cultures of rat skeletal muscle. Mol. Endocrinol. 13:1999;2002-2012.
7. Braiman L., Alt A., Kuroki T., Ohba M., Bak A., Tennenbaum T., Sampson S.R. Activation of protein kinase C ζ induces serine phosphorylation of Vamp2 in the GLUT4 compartment and increases glucose transport in skeletal muscle. Mol. Cell. Biol. 21:2001;7852-7861.
8. Burnette W.N. "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. Anal. Biochem. 112:1981;195-203.
9. Clark S.F., Martin S., Carozzi A.J., Hill M.M., James D.E. Intracellular localization of phosphatidylinositide 3-kinase and insulin receptor substrate-1 in adipocytes: potential involvement of a membrane skeleton. J. Cell. Biol. 140:1998;1211-1225.
10. Dadke S.S., Li H.C., Kusari A.B., Begum N., Kusari J. Elevated expression and activity of protein-tyrosine phosphatase 1B in skeletal muscle of insulin resistant type II diabetic goto-kakizaki rats. Biochem. Biophys. Res. Commun. 274:2000;583-589.
11. Davies S.P., Reddy H., Caivano M., Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 351:(1):2000;95-105.
12. Doering T.L., Masterson W.J., Englund P.T., Hart G.W. Biosynthesis of the glycosyl phosphatidylinositol membrane anchor of the trypanosome variant surface glycoprotein. Origin of the non-acetilated glucosamine. J. Biol. Chem. 264:1989;11168-11173.
13. Drake P.G., Posner B.I. Insulin receptor-associated protein tyrosine phosphatase(s): role in insulin action. Mol. Cell. Biochem. 182:1998;79-89.
14. Elchebly M., Payette P., Michaliszyn E., Cromlish W., Collins S., Lee Loy A., Normandin D. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science. 283:2000;1544-1548.
15. Filippis A., Clark S., Proietto J. Increased flux through the hexosamine biosynthesis pathway inhibits glucose transport acutely by activation of protein kinase C. Biochem. J. 324:1997;981-985.
16. Garvey W.T., Maianu L., Zhu J.H., Brechtel-Hook G., Wallace P., Baron A.D. Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance. J. Clin. Invest. 101:1998;2377-2386.
17. Goldstein B.J., Ahmad F., Ding W., Li P.M., Zhang W.R. Regulation of the insulin signaling pathway by cellular protein-tyrosine phosphatases. Mol. Cell. Biochem. 182:1998;91-99.
18. Goldstein B.J., Bittner-Kowalczyk A., White M.F., Harbeck M. Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adapter protein. J. Biol. Chem. 275:2000;4283-4289.
19. Hawkins M., Hu M., Yu J., Eder H., Vaguin P., She L., Barzilai N., Leiser M., Backer J.M., Rossetti L. Discordant effects of glucosamine on insulin-stimulated glucose metabolism and phosphatidylinostiol 3-kinase activity. J. Biol. Chem. 274:1999;31312-31319.
20. Ishizuka T., Yamamoto M., Kajita K., Nagashima T., Yasuda K., Miura K., Cooper D.R., Farese R.V. Insulin stimulates novel protein kinase C in rat adipocytes. Biochem. Biophys. Res. Commun. 183:1992;814-820.
21. Kang N., Alexander G., Park J.K., Maasch C., Buchwalow L., Luft F.C., Haller H. Differential expression of protein kinase C isoforms in streptozotocin-induced diabetic rats. Kidney Int. 56:1999;1737-1750.
22. Kapor-Drezgic J., Zhou X., Babazono T., Dlugosz J.A., Hohman T., Whiteside C. Effect of high glucose on mesangial cell protein kinase C-delta and -epsilon is polyol pathway-dependent. J. Am. Soc. Nephrol. 10:1999;1193-1203.
23. Kelada A.S.M., Macaulay S.L., Proietto J. Cyclic AMP acutely stimulates translocation of the major insulin-regulatable glucose transporter GLUT4. J. Biol. Chem. 267:1992;7021-7025.
24. Kessler A., Muller G., Wied S., Crecelius A., Eckel J. Signalling pathways of an insulin-mimetic phosphoinositol glycan-peptide in muscle and adipose tissue. Biochem. J. 330:1998;277-286.
25. Kikkawa R., Haneda M., Uzu T., Koya D., Sugimoto T., Shigeta Y. Translocation of protein kinase C alpha and zeta in rat glomerular mesangial cells cultured under high glucose conditions. Diabetologia. 37:1994;838-841.
26. Kim Y.-B., Zhu J.-S., Zierath J.R., Shen H.-Q., Baron A., Kahn B.B. Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/Protein kinase B in skeletal muscle. Diabetes. 48:1999;310-320.
27. Kolm-Litty V., Tippmer S., Haring H.U., Schleicher E. Glucosamine induces translocation of PKC isoenzymes in mesangial cells. Exp. Clin. Endocrinol. Diabetes. 106:1998;377-383.
28. Kuhne M.R., Zhao Z., Rowles J., Lavan B.E., Shen S.H., Fischer E.H., Lienhard G.E. Dephosphorylation of insulin receptor substrate 1 by the tyrosine phosphatase PTP2C. J. Biol. Chem. 269:1994;15833-15837.
29. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
30. Liu J.P. Protein kinase C and its substrates. Mol. Cell. Endocrinol. 116:1996;1-29.
31. Marette A., Dimitrakoudis D., Shi Q., Rodgers C.D., Klip A., Vranic M. Glucose rapidly decreases plasma membrane GLUT4 content in rat skeletal muscle. Endocrine. 10:1999;13-18.
32. Moriya S., Kazlauskas A., Akimoto K., Hirai S., Mizuno K., Takenawa T., Fulkui Y., Watanabe Y., Ozaki S., Ohno S. Platelet-derived growth factor activates protein kinase C epsilon through redundant and independent signaling pathways involving phospholipase C gamma or phosphatidylinositol 3-kinase. Proc. Natl. Acad. Sci. USA. 93:1996;151-155.
33. Nakanishi H., Brewer K.A., Exton J.H. Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 268:1993;13-16.
34. Napoli R., Hirshman M.F., Horton E.S. Mechanisms and time course of impaired muscle glucose transport activity in streptozotocin diabetic rats. J. Clin. Invest. 96:1995;427-437.
35. Nelson B.A., Robinson K., Buse M. High glucose and glucosamine induce insulin resistance via different mechanisms in 3T3-L1 adipocytes. Diabetes. 49:2000;981-991.
36. Patti M.-E., Virkamaki A., Landaker E.J., Kahn R., Yki-Jarvinen H. Activation of the hexosamine biosynthesis pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle. Diabetes. 48:1999;1562-1571.
37. Pick A., Clark J., Kubstrup C., Levisetti M., Pugh W., Bonner-Weir S., Polonsky K.S. Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat. Diabetes. 47:1998;358-364.
38. Rodbell M. Metabolism of isolated fat cells. J. Biol. Chem. 239:1964;375-380.
39. Saltiel A.R. Second messengers of insulin action. Diabetes Care. 13:1990;244-256.
40. Shafrir E., Ziv E., Mosthaf L. Nutritionally induced insulin resistance and receptor defect leading to beta-cell failure in animal models. Ann. N.Y. Acad. Sci. 892:1999;223-246.
41. Standaert M.L., Galloway L., Karnam P., Bandyopadhyay G., Moscat J., Farese R.V. Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport. J. Biol. Chem. 272:1997;30075-30082.
42. Standaert M., Bandyopadhyay G., Galloway L., Ono Y., Mukai H., Fareae R. Comparative effects of GTPgammaS and insulin on the activation of Rho, phosphatidylinositol 3-kinase, and protein kinase N in rat adipocytes. Relationship to glucose transport. J. Biol. Chem. 273:1998;7470-7477.
43. Standaert M.L., Bandyopadhyay G., Perez L., Price D., Galloway L., Poklepovic A., Sajan M.P., Cenni V., Sirri A., Moscat J., Toker A., Farese R.V. Insulin activates protein kinases C-zeta and C-lambda by an autophosphorylation-dependent mechanism and stimulates their translocation to GLUT4 vesicles and other membrane fractions in rat adipocytes. J. Biol. Chem. 274:1999a;25308-25316.
44. Standaert M.L., Bandyopadhyay G., Sajan M.P., Cong L., Quon M.J., Farese R.V. Okadaic acid activates atypical protein kinase C (zeta/lambda) in rat and 3T3/L1 adipocytes. An apparent requirement for activation of Glut4 translocation and glucose transport. J. Biol. Chem. 274:1999b;14074-14078.
45. Storlien L.H., Jenkins A.B., Chisholm D.J., Pascoe W.S., Khouri S., Kraegen E.W. Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid. Diabetes. 40:1991;280-289.
46. Towbin H., Staehelin T., Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA. 76:1979;4350-4354.
47. Traxinger R.R., Marshall S. Role of amino acids in modulating glucose-induced desensitisation of the glucose transport system. J. Biol. Chem. 264:1989;20910-20916.
48. Uysal K.T., Scheja L., Wiesbrock S.M., Bonner-Weir S., Hotamisligil G.S. Improved glucose and lipid metabolism in genetically obese mice lacking aP2. Endocrinology. 141:2000;3388-3396.
49. Whitman M., Downes C.P., Keeler M., Cantley L. Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate. Nature. 332:1988;644-646.
50. Yamada K., Avignon A., Standaert M.L., Cooper D.R., Spencer B., Farese R.V. Effects of insulin on the translocation of protein kinase C-theta and other protein kinase C isoforms in rat skeletal muscles. Biochem. J. 308:(1):1995;177-180.
51. Zisman A., Peroni O.D., Abel E.D., Michael M.D., Mauvais-Jarvis F., Lowell B.B., Wojtaszewski J.F., Hirshman M.F., Viramaki A., Goodyear L.J., Kahn C.R., Kahn B.B. Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nat. Med. 6:2000;924-928.